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公开(公告)号：US07440794B2
公开(公告)日：2008-10-21
申请号：US11037282
申请日：2005-01-19
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译： 在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置 在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。 光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在 信号一次。
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公开(公告)号：US07359825B2
公开(公告)日：2008-04-15
申请号：US11378448
申请日：2006-03-20
IPC分类号： G01C17/00
CPC分类号： G01N21/49 , A61B5/0042 , A61B5/14553 , A61B5/7435
摘要： In order to provide an optical measurement system and an optical measurement method which is suitable for optically measuring a body to be inspected and easily obtaining an image of a desired item based on information obtained by the measurement, an optical measurement method including an initial display process for selectively instructing any one of selection of optical measurement, analysis of said optical measurement result and completion of a program; a process for inputting items of condition including a measurement mode; a process for displaying a light irradiation position and a light detection position and a state expressing measurement position relationship together with said mode; a process for instructing to form a file for storing said optical measurement result; a process for instructing a measurement condition to detect light signals from the inside of a body to be inspected which is irradiated by a multi-wavelength multi-channel; and a process for displaying said signals for each channel detected according to said instructed result.
摘要翻译： 为了提供一种光学测量系统和光学测量方法，该光学测量系统和光学测量方法适合于光学测量待检查的物体，并且基于通过测量获得的信息容易地获得期望项目的图像，包括初始显示处理 用于选择性地指示光学测量的选择，所述光学测量结果的分析和程序的完成中的任何一个; 用于输入包括测量模式的条件项目的处理; 用于显示光照射位置和光检测位置以及表示测量位置关系的状态与所述模式的过程; 用于指示形成用于存储所述光学测量结果的文件的处理; 用于指示测量条件从多波长多通道照射的被检体的内部检测光信号的处理; 以及用于显示根据所述指示结果检测的每个通道的所述信号的处理。
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公开(公告)号：US20070135694A1
公开(公告)日：2007-06-14
申请号：US10577944
申请日：2004-07-01
申请人： Hiroki Sato , Massashi Kiguchi , Atsushi Maki , Tsuyoshi Yamamoto
发明人： Hiroki Sato , Massashi Kiguchi , Atsushi Maki , Tsuyoshi Yamamoto
IPC分类号： A61B5/00
CPC分类号： A61B5/14553
摘要： To control information obtained from inside of a living body with higher precision as compared to that in the conventional technology by controlling a ratio of intensities of light, directed to a trial body, in a plurality of wavelength ranges different in peak wavelength from each other, a measurement error included in information obtained from the living body can be controlled by changing a ratio of intensity of the light in the first wavelength range against that of the light in the second wavelength range. When intensity of irradiated light is limited from the viewpoint of safety to the trial subject, by keeping a ratio of the light irradiated to the trial body in the first wavelength range against that of the light in the second wavelength range under a prespecified value and also by changing the ratio of irradiated light intensities under the prespecified value, a measurement error included in information obtained from the living body can be controlled.
摘要翻译： 通过在峰值波长不同的多个波长范围内控制指向试验体的光的强度比，通过控制比现有技术更高的精度从内部获得的生物体的信息， 可以通过改变第一波长范围内的光的强度与第二波长范围内的光的强度的比例来控制从生物体获得的信息中包括的测量误差。 当照射光的强度从安全性的角度受限于试验对象时，通过将照射到试验体的光在第一波长范围内的光与第二波长范围内的光的比例保持在规定值，并且还 通过改变预定值下的照射光强度的比率，可以控制从活体获得的信息中包括的测量误差。
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公开(公告)号：US20060241361A1
公开(公告)日：2006-10-26
申请号：US11348441
申请日：2006-02-07
申请人： Akiko Obata , Atsushi Maki , Kanehisa Morimoto
发明人： Akiko Obata , Atsushi Maki , Kanehisa Morimoto
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/7264
摘要： There is provided a living body light measuring device capable of monitoring a time curve of a blood substance concentration as time curves of parameters of a signal waveform and judging or analyzing characteristic traits of a subject relevant to the parameters of the signal waveform, wherein a signal processor extracts parameters such as a peak value and latency from a hemoglobin signal waveform measured before and after substance intake of a testee, and generates and displays a time curve graph having a parameter and time respectively as its ordinate and abscissa. Influence of an intake substance upon blood component concentrations and blood flow can be monitored by monitoring the time curves of parameters of the signal waveform. A category processor classifies measurement data into categories, analyzes time curves of a plurality of parameters every category, and displays a result on a result viewer.
