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    SELECTIVE DETECTION OF AROMATIC ALPHA-AMINO ACIDS AND DERIVATIVES THEREOF
    41.
    发明申请
    SELECTIVE DETECTION OF AROMATIC ALPHA-AMINO ACIDS AND DERIVATIVES THEREOF 审中-公开
    芳香族氨基酸及其衍生物的选择性检测

    公开(公告)号：US20120091355A1

    公开(公告)日：2012-04-19

    申请号：US12907590

    申请日：2010-10-19

    申请人： Chebrolu P. RAO ,  Jugun Prakash Chinta ,  Atanu Mitra

    发明人： Chebrolu P. RAO ,  Jugun Prakash Chinta ,  Atanu Mitra

    IPC分类号： G01N21/59 ,  G01N21/64 ,  C07H5/04

    CPC分类号： C07H15/18 ,  G01N21/33 ,  G01N21/64

    摘要： Provided here are complexes useful in the detection of aromatic alpha-amino acids and peptides incorporating aromatic alpha-amino acids, and methods for detecting aromatic alpha-amino acids and peptides incorporating aromatic alpha-amino acids. Accordingly, provided herein are complexes comprising a compound of Formula I: and an aromatic alpha-amino acid, a peptide incorporating an aromatic alpha-amino acid, or a salt or ester of any of the foregoing. Also, provided herein are methods for detecting an aromatic alpha-amino acid, a peptide incorporating an aromatic alpha-amino acid, or a salt or ester of any of the foregoing, by using the fluorescence intensity enhancement, or the hypochromic shift, of the compound of Formula I.

    摘要翻译： 这里提供了可用于检测芳族α-氨基酸和掺入芳族α-氨基酸的肽的复合物，以及用于检测芳族α-氨基酸和掺入芳族α-氨基酸的肽的方法。 因此，本文提供了包含式I化合物和芳族α-氨基酸的复合物，掺入芳族α-氨基酸的肽或任何前述物质的盐或酯。 此外，本文提供的方法是通过使用荧光强度增强或低色度偏移来检测芳族α-氨基酸，掺入芳族α-氨基酸的肽或任何前述任何一种的盐或酯的方法 式Ⅰ化合物。

    2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
    45.
    发明授权
    2'-fluoro substituted carba-nucleoside analogs for antiviral treatment 有权
    用于抗病毒治疗的2'-氟取代的碳 - 核苷类似物

    公开(公告)号：US07973013B2

    公开(公告)日：2011-07-05

    申请号：US12885917

    申请日：2010-09-20

    申请人： Aesop Cho ,  Choung U. Kim ,  Samuel E. Metobo ,  Adrian S. Ray ,  Jie Xu

    发明人： Aesop Cho ,  Choung U. Kim ,  Samuel E. Metobo ,  Adrian S. Ray ,  Jie Xu

    IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H5/04 ,  C07H7/06

    CPC分类号： C07D487/04 ,  C07H7/06 ,  C07H13/08

    摘要： Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 2′ position of the nucleoside sugar is substituted with halogen and carbon substitutents. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections caused by both wild type and mutant strains of HCV.

    摘要翻译： 提供吡咯并[1,2-f] [1,2,4]三嗪基，咪唑并[1,5-f] [1,2,4]三嗪基，咪唑并[1,2-f] [1,2,4 ]三嗪基和[1,2,4]三唑并[4,3-f] [1,2,4]三嗪基核苷，其核苷磷酸酯和前药，其中核苷糖的2'位被卤素和碳 替代品 所提供的化合物，组合物和方法可用于治疗黄病毒科病毒感染，特别是HCV野生型和突变株引起的丙型肝炎感染。

    Process for preparing a sterile high molecular weight hyaluronic acid formulation
    47.
    发明授权
    Process for preparing a sterile high molecular weight hyaluronic acid formulation 有权
    制备无菌高分子量透明质酸配方的方法

    公开(公告)号：US07939655B2

    公开(公告)日：2011-05-10

    申请号：US10523657

    申请日：2003-08-04

    申请人： Stefano Carlino

    发明人： Stefano Carlino

    IPC分类号： C07H5/04 ,  C07H5/06

    CPC分类号： C08B37/0072 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/728 ,  A61K47/36

    摘要： A process for preparing a sterile ready-to-use aqueous pharmaceutical formulation comprises a high molecular weight hyaluronic acid salt (HA) at a specified concentration, comprising the steps of: providing an aqueous formulation comprising high molecular weight HA at a concentration of less than the specified final concentration; passing said aqueous formulation through a filter having a pore sizeless than 0.45 pm; concentrating said aqueous formulation by applying a vacuum and boiling off water until said specified concentration is reached.

    摘要翻译： 一种制备无菌即用型水性药物制剂的方法包括一种特定浓度的高分子量透明质酸盐（HA），包括以下步骤：提供含有浓度小于 指定的最终浓度; 使所述水性制剂通过具有0.45μm以下的孔的过滤器; 通过施加真空和沸腾的水浓缩所述水性制剂直到达到所述指定的浓度。

    Influenza virus binding, sialylated oligosaccharide substance and use thereof
    48.
    发明授权
    Influenza virus binding, sialylated oligosaccharide substance and use thereof 失效
    流感病毒结合，唾液酸化寡糖物质及其用途

    公开(公告)号：US07902170B2

    公开(公告)日：2011-03-08

    申请号：US10311713

    申请日：2001-06-20

    申请人： Halina Miller-Podraza ,  Karl-Anders Karlsson

    发明人： Halina Miller-Podraza ,  Karl-Anders Karlsson

    IPC分类号： A61K31/715 ,  A61K31/739 ,  C07H5/04

    CPC分类号： C07H3/06 ,  A61K31/715 ,  A61K31/739

    摘要： The present invention is directed to human influenza virus binding substance containing at least one oligosaccharide chain, which comprises a terminal NeuNAcα6 linked to: (a) a linear or branched polylactosamine type structure consisting of at least three lactosamine residues, a linear sequence optionally containing one or two α3-linked fucose residues in a non-sialylated lactosamine, a branched structure optionally carrying one or more additional NeuNAcα-residues at a terminal position in a branch, and/or (b) a linear or branched structure with two lactosamine and one lactose residue, a linear structure in addition containing one or two α3-linked fucose residues in a non-sialylated lactosamine or lactose, a branched structure optionally carrying one additional NeuNAcα-residue in a terminal position of the branch, or an analog or derivative of said oligosaccharide chain for use in binding of human influenza virus.

    摘要翻译： 本发明涉及含有至少一个寡糖链的人流感病毒结合物质，其包含与以下连接的末端NeuNAcα6连接的末端NeuNAcα6：（a）由至少三个乳糖胺残基组成的直链或支链多聚乳糖胺型结构，任选地含有一个 或非唾液酸化乳糖胺中的两个α3连接的岩藻糖残基，任选地在支链末端携带一个或多个另外的NeuNAcα残基的支链结构和/或（b）具有两个乳糖胺和一个 乳糖残基，在非唾液酸化乳糖胺或乳糖中另外含有一个或两个α3连接的岩藻糖残基的线性结构，任选地在该分支的末端位置携带一个额外的NeuNAcα-残基的支链结构，或其衍生物 所述寡糖链用于人流感病毒的结合。