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343 条记录 (耗时 0.019 秒)

    Phosphorus-containing cyclic nitroxide free radicals
    41.
    发明授权
    Phosphorus-containing cyclic nitroxide free radicals 失效
    含磷环状氮氧自由基

    公开(公告)号：US5006663A

    公开(公告)日：1991-04-09

    申请号：US433597

    申请日：1989-11-08

    申请人： Yves Berchadsky ,  Nelly Kernevez ,  Francois Le Moigne ,  Anne Mercier ,  Liliane Secourgeon ,  Paul Tordo

    发明人： Yves Berchadsky ,  Nelly Kernevez ,  Francois Le Moigne ,  Anne Mercier ,  Liliane Secourgeon ,  Paul Tordo

    IPC分类号： A61K49/20 ,  C07F9/572 ,  C07F9/59 ,  C07F9/6506 ,  C07F9/653 ,  C07F9/6533

    CPC分类号： A61K49/20 ,  C07F9/5726 ,  C07F9/597 ,  C07F9/65066 ,  C07F9/653 ,  C07F9/6533

    摘要： A nitroxide radical of the formula (I) or (II): ##STR1## in which R.sub.1 and R.sub.2 are independently chosen from among the optionally deuterated alkyl, alkoxyl, dialkylaminyl and phenyl radicals, H, D or Cl; R.sub.3, R.sub.8 and R.sub.9 are independently chosen from among the optionally deuterated alkyl, alkoxyl and phenyl radicals; R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are independently chosen from among the optionally deuterated alkyl, alkoxyl, dialkylaminyl and phenyl radicals, COOH, OH, OD, H, D, a halogen, COOR (in which R is an alkyl radical); R.sub.10 and R.sub.11 are independently chosen from among optionally deuterated alkyl, alkoxyl, dialkylaminyl and phenyl radicals, COOH, OH, OD, H, D, a halogen, COOR (in which R is an alkyl radical) or represent an oxygen atom linked with the cycle of the radical by a double bond is described.

    摘要翻译： 式（I）或（II）的氮氧自由基：其中R 1和R 2独立地选自任选的氘代烷基，烷氧基，二烷基氨基和苯基，H， D或Cl; R3，R8和R9独立地选自任选的氘代烷基，烷氧基和苯基; R 4，R 5，R 6和R 7独立地选自任选的氘代烷基，烷氧基，二烷基氨基和苯基，COOH，OH，OD，H，D，卤素，COOR（其中R是烷基） R 10和R 11独立地选自氘代烷基，烷氧基，二烷基氨基和苯基，COOH，OH，OD，H，D，卤素，COOR（其中R是烷基）或代表与 描述了基团的双键循环。

    Pharmaceuticals, phosphorus-containing 2-isoxazolines and isoxazoles contained therein
    42.
    发明授权
    Pharmaceuticals, phosphorus-containing 2-isoxazolines and isoxazoles contained therein 失效
    药物，其中含有含磷的2-异恶唑啉和异恶唑

    公开(公告)号：US5006515A

    公开(公告)日：1991-04-09

    申请号：US262635

    申请日：1988-10-26

    申请人： Wilfried Schwab ,  Robert R. Bartlett ,  Ulrich Gebert ,  Hans U. Schorlemmer ,  Gerhard Dickneite ,  Hans H. Sedlacek

    发明人： Wilfried Schwab ,  Robert R. Bartlett ,  Ulrich Gebert ,  Hans U. Schorlemmer ,  Gerhard Dickneite ,  Hans H. Sedlacek

    IPC分类号： A61K31/675 ,  A61K39/39 ,  A61P35/00 ,  A61P37/00 ,  C07F9/40 ,  C07F9/653 ,  C07F9/6574

    CPC分类号： C07F9/653 ,  A61K31/675

    摘要： Pharmaceuticals containing or composed of at least one compound of the formula I and/or one of its physiologically tolerated salts where appropriate, where the compounds of the formula I can, where appropriate, be in the form of pure stereoisomers or mixtures thereof; formula I is: ##STR1## in which R.sup.1 =organic radical or halogen,A=C,C single or C,C double bond,n=0, 1 or 2, and ##STR2## R.sup.2 and R.sup.3 =H or optionally substituted aliphatic radical. The pharmaceuticals are suitable for the prophylaxis and/or treatment of diseases of the immune system, especially of tumors, infections and/or autoimmune diseases of the human or animal body and for use as adjuvants for vaccines.Some of the compounds of the formula I are new; the compounds can be prepared by special processes.

