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公开(公告)号：US10028879B2
公开(公告)日：2018-07-24
申请号：US14451315
申请日：2014-08-04
发明人： Hyun-Dong Kim
IPC分类号： A61H1/02
摘要： There is provided an apparatus for automatically lengthening a calf muscle in order to relax fatigue and tension of a calf muscle of a worker who works standing up for a long time or a woman wearing high heels. Accordingly, a calf muscle can be naturally relaxed itself by lengthening a length of the calf muscle that is tense by a repetitive and continuous damage, so that it is possible to reduce a chronic muscle unbalance and a muscular pain of a worker who works standing up for a long time or a young woman wearing high heels and it is possible to improve quality of life and work efficiency in an industrial site.
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公开(公告)号：US09889341B2
公开(公告)日：2018-02-13
申请号：US14764947
申请日：2015-05-12
发明人： Chi Woong Mun , Min Jae Kang , Sun Joung An , Yong Hee Han , Tae Hyung Kim
IPC分类号： A61M16/00 , A63B24/00 , A61H1/00 , A63B23/00 , A63B23/03 , A63B71/06 , A61B5/11 , G06F3/01 , A63F13/21 , A63B69/00 , A63F13/00 , A63B21/00
CPC分类号： A63B24/0087 , A61B5/11 , A61B5/1114 , A61H1/00 , A63B21/00047 , A63B21/4003 , A63B21/4039 , A63B23/00 , A63B23/03 , A63B69/0057 , A63B71/0622 , A63B2022/0092 , A63B2022/0094 , A63B2024/0096 , A63B2071/0625 , A63B2071/063 , A63B2220/13 , A63B2220/53 , A63B2220/801 , A63B2225/09 , A63B2225/093 , A63B2225/20 , A63B2225/50 , A63F13/00 , A63F13/21 , G06F3/011
摘要： The present description relates to a dysphagia rehabilitation apparatus to help tongue muscle rehabilitation exercise during dysphagia rehabilitation. More particularly, it relates to a device that when a patient wearing the dysphagia rehabilitation device contacts the tongue to a position sensing unit configured on the front of a mask, a sensing single according to a change of a physical value of resistance corresponding to the tongue's touching position from the position sensing unit. Then a control unit of a remote device generates a control signal through the transmitted sensing signal, thereby the remote device controls rehabilitation, games and programs of similar functions thereof and induce patient's interest of rehabilitation. Thus, effect of rehabilitation is improved.
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公开(公告)号：US20170319382A1
公开(公告)日：2017-11-09
申请号：US15518245
申请日：2015-10-07
发明人： Sung Hyuk MOON , Won Jae KIM , Su Ho LIM
IPC分类号： A61F9/007 , A61B17/3209 , A61B17/04
CPC分类号： A61B17/0469 , A61B17/04 , A61B17/062 , A61B17/3209 , A61B2017/0472 , A61B2017/06057 , A61B2017/0608 , A61B2017/06095 , A61B2090/034 , A61F9/007
摘要： An automatic suturing hook apparatus comprises a main body having a movement hole formed on one side surface thereof and having a first protrusion hole formed on the front end thereof; a needle part which is provided inside the main body and protrudes from the first protrusion hole; a slide body which slidably moves through the movement hole from one side surface of the main body to the front end or rear end of the main body and comes into close contact with the front end of the main body; a slide part which is provided inside the main body and slidably moves the needle part provided inside the main body to the outside of the main body; and a first trigger which is provided at the bottom of the rear end of the main body and operates the slide part which is provided inside the main body.
