公开(公告)号：US08311630B2

公开(公告)日：2012-11-13

申请号：US13229948

申请日：2011-09-12

申请人： Joseph M. Pastore ,  Rodney W. Salo ,  Julio C. Spinelli ,  Allan C. Shuros ,  Andres Belalcazar

发明人： Joseph M. Pastore ,  Rodney W. Salo ,  Julio C. Spinelli ,  Allan C. Shuros ,  Andres Belalcazar

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/3688

摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.

摘要翻译： 用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。 通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式 。 取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。

公开(公告)号：US20120143031A1

公开(公告)日：2012-06-07

申请号：US13359636

申请日：2012-01-27

申请人： Andres Belalcazar ,  Ji Chen

发明人： Andres Belalcazar ,  Ji Chen

IPC分类号： A61N1/365 ,  A61B5/042 ,  A61B5/0432

CPC分类号： A61B5/0422 ,  A61B5/0031 ,  A61B5/4519

摘要： Electrodes of a subcutaneous monitoring system receive body electrical signals that indicate both cardiac and non-cardiac muscle activity. In general, non-cardiac muscle activity is often correlated with physical activity, and physical activity is typically a strong indicator of patient health. Exemplary systems and methods that detect non-cardiac muscle activity information in sensed body electrical waveforms may provide a diagnostic tool for monitoring physical activity level over time in patients that have subcutaneous monitoring systems. In an illustrative embodiment, systems and methods for presenting patient activity information in a graphical format over intervals of time include processing ECG waveform information to identify and to accumulate non-cardiac muscular activity information during each of the intervals of time. In various implementations, number, intensity, and/or duration of the events that are identified during a time interval may be accumulated and stored for subsequent recall.

摘要翻译： 皮下监测系统的电极接收体内指示心脏和非心脏肌肉活动的电信号。 一般来说，非心肌肌肉活动通常与身体活动相关，身体活动通常是患者健康的强烈指标。 在检测到的身体电波形中检测非心脏肌肉活动信息的示例性系统和方法可提供用于在具有皮下监测系统的患者中随时间监测身体活动水平的诊断工具。 在说明性实施例中，用于以时间间隔以图形格式呈现患者活动信息的系统和方法包括处理ECG波形信息以在每个时间间隔期间识别和累积非心脏肌肉活动信息。 在各种实现中，可以累积并存储在时间间隔期间识别的事件的数量，强度和/或持续时间以用于随后的召回。

公开(公告)号：US08190246B2

公开(公告)日：2012-05-29

申请号：US12163596

申请日：2008-06-27

申请人： Andres Belalcazar ,  Jack D. Stewart ,  Ji Chen

发明人： Andres Belalcazar ,  Jack D. Stewart ,  Ji Chen

IPC分类号： A61B5/04

CPC分类号： A61B5/0031 ,  A61B5/0006 ,  A61B5/411 ,  G06F19/00 ,  G06F19/3418

摘要： A system is provided for obtaining and analyzing biological data of a subject. The system includes a biological data recording device that can sense biological signals of a subject over time and record the sensed biological signals as biological data. The system also includes an event time recording device that is physically separate from, and does not communicate with, the biological data recording device. The event time recording device includes a user actuatable component, and also includes a recording component that records user actuation data, which includes a time stamp indication as to when any instances of user actuation occurred. The system also includes equipment that can periodically receive the recorded biological data from the biological data recording device and the user actuation data from the event time recording device, and can correlate the biological data and the user actuation data to generate correlated biological data.

摘要翻译： 提供用于获得和分析受试者的生物数据的系统。 该系统包括可随时间感测被检者的生物信号并将感测到的生物信号记录为生物数据的生物数据记录装置。 该系统还包括与生物数据记录装置物理分离并且不与生物数据记录装置通信的事件时间记录装置。 事件时间记录装置包括用户可启动部件，并且还包括记录用户致动数据的记录部件，其包括关于何时发生用户致动的时间戳指示。 该系统还包括可以从生物数据记录装置周期性地接收记录的生物数据和来自事件时间记录装置的用户致动数据的设备，并且可以将生物数据与用户致动数据相关联，以产生相关的生物数据。

公开(公告)号：US08096954B2

公开(公告)日：2012-01-17

申请号：US11564637

申请日：2006-11-29

申请人： Jeffrey E. Stahmann ,  Krzysztof Z. Siejko ,  Carlos Haro ,  Abhilash Patangay ,  Gerrard M. Carlson ,  Andres Belalcazar

发明人： Jeffrey E. Stahmann ,  Krzysztof Z. Siejko ,  Carlos Haro ,  Abhilash Patangay ,  Gerrard M. Carlson ,  Andres Belalcazar

IPC分类号： A61B5/02

CPC分类号： A61N1/36514 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/024 ,  A61B5/053 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/1116 ,  A61B5/4806 ,  A61B5/686 ,  A61B5/7275 ,  A61B7/04 ,  A61N1/36578

摘要： A system and method to sense heart sounds with one or more implantable medical devices according to one or more parameters. The system alters one or more of the parameters as a function of one or more triggering events. The system then senses heart sounds with the one or more implantable medical devices according to at least the one or more altered parameters.

