公开(公告)号：US20090175965A1

公开(公告)日：2009-07-09

申请号：US12244728

申请日：2008-10-02

Applicant: Karim Boumediene ,  Jean-Pierre Pujol ,  Georges Bernard Guillou ,  Philippe Msika ,  Chafik Ghayor

Inventor： Karim Boumediene ,  Jean-Pierre Pujol ,  Georges Bernard Guillou ,  Philippe Msika ,  Chafik Ghayor

IPC: A61K36/889 ,  A61K36/00 ,  A61K36/899 ,  A61K36/28 ,  A61K36/73

CPC classification number: A61K36/48 ,  A61K36/28 ,  A61K36/31 ,  A61K36/54

Abstract: The invention relates to the use of at least one unsaponifiable component of vegetable oil, in particular of avocado, soya bean and/or lupin oils, for the preparation of a medicament intended to stimulate the expression of TGF-β or the expression of the plasminogen activator inhibitor PAI-1.The invention also relates to a method of cosmetic treatment comprising the application of at least one unsaponifiable component of vegetable oil as well as the use of the latter as additive in a food for human beings and/or for animals.

Abstract translation: 本发明涉及植物油，特别是鳄梨，大豆和/或羽扇豆油的至少一种不皂化物组分用于制备用于刺激TGF-β的表达或纤溶酶原的表达的药物的用途 活化剂抑制剂PAI-1。 本发明还涉及一种美容治疗方法，其包括施用植物油的至少一种不皂化成分，以及将其用作人类和/或动物食品中的添加剂。

公开(公告)号：US07511010B2

公开(公告)日：2009-03-31

申请号：US10416464

申请日：2001-11-14

Applicant: Philippe Msika ,  Nathalie Piccardi ,  Antoine Piccirilli

Inventor： Philippe Msika ,  Nathalie Piccardi ,  Antoine Piccirilli

IPC: A61K38/00 ,  A61K31/13

CPC classification number: A61K31/13 ,  A61K8/41 ,  A61K8/68 ,  A61K31/045 ,  A61K31/56 ,  A61K36/48 ,  A61K2800/75 ,  A61Q19/00 ,  A61Q19/005 ,  A61K2300/00

Abstract: The invention concerns a pharmaceutical or cosmetic composition, characterised in that it comprises at least a compound for inhibiting Langerhans' cell migration, said active compound being selected in the group consisting of protein kinase C (PKC) inhibiting compounds, matrix metalloprotease (MMP) inhibiting compounds, and combinations thereof, and at least a pharmaceutically or cosmetically acceptable carrier. Said composition enables to inhibit considerably Langerhans' cell migration induced by the presence or an allergenic agent.

Abstract translation: 本发明涉及药物或化妆品组合物，其特征在于其至少包含用于抑制朗格汉斯细胞迁移的化合物，所述活性化合物选自蛋白激酶C（PKC）抑制化合物，基质金属蛋白酶（MMP）抑制剂 化合物及其组合，以及至少一种药学上或化妆品上可接受的载体。 所述组合物能够显着抑制由存在或变应原剂引起的朗格汉斯细胞迁移。

公开(公告)号：US20080292613A1

公开(公告)日：2008-11-27

申请号：US12097505

申请日：2006-12-15

Applicant: Philippe Msika ,  Nathalie Piccardi ,  Pascale Cochet ,  Michel Moreau

Inventor： Philippe Msika ,  Nathalie Piccardi ,  Pascale Cochet ,  Michel Moreau

IPC: A61K38/48 ,  A61K33/30 ,  A61K33/06 ,  A61K33/34 ,  A61K33/04 ,  A61P3/04 ,  A61K33/24 ,  A61K33/26 ,  A61K33/32

CPC classification number: A61K33/24 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/08 ,  A61K31/201 ,  A61K31/202 ,  A61K33/04 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K2300/00 ,  A23V2200/318 ,  A23V2250/704 ,  A23V2250/1642 ,  A23V2250/161 ,  A23V2250/1882

Abstract: The present invention relates to the use of a combination of group B vitamins, trace element(s), at least one oil comprising essential Ω-3 and/or Ω-6 fatty acids and an excipient suitable for oral administration, for use in the simultaneous treatment of excess weight and slackening of the skin localized in the same area. The invention also relates to a corresponding food supplement.

