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公开(公告)号:US20220348615A1
公开(公告)日:2022-11-03
申请号:US17724712
申请日:2022-04-20
Applicant: Norwegian University of Science and Technology (NTNU) , UNIVERSITÄT ULM , NORWEGIAN UNIVERSITY OF LIFE SCIENCES , DANMARKS TEKNISKE UNIVERSITET , UNIVERSITÄT DES SAARLANDES
Inventor: Gerd Michael SEIBOLD , Christoph WITTMANN , Dzung DIEP , Nadav BAR , Christian U. REIDEL , Dominik WEIXLER , Oliver GOLDBECK
IPC: C07K14/34
Abstract: The present invention relates to the production of bacteriocins, and in particular the production of bacteriocins of class I or II by recombinant expression in coryneform bacteria as the bacterial cell host. Also provided are modified coryneform bacteria for use as production hosts for production of bacteriocins.
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公开(公告)号:US11413044B2
公开(公告)日:2022-08-16
申请号:US16881889
申请日:2020-05-22
Inventor: Lars Cato Rekstad , Brynjulf Ystgaard
IPC: A61B17/072 , A61B17/115
Abstract: A surgical stapler includes a proximal end and a distal end and an anvil at the distal end for providing resistance to staples during the stapling operation of the surgical stapler. The anvil may include a number of segments arranged end-to-end. The anvil is elongated in the collapsed state, the anvil being elongated generally in a first direction D1. The anvil is configured such that the segments rotate about a rotation axis along a perpendicular second direction D2 when the anvil is actuated between the deployed and the collapsed states. The anvil is configured such that adjacent segments pivot relative to each other about a pivot axis along a third direction D3 when the anvil is actuated between the deployed and collapsed states. The stapler also includes an actuator mechanism, wherein the actuator mechanism is configured to be controlled from a location on the surgical stapler towards the proximal end.
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公开(公告)号:US11337427B2
公开(公告)日:2022-05-24
申请号:US16592462
申请日:2019-10-03
Inventor: Marit Otterlei , Siri Bachke
IPC: A01N63/50 , A61K38/17 , A61K38/14 , A61K38/16 , A61L2/16 , C07K14/00 , A61K38/00 , A61K31/165 , A61K31/35 , A61K31/397 , A61K31/43 , A61K31/496 , A61K31/7036 , A61K31/7048 , A61K41/00 , A61K45/06 , A61L2/10 , A01N25/08
Abstract: The present invention provides an agent, or a composition containing an agent, for use in treating or preventing a bacterial infection in a subject, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein: X1 is a basic amino acid; X2 is an aromatic amino acid; X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and X5 is a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as antibiotics.
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公开(公告)号:US11261537B2
公开(公告)日:2022-03-01
申请号:US16679832
申请日:2019-11-11
Inventor: Bjørn-Ove Fimland , Dheeraj L. Dasa , Helge Weman
IPC: C30B25/10 , C30B25/18 , C30B29/40 , C30B29/48 , H01L21/02 , H01L29/15 , H01L29/20 , H01L29/22 , C30B29/02 , H01L29/04 , H01L29/16
Abstract: A composition of matter comprising a film on a graphitic substrate, said film having been grown epitaxially on said substrate, wherein said film comprises at least one group III-V compound or at least one group II-VI compound.
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公开(公告)号:US20210015514A1
公开(公告)日:2021-01-21
申请号:US16623027
申请日:2018-06-08
Inventor: Per Even STORLI , Lars Cato REKSTAD , Brynjulf YSTGAARD
Abstract: A surgical retractor tool for removing an object from the stomach or from the oesophagus. The tool includes a flexible steerable tube for insertion into the body via the oral cavity and a gripper at the distal end of the tube for gripping an object in the stomach or the oesophagus in order to allow for removal of the object from the stomach or the oesophagus. The gripper includes first and second rotatable gripper surfaces and a clamping mechanism for moving the gripper surfaces to clamp the object. The rotatable gripper surfaces are arranged to rotate relative to the tube in order to allow a longitudinal axis of a gripped object to move into alignment with a longitudinal axis of the tube.
