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公开(公告)号：US20220409615A1
公开(公告)日：2022-12-29
申请号：US17318693
申请日：2021-05-12
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Elizabeth M. Doherty , Longbin Liu , Matthew Lee , Mark Stuart Chambers , Karine Fabienne Malagu , Perla Breccia , Alan F. Haughan , Huw D. Vater , Andrew J. Stott , William R. K. Esmieu , Stephen John Webster , Amanda J. Van De Poël
IPC: A61K31/497 , C07D471/04 , C07D519/00 , A61K31/4985 , C07D487/04 , C07D403/14 , A61K31/506 , A61K31/501 , C07D413/14 , A61P25/28
Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
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公开(公告)号：US20220372045A1
公开(公告)日：2022-11-24
申请号：US17729881
申请日：2022-04-26
Applicant: CHDI Foundation, Inc.
Inventor： Longbin Liu , Celia Dominguez , Jonathan Bard , Vinod Khetarpal , Ashley Jarvis , Sarah Hayes , John E. Mangette
IPC: C07D498/04 , A61K51/04
Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
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公开(公告)号：US11421007B2
公开(公告)日：2022-08-23
申请号：US16386885
申请日：2019-04-17
Applicant: Sangamo Therapeutics, Inc. , CHDI Foundation, Inc.
Inventor： Steven Froelich , Ignacio Munoz-Sanjuan , Edward J. Rebar , Bryan Zeitler , H. Steve Zhang
Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
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公开(公告)号：US20210380608A1
公开(公告)日：2021-12-09
申请号：US17353627
申请日：2021-06-21
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Daniel Clark-Frew
IPC: C07D519/00 , C07D471/04 , A61K51/04
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US20210379211A1
公开(公告)日：2021-12-09
申请号：US17353611
申请日：2021-06-21
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Thomas Martin Krulle , Daniel Clark-Frew , Sarah Hayes
IPC: A61K51/04 , C07D401/14 , C07D403/04 , C07D401/04 , C07D487/04 , C07D513/04 , C07D513/14
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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Patent Agency Ranking
公开(公告)号：US11173156B2
公开(公告)日：2021-11-16
申请号：US16898239
申请日：2020-06-10
Applicant: CHDI Foundation, Inc.
Inventor： Leticia M. Toledo-Sherman , Celia Dominguez , Vinod Khetarpal , Travis Lee Houston , Stephan D. Parent , Jian-xie Chen , Charles H. Montgomery , Geetha Banda
IPC: A61K31/505 , C07D239/28
Abstract: Forms of 6-(3-chloro-4-cyclopropoxyphenyl)pyrimidine-4-carboxylic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I and salts or co-crystals thereof.
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公开(公告)号：US20210017522A1
公开(公告)日：2021-01-21
申请号：US16988862
申请日：2020-08-10
Applicant: IONIS PHARMACEUTICALS, Inc. , CHDI Foundation, Inc.
Inventor： Gene Hung , C. Frank Bennett , Janet M. Leeds , Susan M. Freier
IPC: C12N15/113
Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin's disease in an individual susceptible to Huntingtin's Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
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公开(公告)号：US10258621B2
公开(公告)日：2019-04-16
申请号：US15326317
申请日：2015-07-17
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Ignacio Muñoz-Sanjuán , Leticia Toledo-Sherman
IPC: C07D239/42 , A61K31/52 , A61K31/70 , A61K31/505 , A61K31/675 , A61K31/506 , A61K31/34 , C07D239/28 , A61K45/06
Abstract: Certain adjunctive therapies comprising a kynurenine-3-monooxygenase inhibitor and an antiviral agent for treating HIV-related disorders are provided herein. These disorders include AIDS dementia complex, AIDS-induced encephalopathy, HIV-associated neurocognitive disorder, asymptomatic neurocognitive impairment, minor neurocognitive disorder, minor cognitive motor disorder, vacuolar myelopathy, peripheral neuropathies, and polymyositis. Also provided are pharmaceutical compositions comprising a kynurenine-3-monooxygenase inhibitor and an antiviral agent.
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公开(公告)号：US10105363B2
公开(公告)日：2018-10-23
申请号：US15411535
申请日：2017-01-20
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Vahri Beaumont , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Alan F. Haughan , Christopher A. Luckhurst , Michael Wall , Gilles Raphy , Beth Thomas
IPC: A61K31/505 , C07D239/26
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US10053434B2
公开(公告)日：2018-08-21
申请号：US15148907
申请日：2016-05-06
Applicant: CHDI Foundation, Inc.
Inventor： Michel C. Maillard , Perla Breccia , Celia Dominguez , Alan F. Haughan , Amanda Van de Poël , Andrew J. Stott , Christopher A. Luckhurst , Elizabeth A. Saville-Stones , Grant Wishart , Michael Wall , Rebecca E. Jarvis
IPC: C07D413/12 , C07D271/06 , C07D471/04
CPC classification number: C07D271/06 , C07D413/12 , C07D471/04
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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