摘要翻译： 本发明提供一种生物体光测定装置，其能够将血液物质浓度的时间曲线作为信号波形的参数的时间曲线进行监视，并且判断或分析与信号波形的参数相关的被检体的特征特征，其中，信号 处理器从被测者的物质摄取之前和之后测量的血红蛋白信号波形提取诸如峰值和延迟的参数，并且生成并显示具有参数和时间的时间曲线图作为其纵坐标和横坐标。 摄入物质对血液成分浓度和血流量的影响可通过监测信号波形参数的时间曲线来监测。 类别处理器将测量数据分类，分析每个类别的多个参数的时间曲线，并在结果查看器上显示结果。
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公开(公告)号：US07072700B2
公开(公告)日：2006-07-04
申请号：US10148991
申请日：2000-11-29
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Michiyuki Fujiwara , Mikihiro Kaga
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Michiyuki Fujiwara , Mikihiro Kaga
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/0059 , A61B5/0261 , A61B5/14553 , A61B2562/0233 , A61B2562/046
摘要： The invention provides a biological photometric device characterized by a method of disposing a light source and a light detector, capable of measuring a distribution of concentrations at different depths and changes in the concentration in the case of measuring and forming an image of the concentration of metabolites in an organ and changes in the concentration. The light sources and light detectors are disposed on the subject so that, in the case of measuring a concentration of metabolites in an organ and changes in the concentration in a shallow portion in the subject by using an about midpoint position between each of the light sources and each of the light detectors as a sampling point, measurement is performed by using a sampling point of a pair of the light source and said light detector which are disposed at a small interval. In the case of measurement in a deep portion in the subject, a sampling point of a pair of the light source and the light detector which are disposed at a large interval is used.
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公开(公告)号：US07047149B1
公开(公告)日：2006-05-16
申请号：US09674008
申请日：1999-04-26
IPC分类号： G01C17/00
CPC分类号： G01N21/49 , A61B5/0042 , A61B5/14553 , A61B5/7435
摘要： An optical measurement system for optically measuring a body to be inspected and obtaining an image of a desired item based on information obtained by the measurement includes means for displaying a number of measurement points, means for indicating a light irradiation position and a light detecting position and means for displaying a measurement position and a state of allocating a number to the measurement position. The system further includes means for displaying measuring time sequence data, means for setting a condition of acquiring data, means for displaying a status of acquiring the data, means for instructing control of measurement and means for marking a mark at a position measuring time sequence data.
摘要翻译： 一种光学测量系统，用于光学测量待检查的物体，并且基于通过测量获得的信息获得期望项目的图像，包括显示多个测量点的装置，用于指示光照射位置和光检测位置的装置，以及 用于显示测量位置和向测量位置分配数字的状态的装置。 该系统还包括用于显示测量时间序列数据的装置，用于设置获取数据的条件的装置，用于显示获取数据的状态的装置，用于指示测量的控制的装置和用于在测量时间序列数据的位置处标记标记的装置 。
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公开(公告)号：US06907279B2
公开(公告)日：2005-06-14
申请号：US10452052
申请日：2003-06-03
申请人： Hiroki Sato , Atsushi Maki , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Masashi Kiguchi
IPC分类号： G01N21/17 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B10/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/7264 , A61B2562/0233 , A61B2562/046
摘要： The invention provides optical technique for measuring metabolism in a living body that can further reduce an error in measurement even if distance between irradiation and detection is fixed. The living body is classified into measurement regions and different measuring wavelengths are set according to the classification. For example, the head is classified into four regions of a parietal region, a frontal region, a temporal region and an occipital region and a wavelength according to each tissue is set in a wavelength selecting system. In measurement, wavelengths according to each measurement region are selected by multiple wavelengths-light radiating means. Besides, for a region having large personal difference, premeasurement is made using plural combinations of wavelengths and wavelengths are selected using a calculated error in measurement as a criterion.
摘要翻译： 本发明提供了用于测量生物体内新陈代谢的光学技术，即使照射和检测之间的距离固定也能进一步降低测量误差。 将生物体分为测量区域，根据分类设置不同的测量波长。 例如，在波长选择系统中设置头部分为顶叶区域，正面区域，时间区域和枕骨区域的四个区域，并且根据每个组织设置波长。 在测量中，根据每个测量区域的波长由多个波长 - 光辐射装置选择。 此外，对于具有大的个人差异的区域，使用多个波长组合进行预测量，并且使用计算的测量误差作为标准来选择波长。
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公开(公告)号：US06901284B1
公开(公告)日：2005-05-31
申请号：US09913323
申请日：2000-02-18
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/7445 , A61B2562/0233 , A61B2562/046
摘要： An optical measuring apparatus for optically measuring a sample includes a plurality of parts for applying light beams to the sample, a plurality of detecting parts for detecting light beams from the light applying parts which come through the sample, a memory part which receives signals from the detecting parts, converts them into digital signals and stores the digital signals as measuring positions between the light applying part and the light detecting part. Further, there is provided a first display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts on the sample, and a second display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts which are shown on the first display part.
