公开(公告)号：US20110313284A1

公开(公告)日：2011-12-22

申请号：US12964511

申请日：2010-12-09

Applicant: Gil COHEN ,  Dan HASHIMSHONY

Inventor： Gil COHEN ,  Dan HASHIMSHONY

IPC: A61B5/05

CPC classification number: A61B19/5244 ,  A61B34/20 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/3908

Abstract: A mapping system (200) including: (a) at least one external marker (210,212,214,216) adapted for positioning outside a target (520) to define a target context; (b) at least one target marker (230) adapted for positioning with the target; (c) a data acquisition tool (221) configured to provide position coordinates for at least one data point (220) at the target (520); and (d) a registration module (300) adapted to output position coordinates of said at least one data point relative to at least a portion of the target context.

Abstract translation: 一种映射系统（200），包括：（a）适于定位在目标外部（520）以限定目标上下文的至少一个外部标记（210,212,214,216） （b）至少一个适于与靶标定位的靶标记物（230）; （c）数据采集工具（221），被配置为提供所述目标（520）处的至少一个数据点（220）的位置坐标; 和（d）适于相对于所述目标上下文的至少一部分输出所述至少一个数据点的位置坐标的注册模块（300）。

公开(公告)号：US20090322347A1

公开(公告)日：2009-12-31

申请号：US12147090

申请日：2008-06-26

Applicant: Dan HASHIMSHONY ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan HASHIMSHONY ,  Gil Cohen ,  Iddo Geltner

IPC: G01R35/00

CPC classification number: G01R27/32 ,  G01R35/007

Abstract: A measurement device is presented being configured to be connectable to an analyzer unit (comprising a network analyzer). The measurement device comprises a measuring unit and a calibration and control unit connected to and integral with the measuring unit. The calibration and control unit is configured to enable connection of the measuring unit to the analyzer unit. The calibration and control unit comprises a number of terminals of known RF reflection coefficients respectively and comprises a memory utility carrying recorded data indicative of said RF reflection coefficients and recorded data indicative of RF transfer coefficients of the calibration and control unit. This configuration enables calculation of the RF response of the measuring unit while remaining integral with the calibration and control unit.

Abstract translation: 呈现配置为可连接到分析器单元（包括网络分析器）的测量装置。 测量装置包括测量单元和连接到测量单元并与其成一体的校准和控制单元。 校准和控制单元被配置为使得测量单元能够连接到分析器单元。 校准和控制单元分别包括多个已知RF反射系数的终端，并且包括一个存储器实用工具，其承载表示所述RF反射系数的记录数据和表示校准和控制单元的RF传输系数的记录数据。 该配置使得能够计算测量单元的RF响应，同时与校准和控制单元保持一体。

公开(公告)号：US20120316463A1

公开(公告)日：2012-12-13

申请号：US13547950

申请日：2012-07-12

Applicant: Dan HASHIMSHONY ,  Gil COHEN ,  Iddo GELTNER

Inventor： Dan HASHIMSHONY ,  Gil COHEN ,  Iddo GELTNER

IPC: A61B10/02 ,  A61B17/3205

CPC classification number: A61B10/0275 ,  A61B17/3205 ,  A61B2017/00026 ,  A61B2017/00039 ,  A61B2017/00057

Abstract: A medical device including a tissue characterization probe having an elongated carrier for carrying an array of tissue characterization sensors arranged in a spaced-apart relationship at least along an axis of said carrier within at least a distal portion thereof, such that progression of the probe through a tissue mass provides for locating and determining a dimension of an abnormal tissue specimen inside said tissue mass based on characterization signals from the sensors in the array. The elongated carrier has two integral portions including said distal portion and a hollow portion extending between a proximal end of the carrier and said distal portion. The carrier is configured for passing a predetermined treatment tool through the hollow portion thereof and enabling at least a part of the treatment tool to project from the hollow portion and extend along the distal portion.

Abstract translation: 一种医疗装置，其包括具有细长载体的组织表征探针，所述细长载体用于承载至少沿所述载体的至少其远端部分的轴线以间隔开的关系布置的组织表征传感器阵列，使得探针的进展通过 组织块基于来自阵列中的传感器的表征信号，提供定位和确定所述组织块内的异常组织标本的尺寸。 细长的载体具有包括所述远端部分和在载体的近端和所述远端部分之间延伸的中空部分的两个整体部分。 载体构造成使预定处理工具通过其中空部分，并且使得处理工具的至少一部分能够从中空部分突出并且沿着远端部分延伸。

