摘要:
The invention provides probes with formula (I): in which: X1═NH, O, or S; X2═O or S; SE is a labile group, which may be eliminated under the action of a stimulus that may in particular be the presence of an enzyme, a chemical compound, or a physicochemical characteristic of the medium in which the probe is located; A is an aromatic group that, following cleavage of the C(X2)—O bond in aqueous solution, leads to the liberation of a chromophore or a fluorophore, R represents a hydrogen atom or -(L)n-GP, in which n is equal to 0 or 1, L is a linker arm, and GP is a hydrosolubilizing group; as well as their physiologically acceptable salts, solvates, or hydrates. The invention also provides intermediates for the synthesis thereof and detection methods employing them.
摘要:
The present invention relates to a therapeutic compound comprising: an agent that inhibits the activity of at least one gene selected from the group consisting of MAF, MEOX2, SIX2 and homologs thereof having at least 50% identity with said genes and/or an agent that enhances the activity of at least one gene selected from the group consisting of CREB5, E2F1, EGR2, HIC1, IRF7, JUN, MYC, SRF, STAT4, TCF4, FOXS1, GLI1, SOX9 and homologs thereof having at least 50% identity with said gene for use in the treatment of wounds, preferably chronic wounds.
摘要:
The disclosure relates to a method for transmitting an item of information in a communication channel linking a transmitter to a recipient, the method including the following successive steps: the determination, by the transmitter, of a first intelligible sound signal representative of the item of information to be transmitted, the acoustic processing, by the transmitter, of the first sound signal so as to produce a second sound signal unintelligible to the recipient, the transmission of the second sound signal from the transmitter to the recipient, the transmission of the first sound signal from the transmitter to the recipient, the transmission of the first sound signal being triggered by the transmission of the second sound signal, the second transmission of the second sound signal from the transmitter to the recipient, the second transmission of the second sound signal being triggered by the transmission of the first signal.
摘要:
The present invention relates to a therapeutic compound comprising: an agent that inhibits the activity of at least one gene selected from the group consisting of HIC1, FOXS1, CREB5, IRF7, POU2F2, STAT4, TCF4, and/or an agent that enhances the activity of at least one gene selected from the group consisting of MAF, MEOX2, SIX2.
摘要:
A passive resonant optical gyroscope comprising a cavity and operating with three frequencies comprises: a first injecting laser to inject a first optical beam into the cavity in a first direction; a second injecting laser to inject a second optical beam into the cavity in an opposite direction; a third injecting laser to inject a third optical beam into the cavity in one of the aforementioned directions, one laser amongst the injecting lasers having a master frequency, the two other injecting lasers, called the first and second slave lasers, respectively having a first slave frequency and a second slave frequency; a master servocontrol device; a first servocontrol stage comprising first and second slave devices; and a second servocontrol stage comprising first and second optical phase-locking devices respectively comprising a first and second slave oscillator to generate a first radiofrequency offset signal and a second radiofrequency offset signal.
摘要:
In the field of methods of three-dimensional measurement of an object by stereo-correlation, methods require at least two cameras connected to image processing means. These methods include at least a first step of calibration of the two image planes and a second step of spatial matching between these two image planes. These two steps can be followed by a third step of temporal matching. The method provided requires objects, the surface of which has a parametric representation, i.e. a mathematical representation of the object surface having the form of a decomposition over a scalar function basis. The parametric representation is implemented during the first calibration step and/or during the second and third steps of spatial or temporal matching.
摘要:
Tomographs comprise at least one first emission source, one first matrix detector and calculation means arranged to produce an initial tomograph of an object on the basis of radiographs arising from the first matrix detector taken from various angles. The tomography scanner comprises a second emission source and a second matrix detector arranged so that, when the object is subjected to a stress which is known at a given instant in time, the calculation means determine the changes in the object subjected to stress based only on the information from a first radiograph of the object under stress arising from the first matrix detector, from a second radiograph of the object under stress arising from the second matrix detector and the initial tomograph, the first radiograph and the second radiograph being taken at the same given instant in time.
摘要:
The invention concerns novel glycosidase substrates of formula (I): where R0, R1, R2, R3, and R4 are such as defined in claim 1; and a method for detecting the presence of a catalytically active glycosidase using one of these substrates.
摘要:
Method for detection of at least one reversibly photo-convertible fluorescent species (P), comprising the following steps: a) illumination of a sample comprising said or at least one of said reversibly photo-convertible fluorescent species by a periodically modulated illuminating light (FEX); and b) detection of fluorescent emission (FLU) emitted by the sample thus illuminated; characterized in that the method further comprises the following step: c) extraction of the amplitude (IFOUt) of the intensity component of said fluorescent emission exhibiting the same periodicity as said periodically modulated illuminating light and a phase quadrature with respect to the same; and in that the mean intensity of said illuminating light and the modulation frequency of the same are chosen in such a way as to maximise said amplitude of the intensity component of said fluorescent emission.
摘要:
The present invention relates to a system of nanopore sequencing using nucleic-acid binding proteins wherein the activity of the said protein and the passage of the sequenced nucleic acid molecule through the nanopore are coordinated. In particular, the present invention enables an easy synchronization of nanopore capture with polynucleotide unwinding, which in turn affords an easy way to repeat the whole process of capture and nucleotide characterization.