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公开(公告)号：US20180216063A1
公开(公告)日：2018-08-02
申请号：US15746477
申请日：2016-07-21
发明人： Sharon Gerecht , Xin Yi Chan , Quinton Smith , Yu-I Shen
CPC分类号： C12N5/069 , A61K9/0024 , A61K9/06 , A61K35/00 , A61K35/545 , A61K47/36 , A61K47/42 , A61L27/24 , A61P31/02 , C12N2500/44 , C12N2501/165 , C12N2501/727 , C12N2501/999 , C12N2506/45 , C12N2533/80
摘要： Early vascular cells (EVCs), including endothelial cells and pericytes, are generated from hiPSCs. Unlike the isolated endothelial progenitor cells, the differentiated ECs mature and are functional. When encapsulated in synthetic hydrogel, EVCs respond to matrix cues and self-assembled to form three-dimensional EVCs. Moreover, these EVCs respond to hypoxic microenvironment and undergo vasculogenesis to form complex 3D networks.
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公开(公告)号：US11871750B2
公开(公告)日：2024-01-16
申请号：US17688915
申请日：2022-03-08
IPC分类号： A01N59/16 , A01N25/08 , A01N59/06 , A01N59/00 , A61K9/00 , A61K33/30 , A61K33/24 , A61K33/06 , A61K33/00 , A61K47/02 , A01P1/00 , A61P31/02 , C09D5/14 , A61L15/44 , A61L15/18
CPC分类号： A01N59/16 , A01N25/08 , A01N59/00 , A01N59/06 , A01P1/00 , A61K9/0014 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K47/02 , A61L15/18 , A61L15/44 , A61P31/02 , C09D5/14 , A61L2300/102 , A61L2300/404
摘要： Described herein are co-doped magnesium oxide nanocomposites with antimicrobial properties for industrial and biomedical applications. Methods of inhibiting microbial and/or eliminating microbial growth with the disclosed compounds on biological and inanimate surfaces are also described.
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公开(公告)号：US11826332B2
公开(公告)日：2023-11-28
申请号：US17360966
申请日：2021-06-28
发明人： Joel Rosenblatt , Issam Raad
IPC分类号： A61K31/20 , A61K45/06 , A61K31/21 , A61K31/715 , A61K31/732 , C08L5/00 , C08L5/06 , C08L5/08 , C08L89/00 , A61L29/04 , A61L29/16 , A61K33/40 , A61P31/02 , A61D7/00 , A61M3/02 , A61M25/00 , A61M25/10 , A61M39/22
CPC分类号： A61K31/20 , A61D7/00 , A61K31/21 , A61K31/715 , A61K31/732 , A61K33/40 , A61K45/06 , A61L29/043 , A61L29/16 , A61M3/0262 , A61M3/0283 , A61M25/0017 , A61M25/1011 , A61M39/22 , A61P31/02 , C08L5/00 , C08L5/06 , C08L5/08 , C08L89/00 , A61L2300/404 , A61L2300/406 , A61M2210/0693 , A61M2210/1082 , A61M2210/1089 , A61M2210/12 , A61M2250/00 , C08L89/00 , C08L5/00 , C08L89/00 , C08L5/08 , C08L89/00 , C08L5/06 , A61K31/715 , A61K2300/00 , A61K31/732 , A61K2300/00 , A61K31/20 , A61K2300/00 , A61K31/21 , A61K2300/00 , A61K33/40 , A61K2300/00 , A61L29/043 , C08L5/08 , A61L29/043 , C08L5/06
摘要： In some aspects, provided herein are antimicrobial compositions comprising partially esterified polygalacturonic acid and certain fatty acids (e.g., caprylic acid). In some embodiments, the antimicrobial composition may be administered (e.g., topically or orally) to a subject, such as a human patient to treat an infection (e.g., an infection comprising a biofilm). In some aspects, improved catheters are provided.
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公开(公告)号：US11801262B2
公开(公告)日：2023-10-31
申请号：US16876592
申请日：2020-05-18
发明人： Arne Holmgren , Jun Lu , Lili Zou
CPC分类号： A61K33/04 , A61K9/0014 , A61K9/0056 , A61K33/38 , A61L24/0015 , A61L24/02 , A61P31/02 , A61P31/04 , A61L2300/104 , A61L2300/406 , Y02A50/30 , A61K33/04 , A61K2300/00 , A61K33/38 , A61K2300/00
摘要： Disclosed herein are antibiotic compositions, for example compositions that comprise a metal-containing agent and an organoselenium agent, and uses thereof.
