公开(公告)号：US20170074878A1

公开(公告)日：2017-03-16

申请号：US15363991

申请日：2016-11-29

Applicant: Meso Scale Technologies, LLC. ,  Crescendo Bioscience ,  Oklahoma Medical Research Foundation

Inventor： Pankaj Oberoi ,  Steven C. Hoffmann ,  Guy L. Cavet ,  Yijing Shen ,  Nicholas Knowlton ,  Michael Centola

IPC: G01N33/564

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/564 ,  G01N2333/4709 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/485 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70578 ,  G01N2333/72 ,  G01N2333/96494 ,  G01N2800/102 ,  G01N2800/60 ,  G16B40/00

Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).

Abstract translation: 提供了用于诊断和评估炎性疾病的生物标志物，以及用于测量其表达的试剂盒。 本发明还提供了基于生物标志物的预测模型，以及用于评分和可选地分类样品的模型的计算机系统和软件实施方案。 生物标志物包括至少两种选自DAIMRK组的生物标志物，得分是疾病活动指数（DAI）。

公开(公告)号：US20160283594A1

公开(公告)日：2016-09-29

申请号：US15178964

申请日：2016-06-10

Applicant: Meso Scale Technologies, LLC.

Inventor： Xinri Cong ,  Jerome Jackson ,  Carl Stevens ,  Michael Vock ,  Jacob N. Wohlstadter

IPC: G06F17/30 ,  G06F19/00 ,  G01N35/04 ,  G01N35/00 ,  G01N35/10 ,  G06Q30/02 ,  G06Q10/10

CPC classification number: G06F17/30864 ,  G01N35/00871 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/1002 ,  G01N2035/00881 ,  G01N2035/0425 ,  G01N2035/0475 ,  G06F17/30289 ,  G06F19/00 ,  G06F19/28 ,  G06Q10/06 ,  G06Q10/10 ,  G06Q30/0201 ,  G06Q30/0625 ,  G07C9/00103 ,  G16H10/40

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.

公开(公告)号：US09377476B2

公开(公告)日：2016-06-28

申请号：US14719818

申请日：2015-05-22

Applicant: Meso Scale Technologies, LLC.

Inventor： Xinri Cong ,  Jerome Jackson ,  Carl Stevens ,  Michael Vock ,  Jacob N. Wohlstadter

IPC: G01N35/00 ,  G06F19/00 ,  G06Q10/10 ,  G06F17/30 ,  G07C9/00 ,  G01N35/04 ,  G01N35/10 ,  G06F19/28

CPC classification number: G06F17/30864 ,  G01N35/00871 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/1002 ,  G01N2035/00881 ,  G01N2035/0425 ,  G01N2035/0475 ,  G06F17/30289 ,  G06F19/00 ,  G06F19/28 ,  G06Q10/06 ,  G06Q10/10 ,  G06Q30/0201 ,  G06Q30/0625 ,  G07C9/00103 ,  G16H10/40

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.

Abstract translation: 本发明涉及将消费品数据与生物测定中使用的测定消耗品相关联的方法，装置和系统。 提供了测定系统和相关的消耗品，其中测定系统基于该消耗品特有的消耗性数据来调整测定方案的一个或多个步骤。 描述了各种类型的消耗品数据，以及在通过测定系统进行测定时使用这些信息的方法。

公开(公告)号：USD748115S1

公开(公告)日：2016-01-26

申请号：US29451051

申请日：2013-03-27

Applicant: Meso Scale Technologies, LLC

Designer： Xinri Cong ,  Thomas L. Hampton ,  Carl Stevens ,  Michael Vock ,  Edmund Wong

公开(公告)号：US20140378347A1

公开(公告)日：2014-12-25

申请号：US14478221

申请日：2014-09-05

Applicant: Meso Scale Technologies, LLC

Inventor： Jeff D. Debad ,  Eli N. Glezer ,  Sudeep M. Kumar

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/6863 ,  G01N2333/523 ,  G01N2333/525 ,  G01N2333/70578 ,  G01N2800/065 ,  G01N2800/52

Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

Abstract translation: 公开了用于进行诸如克罗恩病和溃疡性结肠炎的炎症性肠病的检测的诊断测试的方法。 还描述了通过管理本发明的测试来监测患者的方法。 还描述了通过管理本发明的测试来监测患者治疗的方法。 还描述了通过将本发明的试验施用于用药物或候选药物治疗的患者，动物模型和细胞培养物的样品来评价药物或药物候选物的有效性的方法。 还公开了用于确定分析物的有用性的方法，例如， 用作本发明各种方法中用于炎性肠病的诊断和监测标志物的细胞因子。

公开(公告)号：US20140255916A1

公开(公告)日：2014-09-11

申请号：US14285086

申请日：2014-05-22

Applicant: Meso Scale Technologies, LLC.

