公开(公告)号：US20160007975A1

公开(公告)日：2016-01-14

申请号：US14769911

申请日：2014-01-03

Applicant: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Sung Min KIM ,  In Chul Yang ,  In Sung Moon ,  Ji Il Kim ,  Sun Cheol Park ,  Jeong Kye Hwang

IPC: A61B10/02 ,  A61M5/32 ,  A61B8/12

CPC classification number: A61B10/0275 ,  A61B8/0833 ,  A61B8/12 ,  A61B10/0283 ,  A61B2010/0208 ,  A61B2010/045 ,  A61B2017/00495 ,  A61B2017/0065 ,  A61B2017/3413 ,  A61B2090/3925 ,  A61M5/32

Abstract: The present invention relates to a biological tissue biopsy device including a body extending in a longitudinal direction, an outer needle installed to be connected to one side of the body and be extended in a longitudinal direction and including a first tube having a hollow portion formed therein and a second tube disposed in a direction parallel to the first tube to guide a hemostatic substance, an inner needle provided inside the first tube and extending in a longitudinal direction, and a sliding means provided in the body and installed to be connected to one end of the inner needle so as to enable the inner needle to move forward and backward. Here, the sliding means causes the inner needle to move a predetermined distance from the hollow portion of the first tube and be inserted into a target site.

Abstract translation: 本发明涉及一种生物组织活检装置，其包括沿纵向方向延伸的主体，外针安装成连接到主体的一侧并沿纵向方向延伸，并且包括形成有中空部的第一管 以及第二管，其设置在与所述第一管平行的方向上，以引导止血物质，设置在所述第一管内并沿纵向方向延伸的内针，以及设置在所述主体中并安装成连接到所述第一管的一端的滑动装置 以使内针能够向前后移动。 这里，滑动装置使内针从第一管的中空部移动预定距离并插入目标位置。

公开(公告)号：US20150086527A1

公开(公告)日：2015-03-26

申请号：US14493375

申请日：2014-09-23

Applicant: Chung-Ang University Industry-Academy Cooperation Foundation ,  Chungbuk National University Industry-Academic Cooperation Foundation ,  Industry Academic Cooperation Foundation, Hallym University

Inventor： Jae Chan Kim ,  Kyoung Woo Kim ,  Yeoun Sook Chun ,  Soo Hyun Park ,  Sung Wook Wee ,  Soo Ik Chang ,  Kyong Mi Min ,  Kyu Wan Kim ,  Young Joo Shin

IPC: A61K38/46

CPC classification number: A61K38/1891 ,  A61K38/465 ,  C07K14/515 ,  C12Y301/27008

Abstract: Provided is a pharmaceutical composition for treating corneal endothelium wounds, the composition including angiogenin as an effective ingredient. The present invention relates to a new topical therapeutic use of angiogenin for treatment of corneal endothelium wounds, wherein the angiogenin that is generally known to be involved in angiogenesis activates a PI3K/Akt/eNOS pathway thereof in ocular corneal endothelium to increase migration and proliferation of corneal endothelial cells that are not capable of self-proliferation and to promote prevention and treatment of corneal endothelial cell wounds.

Abstract translation: 本发明提供一种用于治疗角膜内皮伤口的药物组合物，该组合物包含血管生成素作为有效成分。 本发明涉及用于治疗角膜内皮创伤的血管生成素的新的局部治疗用途，其中通常已知参与血管发生的血管生成素在眼角膜内皮中激活PI3K / Akt / eNOS途径以增加角膜内皮细胞的迁移和增殖 角膜内皮细胞不能自我增殖并促进预防和治疗角膜内皮细胞创伤。

公开(公告)号：US12275977B2

公开(公告)日：2025-04-15

申请号：US17288761

申请日：2019-10-28

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY ,  KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Seon Won Kim ,  Seong Hee Jeong ,  Kyung Jin Kim ,  Zada Bakht

IPC: C12P7/28 ,  C12N1/20 ,  C12N9/10 ,  C12N9/16 ,  C12N15/52 ,  C12R1/19

Abstract: A method for biologically producing acetin such as monoacetin, diacetin, or triacetin according to an embodiment of the present disclosure includes reacting acetyl-CoA with glycerol in the presence of a first O-acetyl transferase to obtain the acetin. With the method, acetin which is sustainable and safe, and has more excellent quality while not causing environmental pollution may be obtained.