摘要翻译： 根据一个或多个参数用一个或多个可植入医疗装置感测心脏声音的系统和方法。 系统根据一个或多个触发事件改变一个或多个参数。 该系统然后根据至少一个或多个改变的参数用一个或多个可植入医疗装置感测心脏声音。

公开(公告)号：US08095207B2

公开(公告)日：2012-01-10

申请号：US11626329

申请日：2007-01-23

申请人： Andres Belalcazar ,  Robert Patterson

发明人： Andres Belalcazar ,  Robert Patterson

IPC分类号： A61B5/0402

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/04011

摘要： An implantable medical device includes a voltage measurement circuit to measure a potential difference between implanted electrodes in a thorax of a living being, the potential difference resulting from an electrical P-wave cardiac signal. The implantable medical device also includes a processing unit to calculate a vector corresponding to the P-wave cardiac signal, the vector comprising a magnitude and a direction, and derived from measured potential differences and orientations defined by locations of the implanted electrodes. The implantable medical device further includes a monitoring unit to track a rotation of the vector corresponding to the P-wave cardiac signal. In various implementations, the monitoring unit may use the rotation to detect an inter-atrial block condition.

摘要翻译： 可植入医疗装置包括电压测量电路，用于测量生物胸部中植入的电极之间的电位差，由电P波心脏信号产生的电位差。 可植入医疗装置还包括处理单元，用于计算对应于P波心脏信号的矢量，所述矢量包括幅度和方向，并且从测量的电位差和由注入电极的位置定义的取向导出。 可植入医疗装置还包括监测单元，用于跟踪对应于P波心脏信号的矢量的旋转。 在各种实现中，监视单元可以使用旋转来检测心房间块状况。

公开(公告)号：US08019416B2

公开(公告)日：2011-09-13

申请号：US11615383

申请日：2006-12-22

申请人： Joseph M. Pastore ,  Rodney W. Salo ,  Julio C. Spinelli ,  Allan C. Shuros ,  Andres Belalcazar

发明人： Joseph M. Pastore ,  Rodney W. Salo ,  Julio C. Spinelli ,  Allan C. Shuros ,  Andres Belalcazar

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/3688

摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.

摘要翻译： 用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。 通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式 。 取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。

公开(公告)号：US20110172572A1

公开(公告)日：2011-07-14

申请号：US13070504

申请日：2011-03-24

申请人： Hugo Andres Belalcazar

发明人： Hugo Andres Belalcazar

IPC分类号： A61H31/00

CPC分类号： A61H31/00 ,  A61H31/006 ,  A61H31/007 ,  A61H2201/123 ,  A61H2201/5007 ,  A61H2201/5061 ,  A61H2201/5097 ,  A61M16/06 ,  A61M16/0677 ,  A61M16/10 ,  A61M16/202 ,  A61M16/203 ,  A61M16/208 ,  A61M2202/0208 ,  A61M2205/332

摘要： A cardio pulmonary CPR device and method provides enhanced circulation by an inventive sequence of states of chest compression and airway valve opening and closure. The embodiments of the invention produce enhanced circulation during cardiac arrest, while maintaining a degree of ventilation to the patient, including oxygen delivery in some embodiments. Some embodiments include mechanical compression units. Other embodiments include a compression sensor to detect manually delivered compressions.

摘要翻译： 心肺CPR装置和方法通过胸部压缩和气道开阀和关闭的创造性状态提供增强的循环。 在一些实施方案中，本发明的实施方案在心脏骤停期间产生增强的循环，同时在患者体内保持一定程度的通气，包括氧气输送。 一些实施例包括机械压缩单元。 其他实施例包括用于检测手动递送的压缩的压缩传感器。

公开(公告)号：US07860567B2

公开(公告)日：2010-12-28

申请号：US11469018

申请日：2006-08-31

申请人： Andres Belalcazar ,  Jeffrey E. Stahmann

发明人： Andres Belalcazar ,  Jeffrey E. Stahmann

IPC分类号： A61N1/08

CPC分类号： A61N1/3627 ,  A61N1/36514 ,  A61N1/3704 ,  A61N1/37288 ,  A61N1/378

摘要： A sensor is located within the body of a subject, such as for capturing pacing pulses transmitted as part of cardiac therapy from an implanted cardiac function management device. Counted pulses may be used to derive the onset of pulmonary edema within the body through pulse characteristics such as frequency and amplitude. The sensor may be anchored within mediastinal pleura or the airway of the body with the ability to communicate wirelessly to one or more other medical devices, such as an implanted cardiac function management device. It may also adjust transmission of the communication to discriminate among multiple sensors. Methods of use are also described.

