公开(公告)号：US20170095201A1

公开(公告)日：2017-04-06

申请号：US15382469

申请日：2016-12-16

Applicant: Varian Medical Systems International AG

Inventor： Karl OTTO

IPC: A61B5/00 ,  A61B5/08 ,  A61B5/113 ,  A61N5/10

CPC classification number: A61B5/4836 ,  A61B5/08 ,  A61B5/113 ,  A61B34/10 ,  A61B2034/101 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

公开(公告)号：US20170001036A1

公开(公告)日：2017-01-05

申请号：US15266264

申请日：2016-09-15

Applicant: Varian Medical Systems International AG

Inventor： Karl OTTO

IPC: A61N5/10

CPC classification number: A61B5/4836 ,  A61B5/08 ,  A61B5/113 ,  A61B34/10 ,  A61B2034/101 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods for planning delivery of radiation dose to a target region within a subject comprise: iteratively optimizing a simulated dose distribution relative to a set of one or more optimization goals comprising a desired dose distribution in the subject over a first plurality of control points located on a trajectory, the trajectory comprising relative movement between a radiation source and the subject; reaching one or more initial termination conditions, and after reaching the one or more initial termination conditions: specifying a second plurality of control points along the trajectory and comprising a larger number control points than the first plurality of control points; and iteratively optimizing a simulated dose distribution relative to the set of one or more optimization goals over the second plurality of control points to thereby determine a radiation delivery plan.

Abstract translation: 将辐射剂量递送到受试者内的目标区域的方法包括：相对于一组一组或多项优化目标迭代地优化模拟剂量分布，所述一组或多项优化目标包括在对象上的第一多个控制点上的期望剂量分布 轨迹，轨迹包括辐射源和被摄体之间的相对运动; 达到一个或多个初始终止条件，并且在达到一个或多个初始终止条件之后：沿着所述轨迹指定第二多个控制点，并且包括比所述第一多个控制点更大的控制点; 以及相对于所述第二多个控制点上的一个或多个优化目标的集合迭代地优化模拟剂量分布，从而确定辐射递送计划。

公开(公告)号：US20160325119A1

公开(公告)日：2016-11-10

申请号：US15109430

申请日：2015-01-05

Applicant: Xinsheng Cedric YU

Inventor： Xinsheng Cedric YU

IPC: A61N5/10

CPC classification number: A61N5/1047 ,  A61B6/032 ,  A61B6/035 ,  A61B6/4429 ,  A61B6/4435 ,  A61B6/4441 ,  A61B6/4452 ,  A61N5/10 ,  A61N5/1036 ,  A61N5/1039 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1082 ,  A61N2005/1052 ,  A61N2005/1054 ,  A61N2005/1055 ,  A61N2005/1061

Abstract: A method of irradiating a target in a patient comprising directing a beam of radiation from an external source of radiation 24 at the target in the patient from numerous directions in a broad solid angle by longitudinally rotating the external source of radiation 24 around a central axis and simultaneously or sequentially, in either order, latitudinally rotating the external source of radiation 24; a globe gantry 21 comprising (i) a front opening ring 22 with its origin on the central axis of the globe gantry 21, (ii) at least one arc-shaped, gantry support arm 23, which has a front end and a rear end and is part of a circle, (iii) an external source of radiation 24, which is mounted on at least one arc-shaped, gantry support arm 23 and is movable along the gantry support arm to vary the latitude of the beam angle, (iv) a rear rotational axle 25 with an axis along the central axis of the globe gantry 21, (v) a support base 27, and (vi) a rear housing 26 comprising a source of power, mechanisms for moving components of the globe gantry 21, and controllers for controlling the movement of the components of the globe gantry 21 and the irradiation of the target in the patient; a system 20 comprising the globe gantry 21; and a method of irradiating a target in a patient using the system.

