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公开(公告)号：US20180087057A1
公开(公告)日：2018-03-29
申请号：US15834110
申请日：2017-12-07
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yosef Shaul , Peter Tsvetkov , Julia Adler
IPC: C12N15/113
CPC classification number: C12N15/1137 , A61K31/713 , C12N15/1135 , C12N2310/14 , C12Q1/025 , C12Q1/68 , G01N33/5011 , G01N2333/4703 , G01N2500/04 , G01N2500/10
Abstract: A method of treating cancer is disclosed. The method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising an agent which induces a dissociation of the 26S proteasomal complex into a 20S component and a 19S component to thereby inhibit 26S proteasomal activity, wherein the pharmaceutical agent is devoid of a chemotherapeutic agent.
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公开(公告)号：US09873612B2
公开(公告)日：2018-01-23
申请号：US15031749
申请日：2014-10-28
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD
Inventor： Ronny Neumann , Bidyut-Bikash Sarma
IPC: C01B3/16 , C10K3/04 , C10G1/06 , C10G3/00 , C25B1/00 , C25B1/02 , B01J27/199 , C01B3/02 , C07C51/235 , C10K3/06
CPC classification number: C01B3/16 , B01J27/199 , C01B3/02 , C01B2203/0283 , C01B2203/1041 , C07C51/235 , C10G1/065 , C10G3/44 , C10K3/04 , C10K3/06 , C25B1/00 , C25B1/02 , Y02E60/366 , Y02P30/20
Abstract: The present invention relates to methods of preparing carbon monoxide (CO) and hydrogen (H2) by reacting biomass, a biomass component (e.g., lignin, ligno-cellulose, cellulose, hemiceullose or combination thereof) or a carbohydrate from any source with a polyoxometalate catalyst such as H5PV2Mo10O40, or solvates thereof, in the presence of a concentrated acid, under conditions sufficient to yield carbon monoxide (CO); followed by electrochemical release of hydrogen (H2). The carbon monoxide (CO) and hydrogen (H2) may be combined in any desired proportion to yield synthesis gas (Syngas). The present invention further relates to methods for preparing H2, CO and formic acid/formaldehyde from biomass, a biomass component and/or from carbohydrates.
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公开(公告)号：US20180009853A1
公开(公告)日：2018-01-11
申请号：US15547499
申请日：2016-01-26
Applicant: Yeda Research And Development Co. Ltd.
Inventor： Ada YONATH , Zohar EYAL , Donna MATZOV , Haim ROZENBERG , Ella ZIMMERMAN , Anat BASHAN
IPC: C07K14/31 , C07H17/08 , C07D211/54 , C07D263/20 , G06F19/00 , G06F19/16
CPC classification number: C07K14/31 , C07D211/54 , C07D263/20 , C07H17/08 , C07K2299/00 , G16B15/00 , G16B30/00 , G16B35/00 , G16C20/50 , G16C20/60
Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.
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公开(公告)号：US20180004872A1
公开(公告)日：2018-01-04
申请号：US15706720
申请日：2017-09-17
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Tali KIMCHI , Aharon WEISSBROD , Genadiy VASSERMAN
CPC classification number: G06F17/5009 , A01K1/031 , A01K29/005 , G01S3/14 , G01S3/7864 , G06K9/6282
Abstract: A method of identifying and classifying social complex behaviors among a group of model organisms, comprising implanting at least one RFID transponder in each model organism in said group of model organisms; enclosing said group of model organisms in a monitored space divided into RFID monitored segments; RFID tracking a position of each model organism by reading said at least one RFID transponder in each model organism over a period of time; capturing a sequence of images of each model organism over said period of time; and calculating at least one spatiotemporal model of each model organism based on time synchronization of said RFID tracked position of said model organism with said sequence of images.
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公开(公告)号：US20170307625A1
公开(公告)日：2017-10-26
申请号：US15640545
申请日：2017-07-02
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David MARGULIES , Leila MOTIEI , Linor UNGER
IPC: G01N33/58 , C07D417/14 , C09K11/06 , C07D417/06 , G01N33/573 , C07K7/06 , G01N33/574
CPC classification number: G01N33/582 , C07D417/06 , C07D417/14 , C07F9/65583 , C07K7/06 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C09K11/06 , C09K2211/1029 , C09K2211/1037 , C12N9/1088 , G01N33/573 , G01N33/574 , G01N2333/91177 , G01N2333/918 , G01N2333/96494
Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.
