公开(公告)号：US20130085077A1

公开(公告)日：2013-04-04

申请号：US13622487

申请日：2012-09-19

Applicant: The Ohio State University Research Foundation ,  The Government of United States of America, as represented by the Secretary of the Department of Health and Human

Inventor： Carlo M. Croce ,  Stefan Ambs

IPC: C12Q1/68

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/30 ,  C12N2320/31 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Methods and compositions for the diagnosis, prognosis and/or treatment of prostate associated disorders are disclosed.

Abstract translation: 公开了用于诊断，预后和/或治疗前列腺相关疾病的方法和组合物。

公开(公告)号：US20040210957A1

公开(公告)日：2004-10-21

申请号：US10656394

申请日：2003-09-05

Applicant: The Ohio State University

Inventor： Shaohong Qu ,  Guo-liang Wang ,  Bo Zhou

IPC: C12N015/29 ,  C07H021/04 ,  C12N015/82 ,  A01H005/00 ,  C12N015/87 ,  C12N015/63

CPC classification number: C12N15/8282 ,  C07K14/415

Abstract: Compositions and methods for enhancing or creating plant disease resistance to plant pests are provided. Transforming a plant with a novel rice Pi2-like disease resistance gene of the invention enhances disease resistance of the plant. Transformed plants, plant cells, tissues, and seed having enhanced disease resistance are also provided.

Abstract translation: 提供了用于增强或产生对植物害虫的植物病害抗性的组合物和方法。 用本发明的新型水稻Pi2样抗病基因转化植物提高了植物的抗病性。 还提供了具有增强的抗病性的转化植物，植物细胞，组织和种子。

公开(公告)号：US20040150555A1

公开(公告)日：2004-08-05

申请号：US10355627

申请日：2003-01-31

Applicant: The Ohio State University

Inventor： Eric K. Walton

IPC: G01S007/28

CPC classification number: G01S7/023 ,  G01S7/35 ,  G01S13/346 ,  G01S13/931 ,  G01S2013/0281

Abstract: A radar system that utilizes predetermined, pseudorandom, or random waveforms that may be substantially matched to the impulse response of the radar and any surrounding clutter such that the signal-to-clutter ratio may be optimized and/or such that specific targets may be identified and/or classified.

Abstract translation: 利用预定的伪随机波形或随机波形的雷达系统，其可以与雷达的脉冲响应和任何周围的杂波基本相匹配，使得信号与杂波比可以被优化和/或使得可以识别特定目标 和/或分类。

公开(公告)号：US20040113860A1

公开(公告)日：2004-06-17

申请号：US10310670

申请日：2002-12-04

Applicant: The Ohio State University

Inventor： Eric K. Walton

IPC: H01Q001/42

CPC classification number: H01Q1/1271 ,  H01Q1/002 ,  H01Q15/0013 ,  H05B3/84 ,  H05B2203/013 ,  Y02B30/26

Abstract: A region in a metallic panel that facilitates the transmission of radio frequency signals. The metallic panel may be included in a window such as the window of a vehicle or building. For example, the metallic panel may be used for heating or to reflect infrared radiation. An aperture is formed in the metallic panel to enable radio frequency signals to be transmitted through the metallic panel. The design of the aperture may be selected to enable the transmission of the desired frequency band. In an embodiment in which the metallic panel is used to conduct electric current, the aperture may be oriented such that the current may flow between the openings of the aperture. Accordingly, there may be uniform heating across the metallic panel without blocking the transmission of radio frequency signals in the desired frequency band.

Abstract translation: 金属面板中有助于射频信号传输的区域。 金属面板可以包括在诸如车辆或建筑物的窗户的窗户中。 例如，金属面板可以用于加热或反射红外辐射。 在金属面板上形成一个孔，以使射频信号能够通过金属面板传递。 可以选择孔径的设计以使得能够传输期望的频带。 在金属板用于传导电流的实施例中，孔可以被定向成使得电流可以在孔的开口之间流动。 因此，可以在金属面板上均匀加热，而不会阻挡在期望频带中的射频信号的传输。

公开(公告)号：US20030121780A1

公开(公告)日：2003-07-03

申请号：US10040036

申请日：2002-01-03

Applicant: The Ohio State University

Inventor： Prabir K. Dutta ,  Nicholas F. Szabo ,  Hongbin Du ,  Sheikh A. Akbar

IPC: H01C007/00 ,  G01N027/407

CPC classification number: H01C7/003 ,  C04B35/486 ,  C04B2235/3225 ,  C04B2235/604 ,  G01N27/4074

Abstract: A potentiometric sensor for nitrogen oxide (NOX) measurement based on yttria-stabilized zirconia with a zeolite-modified electrode is presented. A potentiometric sensor of the present invention comprises a tube having an interior and an exterior. A cap member comprising yttria-stabilized zirconia closes one end of the tube. The cap member has an interior surface exposed to the interior of the tube where a first electrode is disposed. The first electrode is then covered with a zeolite layer. A second electrode is disposed on the exterior of the cap member.