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公开(公告)号：US09739766B2
公开(公告)日：2017-08-22
申请号：US14894522
申请日：2013-12-18
发明人： Dae Young Hur , Ga Bin Park , Yeong Seok Kim , Dae Jin Kim , Seong Han Kim , Hyun Kyung Lee , Jae Wook Yang
IPC分类号： G01N33/50 , C12N5/079 , G01N33/569 , C07K14/005 , C07K14/52 , C12N7/00 , A61K39/245 , A61K39/12 , A61K31/00 , A61K38/20
CPC分类号： G01N33/5047 , C12N5/0621 , G01N33/5044 , G01N33/56994 , G01N2333/05 , G01N2800/16 , G01N2800/7014
摘要： The present invention relates to a cell model for diseases associated with corneal neovascularization by using Epstein Barr virus (EBV)-infected human corneal epithelial cells (HCECs). Provided are a method for preparing a cell model for diseases associated with corneal neovascularization by using EBV-infected HCECs, the method including: infecting HCECs with EBV; culturing the infected HCECs; and determining whether the cultured HCECs are infected with EBV. In addition, provided is a method for screening diseases associated with corneal neovascularization prepared by the cell model for diseases associated with corneal neovascularization.
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公开(公告)号：US09714935B2
公开(公告)日：2017-07-25
申请号：US14378092
申请日：2013-07-29
发明人： Chi Woong Mun , Moo Young Jang , Song I Chun , Bok Man Kang , So Young Kwak
IPC分类号： G01N33/48 , G01N33/50 , G01N24/08 , G01R33/465 , G06G7/58
CPC分类号： G01N33/5005 , G01N24/08 , G01N2405/00 , G01N2410/00 , G01R33/465
摘要： Provided are a noninvasive measurement of cell signals and a method thereof, wherein the measurement method can ascertain cell proliferation and differentiation states using MRS and can enable cells to be reused so that cell states can be evaluated with improved reproducibility and reliability. And since the cell signals are noninvasively measured using the MRS, the corresponding cells can be reused so that the cost and time needed for one experiment can be remarkably reduced.
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56.发明授权N-acylhydrazone derivatives for selective T cell inhibitor and anti-lymphoid malignancy drug 有权用于选择性T细胞抑制剂和抗淋巴恶性肿瘤药物的N-酰腙衍生物公开(公告)号：US09447083B2
公开(公告)日：2016-09-20
申请号：US14424749
申请日：2013-08-29
发明人： HoJin Choi , JaeWon Lee , ChangGon Lee , NiNa Ha , Su Kil Seo , SunMi Lee , Song-Min Lee
IPC分类号： C07D409/12 , C07D209/08 , C07D409/14 , C07D403/12 , C07D401/14 , C07D235/08 , C07D401/12 , C07D405/12 , C07D285/14
CPC分类号： C07D409/14 , C07D209/08 , C07D235/08 , C07D285/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to novel N-acylhydrazone derivatives, and more particularly to novel N-acylhydrazone derivatives having selective T cell inhibitory activity and/or anti-lymphoid malignancy activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, the use thereof for preparing pharmaceutical compositions, pharmaceutical compositions containing the same, treatment methods using the compositions, and methods for preparing the novel N-acylhydrazone derivatives.
摘要翻译： 本发明涉及新的N-酰腙衍生物，更具体地说，涉及具有选择性T细胞抑制活性和/或抗淋巴恶性肿瘤活性的新型N-酰腙衍生物，其立体异构体，其药学上可接受的盐，其制备药物组合物的用途 ，含有该组合物的药物组合物，使用该组合物的治疗方法，以及制备新N-酰腙衍生物的方法。
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57.发明申请METHOD FOR CULTURING CARDIAC PROGENITOR CELLS AND USE OF CARDIAC PROGENITOR CELLS 审中-公开培养心脏病原体细胞的方法和使用心脏原细胞细胞公开(公告)号：US20130295060A1
公开(公告)日：2013-11-07
申请号：US13886663
申请日：2013-05-03
申请人： Inje University Industry-Academic Cooperation Foundation , Ewha University-Industry Collaboration Foundation
发明人： Young Il YANG , Seung Jin Lee , Hyeong In Kim , Jong Tae Kim , Soon Ho Cheong
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , C12N5/0657 , C12N5/0692 , C12N2501/999 , C12N2533/52
摘要： Disclosed is a method for culturing myocardium-resident cardiac progenitor cells, comprising: embedding myocardial fragments into hydrogel; culturing the myocardial fragment into hydrogel; degrading only the hydrogel to recover cardiac progenitor cells grown out of the myocardial fragment to the hydrogel; and amplifying the cardiac progenitor cells in vitro. Also, the cardiac progenitor cells, a method for differentiating the same, and the use thereof as cell therapeutic agent for heart diseases are provided. In addition to possessing the potential to differentiate into cardiomyocytes, osteoblasts, adipocytes, chondrocytes, vascular endothelial cells, smooth muscle cells, neural cells, and skeletal muscle cells, the myocardium-resident cardiac progenitor cells can spontaneously differentiate into cardiomyocytes even in the absence of a special differentiation inducing agent. Thus, the cardiac progenitor cells can be used to produce bio-active medicines such as cell therapeutics and tissue engineering therapeutics with high industrial applicability.
