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    Controlled delivery system
    42.
    发明授权
    Controlled delivery system 有权
    受控输送系统

    公开(公告)号：US08846072B2

    公开(公告)日：2014-09-30

    申请号：US13789416

    申请日：2013-03-07

    Applicant: Durect Corporation

    Inventor： A. Neil Verity

    IPC: A61F2/00 ,  A61K31/445 ,  A61K31/045 ,  A61P23/00 ,  A61K9/08 ,  A61K9/00 ,  A61K47/26 ,  A61K47/22

    CPC classification number: A61K31/445 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/08 ,  A61K9/107 ,  A61K9/7015 ,  A61K45/06 ,  A61K47/22 ,  A61K47/26

    Abstract: The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided.

    Abstract translation: 本发明涉及含有非聚合物载体材料和麻醉剂的新型麻醉剂组合物，其中组合物适合于提供持续的局部麻醉而没有初始爆发并具有约24小时或更长时间的持续时间。 还提供了包括第一麻醉剂和第二麻醉剂的某些组合物。 在这种组合物中，第二麻醉剂是用于第一麻醉剂的溶剂，并且在给予受试者时提供初始麻醉效果。 非聚合物载体可以任选地是高粘度液体载体材料，例如合适的糖酯。 组合物还可以包括一种或多种另外的成分，包括活性和非活性材料。 还提供了使用本发明组合物在受试者的部位产生持续麻醉效果的方法。

    TINTED ANTISEPTIC SOLUTIONS HAVING IMPROVED STABILITY
    44.
    发明申请
    TINTED ANTISEPTIC SOLUTIONS HAVING IMPROVED STABILITY 有权
    具有改进的稳定性的TINTED抗体解决方案

    公开(公告)号：US20140261454A1

    公开(公告)日：2014-09-18

    申请号：US13841297

    申请日：2013-03-15

    Applicant: CAREFUSION 2200, INC.

    Inventor： Kenneth M. DOKKEN ,  Tenoch BENITEZ ,  James BARDWELL

    IPC: A61K47/32 ,  A61K31/444 ,  A61B19/08 ,  A61K31/155

    CPC classification number: A61K47/32 ,  A61B46/40 ,  A61K9/0014 ,  A61K9/7015 ,  A61K31/155 ,  A61K31/444 ,  A61L26/0014 ,  A61L26/0066 ,  A61L2300/404 ,  C08L33/08

    Abstract: An antiseptic solution including, a cationic antiseptic agent, a film forming polymer, an anionic tinting agent, and a solvent, wherein the cationic antiseptic agent, the film forming polymer and the anionic tinting agent each remain solubilized within the solution for greater than about 1 hour at 25° C. and 60% relative humidity. The antiseptic agent is preferably octenidine dihydrochloride or chlorhexadine gluconate. The film forming polymer is preferably an acrylate polymer. The solvent is preferably ethanol, isopropanol, and n-propanol. When a drape is adhered to a dried surgical film via the antiseptic solution, the force required to peel the drape from the surgical film is at least about 105 g/25 mm.

    Abstract translation: 包括阳离子防腐剂，成膜聚合物，阴离子着色剂和溶剂的防腐溶液，其中阳离子防腐剂，成膜聚合物和阴离子着色剂各自保持溶解在溶液中大于约1 小时在25°C和60％相对湿度。 防腐剂优选为二辛酸二辛酯或葡萄糖酸氯己定。 成膜聚合物优选为丙烯酸酯聚合物。 溶剂优选为乙醇，异丙醇和正丙醇。 当通过防腐溶液将悬垂布贴在干燥的手术膜上时，从手术膜剥离悬垂液所需的力至少约为105克/ 25毫米。

    TOPICAL COMPOSITIONS AND METHODS OF TREATMENT OF ANORECTAL AND GENITAL DISORDERS
    45.
    发明申请
    TOPICAL COMPOSITIONS AND METHODS OF TREATMENT OF ANORECTAL AND GENITAL DISORDERS 审中-公开
    局部组合物和治疗异位性和遗传性疾病的方法

    公开(公告)号：US20140255522A1

    公开(公告)日：2014-09-11

    申请号：US14203329

    申请日：2014-03-10

    Applicant: PeriTech Pharma Ltd.