Abstract translation: 一种照射患者中的靶的方法，包括：通过围绕中心轴线纵向旋转外部辐射源24，以宽广立体角度从多个方向将来自外部辐射源24的辐射束定向在患者的目标上;以及 同时或顺序地以任何顺序，横向旋转外部辐射源24; 地球台架21包括（i）其前端开口环22，其原点在球形台架21的中心轴线上，（ii）至少一个弧形的龙门架支撑臂23，其具有前端和后端 并且是圆的一部分，（iii）外部辐射源24，其被安装在至少一个弧形的龙门架支撑臂23上，并且可沿台架支撑臂移动以改变光束角的纬度（ iv）具有沿着球形台架21的中心轴的轴线的后旋转轴25，（v）支撑基座27，以及（vi）包括动力源的后壳体26，用于移动地球台架的部件的机构 21，以及用于控制地球台架21的部件的移动和患者体内的靶的照射的控制器; 包括地球台架21的系统20; 以及使用该系统照射患者中的靶的方法。

公开(公告)号：US20160089549A1

公开(公告)日：2016-03-31

申请号：US14785751

申请日：2014-04-17

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Vaitheeswaran RANGANATHAN ,  Gipson JOE ANTO ,  Prashant KUMAR ,  Sivaramakrishnan KRISHNAIYER RAMAN ,  Deepak Uddhavrao MAHAJAN

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1036 ,  A61N5/1045 ,  A61N5/1077 ,  A61N2005/1074 ,  G06F19/00

Abstract: A method for dose-gradient based optimization of an intensity modulated radiation therapy plan. First, an optimizer (6) performs a first optimization (40) of the plan to generate dose distributions corresponding to the plan. Next, the optimizer (6) generates a beam specific dose gradient map (42) for each beam of the plan. Then, new dose gradients are specified (44) for the plan. Last, the optimizer (6) performs a final optimization (46) using the new dose gradients. The final optimization is given the new dose gradients as soft constraints into an objective function. The optimizer (3) applies a limiting factor to the objective function such that a first dose gradient is limited by the optimizer only if the first dose gradient exceeds the new dose gradient for a specific beamlet.

Abstract translation: 一种强度调制放射治疗计划的剂量梯度优化方法。 首先，优化器（6）执行计划的第一优化（40）以产生对应于该计划的剂量分布。 接下来，优化器（6）针对该计划的每个波束产生波束特定剂量梯度图（42）。 然后，规定新剂量梯度（44）。 最后，优化器（6）使用新的剂量梯度进行最终优化（46）。 最终优化给出了新的剂量梯度作为目标函数的软约束。 优化器（3）对目标函数应用限制因子，使得仅当第一剂量梯度超过特定子束的新剂量梯度时，优化器才限制第一剂量梯度。

公开(公告)号：US20150335914A1

公开(公告)日：2015-11-26

申请号：US14710485

申请日：2015-05-12

Applicant: Karl OTTO

Inventor： Karl OTTO

IPC: A61N5/10 ,  A61B19/00

CPC classification number: A61B5/4836 ,  A61B5/08 ,  A61B5/113 ,  A61B34/10 ,  A61B2034/101 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

Abstract translation: 提供了方法和装置，用于通过模式来规划和传送辐射治疗，所述模式涉及沿着相对于受试者的轨迹移动辐射源，同时向受试者传送辐射。 在一些实施例中，辐射源沿轨迹连续移动，而在一些实施例中，辐射源间歇地移动。 一些实施例涉及辐射递送计划的优化以满足各种优化目标，同时满足许多约束。 对于沿着轨迹的多个控制点中的每一个，辐射递送计划可以包括：一组运动轴参数，一组波束形状参数和波束强度。

公开(公告)号：US20150265851A1

公开(公告)日：2015-09-24

申请号：US12932666

申请日：2011-03-02

Applicant: Yunzhi Ma ,  Paul J. Keall ,  Lei Xing

Inventor： Yunzhi Ma ,  Paul J. Keall ,  Lei Xing

IPC: A61N5/10 ,  A61B19/00

CPC classification number: A61N5/1031 ,  A61B2090/3966 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1077 ,  A61N2005/1035 ,  A61N2005/1061

Abstract: An inverse planning method that is capable of controlling the appearance of the implanted fiducial(s) in segmented IMRT fields for cine MV or combined MV/kV image-guided IMRT is provided. The method for radiation treatment includes computing a radiation treatment plan and delivering beams to a target in accordance with the radiation treatment plan, where computing the radiation treatment plan includes introducing a penalty in an inverse planning objective function optimization calculation to discourage or avoid blockage of one or more fiducials in optimized multi-leaf collimator (MLC) apertures.

