利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

159 条记录 (耗时 0.013 秒)

    Process for preparing s-adenosyl homocysteine
    53.
    发明授权
    Process for preparing s-adenosyl homocysteine 失效
    制备S-腺嘧啶胞嘧啶的方法

    公开(公告)号：US3642772A

    公开(公告)日：1972-02-15

    申请号：US3642772D

    申请日：1969-08-29

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： HAID ERICH ,  WEIMANN GUNTER

    IPC分类号： C07H19/16 ,  C07D51/54

    CPC分类号： C07H19/16

    摘要： PROCESS FOR PREPARING S-ADENOSYL HOMOCYSTEIN BY DEMETHYLATION OF S-ADENOSYL METHIONINE WHICH COMPRISES REACTING AN S-ADENOSYL METHIONINE SALT IN A POLAR ORGANIC SOLVENT THEREFOR WITH AN ALKALI METAL OR ALKALINE EARTH METAL HALIDE OR PSEUDOHALIDE AT A TEMPERATURE OF ABOUT 10 TO 100*C.

    Diagnostic agents for the detection of urobilinogen materials in body fluids
    54.
    发明授权
    Diagnostic agents for the detection of urobilinogen materials in body fluids 失效
    用于检测身体液体中的尿素物质的诊断试剂

    公开(公告)号：US3630680A

    公开(公告)日：1971-12-28

    申请号：US3630680D

    申请日：1968-10-18

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： RITTERSDORF WALTER ,  RIECKMANN PETER

    IPC分类号： G01N33/72 ,  G01N21/06 ,  G01N31/22 ,  G01N33/16

    CPC分类号： G01N33/72 ,  Y10T436/146666

    摘要： Diagnostic agents for use in the detection of urobilinogen materials in body fluids such as urine, the agents comprising at least one strong acid and at least one compound which reacts with urobilinogen materials present in the body fluids to provide analytically measurable dyestuffs wherein said compound has the formula:

    IN WHICH R1 and R2 which may be the same or different, each represent halogen, cyano, nitroso, carbalkoxy, carbamido, hydroxy, acyloxy, alkoxy, straight-chained and cyclic, saturated and unsaturated secondary and tertiary amino, or R1 and R2 together represent oxygen, sulfur, sulfonyl, alkylthionium, imino, alkylimino, substituted or unsubstituted arylimino or open-chained, alicyclic or heterocyclic dialkylimino, R2 can also represent the residue of secondary straight or branched, openchained or mono- or polycyclic alkyl or aralkyl and wherein one of R1 and R2 can also represent hydrogen, R3 is hydrogen or alkyl, and n and m which may be the same or different each have a value of 0, 1, 2 or 3.

    Diagnostic agents for use in the determination of hydroperoxides and of peroxidate-active substances and methods for manufacturing and using the same
    55.
    发明授权
    Diagnostic agents for use in the determination of hydroperoxides and of peroxidate-active substances and methods for manufacturing and using the same 失效
    用于确定氢过氧化物和过氧化物活性物质的诊断试剂及其制备和使用方法

    公开(公告)号：US3558435A

    公开(公告)日：1971-01-26

    申请号：US3558435D

    申请日：1967-08-04

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： REY HANS-GEORG ,  WIELINGER HANS ,  RIECKMANN PETER

    IPC分类号： G01N33/50 ,  C12Q1/28 ,  C12Q1/54 ,  G01N33/00 ,  G01N31/14 ,  G01N31/22

    CPC分类号： C12Q1/28 ,  C12Q1/54 ,  C12Q2326/00 ,  Y10S435/805 ,  Y10S436/904 ,  Y10T436/144444 ,  Y10T436/148888 ,  Y10T436/206664

    摘要： THERE ARE DISCLOSED DIAGNOSTIC AGENTS SUITABLE FOR USE IN CARRYING OUT RAPID ANALYTICAL DETERMINATIONS OF THE PRESENCE AND/OR CONCENTRATION OF HYDROPEROXIDE, SUBSTANCES WHICH REACT WITH THE LIBERATION OF JYDROGEN PEROXIDE, PEROXIDASE AND PEROXIDATE-ACTIVE SUBSTANCES. THE DIAGNOSTIC AGENTS OF THE INVENTION ARE ADAPTED FOR USE IN TEST PROCEDURES INVOLVING OPTICAL INSTUMENTS SUCHAS COLORMETERS AND PHOTOMETERS AND ALSO IN TEST PROCEDURES INVOLVING TEST PAPERS. THE DIAGNOSTIC AGENTS AS TAUGHT HEREIN COMPRISE AN INDICATOR I.E., CHROMOGEN, WHICH IS OXIDIZED BY HYDROGEN PEROXIDE AND PEROXIDASE OR PEROSIDATE ACTIVE SUBSTANCES TO FORM A DYESTUFF WHOSE INTENSITY IS DEPENDENT ON THE CONCENTRATION OF THE PEROXIDE, PEROXIDASE OR PEROXIDATE ACTIVE SUBSTANCE PRESENT IN THE TEST SAMPLE. THE INDICATOR I.E., CHROMOGEN IS A COMPOUND OF THE FORMULA:

