公开(公告)号：US20080279871A1

公开(公告)日：2008-11-13

申请号：US11894643

申请日：2007-08-20

Applicant: Thomas R. Cech ,  Joachim Lingner ,  Toru M. Nakamura ,  Karen B. Chapman ,  Gregg B. Morin ,  Calvin B. Harley ,  William H. Andrews

Inventor： Thomas R. Cech ,  Joachim Lingner ,  Toru M. Nakamura ,  Karen B. Chapman ,  Gregg B. Morin ,  Calvin B. Harley ,  William H. Andrews

IPC: A61K39/00 ,  C07K7/00 ,  C07K14/00

CPC classification number: A61K39/0011 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/0005 ,  A61K39/39 ,  A61K48/00 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/43504 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/1241 ,  C12N9/1276 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/15 ,  C12N2310/315 ,  C12Q1/6895 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y207/07049

Abstract: The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

Abstract translation: 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。

公开(公告)号：US20040247613A1

公开(公告)日：2004-12-09

申请号：US10877022

申请日：2004-06-24

Applicant: GERON CORPORATION ,  UNIVERSITY TECHNOLOGY CORPORATION

Inventor： Thomas R. Cech ,  Joachim Lingner ,  Toru Nakamura ,  Karen B. Chapman ,  Gregg B. Morin ,  Calvin B. Harley ,  William H. Andrews

IPC: A61K039/00

CPC classification number: C12N15/1137 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/1241 ,  C12N9/1276 ,  C12N15/113 ,  C12N2310/15 ,  C12N2310/315 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Y207/07049

Abstract: The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

Abstract translation: 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。

公开(公告)号：US20020132007A1

公开(公告)日：2002-09-19

申请号：US09877330

申请日：2001-06-07

Applicant: University Technology Corporation

Inventor： Theodore W. Randolph ,  Mark C. Manning ,  Richard F. Falk

IPC: A61K009/14

CPC classification number: A61K9/1694 ,  A61K47/541 ,  A61K47/554 ,  Y10S514/937 ,  Y10S514/951

Abstract: Provided is a sustained release composition for sustained release of a pharmaceutical substance. The composition includes a biocompatible polymer that is highly amorphous and a pharmaceutical substance in a hydrophobic ion complex with an amphiphilic material. Also provided a compressed antisolvent method for manufacturing the composition, various product forms incorporating the composition and various uses for the composition.

Abstract translation: 提供用于药物物质的持续释放的持续释放组合物。 该组合物包括高度无定形的生物相容性聚合物和与两亲性物质在疏水性离子络合物中的药物。 还提供了用于制造组合物的压缩抗溶剂方法，包含组合物的各种产品形式和用于组合物的各种用途。

公开(公告)号：US20020032166A1

公开(公告)日：2002-03-14

申请号：US09924898

申请日：2001-08-07

Applicant: University Technology Corporation

Inventor： Eli Shefter ,  James A. Ruth ,  Jeffrey D. Meyer ,  Mark C. Manning ,  David J. Kroll ,  David J. Claffey

IPC: A61K048/00 ,  A61K031/57 ,  C07J041/00

CPC classification number: B82Y5/00 ,  A61K9/0073 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5123 ,  A61K9/5153 ,  A61K9/5192 ,  A61K38/046 ,  A61K38/09 ,  A61K38/095 ,  A61K38/10 ,  A61K38/27 ,  A61K38/28 ,  A61K38/57 ,  A61K47/183 ,  A61K47/28 ,  A61K47/541 ,  A61K47/6927 ,  B01F3/0092 ,  B01F2003/0064 ,  C07J41/0055 ,  C07K1/32 ,  Y02P20/544

Abstract: Provided is a method for preparing a true, homogeneous solution of a pharmaceutical substance dissolved in an organic solvent in which the pharmaceutical substance is not normally soluble. Solubilization is obtained by forming a hydrophobic ion pair complex involving the pharmaceutical substance and an amphiphilic material. The resulting organic solution may be further processed to prepare pharmaceutical powders. A biodegradable polymer may be co-dissolved with the pharmaceutical substance and the amphiphilic material and may be incorporated into a pharmaceutical powder. A preferred method for preparing pharmaceutical powders is to subject the organic solution to gas antisolvent precipitation using a supercritical gas antisolvent such as carbon dioxide. Also provided is a method for making hollow particles having a fiber-like shape which would provide enhanced retention time in the stomach if ingested by a human or animal host. Further provided are novel biocompatible cationic surfactants and uses therefor, including the delivery, in vitro and in vivo, of nucleic acids into cells to transform the cells.

