-
公开(公告)号：US5061705A
公开(公告)日：1991-10-29
申请号：US476875
申请日：1990-02-08
IPC分类号： A61K31/00 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/496 , A61K31/50 , A61K31/505 , A61P17/00 , A61P17/10 , A61P29/00 , A61P35/00 , C07D207/32 , C07D207/323 , C07D207/325 , C07D207/337 , C07D231/06 , C07D231/12 , C07D231/20 , C07D231/22 , C07D231/24 , C07D233/54 , C07D233/64 , C07D233/84 , C07D237/08 , C07D239/36 , C07D261/08 , C07D263/04 , C07D263/10 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/20 , C07D277/22 , C07D277/30 , C07D307/36 , C07D307/38 , C07D307/40 , C07D307/54 , C07D333/08 , C07D333/18 , C07D333/24 , C07D521/00
CPC分类号： C07D207/323 , C07D207/325 , C07D207/337 , C07D231/06 , C07D231/12 , C07D231/22 , C07D231/24 , C07D233/64 , C07D233/84 , C07D237/08 , C07D239/36 , C07D261/08 , C07D263/04 , C07D263/10 , C07D263/32 , C07D271/06 , C07D271/107 , C07D277/30 , C07D307/36 , C07D307/38 , C07D307/40 , C07D307/54 , C07D333/08 , C07D333/18 , C07D333/24 , Y10S514/844 , Y10S514/859 , Y10S514/861 , Y10S514/863 , Y10S514/915
摘要： Compounds of formula I ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen or methyl, A is an ethylene or methylene radical which is unsubstituted or substituted by methyl, hydroxyl or oxo, L is a saturated or unsaturated five-membered or six-membered heterocyclic structure which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.6 -alkyl, or C.sub.1 -C.sub.4 -alkanoyl and has from 1 to 3 heteroatoms from the group consisting of N, O and S, the second and third heteroatoms being a nitrogen atom,R.sup.3 is hydrogen, a hydroxy or C.sub.1 -C.sub.6 -alkoxy group,R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen or methoxy,R.sup.5 is hydrogen or methoxy or tert-butyl,R.sup.6 is hydrogen, methyl, nitrile or a C.sub.2 -C.sub.10 -ketal group or the radical --CHR.sup.7 OR.sup.8 --CHR.sup.7 --NR.sup.9 R.sup.10, --COR.sup.11, --SR.sup.12, ##STR2## in which R.sup.7 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.20 -alkanoyl or is benzoyl which is unsubstituted or substituted by methoxy, nitro, methyl or chlorine,R.sup.9 and R.sup.10 are each hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.6 -alkanoyl or are each benzoyl which is unsubstituted or substituted as for R.sup.8, or R.sup.9 and R.sup.10, together with the nitrogen atom to which they are bonded, form a saturated, 5-membered or 6-membered heterocyclic radical which may contain oxygen as the second heteroatom,R.sup.11 is hydrogen, C.sub.1 -C.sub.4 -alkyl, --OR.sup.13 or --NR.sup.14 R.sup.15, where R.sup.13 is hydrogen, unsubstituted or hydroxyl-substituted C.sub.1 -C.sub.8 -alkyl, aryl or aralkyl which is unsubstituted or substituted by chlorine, bromine, methyl, methoxy or nitro, substitution in the case of the aralkyl group being in the aryl moiety, and where R.sup.14 and R.sup.15 are each hydrogen, unsubstituted or hydroxyl-substituted C.sub.1 -C.sub.6 -alkyl or an aralkyl or aryl group which is unsubstituted or substituted as for R.sup.13, or R.sup.14 and R.sup.15, together with the nitrogen atom to which they are bonded, form a heterocyclic radical as defined above for R.sup.9 and R.sup.10, andR.sup.12 is C.sub.1 -C.sub.4 -alkyl,and compounds of formula Ia ##STR3## where R.sup.3, R.sup.4, R.sup.6 and L have the abovementioned meanings and R.sup.17 is hydrogen or hydroxyl, and their physiologically tolerated salts, processes for their preparation and drugs and cosmetics prepared therefrom.