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Patent Agency Ranking
公开(公告)号：US20170298297A1
公开(公告)日：2017-10-19
申请号：US15516407
申请日：2015-10-01
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Ronit GOLDBERG , Weifeng LIN , Sabrina JAHN
CPC classification number: C11D3/0078 , A01N25/26 , A61K31/78 , C11D3/222 , C11D3/225 , C11D3/365 , G02C7/04
Abstract: A method of inhibiting adsorption of a biofouling-promoting agent on a surface of a substrate and a method of inhibiting biofilm formation on a surface of a substrate are disclosed herein. The methods comprise comprising contacting the substrate with a composition which comprises liposomes. Further disclosed herein is a composition comprising liposomes, identified for use in inhibiting adsorption of a biofouling-promoting agent on a surface of a substrate and/or inhibiting biofilm formation on a surface of a substrate. Further disclosed are articles comprising a substrate and a composition described herein being applied on a surface of the substrate, and a method of treating keratitis in a contact lens-wearing subject, by rinsing and/or immersing a contact lens in a solution comprising liposomes.
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公开(公告)号：US09707540B2
公开(公告)日：2017-07-18
申请号：US15079903
申请日：2016-03-24
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Milko E. Van Der Boom , Michal Lahav , Shira Hamami , Maria-Chiara Di-Gregorio , Qiang Wen , Sreejith Shankar Pooppanal
IPC: C07D213/06 , B01J20/22 , C07D213/42
CPC classification number: B01J20/226 , C07B2200/13 , C07C2603/74 , C07D213/06 , C07D213/42
Abstract: The present invention provides metal-organic materials, more specifically organometallic polymers, comprising polypyridyl organic ligands such as tetrakis(4-(pyridin-4-ylethynyl)phenyl)methane, tetrakis(4-(2-(pyridin-4-yl)vinyl)phenyl)methane, 1,3,5,7-tetrakis(4-(pyridin-4-ylethynyl)phenyl)adamantane or 1,3,5,7-tetrakis(4-(2-(pyridine-4-yl)vinyl)phenyl) adamantine, and metal ions structurally coordinated with said ligands, and having three-dimensional crystalline micro or sub-micro structure; as well as a method for the preparation thereof. These metal-organic materials are useful as adsorbents in processes for gas adsorption or separation.
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公开(公告)号：US20170173573A1
公开(公告)日：2017-06-22
申请号：US15403199
申请日：2017-01-11
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Brian BERKOWITZ , Ishai DROR , Moshe BEN SASSON , Sethu KALIDHASAN
IPC: B01J31/16 , C08K3/36 , B01J21/08 , C02F1/78 , B01J35/00 , B01J37/04 , B01J37/00 , C02F1/72 , C08K3/08 , B01J21/16
Abstract: The present invention is directed to a degradation composition, methods and kits for degrading organic pollutants comprising reduced copper based nanoparticles-polymer complex (Cu-NPs) and an oxidant.
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公开(公告)号：US20170137806A1
公开(公告)日：2017-05-18
申请号：US15412122
申请日：2017-01-23
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Diego JAITIN , Ido Amit , Hadas Keren-Shaul , Liran Valadarsky
CPC classification number: C12N15/1065 , C12N15/1096 , C12Q1/6806 , C12Q1/6809 , C12Q2521/119 , C12Q2521/501 , C12Q2525/143 , C12Q2525/173 , C12Q2539/103 , C12Q2563/179
Abstract: Kits and methods for single cell or multiple cell transcriptome analysis are provided. An adapter polynucleotide is disclosed which comprises a double-stranded DNA portion of 15 base pairs and no more than 100 base pairs with a 3′single stranded overhang of at least 3 bases and no more than 10 bases, wherein said double stranded DNA portion is at the 5′ end of the polynucleotide and wherein the sequence of said 3′ single stranded overhang is selected from the group consisting of SEQ ID NOs: 1-8 and 9, wherein the 5′ end of the strand of said double-stranded DNA which is devoid of said 3′ single stranded overhang comprises a free phosphate.
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公开(公告)号：US20170119847A1
公开(公告)日：2017-05-04
申请号：US15391979
申请日：2016-12-28
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Tsvee LAPIDOT , Alexander KALINKOVICH , Matityahu FRIDKIN
CPC classification number: A61K38/1729 , A61K38/00 , A61K38/12 , A61K38/193 , C07K7/52 , C07K14/4723
Abstract: The invention is directed to β-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem cells and progenitor cells. Specifically, the invention provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. The invention further provides compositions and methods useful in the treatment of cancer.
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