Abstract translation: 提供了制备溶解在药物通常不溶于其中的有机溶剂中的药物的真实均匀溶液的方法。 通过形成涉及药物物质和两亲性物质的疏水性离子对络合物来获得溶解。 所得到的有机溶液可以进一步加工以制备药物粉末。 可生物降解的聚合物可以与药物物质和两亲物质共溶，并且可以并入药物粉末中。 用于制备药物粉末的优选方法是使用超临界气体反溶剂如二氧化碳对有机溶液进行气体反溶剂沉淀。 还提供了一种制备具有纤维状形状的中空颗粒的方法，其将在人或动物宿主摄入时提供增强的胃中的停留时间。 还提供了新颖的生物相容性阳离子表面活性剂及其用途，包括将细胞在体外和体内递送到细胞中以转化细胞。

公开(公告)号：US06165471A

公开(公告)日：2000-12-26

申请号：US109036

申请日：1998-07-02

Applicant: Robert L. Garcea ,  JoAnn A. Suzich ,  Michael P. McCarthy ,  Robert C. Rose

Inventor： Robert L. Garcea ,  JoAnn A. Suzich ,  Michael P. McCarthy ,  Robert C. Rose

IPC: A61K39/00 ,  A61K39/12 ,  A61P31/12 ,  C07K14/025

CPC classification number: C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5258 ,  C07K14/005 ,  C12N2710/20022 ,  C12N2710/20023 ,  C12N2710/20034 ,  Y10S977/804 ,  Y10S977/917 ,  Y10S977/92 ,  Y10S977/928

Abstract: The present invention relates to stable HPV capsomeres which express at least one virus-neutralizing conformational epitope of a native HPV L1 protein which are substantially incapable of assembly into virus-like particles. These capsomeres, because of their smaller size, and immunogenic properties are well suited for use in HPV vaccines and as diagnostic agents. Moreover, because of their smaller size (relative to VLPs), these stable capsomeres may be easily purified and should result in HPV vaccines of enhanced homogeneity.

Abstract translation: 本发明涉及表达天然HPV L1蛋白质的至少一种病毒中和构象表位的稳定的HPV病毒颗粒，其基本上不能组装成病毒样颗粒。 由于其较小的尺寸和免疫原性，这些壳聚糖非常适合用于HPV疫苗和诊断剂。 此外，由于它们的尺寸较小（相对于VLP），这些稳定的壳体可以容易地纯化，并且应该导致增强的均匀性的HPV疫苗。

公开(公告)号：US6090442A

公开(公告)日：2000-07-18

申请号：US942522

申请日：1997-10-02

Applicant: Jason Klaus ,  Ofer Sneh ,  Steven M. George

Inventor： Jason Klaus ,  Ofer Sneh ,  Steven M. George

IPC: C23C16/34 ,  C23C16/40 ,  C23C16/44 ,  C23C16/455

CPC classification number: C23C16/45534 ,  C23C16/345 ,  C23C16/402 ,  C23C16/44

Abstract: The present invention provides a method for growing atomic layer thin films on functionalized substrates at room temperature using catalyzed binary reaction sequence chemistry. Specifically, the atomic layer films are grown using two half-reactions. Catalysts are used to activate surface species in both half-reactions thereby enabling both half-reactions to be carried out at room temperature.

Abstract translation: 本发明提供了一种使用催化二元反应序列化学在室温下在官能化底物上生长原子层薄膜的方法。 具体地，使用两个半反应生长原子层膜。 催化剂用于在两个半反应中活化表面物质，从而使得半反应能够在室温下进行。

公开(公告)号：US6040883A

公开(公告)日：2000-03-21

申请号：US775952

申请日：1997-01-03

Applicant: Kristina M. Johnson ,  Chong Chang Mao

Inventor： Kristina M. Johnson ,  Chong Chang Mao

IPC: G02F1/05 ,  G02F1/1362 ,  G02F1/141 ,  G03H1/02 ,  G03H1/04 ,  G03H1/08 ,  G11C7/00 ,  G11C13/04 ,  G02F1/133 ,  G02F1/13

