公开(公告)号：US12226552B2

公开(公告)日：2025-02-18

申请号：US17038171

申请日：2020-09-30

Applicant: Surmodics, Inc.

Inventor： Joram Slager

IPC: A61L31/04 ,  A61L31/10 ,  A61L31/16

Abstract: Embodiments herein relate to active agent depots formed in situ and related methods. In various embodiments, a method of forming an active agent depot in situ is included. The method can include contacting a composition with a vessel wall, wherein the composition includes an active agent and a fibrin promoting vessel wall transfer agent wherein the ratio of active agent to fibrin promoting vessel wall transfer agent (wt./wt.) is at least 5:1. The method also includes transferring the composition from a device surface to the vessel wall surface. The method also includes forming a fibrin matrix around the composition. Other embodiments are also included herein.

公开(公告)号：US11529440B2

公开(公告)日：2022-12-20

申请号：US16847272

申请日：2020-04-13

Applicant: Surmodics, Inc.

Inventor： Joram Slager ,  Toni M. Heyer ,  David E. Babcock

IPC: A61L29/08 ,  A61L29/16 ,  A61L29/14 ,  A61K31/337 ,  A61K31/713 ,  A61K47/34 ,  A61M25/10 ,  C12N15/113 ,  A61K9/50

Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.

公开(公告)号：US09999675B2

公开(公告)日：2018-06-19

申请号：US15357496

申请日：2016-11-21

Applicant: Surmodics, Inc.

Inventor： Joseph Ventura ,  Shannon Wadman ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

IPC: A61K31/337 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61K9/08 ,  A61K9/00

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/337 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/416 ,  A61L2300/63 ,  A61L2400/06 ,  C08L79/02

Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.

公开(公告)号：US09949957B2

公开(公告)日：2018-04-24

申请号：US15262465

申请日：2016-09-12

Applicant: Surmodics, Inc.

Inventor： Joram Slager

IPC: A61K31/436 ,  A61K9/00 ,  A61K9/107 ,  A61K9/19 ,  A61K9/51 ,  A61L29/08 ,  A61L29/16 ,  A61K9/14 ,  A61K9/16

CPC classification number: A61K31/436 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/145 ,  A61K9/1688 ,  A61K9/19 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5146 ,  A61L29/085 ,  A61L29/16 ,  Y02A50/402 ,  Y02A50/478 ,  Y10T428/2982

Abstract: The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 μm to 10 μm, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.

公开(公告)号：US09155671B2

公开(公告)日：2015-10-13

申请号：US14055654

申请日：2013-10-16

Applicant: SurModics, Inc.

Inventor： Shawn Fuller ,  Bryan A. Claseman ,  Joram Slager ,  Jeffrey J. Missling ,  Gary Maharaj ,  Gary W. Opperman ,  Nathan Lockwood ,  Robert W. Hergenrother ,  Charles Olson

IPC: A61F13/00 ,  A61F13/84 ,  A61L15/22 ,  A61L15/44 ,  A61L15/60

CPC classification number: A61F13/00068 ,  A61F13/00021 ,  A61F13/00029 ,  A61F13/8405 ,  A61F2013/00153 ,  A61F2013/00327 ,  A61F2013/00331 ,  A61F2013/00357 ,  A61F2013/00557 ,  A61L15/22 ,  A61L15/44 ,  A61L15/60 ,  A61L2300/102 ,  A61L2300/208

Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.

Abstract translation: 本发明的实施例包括伤口包装装置及其制造和使用方法。 在一个实施方案中，本发明包括包含能够吸收渗出物的多个间隔元件的伤口包装装置，其中间隔元件的表面抵抗微生物的定居。 卷绕包装装置还可以包括将多个间隔元件彼此连接的连接器。 本文还包括其它实施例。

公开(公告)号：US20230338623A1

公开(公告)日：2023-10-26

申请号：US18139125

申请日：2023-04-25

Applicant: Surmodics, Inc.

