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67 条记录 (耗时 0.049 秒)

    Novel ectoparasite saliva proteins and apparatus to collect such proteins
    41.
    发明申请
    Novel ectoparasite saliva proteins and apparatus to collect such proteins 有权
    新型外寄生唾液蛋白质和收集这些蛋白质的装置

    公开(公告)号：US20030185755A1

    公开(公告)日：2003-10-02

    申请号：US10271344

    申请日：2002-10-14

    申请人： Heska Corporation.

    发明人： Glenn R. Frank ,  Shirley W. Hunter ,  Lynda Wallenfels

    IPC分类号： A61K049/00 ,  A61K039/00 ,  A01K001/03

    CPC分类号： C07K14/4359 ,  A61K38/17 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  Y10S530/855 ,  Y10S530/858 ,  Y10S530/868

    摘要： The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention includes a saliva protein collection apparatus capable of collecting ectoparasite saliva proteins substantially free of contaminating material. The present invention also relates to ectoparasite saliva proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to obtain such proteins and to use such proteins to identify animals susceptible to or having allergic dermatitis. The present invention also includes therapeutic compositions comprising such proteins and their use to treat animals susceptible to or having allergic dermatitis.

    摘要翻译： 本发明涉及一种用于分离异位唾液蛋白的新产品和方法，以及用于在动物中检测和/或治疗过敏性皮炎的新产品和方法。 本发明包括能够收集基本上不含污染物质的外寄生唾液蛋白质的唾液蛋白质收集装置。 本发明还涉及外寄生物唾液蛋白质，具有编码这种蛋白质的序列的核酸分子和针对这种蛋白质产生的抗体。 本发明还包括获得这种蛋白质和使用这些蛋白质鉴定易感或具有过敏性皮炎的动物的方法。 本发明还包括包含这些蛋白质的治疗组合物及其用于治疗易感或具有过敏性皮炎的动物的用途。

    Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof
    42.
    发明申请
    Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof 审中-公开
    跳蚤头，神经线，后肠和恶臭小管核酸分子，蛋白质及其用途

    公开(公告)号：US20030073827A1

    公开(公告)日：2003-04-17

    申请号：US09991936

    申请日：2001-11-21

    发明人： Kevin S. Brandt ,  Patrick J. Gaines ,  Dan T. Stinchcomb ,  Nancy Wisnewski

    IPC分类号： C07H021/04 ,  C12Q001/68 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06

    CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

    摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.

    摘要翻译： 本发明涉及跳蚤头，神经根，后肠和马鞭状小管蛋白; 跳蚤头，神经线，后肠和马鞭状小管核酸分子，包括编码这种跳蚤头，神经线，后肠和马鞭状小管蛋白的那些; 针对这种跳蚤头，神经线，后肠和马鞭状小管蛋白质产生的抗体; 以及抑制跳蚤头，神经丝，后肠和马鞭状小管蛋白活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含衍生自本发明蛋白质的蛋白质，核酸分子或保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。 本发明还包括使用跳蚤头，神经根，后肠和马鞭状小管蛋白来衍生抑制性化合物。

    NOVEL ECTOPARASITE SALIVA PROTEINS AND APPARATUS TO COLLECT SUCH PROTEINS
    43.
    发明申请
    NOVEL ECTOPARASITE SALIVA PROTEINS AND APPARATUS TO COLLECT SUCH PROTEINS 无效
    新型ECTOPARASITE SALIVA蛋白质和收集这种蛋白质的装置

    公开(公告)号：US20020169104A1

    公开(公告)日：2002-11-14

    申请号：US08809423

    申请日：1997-05-01

    发明人： GLENN FRANK ,  SHIRLEY HUNTER ,  LYNDA WALLENFELS

    IPC分类号： A01N037/18 ,  A61K038/00 ,  A01N025/00

    CPC分类号： C07K14/4359 ,  A61K38/17 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  Y10S530/855 ,  Y10S530/858 ,  Y10S530/868

    摘要： The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention includes a saliva protein collection apparatus capable of collecting ectoparasite saliva proteins substantially free of contaminating material. The present invention also relates to ectoparasite saliva proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to obtain such proteins and to use such proteins to identify animals susceptible to or having allergic dermatitis. The present invention also includes therapeutic compositions comprising such proteins and their use to treat animals susceptible to or having allergic dermatitis.

    摘要翻译： 本发明涉及一种用于分离异位唾液蛋白的新产品和方法，以及用于在动物中检测和/或治疗过敏性皮炎的新产品和方法。 本发明包括能够收集基本上不含污染物质的外寄生唾液蛋白质的唾液蛋白质收集装置。 本发明还涉及外寄生物唾液蛋白质，具有编码这种蛋白质的序列的核酸分子和针对这种蛋白质产生的抗体。 本发明还包括获得这种蛋白质和使用这些蛋白质鉴定易感或具有过敏性皮炎的动物的方法。 本发明还包括包含这些蛋白质的治疗组合物及其用于治疗易感或具有过敏性皮炎的动物的用途。

    FLEA PERITROPHIN NUCLEIC ACID MOLECULES
    49.
    发明申请
    FLEA PERITROPHIN NUCLEIC ACID MOLECULES 失效
    FLEA PERITROPHIN核酸分子

    公开(公告)号：US20080014624A1

    公开(公告)日：2008-01-17

    申请号：US11778533

    申请日：2007-07-16

    申请人： Patrick Gaines ,  Nancy Wisnewski

    发明人： Patrick Gaines ,  Nancy Wisnewski

    IPC分类号： C07H21/04 ,  C12N1/10 ,  C12N1/14 ,  C12N1/21 ,  C12N5/14 ,  C12N5/16 ,  C12N7/01

    CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

    摘要： The present invention relates to flea peritrophin proteins; to flea peritrophin nucleic acid molecules, including those that encode such flea peritrophin proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain and use such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea peritrophin activity, as well as the use of such therapeutic compositions to treat animals.

    摘要翻译： 本发明涉及跳蚤培养蛋白; 跳蚤培养蛋白核酸分子，包括编码这种跳蚤培养蛋白的蛋白质; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得和使用这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这种抑制性化合物，特别是那些特异性抑制跳蚤营养不良蛋白活性的化合物的治疗组合物，以及这些治疗组合物用于治疗动物的用途。

    Flea allantoinase nucleic acid molecules, proteins and uses thereof
    50.
    发明申请
    Flea allantoinase nucleic acid molecules, proteins and uses thereof 审中-公开
    蚕丝尿蛋白酶核酸分子，蛋白质及其用途

    公开(公告)号：US20050202031A1

    公开(公告)日：2005-09-15

    申请号：US11121635

    申请日：2005-05-04

    申请人： Patrick Gaines ,  Nancy Wisnewski

    发明人： Patrick Gaines ,  Nancy Wisnewski

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/435 ,  C07H21/04 ,  A61K39/38 ,  C12N5/06 ,  C12N9/80

    CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

    摘要： The present invention relates to flea allantoinase proteins; to flea allantoinase nucleic acid molecules, including those that encode such flea allantoinase proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea allantoinase activity, as well as the use of such therapeutic compositions to treat animals.

    摘要翻译： 本发明涉及跳蚤尿囊素蛋白; 包括那些编码这种跳蚤尿囊素酶蛋白质的尿蛋白酶核酸分子; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这种抑制性化合物的治疗组合物，特别是那些特异性抑制跳蚤尿囊炎活性的化合物，以及使用这些治疗组合物来治疗动物。