Psod expression units
    51.
    发明授权
    Psod expression units 有权
    Psod表达单位

    公开(公告)号:US08071365B2

    公开(公告)日:2011-12-06

    申请号:US12030575

    申请日:2008-02-13

    IPC分类号: C12N15/00 C12N1/20

    CPC分类号: C12N15/77

    摘要: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

    摘要翻译: 本发明涉及核酸序列用于调节基因的转录和表达,新型启动子和表达单元本身的用途,用于改变或引起基因的转录速率和/或表达速率的方法,包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物,以及通过培养转基因微生物来制备生物合成产物的方法。

    PGRO EXPRESSION UNITS
    52.
    发明申请
    PGRO EXPRESSION UNITS 有权
    PGRO表达单位

    公开(公告)号:US20080286841A1

    公开(公告)日:2008-11-20

    申请号:US12038642

    申请日:2008-02-27

    CPC分类号: C12N15/77 C12P13/08

    摘要: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

    摘要翻译: 本发明涉及核酸序列用于调节基因的转录和表达,新型启动子和表达单元本身的用途,用于改变或引起基因的转录速率和/或表达速率的方法,包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物,以及通过培养转基因微生物来制备生物合成产物的方法。

    P Ef-Tu Expression Units
    54.
    发明申请
    P Ef-Tu Expression Units 有权
    P Ef-Tu表达单位

    公开(公告)号:US20080118948A1

    公开(公告)日:2008-05-22

    申请号:US10582918

    申请日:2004-12-15

    摘要: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

    摘要翻译: 本发明涉及核酸序列用于调节基因的转录和表达,新型启动子和表达单元本身的用途,用于改变或引起基因的转录速率和/或表达速率的方法,包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物,以及通过培养转基因微生物来制备生物合成产物的方法。

    Methods for the preparation of a fine chemical by fermentation
    56.
    发明申请
    Methods for the preparation of a fine chemical by fermentation 审中-公开
    通过发酵制备精细化学品的方法

    公开(公告)号:US20070134768A1

    公开(公告)日:2007-06-14

    申请号:US10579648

    申请日:2004-12-17

    IPC分类号: C12P13/04 C12N15/74 C12N1/21

    CPC分类号: C12N9/0006 C12P13/08

    摘要: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of the expression of lactate dehydrogenase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

    摘要翻译: 本发明的特征在于通过使酶编码基因(即乳酸脱氢酶)失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。 在优选的实施方案中,本发明提供通过乳酸脱氢酶活性的表达增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸(OAA)的碳通量来生产赖氨酸的新方法。 在优选的实施方案中,本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。