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    INHALER WITH A FORWARD METERING VALVE
    41.
    发明申请
    INHALER WITH A FORWARD METERING VALVE 审中-公开
    吸入与前进的计量阀

    公开(公告)号：US20100043785A1

    公开(公告)日：2010-02-25

    申请号：US12514741

    申请日：2007-11-14

    申请人： Joergen Rasmussen ,  Soeren Christrup

    发明人： Joergen Rasmussen ,  Soeren Christrup

    IPC分类号： A61M11/00 ,  B65B1/04

    CPC分类号： G01F11/22 ,  A61M15/0066 ,  A61M15/0075 ,  A61M15/0081 ,  A61M15/009 ,  G01F11/20

    摘要： A metered dose inhaler for administration a liquid phase medium using a rotating metering element that transports the metered dose from the pressurized canister to the mouthpiece. The metering is improved in that there is an efficient protection against penetration of outside air, and in that the counting of the doses is improved by preventing backwards rotation of the rotating metering element.

    摘要翻译： 一种计量剂量吸入器，用于使用将计量剂量从加压罐输送到接口管的旋转计量元件来施用液相介质。 改进计量是因为有一种有效的防止外部空气穿透的保护，并且通过防止旋转计量元件的向后旋转来改善剂量的计数。

    Dose Information Device
    42.
    发明申请
    Dose Information Device 有权
    剂量信息装置

    公开(公告)号：US20090293870A1

    公开(公告)日：2009-12-03

    申请号：US12293518

    申请日：2007-02-26

    申请人： Lennart Brunnberg ,  Stephan Olson ,  Anders Wieselblad

    发明人： Lennart Brunnberg ,  Stephan Olson ,  Anders Wieselblad

    IPC分类号： A61M15/00 ,  A61M5/31 ,  A61F9/00

    CPC分类号： A61M5/31551 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31556 ,  A61M5/3157 ,  A61M5/31583 ,  A61M5/31593 ,  A61M15/0065 ,  A61M15/0066 ,  A61M15/0073 ,  A61M15/0076 ,  A61M15/0078 ,  A61M15/08 ,  A61M2005/2013 ,  A61M2005/3125 ,  A61M2005/3126 ,  A61M2205/583 ,  A61M2205/585

    摘要： The present invention relates to a device to be used with a medical administration device, which administration device comprises administration drive means for administrating a prescribed dose of medicament; mechanical dose setting means for setting a prescribed dose of medicament to be administered, including a mechanical indicating member (76) fixedly connected to said administration drive means (84) for indicating the prescribed set dose, wherein said device comprises mechanical dose information means for registering the prescribed dose of medicament to be administered including a mechanical information member adjustable to display that said prescribed dose to be administered is correct, and inter-connected to said mechanical indicating member such that when the prescribed dose is set, this is indicated positively by indications on said mechanical information member.

    摘要翻译： 本发明涉及一种与医疗管理装置一起使用的装置，该管理装置包括用于施用规定剂量的药剂的给药驱动装置; 用于设定要施用的规定剂量的药物的机械剂量设定装置，包括固定地连接到所述管理驱动装置（84）的用于指示规定的设定剂量的机械指示构件（76），其中所述装置包括用于登记的机械剂量信息装置 待施用的药物的规定剂量包括可调节以显示所要施用的规定剂量的机械信息构件是正确的，并且与所述机械指示构件相互连接，使得当规定的剂量被设定时，这被指示为积极 在所述机械信息构件上。

    Injection device
    43.
    发明授权
    Injection device 有权
    注射装置

    公开(公告)号：US07597685B2

    公开(公告)日：2009-10-06

    申请号：US10597384

    申请日：2005-11-24

    申请人： Stephan Olson

    发明人： Stephan Olson

    IPC分类号： A61M5/00

    CPC分类号： A61M5/31586 ,  A61M5/19 ,  A61M5/2033 ,  A61M5/24 ,  A61M5/3146 ,  A61M5/31505 ,  A61M5/31525 ,  A61M5/31553 ,  A61M5/3156 ,  A61M5/31563 ,  A61M5/3202 ,  A61M5/3257 ,  A61M5/3272 ,  A61M15/0065 ,  A61M15/0066 ,  A61M2005/2013

    摘要： Injection device comprising a tubular elongated main body, a needle shield slidably arranged in said main body, a needle shield link slidably connected to said needle shield, a enclosure containing medicament arranged in said main body, a needle connected to said enclosure, a plunger operatively arranged to said enclosure for ejecting said medicament through said needle and arranged on its upper part with a number of outwardly extending stop members, spring means arranged to said plunger for operating said plunger, a dose activating means, a needle shield spring surrounding the needle shield link. The invention is characterised in that said injection device further comprises a first tubular member rotationally and slidably arranged inside said needle shield link, said tubular member comprises a number or ridges and protrusions on both its outer and inner surfaces, said ridges and protrusions on the outer surface of the tubular member co-operate with guide members arranged on the inner surface of said needle shield link, said ridges and protrusions on the inner surface of the tubular member co-operate with the outwardly extending stop members of the plunger that said injection device further comprises a second tubular member arranged inside said housing, arranged and designed with a number of ridges and protrusions on its inner and outer surfaces capable of setting and delivering a certain preset dose.

