公开(公告)号：US10328259B2

公开(公告)日：2019-06-25

申请号：US16014822

申请日：2018-06-21

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Shu Xiao ,  Andrei Pakhomov ,  Karl H. Schoenbach

IPC: A61N1/36 ,  A61N2/00 ,  A61N5/02 ,  A61N1/40

Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.

公开(公告)号：US20190038337A1

公开(公告)日：2019-02-07

申请号：US16057115

申请日：2018-08-07

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. SCHOENBACH ,  Richard HELLER ,  James CAMP ,  Stephen P. BEEBE ,  Shu XIAO ,  Amy DONATE

IPC: A61B18/12 ,  A61N5/06 ,  A61N1/32 ,  A61N1/40 ,  A61N5/00 ,  A61N5/02 ,  A61B18/00 ,  A61B18/24 ,  A61B18/20 ,  A61B18/18 ,  A61N5/067

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61N1/327 ,  A61N1/403 ,  A61N5/00 ,  A61N5/025 ,  A61N5/0625 ,  A61N2005/0651 ,  A61N2005/0666 ,  A61N2005/067

Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.

公开(公告)号：US10070914B2

公开(公告)日：2018-09-11

申请号：US14366909

申请日：2012-12-20

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. Schoenbach ,  Richard Heller ,  James Camp ,  Stephen P. Beebe ,  Shu Xiao ,  Amy Donate

IPC: A61N1/30 ,  A61B18/12 ,  A61N1/40 ,  A61N1/32 ,  A61N5/00 ,  A61N5/02 ,  A61N5/06 ,  A61B18/18 ,  A61B18/20 ,  A61B18/24 ,  A61B18/00 ,  A61N5/067

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61N1/327 ,  A61N1/403 ,  A61N5/00 ,  A61N5/025 ,  A61N5/0625 ,  A61N2005/0651 ,  A61N2005/0666 ,  A61N2005/067

Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.

公开(公告)号：US09724011B2

公开(公告)日：2017-08-08

申请号：US14885023

申请日：2015-10-16

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. Schoenbach ,  Shu Xiao

IPC: A61B5/05 ,  A61B6/03

CPC classification number: A61B5/0507 ,  A61B5/05 ,  A61B6/03 ,  A61B2576/00

Abstract: An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.

公开(公告)号：US20160015971A1

公开(公告)日：2016-01-21

申请号：US14869286

申请日：2015-09-29

Applicant: Eastern Virginia Medical School ,  Old Dominion University Research Foundation

Inventor： Richard NUCCITELLI ,  Stephen J. BEEBE ,  Karl H. SCHOENBACH

IPC: A61N1/20

CPC classification number: A61N1/205 ,  A61N1/327

Abstract: Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.

Abstract translation: 提供了通过施加纳秒脉冲电场（“nsPEF”）治疗实体皮肤肿瘤的新的无药物治疗方法。 在本发明的一个实施方案中，细胞是黑素瘤细胞，并且所应用的nsPEFs渗透到肿瘤细胞的内部并使肿瘤细胞核迅速收缩并且肿瘤血流停止。 这种新技术提供了高度定位的肿瘤细胞靶向，对上覆皮肤仅起微量的作用。

公开(公告)号：US20150267141A1

公开(公告)日：2015-09-24

申请号：US14437846

申请日：2013-10-15

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Sandeep Kumar ,  Sergiy Popov ,  Peter J. Majeranowski ,  Igor Kostenyuk

IPC: C11B1/10 ,  C11B1/04

CPC classification number: C11B1/104 ,  C10L5/44 ,  C10L2200/0484 ,  C10L2290/544 ,  C11B1/04 ,  C11B1/10 ,  Y02E50/10 ,  Y02E50/30

Abstract: Provided herein are methods of optimizing energy recovery from oilseeds. The methods disclosed provide at least the ability to swell oilseeds and disrupt the cell walls (hulls) without changing the functionality and quality of oil; the process integration of oil extraction and green coal production to maximize the energy recovery in the form of crude oil and green coal from oilseeds; and heat integration during processing stages including subcritical water pretreatment, oil extraction, and subcritical water carbonization to minimize the process heat requirement.

Abstract translation: 本文提供了优化来自油籽的能量回收的方法。 所公开的方法至少提供膨胀油籽并破坏细胞壁（船体）而不改变油的功能和质量的能力; 石油开采和绿色煤炭生产过程整合，最大限度地发挥油籽原油和绿色煤的能源回收; 和加工阶段的热集成，包括亚临界水预处理，抽油和亚临界水碳化，以最小化工艺热需求。