公开(公告)号：US12116407B2

公开(公告)日：2024-10-15

申请号：US17269991

申请日：2019-09-25

Applicant: Academia Sinica

Inventor： Shie-Liang Hsieh ,  Pei-Shan Sung ,  Ming-Ting Huang ,  An-Suei Yang ,  Chung-Ming Yu

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28 ,  A61P31/20

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61P31/20 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/77

Abstract: Provided herein is a method for treating neurodegenerative diseases, such as Alzheimer's disease (AD), by use of monoclonal antibody, which exhibits a binding affinity to Siglec-3 receptor. According to some embodiments of the present disclosure, the monoclonal antibody is capable of enhancing phagocytosis of neurotoxic peptides by immune cells thereby providing a neuroprotective effect to a subject in need thereof.

公开(公告)号：US20240331862A1

公开(公告)日：2024-10-03

申请号：US18622407

申请日：2024-03-29

Applicant: National Taiwan University ,  National Taiwan University Hospital ,  Academia Sinica ,  National Tsing Hua University

Inventor： Shau-Ping LIN ,  Ruey-Meei WU ,  Frederick Kin Hing Phoa ,  Ming-Che KUO ,  Yi-Tzang TSAI ,  Jing-Wen HUANG ,  Yan-Han LIN ,  Hsiang-Hsuan LIN WANG ,  Chia-Lang HSU ,  Ya-Fang HSU ,  Pin-Jui KUNG

IPC: G16H50/20 ,  C12Q1/6806 ,  C12Q1/6883 ,  G01N33/68 ,  G16H10/60

CPC classification number: G16H50/20 ,  C12Q1/6806 ,  C12Q1/6883 ,  G01N33/6896 ,  G16H10/60 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2333/4706 ,  G01N2333/521 ,  G01N2333/575 ,  G01N2333/7051 ,  G01N2333/70596 ,  G01N2333/726 ,  G01N2333/775 ,  G01N2333/82 ,  G01N2333/90203 ,  G01N2333/91057 ,  G01N2333/91091 ,  G01N2333/91215 ,  G01N2333/96419 ,  G01N2333/99 ,  G01N2800/2821 ,  G01N2800/2835

Abstract: The present invention provides a data analytic scheme for screening biomarkers for differential diagnosis of the status of Parkinson's disease, Parkinson's disease with mild cognitive impairment, Parkinson's disease dementia, Alzheimer's disease, and/or multiple system atrophy, the methodology implementing the same and the results of the screening thereof. Biomedical Oriented Logistic Dantzig Selector (BOLD Selector) was developed to identify candidate microRNAs and extracellular vesicle proteins effective at discerning between any two of the above mentioned disease categories from profiling results. The prediction models are finalized by establishing logistic regression formula for each pair of patient group differentiation.

公开(公告)号：US20240299567A1

公开(公告)日：2024-09-12

申请号：US18272107

申请日：2022-01-14

Applicant: Ming-Che SHIH ,  Academia Sinica

Inventor： Che MA ,  Wen-Hwa LEE ,  Tracer YONG

IPC: A61K47/64 ,  A61K39/00 ,  A61P35/04 ,  C07K14/715

CPC classification number: A61K47/646 ,  A61K47/6415 ,  A61P35/04 ,  C07K14/7155 ,  A61K39/00 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/645 ,  C07K2319/40

Abstract: Disclosed herein is a recombinant polypeptide comprising 1 to 20 copies of an IL-17RB inactivation site (IRIS) sequence. Also disclosed herein is the use of the recombinant polypeptide in the preparation of a conjugate for the treatment of cancers.

公开(公告)号：US12064466B2

公开(公告)日：2024-08-20

申请号：US17730195

申请日：2022-04-27

Applicant: Academia Sinica

Inventor： Hsin-Fang Yang-Yen

IPC: A61K38/17 ,  A61P3/06

CPC classification number: A61K38/1709 ,  A61P3/06

Abstract: The present invention is directed to methods of treating hypertriglyceridemia or hypertriglyceridemia-related diseases in a subject by using recombinant PRAP1 polypeptides. According to some embodiments of the present disclosure, the subject is a human, in which the recombinant PRAP1 polypeptide comprises the amino acid sequence 100% identical to SEQ ID NO: 1 or 2. According to certain embodiments of the present disclosure, the subject is a mouse, in which the recombinant PRAP1 polypeptide comprises the amino acid sequence 100% identical to SEQ ID NO: 3 or 4.