    摘要翻译： 注射装置，其包括管状细长主体，可滑动地布置在所述主体中的针护罩，可滑动地连接到所述针护罩的针护罩连接件，包含布置在所述主体中的药物的外壳，连接到所述外壳的针， 布置到所述外壳上，用于通过所述针头排出所述药物并且在其上部上设置有多个向外延伸的止动构件，弹簧装置布置在所述柱塞上用于操作所述柱塞，剂量启动装置，围绕针护罩的针护罩弹簧 链接。 本发明的特征在于，所述注射装置还包括旋转并可滑动地布置在所述针屏蔽连杆内的第一管状构件，所述管状构件在其外表面和内表面上都包括数个或多个隆起和突起，所述脊和突起在外部 管状构件的表面与布置在所述针屏蔽连杆的内表面上的引导构件相配合，所述管状构件的内表面上的所述脊和突起与柱塞的向外延伸的止动构件相配合，所述注射装置 还包括设置在所述壳体内部的第二管状构件，其布置和设计成在其内表面和外表面上具有若干脊和突起，能够设定和递送特定的预设剂量。

    Method of Use of Monomeric Insulin as a Means for Improving the Reproducibility of Inhaled Insulin
    45.
    发明申请
    Method of Use of Monomeric Insulin as a Means for Improving the Reproducibility of Inhaled Insulin 审中-公开
    使用单体胰岛素作为改善吸入胰岛素再现性的手段的方法

    公开(公告)号：US20080102129A1

    公开(公告)日：2008-05-01

    申请号：US11924483

    申请日：2007-10-25

    申请人： Igor Gonda ,  Reid Rubsamen ,  Stephen Farr

    发明人： Igor Gonda ,  Reid Rubsamen ,  Stephen Farr

    IPC分类号： A61K9/12 ,  A61K9/14 ,  A61K38/28

    CPC分类号： A61K9/007 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0445 ,  A61K9/0073 ,  A61K9/0075 ,  A61K38/28 ,  A61M11/001 ,  A61M15/00 ,  A61M15/0031 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0065 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0085 ,  A61M15/009 ,  A61M16/142 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2205/50 ,  A61M2205/8206

    摘要： The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is improved relative to regular insulin. The blood concentration versus time profile is substantially unaffected by specific aspects of the patient's breathing maneuver at delivery. Further, the rate at which blood glucose is lowered is increased by the use of monomeric insulin. Particles of insulin and in particular monomeric insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The monomeric insulin may be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release.

    摘要翻译： 可以通过递送雾化的单体胰岛素制剂来减少或消除通过注射递送胰岛素的需要。 相对于常规胰岛素，给药的重复性更特别是血液浓度对时间曲线的重复性得到改善。 血液浓度与时间分布基本上不受患者在分娩时呼吸机动的特定方面的影响。 此外，通过使用单体胰岛素来增加血糖降低的速度。 胰岛素的颗粒，特别是递送到肺组织表面的单体胰岛素将被吸收到循环系统中。 单体胰岛素可以是干粉，但是优选地是从手持式独立装置输送到患者的液体制剂，其自动释放雾化的制剂爆发。 该装置包括传感器，其优选是电子的，其测量吸气流量和体积，该测量可用于控制药物释放点。

    METHOD OF USE OF MONOMERIC INSULIN AS A MEANS FOR IMPROVING THE REPRODUCIBILITY OF INHALED INSULIN
    46.
    发明申请
    METHOD OF USE OF MONOMERIC INSULIN AS A MEANS FOR IMPROVING THE REPRODUCIBILITY OF INHALED INSULIN 审中-公开
    使用单一胰岛素作为改善吸入胰岛素可重复性的手段的方法

    公开(公告)号：US20080099010A1

    公开(公告)日：2008-05-01

    申请号：US11924503

    申请日：2007-10-25

    申请人： Igor Gonda ,  Reid Rubsamen ,  Stephen Farr

    发明人： Igor Gonda ,  Reid Rubsamen ,  Stephen Farr

    IPC分类号： A61M11/00

    CPC分类号： A61K9/007 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0445 ,  A61K9/0073 ,  A61K9/0075 ,  A61K38/28 ,  A61M11/001 ,  A61M15/00 ,  A61M15/0031 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0065 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0085 ,  A61M15/009 ,  A61M16/142 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2205/50 ,  A61M2205/8206

    摘要： The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is improved relative to regular insulin. The blood concentration versus time profile is substantially unaffected by specific aspects of the patient's breathing maneuver at delivery. Further, the rate at which blood glucose is lowered is increased by the use of monomeric insulin. Particles of insulin and in particular monomeric insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The monomeric insulin may be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release.

    摘要翻译： 可以通过递送雾化的单体胰岛素制剂来减少或消除通过注射递送胰岛素的需要。 相对于常规胰岛素，给药的重复性更特别是血液浓度对时间曲线的重复性得到改善。 血液浓度与时间分布基本上不受患者在分娩时呼吸机动的特定方面的影响。 此外，通过使用单体胰岛素来增加血糖降低的速度。 胰岛素的颗粒，特别是递送到肺组织表面的单体胰岛素将被吸收到循环系统中。 单体胰岛素可以是干粉，但是优选地是从手持式独立装置输送到患者的液体制剂，其自动释放雾化的制剂爆发。 该装置包括传感器，其优选是电子的，其测量吸气流量和体积，该测量可用于控制药物释放点。

    Devices and methods for nebulizing fluids for inhalation
    47.
    发明授权
    Devices and methods for nebulizing fluids for inhalation 有权
    用于吸入雾化液体的装置和方法

    公开(公告)号：US07360536B2

    公开(公告)日：2008-04-22

    申请号：US10338194

    申请日：2003-01-07

    申请人： Rajan Patel ,  Michael A. Klimowicz

    发明人： Rajan Patel ,  Michael A. Klimowicz

    IPC分类号： A61M11/00

    CPC分类号： A61M15/0085 ,  A61M11/005 ,  A61M11/007 ,  A61M15/0065 ,  A61M15/0066 ,  A61M2016/0021 ,  A61M2016/0024 ,  A61M2205/50 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2205/8206 ,  B05B17/0646

    摘要： A nebulizer comprising an aerosol generator and a titration mechanism comprising a dosing mechanism, a screw assembly, a plunger and an actuator, wherein the dosing mechanism is rotatably mounted in the nebulizer and the plunger is mounted in the nebulizer to travel along a longitudinal axis substantially perpendicular to the plane of rotation of the dosing mechanism. The actuator is mounted to the nebulizer to travel in the direction of the longitudinal axis. The screw mechanism allows the rotation of the dosing mechanism to fix a variable distance of travel of the plunger based on the selected dose, without moving the plunger longitudinally. This allows the user to verify and if necessary correct the selected dose prior to any drug being released from the vial. Operation of the actuator causes longitudinal movement, through the screw mechanism, to the plunger. The actuator always moves a fixed distance along the longitudinal axis, while the plunger always moves a variable distance depending on rotation of the dosing mechanism to a selected dose.

    摘要翻译： 一种喷雾器，包括气溶胶发生器和滴定机构，其包括计量机构，螺杆组件，柱塞和致动器，其中计量机构可旋转地安装在雾化器中，并且柱塞安装在雾化器中以基本上沿着纵向轴线行进 垂直于计量机构的旋转平面。 致动器安装到雾化器以沿纵向轴线的方向移动。 螺杆机构允许计量机构的旋转基于所选择的剂量来固定柱塞的可变行程距离，而不纵向移动柱塞。 这允许用户在从药瓶释放任何药物之前验证并且必要时校正所选择的剂量。 致动器的操作使得纵向运动通过螺杆机构到柱塞。 致动器总是沿着纵向轴线移动固定的距离，而柱塞总是根据给料机构的旋转移动一个可变的距离到一个选定的剂量。

    Storage system for powdered pharmaceuticals, and inhaler equipped with this system
    50.
    发明授权
    Storage system for powdered pharmaceuticals, and inhaler equipped with this system 有权
    粉末药品储存系统和配有该系统的吸入器

    公开(公告)号：US07234464B2

    公开(公告)日：2007-06-26

    申请号：US09739170

    申请日：2000-12-18

    申请人： Joachim Goede ,  Karl-Heinz Lange

    发明人： Joachim Goede ,  Karl-Heinz Lange

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0003 ,  A61M15/0066 ,  A61M2202/064

    摘要： A cartridge for powdered pharmaceuticals. At least two storage spaces are provided which are separate from each other and which are each intended to hold a multiplicity of doses of a medically active substance. The storage spaces are individual cartridges which may be lockingly coupled together to form a single cartridge. Each individual cartridge has a metering cavity.

    摘要翻译： 用于粉末药物的药筒。 提供至少两个彼此分离的储存空间，它们各自用于容纳多种剂量的医用活性物质。 存储空间是可以锁定地联接在一起以形成单个盒的各个盒。 每个单独的墨盒具有计量腔。