公开(公告)号：US20100222647A1

公开(公告)日：2010-09-02

申请号：US12161431

申请日：2007-01-18

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B5/055 ,  A61B5/00

CPC classification number: A61B5/05 ,  A61B1/04 ,  A61B10/0041 ,  A61B10/0275 ,  A61B18/24 ,  A61B18/245 ,  A61B2017/00022 ,  A61B2017/00026 ,  A61B2017/00061 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/00809 ,  A61B2017/320069

Abstract: The invention provides a system and method for analysis and treatment of a tissue site. The system of the invention includes a probe unit containing one or more tissue sensing and monitoring probes configured to measure one or more parameters indicative of one or more states of the tissue site and one or more tissue treatment probes configured to deliver a treatment to the tissue site. A processor receives signals from the sensing and monitoring probes and determines whether the probe unit is located at the tissue site to be treated. The treatment and monitoring probes are activated in order to monitor the state of the tissue site while the treatment is being delivered to the tissue site. The processor receives signals from the sensing and monitoring probes during delivery of the treatment indicative of the state of the tissue site and determines, as the treatment is being carried out, any one or more of whether the treatment carried out so far is adequate, whether an additional treatment needs to be carried out, and whether the parameters of the treatment or the treatment targets need to be modified.

Abstract translation: 本发明提供了用于分析和治疗组织部位的系统和方法。 本发明的系统包括探针单元，其包含一个或多个组织感测和监测探针，所述组织感测和监测探针被配置成测量指示组织部位的一个或多个状态的一个或多个参数，以及被配置为将组织处理递送到组织的一个或多个组织治疗探针 现场。 处理器从感测和监测探头接收信号，并确定探针单元是否位于要治疗的组织部位。 激活治疗和监测探针以便在治疗被递送到组织部位时监测组织部位的状态。 在处理指示组织部位状态的处理期间，处理器接收来自感测和监测探针的信号，并且确定正在进行处理的任何一个或多个是否足以进行处理 需要进行额外的治疗，以及是否需要修改治疗或治疗目标的参数。

公开(公告)号：US20090234235A1

公开(公告)日：2009-09-17

申请号：US12046133

申请日：2008-03-11

Applicant: Dan HASHIMSHONY ,  Gil COHEN ,  Iddo GELTNER ,  David BAR-MOSHE

Inventor： Dan HASHIMSHONY ,  Gil COHEN ,  Iddo GELTNER ,  David BAR-MOSHE

IPC: A61B6/00 ,  G06F17/30

Abstract: Provided a method of automated classifying a tissue and a system thereof. The method comprises predefining a classification set comprising one or more classification parameters; acquiring data indicative of the tissue characteristics and sufficient for deriving values of said classification parameters; processing the acquired data and generating a value vector characterizing the tissue, said vector characterized by values of said classification parameters; matching the value vector to a plurality of predefined classification clusters in order to associate the tissue to be classified to an appropriate cluster, thus giving rise to a matching cluster; transforming the value vector into a score value by use of a transformation algorithm, wherein the transformation algorithm and/or parameters thereof are selected in accordance with the matching cluster; comparing the score value with a classification criterion corresponding to said matching cluster; and providing a classification decision in accordance with results of said comparing.

公开(公告)号：US20090187109A1

公开(公告)日：2009-07-23

申请号：US12334565

申请日：2008-12-15

Applicant: Dan HASHIMSHONY

Inventor： Dan HASHIMSHONY

IPC: A61B6/00 ,  A61B5/053

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

Abstract translation: 一种用于通过使检查组织对包含与选择性地与靶细胞结合的生物载体结合的物理元素的小颗粒的造影剂来检查组织是否存在靶细胞特别是癌细胞的方法，装置和探针。 能量脉冲被施加到被检查的组织。 检测由所施加的能量脉冲产生的被检查组织的阻抗和/或光学特性的变化并用于确定所检查组织中靶细胞的存在。 在所描述的优选实施例中，所施加的能量脉冲包括激光脉冲，并且与生物载体共轭的物理元件是具有在存在光时显着降低的阻抗的光敏半导体。 用于检测靶细胞的相同探针也可用于破坏如此靶向的细胞。