    摘要翻译： 含有或由至少一种式I化合物和/或其适当的生理学耐受盐组成的药物，其中式I化合物在适当时可以是纯立体异构体或其混合物的形式; 式I是：其中R 1 =有机基团或卤素，A = C，C单或C，C双键，n = 0,1或2，X和Y =烷基或= OR 2 或具有R2和R3 = H的NR2R3或任选取代的脂族基团。 该药物适用于预防和/或治疗免疫系统疾病，特别是人或动物体的肿瘤，感染和/或自身免疫性疾病的疾病，并且可用作疫苗佐剂。 一些式I的化合物是新的; 该化合物可以通过特殊方法制备。

    Certain 1-hydroxyethane, 1,1-di-phosphonic acid derivatives useful in treating calcium metabolism disturbances
    45.
    发明授权
    Certain 1-hydroxyethane, 1,1-di-phosphonic acid derivatives useful in treating calcium metabolism disturbances 失效
    某些用于治疗钙代谢紊乱的1-羟基乙烷，1,1-二膦酸衍生物

    公开(公告)号：US4687767A

    公开(公告)日：1987-08-18

    申请号：US759608

    申请日：1985-07-26

    申请人： Elmar Bosies ,  Rudi Gall

    发明人： Elmar Bosies ,  Rudi Gall

    IPC分类号： A61K31/675 ,  A61P3/00 ,  A61P3/14 ,  C07F9/38 ,  C07F9/553 ,  C07F9/58 ,  C07F9/6506 ,  C07F9/6515 ,  C07F9/6518 ,  C07F9/653 ,  C07F9/65 ,  A61K31/44 ,  A61K31/415

    CPC分类号： C07F9/3839 ,  C07F9/582 ,  C07F9/65062 ,  C07F9/65182 ,  C07F9/653

    摘要： The present invention provides diphosphonates of the general formula: ##STR1## wherein Het is an imidazole, oxazole, isoxazole, thiazole, pyridine, 1,2,3-triazole, 1,2,4-triazole or benzimidazole radical, which is optionally substituted by alkyl, alkoxy, halogen, hydroxyl, carboxyl, an amino group optionally substituted by alkyl or alkanoyl radicals or a benzyl radical optionally substituted by alkyl, nitro, amino or aminoalkyl, A is a straight-chained or branched, saturated or unsaturated hydrocarbon chain containing 2 to 8 carbon atoms, X is a hydrogen atom, optionally substituted by alkanoyl, or an amino group optionally substituted by alkyl or alkanoyl radicals and R is a hydrogen atom or an alkyl radical; and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of these diphosphonates and pharmaceutical compositions containing them.

    摘要翻译： 本发明提供了以下通式的二膦酸盐：其中Het是咪唑，恶唑，异恶唑，噻唑，吡啶，1,2,3-三唑，1,2,4-三唑或苯并咪唑基，其中 烷氧基，卤素，羟基，羧基，任选被烷基或烷酰基取代的氨基或任选被烷基，硝基，氨基或氨基烷基取代的苄基，A是直链或支链，饱和或 含有2至8个碳原子的不饱和烃链，X是任选被烷酰基取代的氢原子或任选被烷基或烷酰基取代的氨基，R是氢原子或烷基; 及其药理学上可接受的盐。 本发明还提供了制备这些二膦酸盐和含有它们的药物组合物的方法。