公开(公告)号：US20220025003A1

公开(公告)日：2022-01-27

申请号：US17297606

申请日：2019-12-03

Applicant: University of Washington

Inventor： David BAKER ,  Daniel CUNNINGHAM-BRYANT ,  Emily DIETER ,  Glenna FOIGHT ,  Per GREISEN ,  Dustin MALY ,  Keunwan PARK ,  Zhizhi WANG ,  Cindy WEI

IPC: C07K14/47 ,  C12N9/22 ,  C12N9/50

Abstract: The present disclosure provides danoprevir/NS3a complex reader (DNCR) and grazoprevir/NS3a complex readers (GNCR) polypeptides, fusion proteins, and combinations and their use.

公开(公告)号：US20210363214A1

公开(公告)日：2021-11-25

申请号：US16976350

申请日：2019-02-28

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Peilong LU ,  David BAKER ,  Scott BOYKEN ,  Zibo CHEN ,  Jorge FALLAS ,  George UEDA ,  William H. SHEFFLER

IPC: C07K14/705

Abstract: De novo designed multi-pass transmembrane polypeptides are described, that include 2 or more transmembrane domains that are each between 15 and 35 amino acids in length, include one or more polar residues, and include at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, or more hydrophobic amino acid residues.

公开(公告)号：US20210340519A1

公开(公告)日：2021-11-04

申请号：US17336889

申请日：2021-06-02

Applicant: UNIVERSITY OF WASHINGTON ,  UNIVERSITY OF UTAH

Inventor： Neil KING ,  Wesley SUNDQUIST ,  Joerg VOTTELER ,  Yang HSIA ,  David BAKER ,  Jacob BALE ,  Marc LAJOIE ,  Gabriel BUTTERFIELD ,  Elizabeth GRAY ,  Daniel STETSON

IPC: C12N9/88 ,  C07K14/00 ,  C07K14/435

Abstract: The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.

公开(公告)号：US20210246437A1

公开(公告)日：2021-08-12

申请号：US17230230

申请日：2021-04-14

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Justin Bloomfield SIEGEL ,  David BAKER ,  Ingrid Swanson PULTZ

IPC: C12N9/52 ,  C12N9/64

Abstract: The invention provides compositions and methods for treating celiac sprue.

公开(公告)号：US20210134388A1

公开(公告)日：2021-05-06

申请号：US17096465

申请日：2020-11-12

Applicant: University of Washington ,  University of Queensland

Inventor： David BAKER ,  Christopher BAHL ,  Jason GILMORE ,  Gaurav BHARDWAJ ,  Vikram K. MULLIGAN ,  Peta HARVEY ,  Olivier CHENEVAL ,  David CRAIK

IPC: G16B15/00 ,  C07K7/08 ,  G01N33/68 ,  G16B15/20

Abstract: Hyperstable constrained peptides and methods and apparatus for designing such peptides are provided. A computing device can determine a peptide backbone using a computing device. The computing device can place zero or more disulfide bonds in the peptide backbone. The computing device can design one or more peptide sequences based on the peptide backbone. The computing device can validate at least one validated peptide sequence of the one or more peptide sequences. An output can be generated based on the at least one validated peptide sequence.

公开(公告)号：US20210047373A1

公开(公告)日：2021-02-18

申请号：US17041363

申请日：2019-04-04

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Jiayi DOU ,  Anastassia VOROBIEVA ,  Jason C. KLIMA ,  David BAKER

IPC: C07K14/00 ,  G16B15/20 ,  G01N21/80

Abstract: Disclosed herein are de novo designed beta barrel polypeptides, methods for designing such polypeptides, and methods for their use.

公开(公告)号：US20180320166A1

公开(公告)日：2018-11-08

申请号：US15765045

申请日：2016-10-01

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Marc Joseph LAJOIE ,  Jason Chesler KLEIN ,  Jerrod Joseph SCHWARTZ ,  David BAKER ,  Jay Ashok SHENDURE ,  Lance Joseph STEWART

IPC: C12N15/10

CPC classification number: C12N15/1031 ,  C12N15/10 ,  C12P19/34

Abstract: The present invention provides methods for multiplex assembly of oligonucleotides.

公开(公告)号：US20180030429A1

公开(公告)日：2018-02-01

申请号：US15541201

申请日：2016-02-29

Applicant: UNIVERSITY OF WASHINGTON ,  UNIVERSITY OF UTAH

Inventor： Neil KING ,  Wesley SUNDQUIST ,  Joerg VOTTELER ,  Yang HSIA ,  David BAKER ,  Jacob BALE ,  Marc LAJOIE ,  Gabriel BUTTERFIELD ,  Elizabeth GRAY ,  Daniel STETSON

IPC: C12N9/88

CPC classification number: C12N9/88 ,  C07K14/00 ,  C07K14/435 ,  C07K2319/03 ,  C07K2319/06 ,  C07K2319/735 ,  C12Y401/02014

Abstract: The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.

公开(公告)号：US20170073375A1

公开(公告)日：2017-03-16

申请号：US15120071

申请日：2015-03-20

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Merika Treants KODAY ,  Deborah L. FULLER ,  Aaron CHEVALIER ,  Jorgen NELSON ,  David BAKER

IPC: C07K14/00 ,  G01N33/569

CPC classification number: C07K14/00 ,  A61K9/0043 ,  A61K38/00 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/04

Abstract: Designed polypeptides having the amino acid sequence of SEQ ID NQ: 1 are described that bind with high affinity and selectivity to the influenza hemagglutinin protein, and which can be used for treating and/or limiting an influenza infection, as well as diagnosing an influenza infection and identifying candidate compounds for treating an influenza infection.

Abstract translation: 描述了具有SEQ ID NO：1的氨基酸序列的设计的多肽，其以对流感血凝素蛋白的高亲和力和选择性结合，并且其可用于治疗和/或限制流感感染以及诊断流感感染 并鉴定用于治疗流感感染的候选化合物。

公开(公告)号：US20150376238A1

公开(公告)日：2015-12-31

申请号：US14766375

申请日：2014-03-14

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： David BAKER ,  Eva-Maria STRAUCH ,  David LA

IPC: C07K14/00 ,  C07K7/08

CPC classification number: C07K14/001 ,  A61K38/00 ,  C07K7/08 ,  C07K14/11 ,  C12N2760/16134 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/02

Abstract: Disclosed herein are polypeptides that bind to the hemagglutinin protein of influenza virus, and which can be used for treating and diagnosing influenza infection.

Abstract translation: 本文公开了结合流感病毒血凝素蛋白的多肽，其可用于治疗和诊断流感感染。