公开(公告)号：US20080287750A1

公开(公告)日：2008-11-20

申请号：US11797166

申请日：2007-05-01

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/05 ,  A61B5/00

CPC classification number: A61B5/4312 ,  A61B5/00 ,  A61B5/0055 ,  A61B5/0059 ,  A61B5/01 ,  A61B5/053 ,  A61B5/055 ,  A61B5/444 ,  A61B5/445 ,  A61B6/00 ,  A61B6/037 ,  A61B6/4417 ,  A61B8/00 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4455 ,  A61B90/30 ,  A61B2090/395 ,  A61B2560/0425 ,  B25G1/06 ,  B25G1/102

Abstract: An ergonomic device for intraoperative tissue characterization is provided, having a gripping handle and a sensor head, arranged with an angle α between them, wherein in absolute value, α>10 degrees, and α may be adjusted in one, two, or three planes. The device may further comprise a light fixture, configured for lighting the tissue, as it is characterized, a marking module, configured for marking the tissue, as it is characterized, a vacuum system, for improved contact between a sensing surface and the tissue, and a transparent frame, which enables an operator to observe the tissue, as it is characterized. The device may be operative with at least one sensor, selected from the group consisting of an optical sensor, an X-ray sensor, an RF sensor, a MW sensor, an infrared thermography sensor, an ultrasound sensor, an MR sensor, an impedance sensor, a temperature sensor, a biosensor, a chemical sensor, a radioactive-emission sensor, a nonirradiative RF sensor, and a mechanical sensor.

Abstract translation: 提供了一种用于术中组织表征的符合人体工程学的装置，其具有夹紧手柄和传感器头部，其间以它们之间的角度α布置，其中绝对值为α> 10度，并且可以在一个，两个或三个平面中调整α 。 该装置可进一步包括配置用于照亮组织的灯具，其特征在于，标记模块被构造成用于标记组织，其特征在于，真空系统用于改善感测表面和组织之间的接触， 以及透明框架，其使得操作者能够观察组织的特征。 该装置可以与至少一个传感器一起操作，该传感器选自光学传感器，X射线传感器，RF传感器，MW传感器，红外热像传感器，超声波传感器，MR传感器，阻抗 传感器，温度传感器，生物传感器，化学传感器，放射性发射传感器，非辐射RF传感器和机械传感器。

公开(公告)号：US20050107718A1

公开(公告)日：2005-05-19

申请号：US10965752

申请日：2004-10-18

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: G01N22/00 ,  A61B5/05 ,  A61B5/053 ,  A61B10/00

CPC classification number: A61B5/415 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/418

Abstract: A method and system for examining tissue in order to differentiate it from other tissue according to the dielectric properties of the examined tissue, by: applying a probe to the tissue to be examined, such that the probe generates an electrical fringe field in the zone of the examined tissue and produces a reflected pulse therefrom with negligible radiation penetrating into the tissue itself; detecting the reflected electrical pulse; and comparing electrical characteristics of the reflected electrical pulse with respect to the applied electrical pulse to provide an indication of the dielectric properties of the examined tissue.

Abstract translation: 一种用于根据所检查组织的介电特性来检查组织以便将其与其他组织区分开的方法和系统，方法是：将探针施加到待检查的组织上，使得所述探针在所述检测组织的区域中产生电气边缘区域 所检查的组织并且从其中产生可忽略的辐射穿过组织本身的反射脉冲; 检测反射电脉冲; 并且将反射电脉冲的电特性相对于所施加的电脉冲进行比较，以提供被检查组织的介电性质的指示。

公开(公告)号：US06813515B2

公开(公告)日：2004-11-02

申请号：US10035428

申请日：2002-01-04

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B505

CPC classification number: A61B5/415 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/418

Abstract: A method and system for examining tissue in order to differentiate it from other tissue according to the dielectric properties of the examined tissue, by: applying a probe to the tissue to be examined, such that the probe generates an electrical fringe field in the zone of the examined tissue and produces a reflected pulse therefrom with negligible radiation penetrating into the tissue itself; detecting the reflected electrical pulse; and comparing electrical characteristics of the reflected electrical pulse with respect to the applied electrical pulse to provide an indication of the dielectric properties of the examined tissue.

Abstract translation: 一种用于根据所检查组织的介电特性来检查组织以便将其与其他组织区分开的方法和系统，方法是：将探针施加到待检查的组织上，使得所述探针在所述检测组织的区域中产生电气边缘区域 所检查的组织并且从其中产生可忽略的辐射穿过组织本身的反射脉冲; 检测反射电脉冲; 并且将反射电脉冲的电特性相对于所施加的电脉冲进行比较，以提供被检查组织的介电性质的指示。