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    Human serum albumin binding compounds and fusion proteins thereof
    48.
    发明授权
    Human serum albumin binding compounds and fusion proteins thereof 有权

    公开(公告)号：US09790475B2

    公开(公告)日：2017-10-17

    申请号：US14758339

    申请日：2013-12-18

    申请人： COVAGEN AG

    发明人： Fabian Buller ,  Ulrich Wüllner ,  Irene Zbinden ,  Isabella Attinger-Toller ,  Ulrike Von Der Bey ,  Susann König-Friedrich ,  Julian Bertschinger ,  Dragan Grabulovski ,  Patricia Henne

    IPC分类号： C07K14/00 ,  C12N9/12 ,  C07K14/765 ,  C07K14/47 ,  C07K16/18

    CPC分类号： C12N9/12 ,  C07K14/47 ,  C07K14/765 ,  C07K16/18 ,  C07K2317/31 ,  C07K2319/31 ,  C12Y207/10002

    摘要： The present invention relates to a polypeptide binding to human serum albumin and comprising or consisting of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X1)(X2)(X3)(X4)(X5) (X6)D(X7)SFHKGEKFQIL(X8)(X9)(X10)(X11)(X12)G(X13)(X14)W(X15)(X16)RSLTTG(X17)(X18)G(X19)IPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X1) is A, V, I, L, M, G, P, S, T, N, Q, C, R, H, K, D or E; (X2) is R, H, K, A, V, I, L, M, G, P, S, T, N, Q or C; (X3) is R, H, K, S, T, N, Q, C, F, Y, W, A, V, I, L, M, G or P; (X4) is S, T, N, Q, C, A, V, I, L, M, G, P, R, H, K, F, Y, W, D or E; (X5) is S, T, N, Q, C, D, E, F, Y, W, A, V, I, L, M, G, P, R, H or K; (X6) is F, Y, W, A, V, I, L, M, G, P, R, H, K, S, T, N, Q or C; (X7) is A, V, I, L, M, G, P, R, H or K; (X8) is S, T, N, Q, C, D or E; (X9) is S, T, N, Q, C, D, E, A, V, I, L, M, G, P, F, Y or W; (X10) is A, V, I, L, M, G or P; (X11) is F, Y, W, R, H or K; (X12) is S, T, N, Q, C, F, Y or W; (X13) is F, Y, W, R, H, K, S, T, N, Q, C, D, E, A, V, I, L, M, G or P; (X14) is F, Y, W, A, V, I, L, M, G or P; (X15) is D, E, A, V, I, L, M, G or P; (X16) is A, V, I, L, M, G or P; (X17) is D, E, A, V, I, L, M, G, P, R, H or K; (X18) is S, T, N, Q, C, A, V, I, L, M, G or P; (X19) is F, Y, W, S, T, N, Q or C; and (b) an amino acid sequence which is at least 90% identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X1) to (X19).