    (R4,R5,R6-PHENYL)-C(-R3)=N-(N(-R2))N-C(=X)-R1

    WHERIN R1 IS AMINO OR AN ALIPHATIC, ARALIPHATIC, AROMATIC OR HETEROCYCLIC RADICAL WHICH MAY CARRY ONE OR MORE SUBSTITUENTS, OR A GROUP HAVING THE FORMULA:

    (R4,R5,R6-PHENYL)-C(-R3)=N-(N(-R2))N-C(=X)-(CH(-OH))M-

    WHEREIN R2 IS HYDROGEN, AN ALIPHATIC, AROMATIC OR HETEROCYCLIC RADICAL WHICH MAY CARRY ONE OR MORE SUBSTITUENTS, R3 IS HYDROGEN, ALKYL OR PHENYL AND MAY BE MONO- OR POLY SUBSTITUTED, R4 IS AMINO, HYDROXYL OR ALKOXY, R5 AND R6 ARE EACH HYDROGEN, AMINO, HYDROXY,ALKOXY OR ALKYL, X IS OXYGEN, SULFUR OR IMINO WHICH MAY BE SUBSTITUTED BY A GROUP AS DEFINED BY R1, N IS 0 OR 1, M IS 0,1 OR 2; AND WHEREIN X AND R1 AND R2 OR R1 AND R3 CAN BE JOINED TOGETHER TO FORM A RING. THE DIAGNOSTIC AGENTS CAN BE USED FOR ANALYTICAL DETERMINATIONS INVOLVING, FOR EXAMPLE, GLUCOSE, GALACTOSE, AMINO ACIDS, URIC ACID, PEROXIDE, HEMOGLOBIN, PEROXIDASE, ETC. IN SAMPLES, FOR EXAMPLE, CONSTITUTING BIOLOGICAL FLUIDS SUCH AS BLOOD, URINE, SPINAL FLUID, ETC., MILK, COSMETIC AND DRUG FORMULATIONS, ETC.

    摘要翻译： 适用于进行快速分析测定氢过氧化物，与释放过氧化氢，过氧化物酶或过氧化物活性物质反应的物质的快速分析测定，包括在过氧化物酶存在下被氢过氧化物氧化的色原体 或过氧化物活性物质形成染料，其颜色强度取决于测试样品中存在的过氧化物，过氧化物酶或过氧化物活性物质的量，其中色原是具有下式的化合物：

    Digitoxigenin alpha-L-arabinoside compounds and therapeutic compositions for combating cardiac insufficiency
    60.
    发明授权
    Digitoxigenin alpha-L-arabinoside compounds and therapeutic compositions for combating cardiac insufficiency 失效
    Digitoxigenin alpha-L-阿拉伯糖苷化合物和用于治疗心功能不全的治疗组合物

    公开(公告)号：US3915957A

    公开(公告)日：1975-10-28

    申请号：US45025574

    申请日：1974-03-11

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： KAISER FRITZ ,  LUBS HANS JOACHIM ,  SCHAUMANN WOLFGANG ,  VOIGTLANDER WOLFGANG

    IPC分类号： C07J19/00 ,  A61K31/585 ,  A61K31/704 ,  A61P9/00

    摘要： New digitoxigenin Alpha -L-arabinoside compound of the formula

    WHEREIN R1, R2 and R3, which may be the same or different, are acyl (i.e., alkanoyl) or alkyl of up to 3 carbon atoms and one or two of R1, R2 and R3 can also be hydrogen atoms; R1 and R2 together can represent an acetal or ketal grouping containing from 2 to 10 carbon atoms, ARE OUTSTANDINGLY EFFECTIVE IN THE ORAL THERAPY OF CARDIAC INSUFFICIENCY.

    摘要翻译： 式WHEREIN R1，R2和R3可以相同或不同的新的洋地黄毒苷α-α-阿拉伯糖苷化合物是酰基（即烷酰基）或至多3个碳原子的烷基和R1，R2和R2中的一个或两个 R3也可以是氢原子; R1和R2一起可以代表含有2至10个碳原子的缩醛或缩酮基团，在心脏缺血症的口腔治疗中是非常有效的。