公开(公告)号：US20050077176A1

公开(公告)日：2005-04-14

申请号：US10624795

申请日：2003-07-22

申请人： Alastair Hodges ,  Thomas Beck ,  Oddvar Johansen

发明人： Alastair Hodges ,  Thomas Beck ,  Oddvar Johansen

IPC分类号： C12Q1/00 ,  G01N27/327 ,  G01N27/49 ,  G01N27/26

CPC分类号： G01N27/403 ,  C12Q1/004 ,  G01N27/3272 ,  G01N27/3273 ,  Y10T29/49117

摘要： This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.

公开(公告)号：US20050048679A1

公开(公告)日：2005-03-03

申请号：US10835181

申请日：2004-04-29

申请人： Christian Krueger ,  Thomas Feudel ,  Aranka Kern ,  Thomas Beck

发明人： Christian Krueger ,  Thomas Feudel ,  Aranka Kern ,  Thomas Beck

IPC分类号： H01J37/317 ,  H01L21/00

CPC分类号： H01J37/3171 ,  H01J2237/31703

摘要： By significantly suppressing or eliminating the channeling effects during implantation of a dopant species into the semiconductor region, the contribution of energy contamination may be studied and the corresponding results may be used in selecting appropriate tool settings for an actual implantation process. In this way, the vertical dopant profile may be controlled more precisely than in conventional processes. In one particular embodiment, the channeling effect is suppressed by an appropriately performed amorphization implantation process.

摘要翻译： 通过显着地抑制或消除将掺杂剂物质注入半导体区域期间的沟道效应，可以研究能量污染的贡献，并且相应的结果可用于为实际的注入工艺选择合适的工具设置。 以这种方式，可以比常规方法更精确地控制垂直掺杂剂分布。 在一个具体实施例中，通过适当地进行的非晶化注入工艺来抑制沟道效应。

公开(公告)号：US20050011748A1

公开(公告)日：2005-01-20

申请号：US10487817

申请日：2002-08-22

申请人： Thomas Beck ,  Alexander Schattke ,  Sascha Henke ,  Veit Schier

发明人： Thomas Beck ,  Alexander Schattke ,  Sascha Henke ,  Veit Schier

IPC分类号： B23B51/00 ,  B23B27/14 ,  B23P15/28 ,  C23C14/06 ,  C23C14/34 ,  C23C14/35 ,  H05H1/10 ,  C23C14/32

CPC分类号： C23C14/354 ,  C23C14/06 ,  C23C14/352 ,  Y10T428/25 ,  Y10T428/252 ,  Y10T428/30

摘要： A method for producing a nanostructured, in particular a ceramic-like functional coating on a substrate is described. To that end, using at least one plasma source, a pulsed plasma is produced with which a matrix phase and at least one nano-scale interstitial phase embedded in it are deposited on the substrate via a material input. Preferably a plurality of pulsed plasma sources that are time-correlated or synchronized with each other are used. Also proposed is a nanostructured functional coating, in particular one producible by this method, which is free of chlorine and/or sulfur, and which contains at least one metal and/or at least one element selected from the group oxygen, hydrogen, nitrogen, carbon, helium, argon or neon.

摘要翻译： 描述了在衬底上制造纳米结构的材料，特别是陶瓷状功能涂层的方法。 为此，使用至少一个等离子体源，产生脉冲等离子体，通过该脉冲等离子体通过材料输入将基质相和嵌入其中的至少一个纳米级间隙相沉积在基底上。 优选使用彼此时间相关或同步的多个脉冲等离子体源。 还提出了一种纳米结构功能涂层，特别是可通过该方法生产的，其不含氯和/或硫，并且其包含至少一种金属和/或至少一种选自氧，氢，氮， 碳，氦，氩或氖。

公开(公告)号：US5231172A

公开(公告)日：1993-07-27

申请号：US964516

申请日：1992-10-21

申请人： Thomas Beck ,  Werner H. Russ ,  Wilhelm Muhlig

发明人： Thomas Beck ,  Werner H. Russ ,  Wilhelm Muhlig

IPC分类号： C09B62/503 ,  C09B62/505 ,  C09B62/51 ,  C09B62/513 ,  C09B62/515 ,  C09B62/517 ,  D06P3/14 ,  D06P3/24 ,  D06P3/66

CPC分类号： C09B62/503

摘要： There are described water-soluble fiber-reactive dye-stuffs which possess a triazinylamino radical to which is bonded as second substituent an amino group or an N-containing heterocyclic group which, bonded via an arylene, alkylene or aralkyl radical, possesses a fiber-reactive grouping of the vinyl sulfone series, and to which is bonded as third substituent a sulfonamide group, wherein the sulfone radical is substituted by optionally substituted aryl, alkylenearyl or arylenealkyl or optionally substituted amino groups.The dyestuffs are used for dyeing hydroxy - and/or carboxamido-containing material, in particular fiber material, such as cellulose fibers, wool and synthetic polyamide.