摘要翻译： 公开了一种培养心肌驻留心脏祖细胞的方法，包括：将心肌片段包埋在水凝胶中; 将心肌片段培养成水凝胶; 仅降解水凝胶以将从心肌片段生长的心脏祖细胞回收至水凝胶; 并在体外扩增心脏祖细胞。 此外，提供了心脏祖细胞，其分化方法及其作为心脏病的细胞治疗剂的用途。 除了具有分化成心肌细胞，成骨细胞，脂肪细胞，软骨细胞，血管内皮细胞，平滑肌细胞，神经细胞和骨骼肌细胞的潜力之外，心肌驻留的心脏祖细胞也可以自发分化成心肌细胞，即使没有 一种特殊的分化诱导剂。 因此，心脏祖细胞可用于生产具有高工业应用性的生物活性药物，例如细胞治疗剂和组织工程治疗剂。
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公开(公告)号：US12059678B2
公开(公告)日：2024-08-13
申请号：US17281297
申请日：2019-11-19
发明人： Ki-Ho Han , Jin-Ho Kim
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502761 , B01L2200/0652 , B01L2300/0645 , B01L2300/0816 , B01L2300/0848 , B01L2300/0861 , B01L2300/0887 , B01L2300/1827 , B01L2400/043 , B01L2400/0487
摘要： Provided is a microfluidic device including a lower panel including flow velocity measuring structures for measuring a flow velocity of a fluid; an upper panel separated from the lower panel and including a microfluidic channel through which a sample passes; a thin film provided at a portion where the lower panel and the upper panel adjoin each other in order to prevent the sample passing through the microfluidic channel from coming into direct contact with the flow velocity measuring structures, the thin film being configured to separate the lower panel and the upper panel to enable the lower panel to be repeatedly used multiple times; a specific functional unit configured to perform a specific operation on the sample passing through the microfluidic channel; and a negative pressure forming means configured to suck the lower panel and the upper panel with a negative pressure.
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公开(公告)号：US20240228923A1
公开(公告)日：2024-07-11
申请号：US18432112
申请日：2024-02-05
发明人： Se Hoon JEONG , Soo Min LEE
摘要： A culture device for manufacturing an organoid of a 3D shape according to an embodiment includes: a culture plate provided with one or more insertion grooves; and an organoid device inserted to and removed from the insertion grooves and provided with one or more culture grooves, wherein the culture grooves provided on the culture plate may be formed in a pattern having a predetermined diameter on the surface of the culture plate.
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公开(公告)号：US11979504B2
公开(公告)日：2024-05-07
申请号：US17268389
申请日：2018-12-31
CPC分类号： H04L9/3247 , G06F21/6227 , G06F21/6254 , H04L9/3236 , H04L9/50
摘要： Incidents involving confidentiality and vigilance against user privacy invasions raise doubts as to current third-party data collection procedures. Personally identifiable information (PII) is being abused for medical data breaches, identity theft, spam, phishing, cyber spying, etc. A great amount of data is flowing from users to companies for prediction and analysis of data-centric markets. It is thus difficult to track PII flow and genuineness. Blockchain technology, which is an “immutable” distributed ledger, can efficiently track PII exchange, storing, and distribution. In contrast, the EU general data protection regulation (GDPR) in progress claims “a right to forget” and a right “to delete”. However, the present specification proposes an off-chain blockchain architecture using both a local database and a distributed ledger to guarantee a trustable PII life cycle.
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