Inventor： Joram Slager ,  Michael Schneider ,  Sedef Piril Ertem ,  Travis Lemke ,  Ralph A. Chappa

IPC: A61L29/16 ,  A61L29/08

CPC classification number: A61L29/16 ,  A61L29/085 ,  A61L2300/216 ,  A61L2300/802 ,  A61L2300/416

Abstract: Embodiments herein relate to medical devices and coatings for the same. In an embodiment, a drug delivery coating can be included having a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The drug delivery coating can also include an active agent layer disposed over the polymeric layer. The active agent layer can include a microcrystalline active agent and a cationic agent. Other embodiments are also included herein.

公开(公告)号：US11712545B2

公开(公告)日：2023-08-01

申请号：US15704765

申请日：2017-09-14

Applicant: SURMODICS, Inc.

Inventor： Amy Trocke ,  Gregg Sutton ,  Joram Slager

IPC: A61M25/10 ,  A61M25/06 ,  A61M25/00 ,  A61M39/06

CPC classification number: A61M25/1002 ,  A61M25/0668 ,  A61M25/0097 ,  A61M39/06 ,  A61M2025/1004 ,  A61M2025/105 ,  A61M2025/1079 ,  A61M2025/1081 ,  A61M2205/6081

Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body, and that can provide advantages in terms of balloon insertion, safety, and drug delivery. The insertion tool includes a tubular portion that accommodates a balloon portion of a balloon catheter, and one or more separation margin(s) in the wall of the tubular portion or one or more split(s) in the tubular wall. The insertion tool also includes a proximal tab that extends from a second lengthwise half having a portion at an angle skew to the lengthwise axis, or that is in the form of a solid article comprising a concave surface that is fastened to an outer surface of the second lengthwise half of the tubular portion; or first and second tabs that extend from first and second lengthwise halves of the tubular portion, respectively.

公开(公告)号：US11174447B2

公开(公告)日：2021-11-16

申请号：US16505145

申请日：2019-07-08

Applicant: Surmodics, Inc.

Inventor： David E. Babcock ,  Joram Slager ,  Robert W. Hergenrother

IPC: B32B27/30 ,  A61L27/34 ,  A61L27/28 ,  A61L31/10 ,  A61L31/08 ,  A61L29/08 ,  C10M107/26 ,  C10M107/46 ,  C10M107/42 ,  A61M25/10 ,  B32B27/00 ,  C10N40/00 ,  C10N50/08

Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.

公开(公告)号：US10806904B2

公开(公告)日：2020-10-20

申请号：US15467554

申请日：2017-03-23

Applicant: Surmodics, Inc.

Inventor： Bruce M. Jelle ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Nathan A. Lockwood

IPC: A61M25/06 ,  A61M25/00 ,  A61M39/06

Abstract: Embodiments herein include an insertion tool for inserting a medical device into another medical device, such as a hemostasis sealing valve, and related methods. In an embodiment, an insertion tool includes a guide sheath and a protection tube. The guide sheath can include a flared proximal end. The guide sheath can further include a central lumen. The guide sheath can further include a locking notch disposed on the inner surface between the proximal end and the distal end. The protection tube can include a flared proximal end. A portion of the protection tube can be situated within the central lumen of the guide sheath. The flared proximal end of the protection tube can be sized to fit within the locking notch and can have an outer diameter larger than portions of the inner surface immediately adjacent to the locking notch. Other embodiments are also included herein.

公开(公告)号：US10342898B2

公开(公告)日：2019-07-09

申请号：US15375442

申请日：2016-12-12

Applicant: Surmodics, Inc.

Inventor： David E. Babcock ,  Joram Slager ,  Robert W. Hergenrother

IPC: B05D7/02 ,  B05D5/08 ,  B05D1/18 ,  A61L29/14 ,  A61L29/08 ,  B05D3/00 ,  B05D3/06 ,  B05D7/00

Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.