Abstract translation: 本发明涉及B组维生素，微量元素，至少一种包含必需的ω-3和/或ω-6脂肪酸的油和适于口服给药的赋形剂的组合的用途，用于 同时治疗局部在同一区域的多余重量和松弛的皮肤。 本发明还涉及相应的食品补充剂。

公开(公告)号：US20080219937A1

公开(公告)日：2008-09-11

申请号：US12064878

申请日：2006-08-30

Applicant: Philippe Msika ,  Nathalie Piccardi

Inventor： Philippe Msika ,  Nathalie Piccardi

IPC: A61K8/49 ,  A61Q17/04 ,  A61Q19/02

CPC classification number: A61K8/4973 ,  A61Q19/02

Abstract: The invention concerns the cosmetic use of at least one 2-alkyl furan, as depigmenting active principle, in a depigmenting composition, as well as the associated cosmetic treatment method. The invention also concerns the use of at least one 2-alkyl furan for preparing an active drug as depigmenting agent. The invention further concerns a depigmenting cosmetic composition comprising as depigmenting active principle at least one 2-alkyl furan.

Abstract translation: 本发明涉及在脱色组合物中至少一种2-烷基呋喃作为脱色素活性成分的化妆品用途，以及相关的美容治疗方法。 本发明还涉及至少一种2-烷基呋喃用于制备活性药物作为脱色素的用途。 本发明还涉及一种脱色的化妆品组合物，其包含至少一种2-烷基呋喃作为脱色活性成分。

公开(公告)号：US20080194476A1

公开(公告)日：2008-08-14

申请号：US11587960

申请日：2005-04-29

Applicant: Antoine Piccirilli ,  Nathalie Piccardi ,  Philippe Msika ,  Francois Paul ,  Stephanie Bredif

Inventor： Antoine Piccirilli ,  Nathalie Piccardi ,  Philippe Msika ,  Francois Paul ,  Stephanie Bredif

IPC: A61K38/16 ,  A61K38/04 ,  A61K38/10 ,  A61K38/08 ,  A61P43/00

CPC classification number: A61K36/54 ,  A61K31/198 ,  A61K2300/00

Abstract: The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose and/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.

Abstract translation: 本发明涉及一种药物，其包含鳄梨的肽提取物，其还可以包含含有D-甘露庚酮糖和/或去糖醇的组合物，例如鳄梨糖的水溶性提取物和/或羽扇豆肽提取物。 本发明的药物旨在通过增加抗微生物肽（优选hBD-2）的产生而不诱导炎症反应来治疗和/或预防与先天和/或获得性免疫的变化有关的疾病， 激怒或不宽容

公开(公告)号：US12109245B2

公开(公告)日：2024-10-08

申请号：US16580826

申请日：2019-09-24

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Alex Saunois ,  Caroline Baudouin ,  Sophie Leclere-Bienfait ,  Sebastien Garnier ,  Philippe Msika

IPC: A61K8/49 ,  A23L33/105 ,  A61K8/368 ,  A61K8/9789 ,  A61K31/05 ,  A61K31/197 ,  A61K31/198 ,  A61K31/201 ,  A61K31/341 ,  A61K31/42 ,  A61K31/57 ,  A61K31/585 ,  A61K31/715 ,  A61K31/717 ,  A61K33/30 ,  A61K36/28 ,  A61K36/31 ,  A61K36/48 ,  A61K36/54 ,  A61K36/899 ,  A61K38/00 ,  A61K45/00 ,  A61Q19/08

CPC classification number: A61K36/31 ,  A23L33/105 ,  A61K8/368 ,  A61K8/498 ,  A61K8/9789 ,  A61K31/05 ,  A61K31/197 ,  A61K31/198 ,  A61K31/201 ,  A61K31/341 ,  A61K31/42 ,  A61K31/57 ,  A61K31/585 ,  A61K31/715 ,  A61K31/717 ,  A61K33/30 ,  A61K36/28 ,  A61K36/48 ,  A61K36/54 ,  A61K36/899 ,  A61K38/00 ,  A61K45/00 ,  A61Q19/08 ,  A61K2800/805

Abstract: The invention relates to an extract of aerial parts of Maca rich in polyphenols, and also to a composition comprising such an extract and, where appropriate, a suitable excipient. The invention also relates to a process for extracting an extract of aerial parts of Maca rich in polyphenols, and also to the extract that can be obtained by means of said process. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths and/or for use thereof in preventing and/or treating vascular disorders. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which comprises the administration of such a composition or of such an extract.