公开(公告)号：US20090253978A1

公开(公告)日：2009-10-08

申请号：US12483738

申请日：2009-06-12

Applicant: Dan HASHIMSHONY ,  Orit YARDEN ,  Gal AHARONOWITZ ,  Gil COHEN

Inventor： Dan HASHIMSHONY ,  Orit YARDEN ,  Gal AHARONOWITZ ,  Gil COHEN

IPC: A61B5/00 ,  G06F3/048 ,  G01M19/00

CPC classification number: A61B5/05 ,  A61B5/0084 ,  A61B5/015 ,  A61B5/053 ,  A61B5/06 ,  A61B5/064 ,  A61B8/0858 ,  A61B8/12 ,  A61B34/20 ,  A61B34/25 ,  A61B34/30 ,  A61B2090/061 ,  A61B2562/0233 ,  A61B2562/046 ,  G06F3/0481 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3481 ,  G16H40/63 ,  G16H50/50

Abstract: A graphical user interface (GUI) including: (a) a group definition module adapted to accept a user input defining groups; (b) a data receiver operable to receive a plurality of individual measurement input datum indicative of status of a substrate; (c) a grouping module configured to assign each of said individual measurement input datum to one of said groups to produce grouped data; and (d) an output module adapted to output the grouped data.

Abstract translation: 一种图形用户界面（GUI），包括：（a）适合于接受定义组的用户输入的组定义模块; （b）数据接收器，用于接收指示衬底状态的多个单独的测量输入数据; （c）分组模块，其被配置为将每个所述个体测量输入数据分配给所述组中的一个以产生分组数据; 和（d）适于输出分组数据的输出模块。

公开(公告)号：US20120238867A1

公开(公告)日：2012-09-20

申请号：US13485412

申请日：2012-05-31

Applicant: Dan HASHIMSHONY

Inventor： Dan HASHIMSHONY

IPC: A61B5/00 ,  A61B5/053 ,  A61B6/00

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

Abstract translation: 一种用于通过使检查组织对包含与选择性地与靶细胞结合的生物载体结合的物理元素的小颗粒的造影剂来检查组织是否存在靶细胞特别是癌细胞的方法，装置和探针。 能量脉冲被施加到被检查的组织。 检测由所施加的能量脉冲产生的被检查组织的阻抗和/或光学特性的变化并用于确定所检查组织中靶细胞的存在。 在所描述的优选实施例中，所施加的能量脉冲包括激光脉冲，并且与生物载体共轭的物理元件是具有在存在光时显着降低的阻抗的光敏半导体。 用于检测靶细胞的相同探针也可用于破坏如此靶向的细胞。

公开(公告)号：US20090234235A1

公开(公告)日：2009-09-17

申请号：US12046133

申请日：2008-03-11

Applicant: Dan HASHIMSHONY ,  Gil COHEN ,  Iddo GELTNER ,  David BAR-MOSHE

Inventor： Dan HASHIMSHONY ,  Gil COHEN ,  Iddo GELTNER ,  David BAR-MOSHE

IPC: A61B6/00 ,  G06F17/30

Abstract: Provided a method of automated classifying a tissue and a system thereof. The method comprises predefining a classification set comprising one or more classification parameters; acquiring data indicative of the tissue characteristics and sufficient for deriving values of said classification parameters; processing the acquired data and generating a value vector characterizing the tissue, said vector characterized by values of said classification parameters; matching the value vector to a plurality of predefined classification clusters in order to associate the tissue to be classified to an appropriate cluster, thus giving rise to a matching cluster; transforming the value vector into a score value by use of a transformation algorithm, wherein the transformation algorithm and/or parameters thereof are selected in accordance with the matching cluster; comparing the score value with a classification criterion corresponding to said matching cluster; and providing a classification decision in accordance with results of said comparing.

公开(公告)号：US20090187109A1

公开(公告)日：2009-07-23

申请号：US12334565

申请日：2008-12-15

Applicant: Dan HASHIMSHONY

Inventor： Dan HASHIMSHONY

IPC: A61B6/00 ,  A61B5/053

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

Abstract translation: 一种用于通过使检查组织对包含与选择性地与靶细胞结合的生物载体结合的物理元素的小颗粒的造影剂来检查组织是否存在靶细胞特别是癌细胞的方法，装置和探针。 能量脉冲被施加到被检查的组织。 检测由所施加的能量脉冲产生的被检查组织的阻抗和/或光学特性的变化并用于确定所检查组织中靶细胞的存在。 在所描述的优选实施例中，所施加的能量脉冲包括激光脉冲，并且与生物载体共轭的物理元件是具有在存在光时显着降低的阻抗的光敏半导体。 用于检测靶细胞的相同探针也可用于破坏如此靶向的细胞。