Inventor： George Sigal

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  G01N33/54313 ,  G01N33/566 ,  G01N2500/02

Abstract: The invention provides methods and kits for measuring the ability of a test sample to inhibit the binding of a receptor expressed by a pathogen to a host cell ligand of the pathogen.

Abstract translation: 本发明提供了用于测量测试样品抑制由病原体表达的受体与病原体的宿主细胞配体的结合的能力的方法和试剂盒。

公开(公告)号：US20140252088A1

公开(公告)日：2014-09-11

申请号：US14283689

申请日：2014-05-21

Applicant: Meso Scale Technologies, LLC.

Inventor： Xinri Cong ,  Jerome Jackson ,  Carl Stevens ,  Michael Vock ,  Jacob N. Wohlstadter

IPC: G07C9/00 ,  G06F17/30

CPC classification number: G06F17/30864 ,  G01N35/00871 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/1002 ,  G01N2035/00881 ,  G01N2035/0425 ,  G01N2035/0475 ,  G06F17/30289 ,  G06F19/00 ,  G06F19/28 ,  G06Q10/06 ,  G06Q10/10 ,  G06Q30/0201 ,  G06Q30/0625 ,  G07C9/00103 ,  G16H10/40

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.

Abstract translation: 本发明涉及将消耗品数据与生物测定中使用的测定消耗品相关联的方法，装置和系统。 提供了测定系统和相关的消耗品，其中测定系统基于该消耗品特有的消耗性数据来调整测定方案的一个或多个步骤。 描述了各种类型的消耗品数据，以及在通过测定系统进行测定时使用这些信息的方法。

公开(公告)号：US20140221325A1

公开(公告)日：2014-08-07

申请号：US14168688

申请日：2014-01-30

Applicant: Meso Scale Technologies, LLC

Inventor： Eli N. Glezer ,  John Kenten ,  Galina Nikolenko

IPC: G01N33/68 ,  A61M1/36 ,  A61M1/16 ,  A61M1/34

CPC classification number: G01N33/6893 ,  G01N2800/347 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

Abstract translation: 本发明涉及诊断患者的肾小球肾炎（GN）的方法以及监测GN进展的方法和/或监测治疗剂或治疗方案的治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。

公开(公告)号：US20250123299A1

公开(公告)日：2025-04-17

申请号：US18825344

申请日：2024-09-05

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Dimitri Mikael MOFFITT ,  Aaron LEIMKUEHLER ,  Victor PELLICIER ,  Todd Stanley SMITH ,  Gary I. KRIVOY ,  Eric M. JONES ,  Jennifer PARKER ,  Slavi MIRTCHEV ,  Nicholas SAMMONS ,  Manish KOCHAR ,  Jacob N. WOHLSTADTER ,  Robert CAUSEY

IPC: G01N35/00 ,  B01L3/00 ,  B65D43/02 ,  B65D43/26 ,  B65D51/24

Abstract: The present disclosure relates to an automated assay system adapted to receive consumables in the conduct of an assay. The assay system includes at least one of a loading cart, a door support system, a waste storage unit, and a robotic subsystem. The loading cart is configured to organize and transport consumables necessary for the performance of the assay system. The door support system is configured to maintain stability of doors of the automated assay system. The waste storage unit is configured to provide convenient disposal of consumables associated with the automated assay system. The robotic subsystem is configured to transport consumables within the automated assay system.

公开(公告)号：US20250060361A1

公开(公告)日：2025-02-20

申请号：US18938922

申请日：2024-11-06

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit AGHVANYAN ,  Eli N. GLEZER ,  John KENTEN ,  George SIGAL ,  Martin STENGELIN

IPC: G01N33/53 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/533 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.