Abstract translation: 提供了一种能够控制电影MV或组合MV / kV图像引导IMRT的分段IMRT场中植入基准的外观的逆规划方法。 放射治疗的方法包括计算辐射治疗计划并根据放射治疗计划将光束输送到目标，其中计算辐射治疗计划包括在逆规划目标函数优化计算中引入惩罚，以阻止或避免阻塞一个 或更多的基准在优化的多叶准直器（MLC）孔。

公开(公告)号：US20150165233A1

公开(公告)日：2015-06-18

申请号：US14617652

申请日：2015-02-09

Applicant: ViewRay Incorporated

Inventor： James F. Dempsey ,  Iwan Kawrykow

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1036 ,  A61N5/1045 ,  A61N5/1071 ,  A61N5/1077

Abstract: The subject matter described herein provides methods for developing an IMRT treatment plan for a radiotherapy system. In one aspect, the method can include providing initial treatment parameters. These parameters can include a number of isotopic beams, a transmission angle for each beam, a prescribed dose for a target, and dose volume histogram constraints. The method can further include determining an initial fluence map including one or more beamlets. The initial fluence map can specify a fluence value for each beamlet. The method can further include determining a delivery sequence for the fluence values in the initial fluence map. The delivery sequence can include one or more apertures formed by the leaves of a collimator. These apertures can have a specified size constrained to substantially less than a maximum size associated with the collimator, when the isotopic beam is near a critical structure. Related apparatus and systems are also described.

Abstract translation: 本文所述的主题提供了用于开发用于放射治疗系统的IMRT治疗计划的方法。 在一个方面，该方法可以包括提供初始治疗参数。 这些参数可以包括多个同位素束，每个束的传播角，目标的规定剂量以及剂量体积直方图约束。 该方法还可以包括确定包括一个或多个子束的初始注量图。 初始注量图可以为每个子束指定注量值。 该方法还可以包括确定初始注量图中的能量密度值的递送序列。 递送顺序可以包括由准直器的叶形成的一个或多个孔。 当同位素束接近临界结构时，这些孔可以具有被限制为基本上小于与准直器相关联的最大尺寸的规定尺寸。 还描述了相关装置和系统。

公开(公告)号：US08961382B2

公开(公告)日：2015-02-24

申请号：US13356835

申请日：2012-01-24

Applicant: Janne Nord ,  Perttu Niemelä ,  Esa Kuusela

Inventor： Janne Nord ,  Perttu Niemelä ,  Esa Kuusela

IPC: A61N5/10

CPC classification number: A61N5/1036 ,  A61N5/1031 ,  G06F19/00

Abstract: A control circuit optimizes a radiation-treatment plan to provide an initially-optimized radiation-treatment plan and then modifies that initially-optimized radiation-treatment plan to reduce corresponding monitor units (MU's) to provide a radiation-treatment plan that is further optimized for monitor units. This modification can comprise, at least in part, imposing a stronger smoothing constraint with respect to fluence. Optimizing a radiation-treatment plan to provide an initially-optimized radiation-treatment plan can comprise identifying at least one particular leaf pair for a multi-leaf collimator that requires a longest amount of time to move into a position that achieves a particular desired fluence and then selectively smoothing position requirements of that particular leaf pair to reduce the amount of time associated with that particular leaf pair while not also smoothing position requirements for all leaf pairs as comprise that multi-leaf collimator.