公开(公告)号：US20240091294A1

公开(公告)日：2024-03-21

申请号：US18272461

申请日：2022-01-20

Applicant: Laboratoires Expanscience

Inventor： Sophie LECLERE-BIENFAIT ,  Stephanie BREDIF

IPC: A61K36/53 ,  A61K8/9789 ,  A61P17/02 ,  A61P17/18 ,  A61P29/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08

CPC classification number: A61K36/53 ,  A61K8/9789 ,  A61P17/02 ,  A61P17/18 ,  A61P29/00 ,  A61Q17/04 ,  A61Q19/007 ,  A61Q19/08 ,  A61K2236/15 ,  A61K2236/333 ,  A61K2236/53 ,  A61K2800/522

Abstract: The invention relates to an extract of top growth of holy basil, in particular of Ocimum sanctum, a method for preparing the extract, and the extract obtainable by said method. The invention also relates to a composition comprising such an extract, the composition advantageously being a cosmetic, pharmaceutical or dermatological composition. The invention also relates to such a composition or such an extract for use in preventing or treating disorders or diseases of the skin, the mucous membranes or the skin appendages, and for use in preventing or treating vascular disorders. Finallyc the invention relates to a cosmetic care method for the skin, skin appendages or mucous membranes, with a view to improving the condition or appearance thereof, which method consists in administering such a composition or such an extract.

公开(公告)号：US20230277613A1

公开(公告)日：2023-09-07

申请号：US18017011

申请日：2021-07-26

Applicant: Laboratoires Expanscience

Inventor： Sophie LECLERE-BIENFAIT ,  Stephanie BREDIF

IPC: A61K36/185 ,  A61K8/9789 ,  A61Q19/08 ,  A61Q17/00 ,  A61P31/02 ,  A61P17/00 ,  A61P17/10 ,  A61Q15/00

CPC classification number: A61K36/185 ,  A61K8/9789 ,  A61Q19/08 ,  A61Q17/00 ,  A61P31/02 ,  A61P17/00 ,  A61P17/10 ,  A61Q15/00 ,  A61K2236/15 ,  A61K2236/31 ,  A61K2236/331 ,  A61K2236/53 ,  A61K2236/51

Abstract: The invention relates to an extract from the flowers, preferably from the calyxes, of Bombax costatum, to a process for preparing same and to the extract obtained by said process. The invention also relates to a composition comprising such an extract, the composition advantageously being a cosmetic, pharmaceutical or dermatological composition. The invention also relates to such a composition or such an extract for the use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the hair and nails, as well as the imbalance or disorders associated with the imbalance of the microbiota of the skin, the mucous membranes, the hair, the nails and associated skin appendages. Finally, the invention relates to a cosmetic care method for the skin, the hair and nails or the mucous membranes, with a view to improving the condition or the appearance thereof, which method consists in administering such a composition or such an extract.

公开(公告)号：US11026441B2

公开(公告)日：2021-06-08

申请号：US16117511

申请日：2018-08-30

Applicant: Laboratoires Expanscience

Inventor： Alex Saunois ,  Caroline Baudouin ,  Sophie Leclere-Bienfait ,  Sebastien Garnier ,  Philippe Msika

IPC: A61K36/54 ,  A23L19/00 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  A23L33/105 ,  A61K9/00 ,  A61K8/9789 ,  A61K8/9794 ,  A61K8/49 ,  A61K31/353 ,  A61K45/06 ,  A61Q5/12 ,  A61Q17/04

Abstract: The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

公开(公告)号：US20200011854A1

公开(公告)日：2020-01-09

申请号：US16562991

申请日：2019-09-06

Applicant: Laboratoires Expanscience

Inventor： Philippe MSIKA ,  Nadege LACHMANN ,  Joachim FLUHR

IPC: G01N33/50

Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.