公开(公告)号：US20240269630A1

公开(公告)日：2024-08-15

申请号：US18681077

申请日：2022-08-11

Applicant: Academia Sinica

Inventor： Yi-Chung TUNG ,  Dao-Ming CHANG ,  Wei-Hao LIAO ,  Ping-Liang KO

IPC: B01F33/3012 ,  B01F25/314 ,  B01F25/433

CPC classification number: B01F33/3012 ,  B01F25/3141 ,  B01F25/31424 ,  B01F25/4331

Abstract: Disclosed herein is a microfluidic mixer comprising first and second input chambers, first and second flow paths, and an output chamber. According to embodiments of the present disclosure, the first input chamber and the output chamber respectively have their bottom surfaces leveled with that of the first and/or second flow paths, while the second input chamber has its bottom surface protruded below that of the first flow path. Also disclosed herein is a microfluidic system comprising the present microfluidic mixer, and a pump for introducing a first and a second fluid reactants respectively into the first and a second input chambers.

公开(公告)号：US12053777B2

公开(公告)日：2024-08-06

申请号：US16968604

申请日：2019-02-27

Applicant: Academia Sinica ,  National Tsing Hua University

Inventor： Shang-Cheng Hung ,  Yen-Chun Ko ,  Cheng-Fang Tsai ,  Gwo-Bin Lee ,  Wei-Chun Tsai

IPC: B01L3/00 ,  G01N33/543 ,  G01N33/574

CPC classification number: B01L3/502761 ,  G01N33/54326 ,  G01N33/57407 ,  G01N33/57488 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2400/043 ,  G01N2400/12 ,  G01N2446/20

Abstract: Disclosed herein is an integrated microfluidic chip for detecting cancerous cells, particularly, cholangio-cancerous cells, from a biological sample. Also disclosed herein is a method of detecting cholangio-cancerous cells from a biological sample.

公开(公告)号：US20240248033A1

公开(公告)日：2024-07-25

申请号：US18417471

申请日：2024-01-19

Applicant: Academia Sinica

Inventor： Chia-Fu CHOU ,  Pei-Kuen WEI ,  Liang-Kun YU ,  Deng-Kai YANG ,  Jui-Hong WENG ,  Kuang-Li LEE ,  Shu-Cheng LO

IPC: G01N21/552 ,  B82Y15/00 ,  G01N21/19 ,  G01N21/25

CPC classification number: G01N21/554 ,  B82Y15/00 ,  G01N21/19 ,  G01N2021/258 ,  G01N2201/0633

Abstract: A surface plasmon resonance sensor is provided, which comprises: a substrate; an adaptation layer disposed on the substrate and comprising a dielectric material; and a metal layer disposed on the adaptation layer, wherein the metal layer has a grating structure comprising plural metal lines. Furthermore, a surface plasmon resonance sensing instrument comprising the same and a method for detecting an analyte using the same are also provided.

公开(公告)号：US20240219705A1

公开(公告)日：2024-07-04

申请号：US18608490

申请日：2024-03-18

Applicant: Academia Sinica

Inventor： Jung-Chi LIAO ,  Yi-De CHEN ,  Chih-Wei CHANG ,  Weng Man CHONG

IPC: G02B21/36 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/69 ,  H04N23/56 ,  H04N23/74

CPC classification number: G02B21/365 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/693 ,  H04N23/56 ,  H04N23/74

Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.

公开(公告)号：US20240125771A1

公开(公告)日：2024-04-18

申请号：US18358320

申请日：2023-07-25

Applicant: National Taiwan University ,  National Taiwan University Hospital ,  Academia Sinica

Inventor： An-Bang Wang ,  Shih-Yu Chen ,  Tung-Hung Su ,  Chia-Chi Chu ,  Chia-Chien Yen ,  Yu-Wei Chiang

IPC: G01N33/53 ,  G01N1/31 ,  G01N1/34

CPC classification number: G01N33/5304 ,  G01N1/31 ,  G01N1/34 ,  G01N2474/20

Abstract: The present invention relates to a reaction platform, which comprises: a machine body with a bottom plate for placing non-porous substrates; and a coater module configured on the top of the machine body and capable of maintaining a preset of a predetermined height for moving along the surface of non-porous substrate, wherein the coater module has one or more slits, and a target liquid can be directly injected or sucking in from the outside of the coater module through the slit, and spreading the target liquid onto a surface of the non-porous substrate while moving along the non-porous substrate; wherein the surface of the non-porous substrate has a target to be coated. The reaction platform of the present invention can not only save time, labor and cost, but also have accurate and reproducible experimental results, showing better results than traditional methods.

公开(公告)号：US11932973B2

公开(公告)日：2024-03-19

申请号：US17511641

申请日：2021-10-27

Applicant: Academia Sinica

Inventor： Chia-Fu Chou ,  Balchandar Navaneethan

IPC: D03D27/00 ,  D01D5/00

CPC classification number: D03D27/00 ,  D01D5/003 ,  D10B2331/041

Abstract: A method for manufacturing a polymer-based fibrous scaffold is disclosed. The method includes the following step: providing an electrospinning device comprising a collector; and injecting a polymer solution into the electrospinning device to produce a single jet fiber, wherein the single jet fiber is piled on the collector to form a fibrous scaffold.