Abstract translation: 控制电路优化辐射治疗计划，以提供初始优化的辐射治疗计划，然后修改最初优化的辐射治疗计划，以减少对应的监测单位（MU），以提供进一步优化的辐射治疗计划 监控单位。 该修改可以至少部分地包括相对于能量密度的更强的平滑约束。 优化辐射处理计划以提供初始优化的辐射处理计划可以包括为多叶准直器识别至少一个特定叶对，其需要最长的时间来移动到达到特定期望通量的位置， 然后选择性地平滑该特定叶对的位置要求，以减少与特定叶对相关联的时间量，而不对包括该多叶准直器的所有叶对的平滑位置要求进行平滑。

公开(公告)号：US20130216026A1

公开(公告)日：2013-08-22

申请号：US13676370

申请日：2012-11-14

Applicant: Varian Medical Systems International AG

Inventor： Janne Ilmari Nord ,  Tuomas Erik Torsti

IPC: A61N5/10 ,  G21K1/02

CPC classification number: A61N5/1047 ,  A61N5/1036 ,  A61N5/1037 ,  G21K1/02 ,  G21K1/043 ,  G21K1/046

Abstract: A method and system for providing intensity modulated radiation therapy to a moving target is disclosed. According to a preferred embodiment of the invention, a treatment plan for providing radiotherapy using a multi-leaf collimator (“MLC”) comprises a plurality of sub-plans, each of which is optimized for a different phase of target movement. Movements of the treatment target are tracked in real time, and the choice of which sub-plan to implement is made in real time based on the tracked position of the target. Each of the sub-plans is preferably formulated to minimize interplay effects between target movements and MLC leaf movements, consistent with other planning goals. In addition, the sub-plans preferably include a predicted region corresponding to the next anticipated position of the target, in order to facilitate the transition to the next position.

Abstract translation: 公开了一种向移动目标提供强度调制辐射治疗的方法和系统。 根据本发明的优选实施例，使用多叶准直器（“MLC”）提供放射治疗的治疗计划包括多个子计划，每个子计划针对目标运动的不同阶段进行了优化。 治疗目标的移动实时跟踪，根据目标的跟踪位置实时选择实施的子计划。 每个子计划优选地被配制为使目标运动和MLC叶运动之间的相互作用效应最小化，与其他规划目标一致。 此外，子方案优选地包括对应于目标的下一个预期位置的预测区域，以便于向下一个位置的转变。

公开(公告)号：US08503608B2

公开(公告)日：2013-08-06

申请号：US12739206

申请日：2007-10-24

Applicant: Kevin Brown ,  Ralph Streamer ,  Paul Boxall ,  Duncan Bourne ,  Christopher James Gibson

Inventor： Kevin Brown ,  Ralph Streamer ,  Paul Boxall ,  Duncan Bourne ,  Christopher James Gibson

IPC: A61N5/10

CPC classification number: A61N5/103 ,  A61N5/1036 ,  A61N5/1042

Abstract: Apparatus comprising a radiation source which can rotate in an arc around the radiation beam axis, a multi-leaf collimator (MLC), and a controller for the source dose/time rate, the source rotation speed, and the MLC position. The controller calculates the time required for (i) an MLC leaf movement from start to end of an arc-segment at a maximum leaf speed, (ii) rotation of the source from start to end of the arc-segment at a maximum speed, and (iii) delivery of the dose at a maximum dose rate per time, selects the longest of (i), (ii) and (iii), and operates the selected one at its maximum and the others at a reduced rate matching that longest time, the time required for (i) and/or (ii) being the greater of the time to complete the segment at a continuous speed and the time to accelerate the item to that speed.

Abstract translation: 装置包括可围绕辐射束轴旋转的辐射源，多叶准直器（MLC）和用于源剂量/时间速率，源旋转速度和MLC位置的控制器。 控制器计算（i）以最大叶速度从弧段的开始到结束的MLC叶移动所需的时间，（ii）以最大速度从弧段的开始到结束的旋转， 和（iii）以每次最大剂量率递送剂量，选择（i），（ii）和（iii）中最长的剂量，并且以最大的速度操作所选择的剂量，而以与最长剂量率相匹配的降低的速率 时间，（i）和/或（ii）所需的时间是以连续速度完成分段的时间越长，以及将项目加速到该速度的时间。