-
公开(公告)号：US4814487A
公开(公告)日：1989-03-21
申请号：US46802
申请日：1987-05-07
IPC分类号： C07C59/90 , C07C69/716 , A61K31/19 , A61K31/215 , C07C57/40
CPC分类号： C07C59/90
摘要： The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.
摘要翻译： 描述了酰胺取代萘及其中间体的合成。 中间体和酰胺取代的萘可用作抗炎剂。
-
公开(公告)号：US4681894A
公开(公告)日：1987-07-21
申请号：US912901
申请日：1986-09-26
IPC分类号： A61K31/165 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C51/00 , C07C51/347 , C07C59/90 , C07C67/00 , C07C69/738 , C07C239/00 , C07C259/06 , C12N9/99 , C07C83/10 , A61K31/085 , A61K31/185 , A61K31/21
CPC分类号： C07C59/90
摘要： The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.
摘要翻译： 描述了酰胺取代萘及其中间体的合成。 中间体和酰胺取代的萘可用作抗炎剂。
-
54.发明授权Styrene derivatives, their use as antiallergic agents and intemediate epoxides for their synthesis 失效苯乙烯衍生物，它们用作抗过敏剂和中和环氧化物用于它们的合成
公开(公告)号：US4665092A
公开(公告)日：1987-05-12
申请号：US783976
申请日：1985-10-03
IPC分类号： A61K31/335 , C07C317/00 , C07D303/04 , C07D303/14 , C07D303/32 , C07D309/12 , A61K31/35 , A61K31/235 , C07C147/10 , C07D309/10
CPC分类号： C07D303/32 , C07C323/00 , C07D303/04 , C07D303/14
摘要： Alkenes of the formula (I) and epoxides (II) used to make them are useful as anti-inflammatory and antiallergic pharmaceuticals: ##STR1## wherein R.sup.1 =H or CH.sub.3 ; R.sup.2 =phenyl, substituted phenyl, benzyl or a cysteinyl moiety; R.sup.4 and R.sup.5 =alkyl; n=O or 1; and R.sup.3 is as described.
摘要翻译： 用于制备它们的式（I）和环氧化物（II）的烯醇可用作抗炎和抗过敏药物：其中R1 = H或CH3;（I）其中R1 = H或CH3; R2 =苯基，取代的苯基，苄基或半胱氨酰部分; R4和R5 =烷基; n = 0或1; 和R3如上所述。
-
公开(公告)号：US4188328A
公开(公告)日：1980-02-12
申请号：US970726
申请日：1978-12-18
申请人： Michael P. Wachter
发明人： Michael P. Wachter
IPC分类号： C07C43/178 , C07C41/00 , C07C41/48 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/59 , C07C49/175 , C07C49/255 , C07C67/00 , C07D313/04 , C07D317/12 , C07D317/22 , C07D317/24 , C07D339/06 , C07D339/08 , C07D407/12 , C07D409/06 , C07D493/10 , C07D493/20 , C07F7/18 , C07D317/00
CPC分类号： C07D493/10 , C07C41/48 , C07C43/315 , C07C45/292 , C07C45/59 , C07C49/255 , C07D313/04 , C07D317/12 , C07D317/22 , C07D317/24 , C07D339/08 , C07F7/1852 , C07F7/1856
摘要： A method for synthesis of 2S*,3R*-3-benzyloxy-6,6-ethylenedioxy-2-methyl-2-(5'-hydroxy-4'-methylpentyl)-oxepane, an intermediate in the synthesis of 2S*, 2S*,3R*-6-(2"-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonenyl)-oxepan-3-ol, one of the active components of the zoapatle plant, is described. The natural product is useful as a utero-evacuant agent.