摘要翻译： 描述了具有作为第二取代基键合的三嗪基氨基的水溶性纤维反应性染料，氨基或含氮杂环基，其通过亚芳基，亚烷基或芳烷基键合，具有纤维 - 乙烯基砜系列的反应性分组，并且作为第三取代基与磺酰胺基团键合，其中砜基被任选取代的芳基，亚烷基硬脂基或亚芳基烷基或任选取代的氨基取代。 染料用于染色含羟基和/或羧酰胺的材料，特别是纤维材料，如纤维素纤维，羊毛和合成聚酰胺。

公开(公告)号：US08712132B2

公开(公告)日：2014-04-29

申请号：US13092999

申请日：2011-04-25

申请人： Miriam Bauer ,  Thomas Beck ,  Dominik Bernhardt ,  Christina Biermann

发明人： Miriam Bauer ,  Thomas Beck ,  Dominik Bernhardt ,  Christina Biermann

IPC分类号： G06K9/00

CPC分类号： A61B6/504 ,  A61B5/055 ,  A61B6/03 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/487 ,  A61B6/5235 ,  A61B6/5247 ,  G06F19/00 ,  G06T7/12 ,  G06T7/149 ,  G06T7/33 ,  G06T2207/10081 ,  G06T2207/30101 ,  G16H50/20 ,  G16H50/50

摘要： A method and a computer system are disclosed for automatic vectorization of the profile of a vessel tree and at least one of its properties on the basis of tomographic images of an examined patient. In at least one embodiment, using previously established location probabilities of landmarks in the vessel tree, there is an automatic determination of a plurality of distinctive landmarks in the current tomographic image data record of the patient, a registration of the current tomographic image data record to the statistical vessel model, an automatic determination of previously unidentified landmarks in the registered tomographic image data record using characteristic identification features of the previously unidentified landmarks from the statistical vessel model and the statistical location probability thereof, and a determination of at least one current vessel model using the identified landmarks and at least one vessel property at and/or between the identified landmarks.

摘要翻译： 公开了一种方法和计算机系统，用于基于检查的患者的断层图像自动矢量化血管树的轮廓和其属性中的至少一个。 在至少一个实施例中，使用先前建立的血管树中的地标的位置概率，存在对患者的当前断层图像数据记录中的多个独特地标的自动确定，将当前断层图像数据记录登记到 统计血管模型，使用来自统计血管模型的先前未识别的地标的特征识别特征及其统计位置概率来自动确定登记的断层图像数据记录中的先前未识别的地标，以及确定至少一个当前血管模型 在所识别的地标之间和/或之间使用所识别的地标和至少一个船只属性。

公开(公告)号：US08704128B2

公开(公告)日：2014-04-22

申请号：US14062205

申请日：2013-10-24

申请人： Thomas Beck ,  Nigel-Philip Cox ,  Silke Settegast

发明人： Thomas Beck ,  Nigel-Philip Cox ,  Silke Settegast

IPC分类号： F01D5/18 ,  B23K15/08 ,  B23K26/36

CPC分类号： B23K15/085 ,  B23K26/384 ,  B23K26/389 ,  B23K2101/001 ,  F01D5/186 ,  F05D2230/13 ,  Y02T50/67 ,  Y02T50/676 ,  Y10T29/49341

摘要： There are a multiplicity of methods of making through-holes. In particular in the production of a multiplicity of film-cooling holes, as in gas turbine blades or combustion chamber elements, small time advantages are also important when making a hole. The method according to the invention, to make the hole close to the final contour in each case in sections in a top and a bottom region in order to then produce the final contour with other laser parameters, achieves time advantages.

摘要翻译： 有多种形成通孔的方法。 特别是在制造多个薄膜冷却孔时，如在燃气轮机叶片或燃烧室元件中，小的时间优点在制造孔时也是重要的。 根据本发明的方法，为了使其在顶部和底部区域中的每一种情况下，使得孔接近于最终轮廓，以便随后用其他激光参数产生最终轮廓，这实现了时间优点。

公开(公告)号：US08292584B2

公开(公告)日：2012-10-23

申请号：US13214468

申请日：2011-08-22

申请人： Thomas Beck ,  Silke Settegast

发明人： Thomas Beck ,  Silke Settegast

IPC分类号： F01D5/18

CPC分类号： F01D5/186 ,  F01D5/286 ,  F01D5/288 ,  F05D2230/90 ,  F05D2250/324 ,  F05D2300/13 ,  F05D2300/21 ,  F23R3/04 ,  F23R2900/03042 ,  Y02T50/67 ,  Y02T50/676

摘要： Conventionally coated components with film cooling holes are known, comprising a diffuser, extending through the layers into the substrate. According to the invention, the component is embodied such that the whole diffuser is largely arranged in the layer.