CPC classification number: G03H1/0248 ,  G03H1/02 ,  G03H1/08 ,  G03H1/0891 ,  G03H1/2645 ,  G03H1/28 ,  G11C13/042 ,  G11C7/005 ,  G02F1/0541 ,  G02F1/136277 ,  G02F1/141 ,  G02F2202/13 ,  G03H1/0406 ,  G03H1/265 ,  G03H2001/0224 ,  G03H2001/026 ,  G03H2001/0268 ,  G03H2001/2244 ,  G03H2001/2289 ,  G03H2210/562 ,  G03H2222/31 ,  G03H2222/56 ,  G03H2225/22 ,  G03H2225/36 ,  G03H2225/52 ,  G03H2240/53 ,  G03H2260/36

Abstract: A programmable hologram generator comprises a layered structure of a pixelated VLSI chip, a reflective ferroelectric liquid crystal that is physically disposed on the VLSI chip, and a photorefractive crystal that is physically disposed on the liquid crystal. The VLSI chip is controlled by a computer wherein holograms are digitally stored. The reflective state of the individual pixel areas of the liquid crystal are controlled or selected by this computer control of the VLSI chip. A desired hologram is written into the photorefractive crystal by a reference beam that illuminates the photorefractive crystal, and by an illumination beam that is reflected from the selected pixels of the liquid crystal and thereafter interferes with the reference beam. The hologram that is written into the photorefractive crystal is a function of the control of the reflective state of the pixels of the liquid crystal, as this reflective state is in turn controlled by the pixels of the VLSI chip.

Abstract translation: 可编程全息图发生器包括像素化VLSI芯片的层状结构，物理地设置在VLSI芯片上的反射铁电液晶和物理地设置在液晶上的光折射晶体。 VLSI芯片由其中全息图数字存储的计算机控制。 通过VLSI芯片的这种计算机控制来控制或选择液晶的各个像素区域的反射状态。 通过照射光折射晶体的参考光束和从液晶的所选像素反射的照明光束将所需的全息图写入光折射晶体，然后干涉参考光束。 写入光折射晶体的全息图是控制液晶像素的反射状态的函数，因为反射状态又由VLSI芯片的像素控制。

公开(公告)号：US6036746A

公开(公告)日：2000-03-14

申请号：US159296

申请日：1998-09-23

Applicant: Paul Scovazzo ,  Paul W. Todd

Inventor： Paul Scovazzo ,  Paul W. Todd

IPC: B01D53/22 ,  B01D53/26

CPC classification number: B01D53/22 ,  B01D53/229 ,  B01D53/268

Abstract: A condenser system for controlling vapor concentration contained in a flowing airstream is provided. The flowing airstream has an initial temperature upon entering the condenser system and a final temperature upon exiting the condenser system. The condenser system has a membrane member allowing mass transfer of the vapor therethrough with the airstream contacting the membrane member. A condensing member diffuses the vapor from the airstream through the membrane member. An insulating layer is positioned between the membrane member and the condensing member with the insulating layer inhibiting heat transfer between the flowing airstream and the condensing member wherein the final temperature of the airstream is substantially equal to the initial temperature of the airstream.

Abstract translation: 提供了一种用于控制包含在流动气流中的蒸气浓度的冷凝器系统。 流入的气流在进入冷凝器系统时具有初始温度，并且在离开冷凝器系统时具有最终温度。 冷凝器系统具有膜构件，其允许蒸汽通过其与气膜接触的构件传递通过其中。 冷凝构件将来自气流的蒸气扩散通过膜构件。 绝缘层位于膜构件和聚光构件之间，绝缘层阻止流动空气流和冷凝构件之间的热传递，其中空气流的最终温度基本上等于气流的初始温度。

公开(公告)号：US5989897A

公开(公告)日：1999-11-23

申请号：US47026

申请日：1998-03-24

Applicant: Lorraine Pillus ,  Astrid Clarke ,  Joanna Lowell ,  Sandra Jacobson ,  Cheryl Reifsnyder

Inventor： Lorraine Pillus ,  Astrid Clarke ,  Joanna Lowell ,  Sandra Jacobson ,  Cheryl Reifsnyder