    Inventor： Evgenia Lozinsky ,  Eran Eilat

    IPC: A61K31/535 ,  A61K45/06 ,  A61K31/137

    CPC classification number: A61K31/5375 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/06 ,  A61K9/08 ,  A61K9/107 ,  A61K9/7015 ,  A61K31/137 ,  A61K31/535 ,  A61K45/06 ,  A61K47/20 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K2300/00

    Abstract: A topical anorectal or genital composition includes at least one film forming ingredient; at least one surfactant; at least one non-polar volatile siloxane solvent; at least 15% (w/w) water, and a therapeutically effective concentration of at least one pharmaceutical agent, wherein the composition is sufficiently designed to dry within 60 seconds after application to the anorectal or genital surface to form a dried composition, and wherein the dried composition forms: a flexible film, wherein the flexible film closely follows irregularities of the body surface as well as movement of the body surface, and (ii) a durable film, wherein the durable film does not crack or flake off and remains intact for more than 12 hours giving release of the pharmaceutical agent for an extended period of time.

    Abstract translation: 局部肛门直肠或生殖器组合物包括至少一种成膜成分; 至少一种表面活性剂; 至少一种非极性挥发性硅氧烷溶剂; 至少15％（w / w）的水和治疗有效浓度的至少一种药剂，其中所述组合物被充分设计成在施用到肛门直肠或生殖器表面后60秒内干燥以形成干燥的组合物，并且其中 干燥的组合物形成：柔性膜，其中柔性膜紧密地遵循身体表面的不规则性以及身体表面的运动，以及（ii）耐用膜，其中耐久膜不会破裂或剥落并保持完整 持续超过12小时，长时间释放药剂。

    TOPICAL COMPOSITIONS AND METHODS OF TREATMENT OF TOPICAL DISORDERS
    46.
    发明申请
    TOPICAL COMPOSITIONS AND METHODS OF TREATMENT OF TOPICAL DISORDERS 审中-公开
    局部组合物和治疗局限性疾病的方法

    公开(公告)号：US20140255521A1

    公开(公告)日：2014-09-11

    申请号：US14203246

    申请日：2014-03-10

    Applicant: PeriTech Pharma Ltd.

    Inventor： Evgenia Lozinsky ,  Eran Eilat

    IPC: A61K31/5375 ,  A61K45/06 ,  A61K31/137

    CPC classification number: A61K31/5375 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/06 ,  A61K9/08 ,  A61K9/107 ,  A61K9/7015 ,  A61K31/137 ,  A61K31/535 ,  A61K45/06 ,  A61K47/20 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K2300/00

    Abstract: A topical composition includes at least one film forming ingredient; at least one surfactant; at least one non-polar volatile siloxane solvent; at least 15% (w/w) water; and a therapeutically effective concentration of at least one pharmaceutical agent, wherein the composition is sufficiently designed to dry within 60 seconds after application to a body surface to form a dried composition, and wherein the dried composition forms: a flexible film, wherein the flexible film closely follows irregularities of the body surface as well as movement of the body surface, and (ii) a durable film, wherein the durable film does not crack or flake off and remains intact for more than 12 hours giving release of the pharmaceutical agent for an extended period of time.

    Abstract translation: 局部组合物包含至少一种成膜成分; 至少一种表面活性剂; 至少一种非极性挥发性硅氧烷溶剂; 至少15％（w / w）的水; 和至少一种药剂的治疗有效浓度，其中所述组合物被充分设计成在施用于身体表面后60秒内干燥以形成干燥的组合物，并且其中所述干燥的组合物形成：柔性膜，其中所述柔性膜 紧密地跟随身体表面的不规则性以及身体表面的运动，以及（ii）耐久的膜，其中耐久性膜不会破裂或剥落并保持完整超过12小时，释放用于药物的药剂 延长一段时间

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