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公开(公告)号:US20200289121A1
公开(公告)日:2020-09-17
申请号:US16881889
申请日:2020-05-22
Inventor: Lars Cato REKSTAD , Brynjulf YSTGAARD
IPC: A61B17/115 , A61B17/072
Abstract: A surgical stapler includes a proximal end and a distal end and an anvil at the distal end for providing resistance to staples during the stapling operation of the surgical stapler. The anvil may include a number of segments arranged end-to-end. The anvil is elongated in the collapsed state, the anvil being elongated generally in a first direction D1. The anvil is configured such that the segments rotate about a rotation axis along a perpendicular second direction D2 when the anvil is actuated between the deployed and the collapsed states. The anvil is configured such that adjacent segments pivot relative to each other about a pivot axis along a third direction D3 when the anvil is actuated between the deployed and collapsed states. The stapler also includes an actuator mechanism, wherein the actuator mechanism is configured to be controlled from a location on the surgical stapler towards the proximal end.
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公开(公告)号:US10695067B2
公开(公告)日:2020-06-30
申请号:US15551385
申请日:2017-06-28
Inventor: Lars Cato Rekstad , Brynjulf Ystgaard
IPC: A61B17/115 , A61B17/072
Abstract: A surgical stapler includes a proximal end and a distal end and an anvil at the distal end for providing resistance to staples during the stapling operation of the surgical stapler. The anvil may include a number of segments arranged end-to-end. The anvil is elongated in the collapsed state, the anvil being elongated generally in a first direction D1. The anvil is configured such that the segments rotate about a rotation axis along a perpendicular second direction D2 when the anvil is actuated between the deployed and the collapsed states. The anvil is configured such that adjacent segments pivot relative to each other about a pivot axis along a third direction D3 when the anvil is actuated between the deployed and collapsed states. The stapler also includes an actuator mechanism, wherein the actuator mechanism is configured to be controlled from a location on the surgical stapler towards the proximal end.
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公开(公告)号:US20200074625A1
公开(公告)日:2020-03-05
申请号:US16559931
申请日:2019-09-04
Inventor: Andreas ØSTVIK , Erik SMISTAD , Lasse LØVSTAKKEN
Abstract: A method for processing echocardiography data to enable automatic functional measurements based on cardiac ultrasound images as an input, including (i) classification of the cardiac ultrasound images to ensure that relevant images are passed on to the next steps, optionally utilising a first neural network, such as a convolutional neural network, (ii) segmentation and semantic partitioning of the left ventricle (LV) myocardium to extract relevant parts of the image, optionally by using a second neural network, (iii) regional motion estimates to determine a mapping of displacements in the extracted parts of the image and to output estimated tissue motion vectors for the extracted parts of the image, optionally using a third neural network, and (iv) fusion of measurements via state estimation applied to the tissue motion vectors and thereby incorporating a temporal domain to produce data showing variation of the estimated measurements over time.
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公开(公告)号:US20190355868A1
公开(公告)日:2019-11-21
申请号:US16482915
申请日:2018-02-05
Inventor: Bjorn Ove Myking FIMLAND , Heige WEMAN , Dtngding REN
Abstract: A device, such as a light-emitting device, e.g. a laser device, comprising: a plurality of group III-V semiconductor NWs grown on one side of a graphitic substrate, preferably through the holes of an optional hole-patterned mask on said graphitic substrate; a first distributed Bragg reflector or metal mirror positioned substantially parallel to said graphitic substrate and positioned on the opposite side of said graphitic substrate to said NWs; optionally a second distributed Bragg reflector or metal mirror in contact with the top of at least a portion of said NWs; and wherein said NWs comprise aim-type doped region and a p-type doped region and optionally an intrinsic region there between.
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公开(公告)号:US20190223828A1
公开(公告)日:2019-07-25
申请号:US16329568
申请日:2017-09-01
Inventor: Hans TORP , Lasse LOVSTAKKEN
Abstract: An ultrasound imaging method in which ultrasound signals are transmitted into a living organism, reflected from fluid flowing along a path within the organism, and received by an ultrasound transceiver system with a resolution limit in a first direction. These signals are used to generate data representing a sequence of images over time; each image including a speckle pattern arising from interference within the reflected ultrasound signals. A peak-sharpening operation is applied to the image data, generating data representing a sequence of resolution-enhanced images, each having a resolution in the first direction finer than the resolution limit of the transceiver system in that direction, and including a respective peak-sharpened speckle pattern. A combining operation is applied to generate data representing an output image in which the path of the fluid is represented by a superimposition of the peak-sharpened speckle patterns from the resolution-enhanced images.
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