IPC: C07K14/395 ,  C12N1/19 ,  C12N15/81 ,  C12N1/18 ,  C12N15/31 ,  C12N15/63

CPC classification number: C07K14/395 ,  C12N15/81

Abstract: The present invention provides the yeast genes SAS2, SAS3 and ESA1 and the proteins encoded thereby. SAS2, SAS3 and ESA1 genes of members of the genus Saccharomyces are provided, particularly the SAS2, SAS3 and ESA1 genes of S. cerevisiae. Also provided are yeast SAS2, SAS3 and ESA1 coding sequences. Specifically provided are the SAS2, SAS3 and ESA1 coding sequences of members of the genus Saccharomyces, and more specifically of S. cerevisiae. Genes of this invention comprise protein coding sequences as well as the regulatory regions that control expression of the encoded protein. Of most interest are SAS2, SAS3, and ESA1 genes of yeast including those of the genus Saccharomyces which are 90% or more homologous to the corresponding genes of S. cerevisiae. Specifically provided are DNA constructs comprising purified and isolated DNA molecules comprising SAS2, SAS3 or ESA1 coding sequences that encode proteins from a strain of S. cerevisiae.

Abstract translation: 本发明提供了酵母基因SAS2，SAS3和ESA1以及由此编码的蛋白质。 提供了Saccharomyces属的SAS2，SAS3和ESA1基因，特别是酿酒酵母的SAS2，SAS3和ESA1基因。 还提供了酵母SAS2，SAS3和ESA1编码序列。 具体提供的是Saccharomyces属的成员的SAS2，SAS3和ESA1编码序列，更特别的是酿酒酵母。 本发明的基因包括蛋白质编码序列以及控制编码蛋白质表达的调控区域。 最感兴趣的是酵母的SAS2，SAS3和ESA1基因，包括与酿酒酵母的相应基因90％或更多同源的酵母属的那些。 特别提供了包含纯化和分离的DNA分子的DNA构建体，其包含编码来自酿酒酵母菌株的蛋白质的SAS2，SAS3或ESA1编码序列。

公开(公告)号：US5982954A

公开(公告)日：1999-11-09

申请号：US955084

申请日：1997-10-21

Applicant: Nuri Delen ,  Brian Hooker

Inventor： Nuri Delen ,  Brian Hooker

IPC: G02B27/44 ,  G03H1/08 ,  G06K9/32

CPC classification number: G02B27/4266 ,  G03H1/08

Abstract: This invention provides a method and apparatus for analyzing the propagation of optical fields between arbitrarily oriented planes using full scalar diffraction theory. One aspect of the invention allows propagation between tilted planes. A second aspect allows propagation between offset planes. To analyze the propagation of an input optical field from a first plane to a second plane, the input field in the spatial domain is Fourier transformed to obtain the plane wave distribution in the spatial frequency domain. Within the spatial frequency domain the field is propagated from the first plane to the second plane by first multiplying the plane wave distribution by the spatial frequency domain phase accumulation between the first and second planes, and then converting the plane wave distribution from the coordinate system of the first plane to that of the second plane. Finally, the propagated plane wave distribution is inverse Fourier transformed to obtain the propagated optical field. This propagation sequence forms the building block for a numerical method to analyze optical systems using full scalar diffraction theory. To analyze optical systems, the input field is propagated from the plane of the source to the plane of the first optical element and the propagated optical field is multiplied by the transmittance function of the optical element. This invention further includes tolerance analysis of each parameter that affects the image quality and coupling efficiency of the optical system.

Abstract translation: 本发明提供一种用于使用全标量衍射理论来分析任意取向的平面之间的光场的传播的方法和装置。 本发明的一个方面允许在倾斜平面之间传播。 第二方面允许在偏移平面之间传播。 为了分析从第一平面到第二平面的输入光场的传播，空间域中的输入场被傅里叶变换以获得空间频域中的平面波分布。 在空间频域内，通过首先将平面波分布乘以第一和第二平面之间的空间频域相位累积，将场从第一平面传播到第二平面，然后将平面波分布从坐标系 第二架飞机的第一架飞机。 最后，传播的平面波分布进行傅里叶逆变换，以获得传播的光场。 该传播序列形成用于使用全标量衍射理论分析光学系统的数值方法的构建块。 为了分析光学系统，输入场从源的平面传播到第一光学元件的平面，并且传播的光场乘以光学元件的透射函数。 本发明还包括影响光学系统的图像质量和耦合效率的每个参数的容差分析。