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公开(公告)号：US20230146954A1
公开(公告)日：2023-05-11
申请号：US17802819
申请日：2021-02-26
申请人： DENT4YOU AG
IPC分类号： A01N59/00 , A01N25/04 , A61K33/40 , A61K47/24 , A61K9/107 , A01N37/10 , A01N31/14 , A01N25/30 , A01P1/00 , A01P3/00 , A61P31/02 , A61K9/00
CPC分类号： A01N59/00 , A01N25/04 , A61K33/40 , A61K47/24 , A61K9/1075 , A01N37/10 , A01N31/14 , A01N25/30 , A01P1/00 , A01P3/00 , A61P31/02 , A61K9/0063
摘要： The present disclosure relates to micellar compositions conformed by biomimetic phospholipids and nonionic surfactants, among other ingredients, for eliminating one or more types of microorganisms including mycobacteria, bacteria, fungi, and viruses from a surface within a contact time on the surface of less than about 1 minutes and having pH of from about 0.3 to 8. The present invention aims on using 100% bio-based (renewable) biodegradable, non-toxic ingredients to be applied not only to hard inanimate surfaces but also on tissue for endodontic applications.
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公开(公告)号：US20180250292A1
公开(公告)日：2018-09-06
申请号：US15756793
申请日：2016-08-23
IPC分类号： A61K31/496 , A61K47/38 , A61K47/02 , A61K9/06 , A61P31/02
CPC分类号： A61K31/496 , A61K9/06 , A61K31/4164 , A61K47/02 , A61K47/38 , A61K2300/00 , A61P31/02
摘要： Antibiotic gel formulations for use in dental applications are disclosed. More particularly, the present disclosure is directed to antibiotic gel formulations including low concentrations of antibiotics that are capable of killing root canal pathogens without harming the stem cells inside the root canal. Additionally, the present disclosure is directed to delivery systems and methods for applying the antibiotic gel formulations into a subject's intracanal region.
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公开(公告)号：US20240336807A1
公开(公告)日：2024-10-10
申请号：US18579412
申请日：2022-07-18
申请人： BIOINTERACTIONS LTD
IPC分类号： C09D179/02 , A01N33/04 , A01N33/12 , A01N47/28 , A01N47/40 , A01P1/00 , A61K31/785 , A61P31/02 , C09D5/14
CPC分类号： C09D179/02 , A01N33/04 , A01N33/12 , A01N47/28 , A01N47/40 , A01P1/00 , A61K31/785 , A61P31/02 , C09D5/14
摘要： The present disclosure relates to coatings, formulations and coating compositions, methods for using the coatings and coating compositions, and methods for applying the coatings to substrates or articles. The coatings disclosed herein are long-lasting, and are suitable for application to a wide variety of substrates or articles, which may include substrates or articles formed from natural and/or artificial materials, including plastic, metal, textiles and/or other artificial materials, and also to living substrates.
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公开(公告)号：US20230321141A1
公开(公告)日：2023-10-12
申请号：US18165311
申请日：2023-02-06
申请人： Brian Brazzo
发明人： Brian Brazzo
摘要： A stye treatment formulation that includes a colloidal silver concentrate, an arnica extract, a calendula extract, niacinamide, and at least one carrier fluid is described. Methods of using the stye treatment formulation to treat at least one patient in need thereof are also described.
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公开(公告)号：US20230255880A1
公开(公告)日：2023-08-17
申请号：US18170282
申请日：2023-02-16
摘要： The current disclosure provides compositions and methods for treating and/or debriding damaged or dying tissue resulting from a range of injuries and conditions without requiring surgical personnel or facilities. The compositions can be utilized in the field close to where the injury occurred. The compositions include a covalently bonded and immobilized protease enzyme included in a medium that can have a variety of forms and further include a range of additives to further effect the safe and effective removal of dead or damaged tissue. The compositions can be transported and utilized in the field without refrigeration and without any special handling.
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公开(公告)号：US11666621B2
公开(公告)日：2023-06-06
申请号：US16641425
申请日：2018-08-24
申请人： Chul-Gue Joo
发明人： Chul-Gue Joo
IPC分类号： A61K36/87 , A61P31/02 , A61K36/53 , A61K36/752
CPC分类号： A61K36/87 , A61K36/53 , A61K36/752 , A61P31/02
摘要： The present invention relates to an antimicrobial composition comprising a grape extract, a lemon extract, and a lavender extract. Not only providing excellent antiviral, antibacterial, and antifungal effects but also being derived from natural products, the composition of the present invention can be used safely without toxicity and side effects and can find various applications in medicinal products, foods, cosmetic products, quasi-drugs, etc.
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