公开(公告)号：US20250051290A1

公开(公告)日：2025-02-13

申请号：US18723115

申请日：2022-12-26

Applicant: Ajou University Industry-Academic Cooperation Foundation ,  Sangmyung University Cheonan Council for Industry-Academic Cooperation Foundation

Inventor： Yi-Sook Jung ,  Eunha Kim ,  Sunghou Lee ,  Hye Jin Jee ,  Ju-Young Park

IPC: C07D239/95 ,  A61K31/517 ,  A61P25/20 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention relates to a novel compound which can provide a sleep improving effect or the use thereof. Some compounds have an adenosine receptor agonistic activity. The novel compound of the present invention can shorten sleep latency and extend total sleep duration, and thus may be effectively used for a pharmaceutical composition for preventing or treating a sleep disorder, a health functional food composition for preventing or relieving a sleep disorder, a composition for improving sleep, a sleep aid, or a method for treating a sleep disorder.

公开(公告)号：US20250036943A1

公开(公告)日：2025-01-30

申请号：US18760483

申请日：2024-07-01

Applicant: Samsung Electronics Co., Ltd. ,  Seoul National University R&DB Foundation ,  Industry-Academic Cooperation Foundation, Chosun University ,  Chung Ang University Industry Academic Cooperation Foundation ,  POSTECH Research and Business Development Foundation

Inventor： Yongjune KIM ,  Junghyun LEE ,  Young-Sik KIM ,  Jong-Seon NO ,  Jiheon WOO ,  Eunsang LEE ,  Joon-Woo LEE

IPC: G06N3/08 ,  G06N3/04 ,  H04L9/00

Abstract: A processor-implemented method includes receiving data for performing a neural network operation of homomorphic encrypted data and a parameter for generating an approximate polynomial corresponding to the neural network operation, obtaining layer information corresponding to each of a plurality of layers configuring a neural network based on the data, determining layer importance corresponding to each of the plurality of layers, based on the parameter and the layer information, generating an approximate polynomial approximating the neural network operation for each of the plurality of layers, based on the layer importance, and generating an operation result by performing the neural network operation based on the approximate polynomial.

公开(公告)号：US20250036926A1

公开(公告)日：2025-01-30

申请号：US18753611

申请日：2024-06-25

Applicant: Samsung Electronics Co., Ltd. ,  Seoul National University R&DB Foundation ,  Industry-Academic Cooperation Foundation, Chosun University ,  CHUNG ANG UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION ,  POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

Inventor： Joon-Woo LEE ,  Junghyun LEE ,  Yongjune KIM ,  Young-Sik KIM ,  Jong-Seon NO ,  Eunsang LEE

IPC: G06N3/048 ,  G06F11/07 ,  G06F17/17

Abstract: An operation method of performing a neural network operation of fully homomorphic encrypted data is provided. The operation method includes: receiving data for performing the neural network operation and receiving a parameter for generating an approximation polynomial corresponding to the neural network operation; obtaining layer information corresponding to layers of a neural network model, the layer information based on the data; determining importances of the layers, respectively, wherein the determining of the importances is based on the parameter and the layer information; generating an approximation polynomial approximating the neural network operation for each of the layers, wherein the generating is based on the layer importance; and generating an operation result by performing the neural network operation based on the approximation polynomial, wherein the parameter includes a computation time condition that the neural network operation must satisfy.

