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    Neural interface fabrication
    51.
    发明授权
    Neural interface fabrication 有权

    公开(公告)号：US10603486B2

    公开(公告)日：2020-03-31

    申请号：US16309182

    申请日：2017-06-12

    Applicant: GALVANI BIOELECTRONICS LIMITED

    Inventor： Dwight Sherod Walker ,  Daniel John Chew

    IPC: B29C43/18 ,  A61N1/05 ,  A61B5/04 ,  A61B5/00

    Abstract: Methods for fabricating implantable cuff electrodes for contacting or at least partially surrounding internal body tissue such as, e.g., nerves, smooth muscles, striated muscles, arteries, veins, ligamental tissues, connective tissues, cartilage tissues, bones, or other similar body tissues, structures and organs are disclosed. An example method includes preparing a substrate including an implantable cuff electrode shape, applying a mold material to the substrate, curing the mold material to form a mold, releasing the mold from the substrate, inserting at least one conductor into the mold that penetrates through the channel of the mold, pressing a formable material into the channel of the mold to form a body of an implantable cuff electrode about the at least one conductor, curing the body of the implantable cuff electrode, and releasing the body of the implantable cuff electrode from the mold.

    Neuromodulation device
    53.
    发明授权
    Neuromodulation device 有权

    公开(公告)号：US10406362B2

    公开(公告)日：2019-09-10

    申请号：US15551592

    申请日：2016-02-19

    Applicant: GALVANI BIOELECTRONICS LIMITED ,  HUNTINGTON MEDICAL RESEARCH INSTITUTES ,  UNIVERSITY OF CHILE

    Inventor： Hans Jakob Kristoffer Famm ,  Hernan E. Lara ,  Victor Eugene Pikov ,  Arun Sridhar

    IPC: A61N1/36 ,  A61F7/12 ,  A61N1/05 ,  A61N1/20 ,  A61N5/06 ,  A61N7/00

    Abstract: Methods for treating polycystic ovarian syndrome with a neuromodulation device that modulates sympathetic neural activity are described herein. The neuromodulation device is an apparatus for the treatment of polycystic ovarian syndrome. In one aspect, the apparatus decreases the neural activity of a postganglionic ovary-innervating sympathetic nerve. Modulation in neural activity may be achieved using an apparatus comprising one or more stimulators each configured to apply a signal to a postganglionic ovary-innervating sympathetic nerve of the patient, a controller coupled to the one or more stimulators, the controller controlling the signal to be applied by each of the one or more stimulators, such that the signal decreases the neural activity of the nerve to produce a physiological and/or biochemical response in the patient, wherein the physiological and/or biochemical response comprises an improvement in one or more symptoms of polycystic ovarian syndrome.

    System for Wirelessly Coupling in Vivo
    55.
    发明申请
    System for Wirelessly Coupling in Vivo 审中-公开

    公开(公告)号：US20180131415A1

    公开(公告)日：2018-05-10

    申请号：US15803405

    申请日：2017-11-03

    Applicant: Galvani Bioelectronics Limited

    Inventor： Rizwan BASHIRULLAH

    IPC: H04B5/00 ,  A61B5/00

    CPC classification number: H04B5/0075 ,  A61B5/0026 ,  A61B5/0031 ,  A61B5/04001 ,  A61B2560/0219 ,  A61M2205/3538 ,  A61M2205/3569 ,  A61N1/3605

    Abstract: Implantable systems are described that include a stimulation device positionable in vivo and configured to communicatively couple to electrodes configured to stimulate or block body tissue and an auxiliary device positionable in vivo and including one or more coils configured to wirelessly couple, in vivo, to the stimulation device and to wirelessly couple to an ex vivo device. The auxiliary device may include a coil driver and a power source controlled by a processor and memory for storing data instructions for the coil driver and for storing data received from the stimulation device. The auxiliary device may also include a radio transceiver and an antenna. The stimulation device may include a housing, a coil, a power source and an integrated circuit for controlling the electrodes. The stimulation device may be coupled to a cuff via a lead and physically coupled to the auxiliary device.

    Powering an In Vivo Device Using Energy from a Radioactive Source
    56.
    发明申请
    Powering an In Vivo Device Using Energy from a Radioactive Source 审中-公开

    公开(公告)号：US20180126015A1

    公开(公告)日：2018-05-10

    申请号：US15803496

    申请日：2017-11-03

    Applicant: Galvani Bioelectronics Limited

    Inventor： Rizwan BASHIRULLAH

    IPC: A61K51/12 ,  H02H9/00

    CPC classification number: A61K51/1282 ,  G21H1/02 ,  H02H9/002

    Abstract: An implantable system is disclosed that includes an encapsulated housing including a radioactive source. The encapsulated housing is internally coated with a light-generating coating that converts the radioactive energy to light, that is then output in vivo to a photodiode positioned proximate to at least part of the encapsulated housing in vivo. The photodiode is configured to generate electrical current from the light, which electrical current is output to a power conditioning circuit that is configured to use the electrical current as an input electrical current and to output power to a load in vivo. The encapsulated may also be internally coated, at least in part, with a light directing coating that causes light to be directed toward an optical lens that focuses the light on the photodiode. The radioactive source may be a gas having a low half-life and which poses no health risk to a patient if released.

    Neuromodulation of Ganglia
    57.
    发明申请
    Neuromodulation of Ganglia 有权

    公开(公告)号：US20250099762A1

    公开(公告)日：2025-03-27

    申请号：US18924183

    申请日：2024-10-23

    Applicant: Galvani Bioelectronics Limited

    Inventor： Gerald Edwin Hunsberger ,  Arun Sridhar

    IPC: A61N1/36 ,  A61N1/05

    Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.

    Electrode devices for neurostimulation
    60.
    发明授权
    Electrode devices for neurostimulation 有权

    公开(公告)号：US11944812B2

    公开(公告)日：2024-04-02

    申请号：US17739897

    申请日：2022-05-09

    Applicant: GALVANI BIOELECTRONICS LIMITED

    Inventor： Faisal Zaidi ,  Sebastien Ouchouche

    IPC: A61N1/05 ,  A61N1/36

    CPC classification number: A61N1/0556

    Abstract: An extravascular neural interface includes a device containing electrodes for neurostimulation of a vessel. The devices are housed in flexible substrates forming two flaps, an inner flap having a spinal portion for routing leads/conductors into the device for connection to the electrodes and an outer flap that overlaps the inner flap. The inner flap supports and positions the electrodes to be inward facing, i.e., extravascular designs. The electrodes may be circular or elliptical and include a plurality of wings for securing the electrodes within a flap.

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