摘要翻译： 用于光学测量样品的光学测量装置包括用于向样品施加光束的多个部件，用于检测来自样品的光施加部分的光束的多个检测部分， 检测部件将它们转换为数字信号，并将数字信号存储在光施加部分和光检测部分之间的测量位置。 此外，提供了示出样品上的位置与样品上检测部位的位置对应的测量位置之间的关系的第一显示部分和示出样品和测量位置之间的关系的第二显示部分 对应于在第一显示部分上示出的检测部件的位置。
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49.发明授权Optical measurement equipment and recording medium and optical measurement method 有权光学测量设备及记录介质及光学测量方法公开(公告)号：US06542763B1
公开(公告)日：2003-04-01
申请号：US09697327
申请日：2000-10-27
IPC分类号： A61B500
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B2562/02 , A61B2562/0233 , A61B2562/046
摘要： In a system for performing imaging measurement of a test object by mounting many optical fibers to the test object, incident positions of the test object on which to illuminate light, detection positions of the test object from which to detect light and measurement positions which are determined from a positional relationship between the incident positions and the detection positions are displayed as graphic elements on a display unit. A state of detection signal level or a change in the state is displayed as a change in color or in pattern of the graphic element. Further, incident optical fibers for illuminating light to the test object and detection optical fibers for detecting light from the test object are mounted to the test object, and light emitting elements are mounted to probes to be mounted to the test object and interlocked with the change of the graphic elements.
摘要翻译： 在用于通过将许多光纤安装到测试对象上来进行测试对象的成像测量的系统中，用于照亮光的测试对象的入射位置，检测光的测试对象的检测位置和确定的测量位置 根据入射位置与检测位置之间的位置关系在显示单元上显示为图形元素。 检测信号电平状态或状态变化被显示为图形元素的颜色或图案的变化。 此外，将用于向测试对象照射光的入射光纤和用于检测来自测试对象的光的检测光纤安装在测试对象上，并且将发光元件安装到要安装到测试对象上的探针并与变化互锁 的图形元素。
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50.发明授权Optical computed tomography equipment having image inverting optical device 失效具有图像反转光学装置的光学计算机断层摄影设备
公开(公告)号：US5408093A
公开(公告)日：1995-04-18
申请号：US204370
申请日：1994-03-11
CPC分类号： A61B5/0073
摘要： Optical computed tomography equipment adapted to speed up the scanning of a subject under test using irradiated light so as to shorten the measuring time involved. The light from a light source (15-1, 15-2) is guided over an optical fiber thread (12-5c) to an image inverting optical system comprising a dovetail prism (13-1) and two lenses (14-2, 14-1). Past the optical system, the light enters one of the threads making up an optical fiber (12-1). As the dovetail prism (13-1) is rotated around its optical axis, the light from the optical fiber thread (12-5c) consecutively enters different threads of the optical fiber (12-1), causing the irradiation position to scan a subject (11) of the test. The incident light, having passed through the subject (11) in various directions, goes through the respective threads of the optical fiber (12-1) to reach the image inverting optical device. From there, the light enters the corresponding threads of an optical fiber (12-4) and is detected by photo detectors (16-2a, 16-2b, etc.).
摘要翻译： PCT No.PCT / JP93 / 01220 Sec。 371日期：1994年3月11日 102（e）1994年3月11日PCT 1993年8月30日PCT公布。 公开号WO94 / 05209 日期：1994年3月17日。光学计算机断层摄影设备适用于使用照射光加速对受试者的扫描，以缩短测量时间。 来自光源（15-1,15-2）的光被引导到光纤线（12-5c）上，到包括燕尾棱镜（13-1）和两个透镜（14-2）的图像反转光学系统， 14-1）。 通过光学系统，光进入组成光纤的线之一（12-1）。 当燕尾棱镜（13-1）围绕其光轴旋转时，来自光纤线（12-5c）的光连续地进入光纤（12-1）的不同螺纹，使得照射位置扫描对象 （11）的测试。 已经穿过被摄体（11）的各个方向的入射光穿过光纤（12-1）的各个螺纹，到达图像反转光学装置。 从那里，光进入光纤（12-4）的相应螺纹，并由光电检测器（16-2a，16-2b等）检测。
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