摘要:
A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided.The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.
摘要:
The present invention provides a color filter substrate which achieves a sufficient light-shielding effect in a light-shielding region and can prevent a disorder of the alignment of liquid crystals in the vicinity of the light-shielding region. The present invention is a color filter substrate including: a light-shielding layer and a colored layer made of material such as a photosensitive material, on a substrate, wherein the colored layer is arranged from a light transmission region not having the light-shielding layer arranged therein to a light-shielding region having the light-shielding layer arranged therein, and has a smaller thickness in the light-shielding region than in the light transmission region.
摘要:
Disclosed is a compound represented by the formula (I) below, which has a glucokinase-activating effect and is thus useful for treatment of diabetes or obesity, or a pharmaceutically acceptable salt thereof. In the formula, R1 represents an aryl or the like; R11 represents an aryl or the like; R2 represents a formyl or the like, R3 represents a C1-6 alkyl or the like; R3 represents a hydrogen atom or the like; Z1 represents —O— or the like; Z2 represents —O— or the like; Y1-Y4 respectively represent a carbon atom or a nitrogen atom; ring A represents a heteroaryl group; X represents a carbon atom or the like; m represents an integer of 0-2; and q represents an integer of 0-2.
摘要:
The present invention provides a more efficient industrial method for producing a pyrazol-3-yl-benzamide derivative expressed by a formula useful as medicine: wherein R2, R3 and R4 each independently represent a lower alkyl group.
摘要:
Disclosed is a compound represented by the formula (I) below, which has a glucokinase-activating effect and is thus useful for treatment of diabetes or obesity, or a pharmaceutically acceptable salt thereof. In the formula, R1 represents an aryl or the like; R11 represents an aryl or the like; R2 represents a formyl or the like, R3 represents a C1-6 alkyl or the like; R3 represents a hydrogen atom or the like; Z1 represents —O— or the like; Z2 represents —O— or the like; Y1-Y4 respectively represent a carbon atom or a nitrogen atom; ring A represents a heteroaryl group; X represents a carbon atom or the like; m represents an integer of 0-2; and q represents an integer of 0-2.
摘要:
Compounds represented by formula (I): as well as their pharmaceutically acceptable salts are disclosed. The compounds are useful as glucokinase activating agents for the treatment of diabetes and related conditions. Compositions and methods of treatment are also included.
摘要:
An example control signal generating circuit CTL for controlling the writing into pixels PIX instructs a data signal line drive circuit SD2, which is for driving pixels in a non-display area, to write a voltage VB or a voltage VW which are for non-displaying, not only in the first frame but also once in a predetermined number of frames. In other words, the pixels in the display area are refreshed at intervals longer than those in the case of refreshing the pixels in each frame. Thus, even if the mobility of an active element is high and the leak current on the occasion of OFF-state is large, or even if a large amount of electric charge is accumulated because of the photoelectric effect due to the use of a backlight, it is possible to prevent unnecessary displaying on the display area, which is caused because the writing into the pixels in the display area influences on the pixels in the non-display area, and hence it is possible to improve the quality of partial displaying, while restraining the power consumption.
摘要:
An indicator light apparatus of a marine vessel is provided. The indicator light apparatus includes a sensor for detecting a value related to a traveling speed of the marine vessel, an indicator light provided in the marine vessel, and a control device configured to change an illuminating pattern of the indicator light based on the value related to the traveling speed detected by the sensor.
摘要:
An electric power generation control apparatus has a bridge circuit, a voltage detection circuit, an electric generation control circuit, and an operation mode setting circuit. The bridge circuit has power transistors and diodes through which a field current is supplied to a vehicle alternator driven by a vehicle engine. The voltage detection circuit outputs an instruction signal regarding ON and OFF of supply of the field current so that the output voltage of the vehicle alternator becomes an adjusting voltage. The electric generation control circuit controls the ON and OFF of the power transistors according to the instruction signal from the voltage detection circuit. The operation mode setting circuit selects one of a field wheeling mode and a regenerative mode based on the OFF state of one power transistor, and also selects the regenerative mode when receiving a generation halt instruction form an ECU in the vehicle.
摘要:
A four-cycle engine typically including a crankshaft provided with a first gear, a camshaft provided with a second gear, an endless rotation transmission that is installed around the first and second gears and is configured to transmit rotation of the crankshaft to the camshaft, a crank phase detecting device configured to detect a rotational phase of the crankshaft that is obtained by dividing a phase corresponding to one rotation of the crankshaft by a number that is equal to or more than a half of teeth of the second gear of the camshaft, and a cam phase detecting device configured to detect at least one rotational phase of the camshaft.