摘要翻译： 合成2S *，3R * -3-苄氧基-6,6-亚乙二氧基-2-甲基-2-（5'-羟基-4'-甲基戊基） - 氧杂环己烷的方法，2S * ，2S *，3R * -6-（2“ - 羟基亚乙基）-2-甲基-2-（4'，8'-二甲基-5'-氧代-7'-壬烯基） - 氧代环庚烷-3-醇 的Zoapatle植物的活性成分。 天然产物可用作子宫排泄剂。
-
公开(公告)号：US4130556A
公开(公告)日：1978-12-19
申请号：US838527
申请日：1977-10-03
IPC分类号： A61K31/335 , A61K36/28 , C07D313/04 , C07G17/00 , A61K35/78 , C07D301/00
CPC分类号： A61K36/28 , A61K31/335 , C07D313/04
摘要： Novel compounds obtained from the zoapatle plant and methods of obtaining these compounds from the plant material are described. The novel compounds possess useful activity as central nervous system depressants as well as utero-evacuants.
摘要翻译： 描述了从动植物得到的新型化合物和从植物材料获得这些化合物的方法。 新型化合物具有作为中枢神经系统抑制剂以及子宫排斥物的有用活性。
-
公开(公告)号：US08378117B2
公开(公告)日：2013-02-19
申请号：US11688552
申请日：2007-03-20
申请人： Fina Liotta , Mingde Xia , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
发明人： Fina Liotta , Mingde Xia , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
IPC分类号： C07D231/54
CPC分类号： C07D231/54 , C07D403/04
摘要： This invention is directed to a hexahydro-cycloheptapyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
-
公开(公告)号：US08119621B2
公开(公告)日：2012-02-21
申请号：US12836615
申请日：2010-07-15
申请人： Fina Liotta , Mingde Xia , Michael P. Wachter , Scott A. Beers
发明人： Fina Liotta , Mingde Xia , Michael P. Wachter , Scott A. Beers
IPC分类号： A61K31/56 , A61K31/416 , A61K31/496 , A61P3/10 , A61P25/08
CPC分类号： C07D231/54
摘要： This invention is directed to a tetrahydro-cyclopentyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
摘要翻译： 本发明涉及式（I）的四氢 - 环戊基吡唑大麻素调节剂化合物：以及用于治疗，改善或预防大麻素受体介导的综合征，病症或疾病的方法。
-
公开(公告)号：US20100317633A1
公开(公告)日：2010-12-16
申请号：US12868812
申请日：2010-08-26
申请人： Mingde Xia , Fina Liotta , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
发明人： Mingde Xia , Fina Liotta , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
IPC分类号： A61K31/56 , A61K31/416 , A61K31/55 , A61K31/53 , A61K31/4166 , A61K31/57 , A61K31/519 , A61P15/18 , A61P25/08
CPC分类号： C07D231/54 , C07D403/12
摘要： This invention is directed to a hexahydro-cyclooctyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
-
公开(公告)号：US07795294B2
公开(公告)日：2010-09-14
申请号：US11674210
申请日：2007-02-13
申请人： Fina Liotta , Huajun Lu , Michael P. Wachter , Mingde Xia
发明人： Fina Liotta , Huajun Lu , Michael P. Wachter , Mingde Xia
IPC分类号： A01N43/56 , C07D231/00 , C07D231/10 , C07D231/12
CPC分类号： C07D409/04 , C07D231/56 , C07D403/12
摘要： This invention is directed to a tetrahydro-2H-indazole pyrazole cannabinoid modulator compound of formula (I): or a form thereof, wherein p, R1, R2 and Ar are as herein described and * represents a chiral center, and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
摘要翻译： 本发明涉及式（I）的四氢-2H-吲唑吡唑大麻素调节剂化合物或其形式，其中p，R 1，R 2和Ar如本文所述，*表示手性中心，以及使用的方法 治疗，改善或预防大麻素受体介导的综合征，病症或疾病。
-
-
-
-
-
-
-
-
-
搜索结果
77 条记录 (耗时 0.039 秒)