公开(公告)号：US20250025115A1

公开(公告)日：2025-01-23

申请号：US18833237

申请日：2023-01-12

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sheen Woo LEE ,  Kwang Gi KIM

IPC: A61B6/03 ,  A61B6/50

Abstract: An embodiment provides a method for measuring a femoral anterior angle and a tibial torsion angle by using artificial intelligence, the method comprising the steps of: (a) obtaining, by a CT scanner, 2D CT images of the femur, the tibia, and the malleolus of a patient; (b) storing, in a big-data unit, the 2D CT images transmitted from the CT scanner; (c) setting, by an artificial intelligence unit, a first baseline related to the femoral head and neck, a second baseline related to the lower femoral, a third baseline related to the upper tibial, and a fourth baseline related to the malleolus, on the basis of the 2D CT images; and (d) measuring, by an angle measurement unit, a femoral anterior angle formed between the first baseline and the second baseline, and a tibial torsion angle formed between the third baseline and the fourth baseline.

公开(公告)号：US20230331672A1

公开(公告)日：2023-10-19

申请号：US18028100

申请日：2021-09-17

Applicant: CNG BIO CO., LTD. ,  CHUNGBUK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Jaekyung JUNG ,  Mi Kyeong LEE ,  Dae Hee LEE ,  Jae Kang LEE ,  Sun Yeou KIM ,  Da Hye YOON ,  Seong Min HONG

IPC: C07D209/46 ,  C07D491/048 ,  A61P25/16 ,  A61P25/28 ,  A23L33/10

CPC classification number: C07D209/46 ,  C07D491/048 ,  A61P25/16 ,  A61P25/28 ,  A23L33/10

Abstract: The present invention relates to: a novel 6-methoxy-2-phenethyl isoindolin-1-one derivative compound having the ability to promote the increase of nerve growth factor, the ability to promote the growth of nerve cells, and antineuritic activity; and a composition for preventing, improving and treating neurological diseases, comprising the same.

公开(公告)号：US11666604B2

公开(公告)日：2023-06-06

申请号：US15779073

申请日：2017-12-18

Applicant: INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Young-Il Yang ,  Ki-Dong Park ,  Won-Jin Lee ,  Min-Young Choi ,  Kyung-Min Park ,  Yun-Ki Lee

IPC: A61K35/34 ,  C12N5/0775

CPC classification number: A61K35/34 ,  C12N5/0662 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/17 ,  C12N2501/235 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/56

Abstract: Disclosed are a multilayered cell sheet of cardiac stem cells (CSCs) and a method of manufacturing the same. In particular, the present disclosure provides a method of manufacturing a multilayered cell sheet according to a single step culture procedure by using, as a three-dimensional matrix, a biodegradable natural polymer hydrogel and embedding CSCs in the hydrogel. The multilayered cell sheet of the present disclosure does not require any special device for the manufacturing, is manageable with good physicomechanical property, increases a cell engraftment rate after transplantation based on sufficient accumulation of various growth and protective factors and extracellular matrix between cells, and is also self-assembled by the cell-mediated hydrogel compaction, making nutrients transfer easy. Therefore, the multilayered cell sheet of the CSCs is expected to be usefully applicable as a therapeutic agent for myocardium regeneration.

公开(公告)号：US20220387597A1

公开(公告)日：2022-12-08

申请号：US17771160

申请日：2020-10-22

Applicant: SEOUL NATIONAL UNIVERSITY HOSPITAL ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  CHUNG ANG University Industry Academic Cooperation Foundation

Inventor： Se Joon Woo ,  Ki Dong Park ,  Si Min Lee ,  Joo Young Son ,  Wonhee Suh

IPC: A61K47/36 ,  A61K9/06 ,  A61K9/00 ,  C08B37/08 ,  C08J3/075 ,  C08J3/24 ,  A61F9/00

Abstract: Provided are an injectable intraocular microgel and an injectable intraocular hydrogel that are safe to a human body and that can release a drug in the eye for a long period of time. This injectable intraocular microgel may have a form in which a drug is loaded on a hyaluronic acid microgel generated by causing hyaluronic acid copolymers to cross-link with each other through a w/o emulsion method.