公开(公告)号：US20120093720A1

公开(公告)日：2012-04-19

申请号：US13274093

申请日：2011-10-14

申请人： Robert Jones ,  Thomas Beck

发明人： Robert Jones ,  Thomas Beck

IPC分类号： A61K49/00 ,  A61K51/06 ,  C08G65/34

CPC分类号： A61K49/0002 ,  A61K51/06 ,  A61K51/1244 ,  C08G65/329 ,  C08L71/02 ,  C08L2203/02

摘要： The invention described herein provides biocompatible molecularly imprinted polymers (MIPs) that are non-toxic, water soluble, small molecular weight, and degradable in a living body. The MIPs are capable of binding to all or a portion of a specific target macromolecule associated with a disease located within the living body and they are derivatized for stealth for in vivo applications to avoid the reticuloendothelial system. The MIPs of the invention are functionalized to an amine or carboxyl group and are derivatized with an imaging and/or therapeutic agent for taking images of the disease and/or for providing therapy. The macromolecule can be selected from a group consisting of proteins, glycoproteins, lipoproteins, peptidoglycans, peptides, polypeptides, polynucleotides, and polysaccharides. The invention described herein also provides methods and kits wherein MIPs of the invention can be employed as targeted imaging and therapeutic agents.

摘要翻译： 本文描述的本发明提供了生物相容性分子印迹聚合物（MIP），其在生物体中是无毒的，水溶性的，小分子量的和可降解的。 MIP能够结合与位于生物体内的疾病相关的特定目标大分子的全部或一部分，并且它们被衍生化用于隐形以用于体内应用以避免网状内皮系统。 本发明的MIP被官能化为胺或羧基，并且用成像和/或治疗剂衍生以获取疾病图像和/或用于提供治疗。 大分子可以选自蛋白质，糖蛋白，脂蛋白，肽聚糖，肽，多肽，多核苷酸和多糖。 本文所述的发明还提供了本发明的MIP可用作靶向成像和治疗剂的方法和试剂盒。

公开(公告)号：US20120091106A9

公开(公告)日：2012-04-19

申请号：US12223204

申请日：2007-01-05

申请人： Thomas Beck ,  Silke Settegast

发明人： Thomas Beck ,  Silke Settegast

IPC分类号： B23K26/38 ,  B23K26/06 ,  B23K26/42

CPC分类号： B23K26/0648 ,  B23K26/0622 ,  B23K26/064 ,  B23K26/0665 ,  B23K26/389

摘要： There is described a method for producing a hole using e.g. a lasers, wherein short laser pulse durations are used. The laser pulse durations are varied, short laser pulse durations being utilized only in the area to be removed in which an influence on the penetration behavior and discharge behavior is noticeable while longer pulse durations of >0.4 ms are used. This is the case for the inner surface of a diffuser of a hole, for example, which can be produced very accurately by means of short laser pulse durations.

摘要翻译： 描述了使用例如制造孔的方法。 激光器，其中使用短激光脉冲持续时间。 激光脉冲持续时间是变化的，短激光脉冲持续时间仅在要去除的区域中被使用，其中在使用> 0.4ms的较长脉冲持续时间时，对穿透行为和放电行为的影响是显着的。 这是孔的扩散器的内表面的情况，例如，可以通过短的激光脉冲持续时间非常精确地制造。

公开(公告)号：US20110262020A1

公开(公告)日：2011-10-27

申请号：US13092999

申请日：2011-04-25

申请人： Miriam Bauer ,  Thomas Beck ,  Dominik Bernhardt ,  Christina Biermann

发明人： Miriam Bauer ,  Thomas Beck ,  Dominik Bernhardt ,  Christina Biermann

IPC分类号： G06K9/00

CPC分类号： A61B6/504 ,  A61B5/055 ,  A61B6/03 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/487 ,  A61B6/5235 ,  A61B6/5247 ,  G06F19/00 ,  G06T7/12 ,  G06T7/149 ,  G06T7/33 ,  G06T2207/10081 ,  G06T2207/30101 ,  G16H50/20 ,  G16H50/50

摘要： A method and a computer system are disclosed for automatic vectorization of the profile of a vessel tree and at least one of its properties on the basis of tomographic images of an examined patient. In at least one embodiment, using previously established location probabilities of landmarks in the vessel tree, there is an automatic determination of a plurality of distinctive landmarks in the current tomographic image data record of the patient, a registration of the current tomographic image data record to the statistical vessel model, an automatic determination of previously unidentified landmarks in the registered tomographic image data record using characteristic identification features of the previously unidentified landmarks from the statistical vessel model and the statistical location probability thereof, and a determination of at least one current vessel model using the identified landmarks and at least one vessel property at and/or between the identified landmarks.

摘要翻译： 公开了一种方法和计算机系统，用于基于检查的患者的断层图像自动矢量化血管树的轮廓和其属性中的至少一个。 在至少一个实施例中，使用先前建立的血管树中的地标的位置概率，存在对患者的当前断层图像数据记录中的多个独特地标的自动确定，将当前断层图像数据记录登记到 统计血管模型，使用来自统计血管模型的先前未识别的地标的特征识别特征及其统计位置概率来自动确定登记的断层图像数据记录中的先前未识别的地标，以及确定至少一个当前血管模型 在所识别的地标之间和/或之间使用所识别的地标和至少一个船只属性。