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公开(公告)号：US4835141A
公开(公告)日：1989-05-30
申请号：US938219
申请日：1986-12-05
申请人： Walter P. Cullen , James R. Hauske , Hiroshi Maeda , Junsuke Tone
发明人： Walter P. Cullen , James R. Hauske , Hiroshi Maeda , Junsuke Tone
摘要： An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirsutus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.
摘要翻译： 含有三个主要组分的抗生素复合物已经从微生物链霉菌链霉菌（Streptomyces hirsutus）的新菌株的发酵中分离出来。 主要成分是新的，中性的，大环内酯类抗生素化合物，它们可用作针对某些革兰氏阳性菌的抗菌剂。
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公开(公告)号：US4048304A
公开(公告)日：1977-09-13
申请号：US662700
申请日：1976-03-01
摘要： A new polycyclic ether antibiotic with anticoccidial, insecticidal and antimicrobial activity, its production by fermentation and methods for its recovery and purification are described.
摘要翻译： 描述了具有抗球虫，杀虫和抗微生物活性的新型多环醚抗生素，其通过发酵生产及其回收和纯化方法。
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公开(公告)号：US4022885A
公开(公告)日：1977-05-10
申请号：US548421
申请日：1975-02-10
CPC分类号： A61K31/00 , C07G11/00 , Y10S435/886
摘要： A new polycyclic ether antibiotic with anticoccidial, insecticidal and antimicrobial activity, its production by fermentation and methods for its recovery and purification are described.
摘要翻译： 描述了具有抗球虫，杀虫和抗微生物活性的新型多环醚抗生素，其通过发酵生产及其回收和纯化方法。
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公开(公告)号：US4013789A
公开(公告)日：1977-03-22
申请号：US581808
申请日：1975-05-29
CPC分类号： A61K36/06 , C07G11/00 , Y10S435/863
摘要： A new species of Micromonospora, designated Micromonospora lacustris sp. nov. Routien, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of at least thirteen antibiotics. Two of these antibiotics are rifamycin S and rifamycin SV. Two other members of the antibiotic mixture are the 3-methylthio derivatives of rifamycin S and rifamycin SV.
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45.发明授权Process for preparing macrolide antibiotics by culturing streptomyces hirsutus ATCC 53513 失效通过培养高链链霉菌ATCC 53513制备大环内酯类抗生素的方法
公开(公告)号：US4956283A
公开(公告)日：1990-09-11
申请号：US322149
申请日：1989-03-10
申请人： Walter P. Cullen , James R. Hauske , Hiroshi Maeda , Junsuke Tone
发明人： Walter P. Cullen , James R. Hauske , Hiroshi Maeda , Junsuke Tone
CPC分类号： C07H17/08 , C12P19/58 , C12R1/465 , Y10S435/886
摘要： An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirautus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.
摘要翻译： 含有三个主要成分的抗生素复合物已经从微生物链霉菌Streptomyces hirautus的新菌株的发酵中分离出来。 主要成分是新的，中性的，大环内酯类抗生素化合物，它们可用作针对某些革兰氏阳性菌的抗菌剂。
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公开(公告)号：US5494931A
公开(公告)日：1996-02-27
申请号：US350436
申请日：1994-12-06
申请人： Walter P. Cullen , John P. Dirlam , Hiroshi Maeda , Junsuke Tone
发明人： Walter P. Cullen , John P. Dirlam , Hiroshi Maeda , Junsuke Tone
IPC分类号： A23K1/16 , A23K1/17 , A23K1/18 , A61K31/35 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P33/02 , C07D493/10 , C07H17/04 , C07H19/01 , C12P17/18 , C12P19/44 , C12P19/60 , C12R1/03 , C07D309/10
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P17/181 , C12P19/445 , C12R1/01
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55080. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.
摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 55080.这种新型抗生素可用作家禽中的抗球虫，预防和治疗猪痢疾以及作为牛和猪的生长促进剂。
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47.发明授权Acidic polycyclic ether antibiotic having an anticoccidial and growth promotant activity 失效具有抗球虫和生长促进活性的酸性多环醚抗生素
公开(公告)号：US5298524A
公开(公告)日：1994-03-29
申请号：US655440
申请日：1992-03-27
申请人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
发明人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P17/18 , C12P19/44 , Y10S435/825
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53764. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
摘要翻译： PCT No.PCT / US88 / 01954 Sec。 371日期：1992年3月27日 102（e）1992年3月27日PCT PCT。1988年6月9日。具有通过X射线晶体学建立的结构的酸性多环醚抗生素通过新型微生物Actinomadura sp。 ATCC 53764.这种新型抗生素可用作鸡的抗球虫病，预防或治疗猪痢疾，以及作为牛和猪的生长促进剂。
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48.发明授权Acidic polycyclic ether useful as an anticoccidial agent and as a growth promotant 失效酸性聚合物有效地作为抗焦虑剂和作为生长促进剂
公开(公告)号：US5147858A
公开(公告)日：1992-09-15
申请号：US487947
申请日：1990-04-16
申请人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
发明人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
IPC分类号： C12P19/00 , A23K1/16 , A23K1/17 , A61K31/35 , A61K31/70 , A61K31/7028 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P33/02 , C07D493/10 , C07H7/06 , C07H15/04 , C07H17/04 , C07H19/01 , C12N1/20 , C12P17/06 , C12P19/60 , C12R1/03
CPC分类号： C07H19/01 , A23K20/195 , Y10S435/825
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.
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公开(公告)号：US5064855A
公开(公告)日：1991-11-12
申请号：US649120
申请日：1991-01-28
IPC分类号： C07D493/10 , C12P17/06
CPC分类号： C07D493/10 , C12P17/06 , C12R1/465
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 53862. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚类抗生素是通过新型微生物Streptomyces sp。 ATCC 53862.这种新型抗生素可用作鸡的抗球虫，预防或治疗猪痢疾，以及作为牛和猪的生长促进剂。
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50.发明授权
公开(公告)号：US4908316A
公开(公告)日：1990-03-13
申请号：US161630
申请日：1988-02-29
IPC分类号： C07D407/14 , C12P17/16 , C12P19/44
CPC分类号： C07D407/14 , C12P17/16 , C12P19/44 , Y10S435/886
摘要： An antibiotic has been isolated from fermentation of a new Streptomyces culture. The new ionophore is active as an antibacterial and anticoccidial agent.
摘要翻译： 已经从新的链霉菌培养物的发酵中分离出抗生素。 新型离子载体作为抗菌和抗球虫剂具有活性。
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