Abstract translation: 提出了一种基于氧化钇稳定的氧化锆与沸石改性电极进行氮氧化物（NOX）测量的电位传感器。 本发明的电位传感器包括具有内部和外部的管。 包含氧化钇稳定的氧化锆的盖构件封闭管的一端。 盖构件具有暴露于管的内部的内表面，其中设置有第一电极。 然后用沸石层覆盖第一电极。 第二电极设置在盖构件的外部。

公开(公告)号：US20030044515A1

公开(公告)日：2003-03-06

申请号：US10225836

申请日：2002-08-22

Applicant: The Ohio State University

Inventor： Kenneth H. Sandhage

IPC: B05D003/00 ,  C23C016/24 ,  H05H001/24

CPC classification number: B81C1/00

Abstract: The purpose of the present invention is to describe a novel approach for converting 3-dimensional, synthetic micro- and nano-templates into different materials with a retention of shape/dimensions and morphological features. The ultimate objective of this approach is to mass-produce micro- and nano-templates of tailored shapes through the use of synthetic or man-made micropreforms, and then chemical conversion of such templates by controlled chemical reactions into near net-shaped, micro- and nano-components of desired compositions. The basic idea of this invention is to obtain a synthetic microtemplate with a desired shape and with desired surface features, and then to convert the microtemplate into a different material through the use of chemical reactions.

Abstract translation: 本发明的目的是描述一种用于将三维，合成的微型和纳米模板转换成具有保持形状/尺寸和形态特征的不同材料的新方法。 这种方法的最终目标是通过使用合成或人造微变形模块大规模生产定制形状的微米和纳米模板，然后通过受控化学反应将这些模板化学转化成近网状， 和所需组合物的纳米组分。 本发明的基本思想是获得具有所需形状和所需表面特征的合成微型模板，然后通过使用化学反应将微模板转化为不同的材料。

公开(公告)号：US20030039693A1

公开(公告)日：2003-02-27

申请号：US10160292

申请日：2002-05-30

Applicant: The Ohio State University

Inventor： Kenneth H. Sandhage

IPC: B27N003/08 ,  A61K009/14 ,  C23C016/00

CPC classification number: G01N33/54346 ,  B81B2201/034 ,  B81B2201/035 ,  B81C1/00 ,  B81C99/0085 ,  G01N33/54353 ,  G01N33/544 ,  Y10S977/811 ,  Y10S977/84 ,  Y10S977/89 ,  Y10S977/90

Abstract: The present invention is focused on a revolutionary, low-cost (highly-scaleable) approach for the mass production of three-dimensional microcomponents: the biological reproduction of naturally-derived, biocatalytically-derived, and/or genetically-tailored three-dimensional microtemplates (e.g., frustules of diatoms, microskeletons of radiolarians, shells of mollusks) with desired dimensional features, followed by reactive conversion of such microtemplates into microcomponents with desired compositions that differ from the starting microtemplate and with dimensional features that are similar to those of the starting microtemplate. Because the shapes of such microcomponents may be tailored through genetic engineering of the shapes of the microtemplates, such microcomposites are considered to be Genetically-Engineered Materials (GEMs).

Abstract translation: 本发明集中在用于大规模生产三维微型组件的革命性的低成本（高度可扩展）方法：天然衍生的，生物催化衍生的和/或基因定制的三维微型模板的生物繁殖 （例如，硅藻的截头圆锥体，放射体的微骨架，软体动物的壳）具有所需的尺寸特征，随后将这种微模板反应转化成具有与起始微模板不同的所需组成的微组件，并具有与起始微模板类似的尺寸特征 微模板。 因为这些微型组件的形状可以通过微模板的形状的基因工程来定制，所以这种微复合材料被认为是基因工程材料（GEM）。

公开(公告)号：US11524061B2

公开(公告)日：2022-12-13

申请号：US17167893

申请日：2021-02-04

Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ,  THE OHIO STATE UNIVERSITY

Inventor： Ramesh Kumar Selvaraj ,  Gabriel Akerele ,  Sankar Renu ,  Renukaradhya J. Gourapura

IPC: A61K39/08 ,  A61K39/00

Abstract: The present disclosure relates to nanoparticle compositions for use as vaccines against Clostridium perfringens in poultry which causes necrotic enteritis in poultry. Such compositions include one or more Clostridium perfringens extracellular proteins entrapped in a polyanhydride or chitosan nanoparticle. The one or more Clostridium perfringens extracellular proteins may include one or more Clostridium perfringens toxins, such as, for example, alpha toxin (CPA), beta toxin (CPB), epsilon toxin (ETX), iota toxin (ITX), perfringolysin O (PFO), enterotoxin (CPE), beta2 toxin (CPB2), or NetB toxin. In some aspects, the composition further includes a Salmonella enteritidis flagellar protein. The present invention also includes methods for the oral delivery of one or more Clostridium perfringens extracellular proteins to the mucosal membrane of the intestinal tract of a bird of the order Galliformes.

公开(公告)号：US10725040B2

公开(公告)日：2020-07-28

申请号：US16450476

申请日：2019-06-24

Applicant: NATIONWIDE CHILDREN'S HOSPITAL, INC. ,  THE OHIO STATE UNIVERSITY

Inventor： Subinoy Das ,  Lauren O. Bakaletz

IPC: G01N33/53 ,  A61K39/00 ,  A61K39/07 ,  G01N33/569 ,  C12Q1/04 ,  A61B10/00

Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.

公开(公告)号：US10307490B2

公开(公告)日：2019-06-04

申请号：US13900969

申请日：2013-05-23

Applicant: The Ohio State University

Inventor： Robert J. Lee ,  Young Bok Lee ,  Deog Joong Kim ,  Chang Ho Ahn

IPC: A61K38/08 ,  A61K45/06 ,  A61K9/127 ,  A61K31/7088 ,  C12N15/113 ,  A61K31/713 ,  A61K47/64 ,  A61K38/10 ,  A61K38/48 ,  C07K16/00 ,  A61K47/54 ,  A61K47/59 ,  A61K47/69 ,  A61K48/00

Abstract: Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed.