公开(公告)号：US07624487B2

公开(公告)日：2009-12-01

申请号：US10437144

申请日：2003-05-13

Applicant: Michael Trull ,  Perry Genova ,  Robert C. Williams, III

Inventor： Michael Trull ,  Perry Genova ,  Robert C. Williams, III

IPC: B21F25/00 ,  B26D7/14 ,  A61B17/04

CPC classification number: B26D1/0006 ,  A61B17/06166 ,  A61B2017/00526 ,  A61B2017/06176 ,  B26D7/01 ,  B26D2001/006 ,  Y10T29/20 ,  Y10T83/929 ,  Y10T428/29

Abstract: An apparatus for cutting barbs into a suture having a filament supply. The apparatus also has an in-feed collet for holding one end of a filament threaded therethrough. Further the apparatus has an out-feed collet for holding a second end of a filament threaded therethrough. Additionally, the apparatus has a holder positioned between said in-feed and out-feed collets for holding a filament suspended between the in-feed and out-feed collets. The apparatus also has a cutting assembly for cutting barbs in the filament tensioned between the in-feed and out-feed collets.

Abstract translation: 一种用于将倒钩切割成具有丝线供应的缝合线的装置。 该装置还具有用于保持丝杠穿过的长丝的一端的进给夹头。 此外，该装置具有用于保持穿过其中的细丝的第二端的出料夹头。 另外，该装置具有定位在所述进料和出料夹头之间的保持器，用于保持悬挂在进料和出料夹头之间的细丝。 该设备还具有切割组件，用于切割在进给和出料夹头之间张紧的细丝中的倒钩。

公开(公告)号：US20080173301A1

公开(公告)日：2008-07-24

申请号：US11850177

申请日：2007-09-05

Applicant: Daniel Deaton ,  Robert Williams ,  Matthew D. Khare ,  Perry Genova

Inventor： Daniel Deaton ,  Robert Williams ,  Matthew D. Khare ,  Perry Genova

IPC: A61M16/20

CPC classification number: A61M15/009 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0091 ,  A61M15/0098 ,  A61M15/08 ,  A61M2205/502 ,  A61M2205/8206 ,  B65D83/525

Abstract: A variable volume medicament valve, inhaler; and method of treatment including a housing, and a plug insertable into the housing wherein a volume of medicament to be released by the valve is defined by a distance between a lower surface of the plug and a top surface of the housing and wherein the volume is variable.

Abstract translation: 可变容积药物阀，吸入器; 和处理方法，包括壳体和可插入到壳体中的插头，其中由阀门释放的一定体积的药物由插塞的下表面和壳体的顶表面之间的距离限定，并且其中体积是 变量。

公开(公告)号：US20080017189A1

公开(公告)日：2008-01-24

申请号：US11709535

申请日：2007-02-22

Applicant: Tom Ruckdeschel ,  Perry Genova ,  Dan Deaton ,  Matt Khare

Inventor： Tom Ruckdeschel ,  Perry Genova ,  Dan Deaton ,  Matt Khare

IPC: A61M11/08

CPC classification number: A61M15/0091 ,  A61M11/001 ,  A61M15/0026 ,  A61M15/008 ,  A61M15/009 ,  A61M15/0096 ,  A61M2205/16 ,  A61M2205/276 ,  A61M2206/16

Abstract: A breath actuated metered dose inhaler including a housing, a mouthpiece positioned at one end of the housing, and a mechanical release mechanism positioned at another end of the housing. The release mechanism is triggered by a diaphragm and the inhaler is configured such that the air inhalation pathway is unimpeded by the release mechanism.

Abstract translation: 一种呼吸致动计量剂量吸入器，包括壳体，位于壳体一端的吸嘴以及位于壳体另一端的机械释放机构。 释放机构由隔膜触发，并且吸入器构造成使得空气吸入通道不受释放机构的阻碍。

公开(公告)号：US07056494B2

公开(公告)日：2006-06-06

申请号：US10391053

申请日：2003-03-18

Applicant: Akwete L. Adjei ,  Perry Genova ,  Yazping Zhu ,  Federick Sexton

Inventor： Akwete L. Adjei ,  Perry Genova ,  Yazping Zhu ,  Federick Sexton

IPC: A61K9/12 ,  A61M11/00

CPC classification number: A61K9/008

Abstract: A method and dispenser for treating a systemic disease in a patient in need of such treatment is disclosed. The method comprising maintaining the inspiratory flow rate and volume of the patient to a certain value and then administering a medicament aerosol formulation to the patient using a breath activated inhalation device.

Abstract translation: 公开了一种用于治疗需要这种治疗的患者的全身性疾病的方法和分配器。 该方法包括将患者的吸气流速和体积保持在一定值，然后使用呼吸激活吸入装置向患者施用药物气溶胶制剂。

公开(公告)号：US20050028815A1

公开(公告)日：2005-02-10

申请号：US10625359

申请日：2003-07-23

Applicant: Daniel Deaton ,  Thomas Ruckdeschel ,  Perry Genova ,  Warren Jewett

Inventor： Daniel Deaton ,  Thomas Ruckdeschel ,  Perry Genova ,  Warren Jewett

IPC: A61J20060101 ,  A61M11/00 ,  A61M15/00

CPC classification number: A61M15/009 ,  A61M15/0065 ,  A61M15/008

Abstract: An apparatus for dispensing medication having a canister containing medication to be dispensed to a user. The canister is movable in both a first and a second direction. The apparatus also includes a mouthpiece that provides a point of egress for the medication. The medication is dispensed to the user when the canister is moved in the first direction. Also included in the apparatus is a switch for completing an electrical circuit. The switch is activated when the canister is moved in the first direction closing the electrical circuit. The electrical circuit is opened when the canister moves in the second direction. A counter module is disclosed for performing a count upon the closure of the electrical circuit. The counter module also and displays a dispensation history of the medication in the canister. The apparatus also includes a seal for isolating the counter module from the mouthpiece and the canister.

Abstract translation: 一种用于分配药物的装置，其具有包含要分配给使用者的药物的罐。 罐可以在第一和第二方向上移动。 该装置还包括为药物提供出口点的吸嘴。 当罐沿第一方向移动时，将药物分配给使用者。 装置中还包括用于完成电路的开关。 当罐沿着关闭电路的第一方向移动时，开关被激活。 当罐沿第二方向移动时，电路打开。 公开了一种用于在电路闭合时执行计数的计数器模块。 计数器模块还显示药剂在药筒中的分配历史。 该设备还包括用于将计数器模块与吸嘴和容器隔离的密封件。

公开(公告)号：US08926659B2

公开(公告)日：2015-01-06

申请号：US12972802

申请日：2010-12-20

Applicant: Perry Genova ,  Robert C. Williams, III ,  Warren Jewett

Inventor： Perry Genova ,  Robert C. Williams, III ,  Warren Jewett

IPC: A61B17/04 ,  B26D3/08 ,  A61B17/06 ,  A61B17/064 ,  A61B17/00

CPC classification number: B26D3/08 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00526 ,  A61B2017/06176 ,  Y10T29/20 ,  Y10T83/02 ,  Y10T83/0333 ,  Y10T83/0341 ,  Y10T83/0385 ,  Y10T83/04 ,  Y10T83/202 ,  Y10T83/4607 ,  Y10T83/896

Abstract: A barbed suture is disclosed having barbs defined by a variable-angle cut surface. A cutting bed supports the suture during cutting. A cutting device is moved through the suture thread along a selected path. The angle of the cutting device is changed during cutting so that there is a corresponding change in the angle of the cut surface which defines each barb. A cutting arm is articulated to allow change of the angle of the cutting device. The change in the angle of the cutting device is used to control the shape and depth of cut of the barbs.

Abstract translation: 公开了一种有倒钩的缝合线，其具有由可变角度切割表面限定的倒钩。 切割床在切割过程中支撑缝合线。 切割装置沿选定的路径移动穿过缝合线。 在切割期间切割装置的角度发生变化，从而限定每个倒钩的切割面的角度相应变化。 切割臂被铰接以允许切割装置的角度改变。 切割装置的角度变化用于控制倒钩的形状和深度。

公开(公告)号：US08028387B2

公开(公告)日：2011-10-04

申请号：US12850467

申请日：2010-08-04

Applicant: Perry Genova ,  Robert C. Williams, III ,  Warren Jewett

Inventor： Perry Genova ,  Robert C. Williams, III ,  Warren Jewett

IPC: B21F25/00

CPC classification number: B26D3/08 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00526 ,  A61B2017/06176 ,  Y10T29/20 ,  Y10T83/02 ,  Y10T83/0333 ,  Y10T83/0341 ,  Y10T83/0385 ,  Y10T83/04 ,  Y10T83/202 ,  Y10T83/4607 ,  Y10T83/896

Abstract: A system for manufacturing self-retaining suture includes means for supporting the suture during cutting of retainers which protrude from the suture at multiple angles. The system includes an anvil having a channel configured to support a suture during cutting of a retainer at a first angular position while providing for non-interference between the anvil and retainers previously cut on the suture at one or more angular positions different than the first angular position. In embodiments the channel is provided with notches which receive previously-formed retainers during creation of subsequent retainers. The system thereby provides for rotating the suture and supporting the suture with the anvil without interference with previously-formed retainers.

Abstract translation: 用于制造自固位缝线的系统包括用于在切割由多个角度从缝合线突出的保持器时支撑缝合线的装置。 该系统包括具有通道的砧座，该通道被配置为在第一角度位置切割保持器期间支撑缝合线，同时提供在砧座和先前在缝合线上切割的保持器之间的不干涉，该保持器在一个或多个不同于第一角度 位置。 在实施例中，通道设置有在后续保持器的创建期间接收预先形成的保持器的凹口。 该系统由此提供旋转缝合线并且用砧座支撑缝合线，而不会干扰预先形成的保持器。

公开(公告)号：US20110093010A1

公开(公告)日：2011-04-21

申请号：US12972802

申请日：2010-12-20

Applicant: Perry Genova ,  Robert C. Williams, III ,  Warren Jewett

Inventor： Perry Genova ,  Robert C. Williams, III ,  Warren Jewett

IPC: A61B17/04

CPC classification number: B26D3/08 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00526 ,  A61B2017/06176 ,  Y10T29/20 ,  Y10T83/02 ,  Y10T83/0333 ,  Y10T83/0341 ,  Y10T83/0385 ,  Y10T83/04 ,  Y10T83/202 ,  Y10T83/4607 ,  Y10T83/896

Abstract: A barbed suture is disclosed having barbs defined by a variable-angle cut surface. A cutting bed supports the suture during cutting. A cutting device is moved through the suture thread along a selected path. The angle of the cutting device is changed during cutting thereby changing the angle of the cut surface which defines each barb. A cutting arm is articulated to allow change of the angle of the cutting device. The change in the angle of the cutting device is used to control the shape and depth of cut of the barbs.

Abstract translation: 公开了一种有倒钩的缝合线，其具有由可变角度切割表面限定的倒钩。 切割床在切割过程中支撑缝合线。 切割装置沿选定的路径移动穿过缝合线。 在切割期间切割装置的角度改变，从而改变限定每个倒钩的切割表面的角度。 切割臂被铰接以允许切割装置的角度改变。 切割装置的角度变化用于控制倒钩的形状和深度。

公开(公告)号：US20100313730A1

公开(公告)日：2010-12-16

申请号：US12850498

申请日：2010-08-04

Applicant: Perry Genova ,  Robert C. Williams, III ,  Warren Jewett

Inventor： Perry Genova ,  Robert C. Williams, III ,  Warren Jewett

IPC: B26D3/08 ,  B26D5/20 ,  B26D7/00

CPC classification number: B26D3/08 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00526 ,  A61B2017/06176 ,  Y10T29/20 ,  Y10T83/02 ,  Y10T83/0333 ,  Y10T83/0341 ,  Y10T83/0385 ,  Y10T83/04 ,  Y10T83/202 ,  Y10T83/4607 ,  Y10T83/896

Abstract: An automated system for manufacturing self-retaining suture is disclosed. The system includes a cutting bed to which a suture is mounted. A power-operated cutting arm moves a cutting device through the suture along a preselected path and at a preselected angle to create a tissue retainer having a desired geometry. An indexing mechanism moves the suture relative to the cutting device. The operation of the cutting arm in conjunction with the geometry of the cutting device and movement of the suture thread allows for creating a plurality of tissue retainers having a desired geometry distributed along the length of the suture thread.

Abstract translation: 公开了一种用于制造自固定缝线的自动化系统。 该系统包括切割床，缝合线被安装在该切割床上。 动力操作的切割臂沿着预选路径并且以预选的角度移动切割装置穿过缝合线，以产生具有期望几何形状的组织保持器。 分度机构相对于切割装置移动缝合线。 切割臂的操作结合切割装置的几何形状和缝合线的运动允许创建具有沿着缝合线的长度分布的期望几何形状的多个组织保持器。

公开(公告)号：US20100294105A1

公开(公告)日：2010-11-25

申请号：US12850455

申请日：2010-08-04

Applicant: Perry Genova ,  Robert C. Williams, III ,  Warren Jewett

Inventor： Perry Genova ,  Robert C. Williams, III ,  Warren Jewett

IPC: B26D3/08

CPC classification number: B26D3/08 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00526 ,  A61B2017/06176 ,  Y10T29/20 ,  Y10T83/02 ,  Y10T83/0333 ,  Y10T83/0341 ,  Y10T83/0385 ,  Y10T83/04 ,  Y10T83/202 ,  Y10T83/4607 ,  Y10T83/896

Abstract: A method for manufacturing a self-retaining suture is disclosed. A cutting bed supports the suture during cutting. A cutting device is moved through the suture thread along a selected path. The angle of the cutting device is changed during cutting. A cutting arm is articulated to allow change of the angle of the cutting device. The change in the angle of the cutting device is used to control the depth of cut and/or elevate a tissue-retainer away from the suture to better engage tissue.

Abstract translation: 公开了一种用于制造自固位缝合线的方法。 切割床在切割过程中支撑缝合线。 切割装置沿选定的路径移动穿过缝合线。 在切割过程中切割装置的角度发生变化。 切割臂被铰接以允许切割装置的角度改变。 切割装置的角度变化用于控制切割深度和/或使组织保持器远离缝合线，以更好地接合组织。