摘要翻译： 传感器位于受试者的体内，例如用于从植入的心脏功能管理装置捕获作为心脏治疗的一部分传输的起搏脉冲。 计数脉冲可用于通过诸如频率和幅度的脉冲特征来导出身体内肺水肿的发作。 传感器可以锚定在纵膈胸膜或身体的气道中，其能够无线地通信到一个或多个其它医疗装置，例如植入的心脏功能管理装置。 它还可以调整通信的传输以区分多个传感器。 还描述了使用方法。

公开(公告)号：US20100063412A1

公开(公告)日：2010-03-11

申请号：US12621984

申请日：2009-11-19

申请人： Andres Belalcazar

发明人： Andres Belalcazar

IPC分类号： A61B5/053

CPC分类号： A61B5/0537 ,  A61B5/4869

摘要： An amount of fluid in a thoracic or other region of a subject may be monitored by internally injecting an electrical energy stimulus (e.g., constant voltage source) through the region, detecting voltage resulting from the electrical energy stimulus, and calculating a fluid volume indicative signal. The injected energy stimulus creates a first lead field. The responsive voltage is detected using an electrode configuration that defines a second lead field, which is arranged in a negative sensitivity configuration with respect to the first lead field at the region being monitored.

摘要翻译： 可以通过在该区域内部注入电能刺激（例如，恒定电压源）来检测受试者的胸部或其他区域中的流体的量，检测由电能刺激产生的电压，以及计算流体体积指示信号 。 注入能量刺激产生了第一个引线场。 使用限定第二引线场的电极配置来检测响应电压，该引线场在被监视的区域处相对于第一引线场布置成负的灵敏度配置。

公开(公告)号：US20090012416A1

公开(公告)日：2009-01-08

申请号：US11772352

申请日：2007-07-02

申请人： Andres Belalcazar ,  Aaron Lewicke

发明人： Andres Belalcazar ,  Aaron Lewicke

IPC分类号： A61B5/085

CPC分类号： A61N1/3702 ,  A61B5/0031 ,  A61B5/0402 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/087 ,  A61B5/1116 ,  A61B5/416 ,  A61B5/4839 ,  A61B5/4878 ,  A61B5/686 ,  A61B5/7285 ,  A61B2560/0468 ,  A61N1/3627 ,  A61N1/36521 ,  G06F19/00

摘要： This patent document describes, among other things, systems and methods for monitoring lung fluid status, such as monitoring the presence or absence of pulmonary edema, in a subject using information about the cardiac impedance-indicating component of a measured impedance-indicating signal. In various examples, an amplitude or contribution change over multiple cardiac cycles of the cardiac impedance-indicating component is used to compute and provide a lung status indication. In various examples, a decreasing amplitude or contribution trend of the cardiac impedance-indicating component signifies an increasing amount of fluid in the subject's lungs, as a greater portion of an injected thoracic impedance measurement current formerly traversing the heart is rerouted through the lung due to the less resistance path created by the fluid accumulation therein. In another example, measurements of the impedance-indicating signal, and thus the cardiac impedance-indicating component, are taken at one or a combination of end-inspiration or end-expiration.

摘要翻译： 该专利文献尤其描述了使用关于所测量的阻抗指示信号的心脏阻抗指示部件的信息来监测受试者肺部流体状况的系统和方法，例如监测受试者是否存在肺水肿。 在各种示例中，使用心脏阻抗指示组件的多个心动周期的幅度或贡献变化来计算并提供肺状态指示。 在各种示例中，心脏阻抗指示组件的幅度或贡献趋势的减小表示受试者的肺中流体的量增加，因为原先穿过心脏的注射的胸部阻抗测量电流的较大部分通过肺被重新路由，因为 由其中积聚的液体产生的阻力路径越小。 在另一个示例中，阻抗指示信号的测量以及因此的心脏阻抗指示组件的测量以一个或结束吸气或终止呼气的组合进行。