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公开(公告)号：US20210383924A1
公开(公告)日：2021-12-09
申请号：US17288399
申请日：2019-10-25
申请人： QUADRANT BIOSCIENCES INC. , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK , THE PENN STATE RESEARCH FOUNDATION
摘要： A machine learning classifier that diagnoses autism spectrum disorder (ASD) is described that transforms data obtained from a patient medical history and a patients saliva into data that correspond to a test panel of features, the data for the features including human microtranscriptome and microbial transcriptome data, wherein the transcriptome data are associated with respective RNA categories for ASD. The classifier classifies the transformed data by applying the data to the classifier that has been trained to detect ASD using training data associated with the features of the test panel. The trained classifier includes vectors that define a classification boundary and predicts a probability of ASD based on results of the classifying.
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公开(公告)号：US20210382371A1
公开(公告)日：2021-12-09
申请号：US17303741
申请日：2021-06-07
发明人： Xingjie Ni , Xuexue Guo , Yimin Ding , Yao Duan , Xi Chen
IPC分类号： G02F1/295
摘要： Embodiments relate to a photonic component having a metasurface. The metasurface includes a substrate with a thin-layer of meta-atoms disposed thereon. The photonic component includes a waveguide having a top surface, wherein the metasurface is disposed on at least a portion of the top surface such that the meta-atoms form an array on the top surface. The photonic component includes a sandwich nano-bar antenna formed in or on the metasurface.
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公开(公告)号：US20210372948A1
公开(公告)日：2021-12-02
申请号：US17399492
申请日：2021-08-11
摘要： Provided are processes and materials for solving biological or structural information about proteins or other organic molecules. The processes capitalize on a rigid multimeric nanocage formed from self-assembling substructure proteins. The processes and materials allow for recognition and tight, optionally covalent, bonding of any protein molecule with a tag complementary to a capture sequence on the nanocage. The processes and materials may be used to obtain biological or structural information by cryo-electron microscopy and overcome prior limitations of target protein size or salt concentration.
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公开(公告)号：US11173227B2
公开(公告)日：2021-11-16
申请号：US14891862
申请日：2014-05-21
发明人： Jian Yang , Kytai T. Nguyen , Zhiwei Xie
IPC分类号： A61L15/22 , A61L15/44 , A61L15/28 , A61L15/42 , A61L15/26 , A61L15/64 , A61L31/14 , A61L31/04 , A61L31/16 , A61L31/06 , A61L31/12 , C08L67/04
摘要： In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.
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公开(公告)号：US20210347804A1
公开(公告)日：2021-11-11
申请号：US17301711
申请日：2021-04-12
发明人： Gregory Ray Ziegler , Joshua David Lambert , Rachel Marie Shegog , Emmanouil Chatzakis , Deepti Dabas
摘要： The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as red, orange or yellow.
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56.发明申请公开(公告)号：US20210324337A1
公开(公告)日：2021-10-21
申请号：US17269233
申请日：2019-08-22
发明人： Xiaojun LIAN , Chuanxin CHEN
摘要： Provided are methods, compositions and kits for generating beta cells from pluripotent stem cells under growth-factor free, defined culture conditions. The beta cells can be generated under conditions that are free of animal products. The generated beta cells secrete insulin, not glucagon, and the amount of insulin secreted is dependent upon the level of glucose stimulus.
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公开(公告)号：US20210322984A1
公开(公告)日：2021-10-21
申请号：US17259136
申请日：2019-07-11
发明人： Pak Kin WONG , Hui LI
摘要： Provided are devices and methods for detecting the presence, absence, and/or characteristics of bacteria. A microfluidic device for characterizing bacteria is provided. The device contains one or more bacteria trapping channels, and one or more pneumatic channels in contact with the bacteria trapping channels, wherein the one or more pneumatic channels are configured to reduce the height of the one or more bacteria trapping channels to thereby trap bacteria in the one or more bacteria trapping channels if said bacteria are present in a liquid biological sample that is introduced into the microfluidic device. Also provides is a method for identifying bacteria that may be used with the microfluidic device. The method includes contacting a sample that contains bacteria with a carbon nanotube and microwave energy such that a probe is introduced into the bacteria. The probe is a double strand polynucleotide probe having a first strand that includes a detectable label, and a second strand having a quencher moiety that quenches a signal from the detectable label when the probe is double stranded. The method includes allowing hybridization between the labeled strand with a polynucleotide in the bacteria if bacteria are present, and if bacteria are present, detecting a signal from the labeled strand that is hybridized to a polynucleotide in the bacteria to thereby identify the presence of, and/or the type of bacteria in the sample, and if the bacteria are not present, determining a lack of a signal from the labeled strand.
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公开(公告)号：US11141419B1
公开(公告)日：2021-10-12
申请号：US17241894
申请日：2021-04-27
发明人： Suresh Kuchipudi
IPC分类号： A61K31/702 , A61K31/445 , A61P31/14 , A61K31/706 , A61K31/437
摘要： Provided are methods for prophylaxis or treatment of SARS-CoV-2 by administering a composition comprising one or more iminosugars to an individual in need thereof. The compositions may be administered to an individual who is at risk of becoming infected by SARS-CoV-2, or has been diagnosed with a SARS-CoV-2 infection. The iminosugars can inhibit SARS-CoV-2 cell entry and replication. The iminosugars potentiate co-administered antiviral agents, such as nucleoside analogs.
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公开(公告)号：US11141097B2
公开(公告)日：2021-10-12
申请号：US16396316
申请日：2019-04-26
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/316 , A61B5/352 , A61B5/374
摘要： Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.
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公开(公告)号：US20210302287A1
公开(公告)日：2021-09-30
申请号：US17236814
申请日：2021-04-21
发明人： Siyang Zheng , Mauricio Terrones , Yin-Ting Yeh , Yi Tang , Huaguang Lu , Nestor Perea Lopez , Yiqiu Xia
IPC分类号： G01N1/40 , B01L3/00 , G01N33/543 , G01N33/552 , G01N33/569
摘要： The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.
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