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    PROTEIN QUANTITATION DEVICE
    51.
    发明申请
    PROTEIN QUANTITATION DEVICE 有权

    公开(公告)号：US20230026156A1

    公开(公告)日：2023-01-26

    申请号：US17877680

    申请日：2022-07-29

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Evan THRUSH ,  Steven SWIHART ,  William STRONG ,  Trey MARLOWE ,  Li LU

    IPC: G01N21/31 ,  G01N21/3577 ,  G01N21/3563

    Abstract: Systems for protein quantitation using a Fabry-Perot interferometer. In one arrangement, a quantitation device includes an infrared source, a sample holder, and a Fabry-Perot interferometer positioned to receive infrared radiation from the source passing through a sample on the sample holder. A band pass optical filter sets the working range of the interferometer, and radiation exiting the interferometer falls on a detector that produces a signal indicating the intensity of the received radiation. A controller causes the interferometer to be tuned to a number of different resonance wavelengths and receives the intensity signals, for determination of an absorbance spectrum.

    System and method for rapid multiplexed sample processing with applications for nucleic acid amplification assays
    52.
    发明授权
    System and method for rapid multiplexed sample processing with applications for nucleic acid amplification assays 有权

    公开(公告)号：US11547995B2

    公开(公告)日：2023-01-10

    申请号：US17499529

    申请日：2021-10-12

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Kalyan Handique ,  Ronald Lebofsky

    IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/686

    Abstract: The invention(s) cover systems and methods for target detection in a multiplexed and rapid manner. Embodiments of the system can include: a base substrate; and an array of sample processing regions defined at a broad surface of the base substrate, wherein each of the array of sample processing regions includes: a set of microwell subarrays arranged in a gradient by volumetric capacity between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions. The system can support methods, with example implementation by an automated platform, for returning preliminary results from a subset of microwells of the samples processing regions, as well as results pertaining to specific and non-specific amplification, for multiple targets of a sample.

    Method and system for sampling material from cells
    53.
    发明授权
    Method and system for sampling material from cells 有权

    公开(公告)号：US11542541B2

    公开(公告)日：2023-01-03

    申请号：US17105333

    申请日：2020-11-25

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Arkadiusz Bibillo ,  Pranav Patel ,  Christopher Reggiardo ,  Jonathan Petersen

    IPC: C12Q1/68 ,  C12Q1/6806 ,  C12N15/10 ,  C12Q1/6853 ,  C12Q1/6874

    Abstract: Methods, systems, and devices for sampling/isolating material from cells. An exemplary system may comprise a chip including an electrode array of sampling electrodes arranged along a surface of the chip. A cell-receiving area may be located adjacent the surface of the chip. The system also may comprise a tag array of tags supported by the chip and aligned with the electrode array. Each tag of the tag array may include an identifier that is unique to the tag within the tag array. Each tag may be configured to bind nucleic acids, or a capturing agent distinct from the tag may be aligned with each sampling electrode of the electrode array to capture a protein or other analyte of interest. The system further may comprise a control circuit configured to apply an individually controllable voltage to each sampling electrode of the electrode array and measure an electrical property of the sampling electrode.

    Value assignment for customizable quality controls
    58.
    发明授权
    Value assignment for customizable quality controls 有权

    公开(公告)号：US11385245B2

    公开(公告)日：2022-07-12

    申请号：US16880705

    申请日：2020-05-21

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Alireza Ebrahim ,  Karl De Vore ,  Christopher Spates

    IPC: G01N33/96 ,  G01N33/78 ,  G01N33/48

    Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.

    METHOD AND COMPOSITION FOR QUANTIFYING PROTEIN USING TAGGED STANDARDS
    60.
    发明申请
    METHOD AND COMPOSITION FOR QUANTIFYING PROTEIN USING TAGGED STANDARDS 有权

    公开(公告)号：US20220178874A1

    公开(公告)日：2022-06-09

    申请号：US17544591

    申请日：2021-12-07

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Kenneth OH ,  Carl MARLOWE ,  Stephen L. SWIHART ,  Evan THRUSH ,  Michael GRIFFIN

    IPC: G01N27/447 ,  G01N33/68 ,  G01N21/64

    Abstract: Methods and reference compositions for quantifying protein using tagged standards. In an exemplary method, a reference composition and a protein may be electrophoresed in respective lanes of a gel. The reference composition may include quantitation standards of different size and each including a tag present at a different concentration. The quantitation standards and the protein may be transferred from the gel to a solid support to create a blot. Luminescence may be detected from the blot to obtain respective luminescence values separately representing an abundance of the tag of each quantitation standard and an abundance of the protein. A quantity of the protein may be determined using the respective luminescence values.

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