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    NEAR-INFRARED LIGHT-ACTIVATED PROTEINS
    52.
    发明申请
    NEAR-INFRARED LIGHT-ACTIVATED PROTEINS 审中-公开
    近红外光活化蛋白

    公开(公告)号：US20150013024A1

    公开(公告)日：2015-01-08

    申请号：US14326778

    申请日：2014-07-09

    Applicant: University of Wyoming

    Inventor： Mark Gomelsky ,  Min-Hyung Ryu

    IPC: C12N9/88 ,  C07K7/06 ,  C12N9/50

    CPC classification number: C12N9/88 ,  A61K31/711 ,  A61K31/713 ,  C07K7/06 ,  C07K14/195 ,  C07K2319/60 ,  C12N9/50 ,  C12N9/6472 ,  C12N9/6475 ,  C12N15/62 ,  C12Y304/22056 ,  C12Y406/01001 ,  C12Y406/01002 ,  G01N33/5023

    Abstract: Methods and constructs are provided for controlling processes in live animals, plants or microbes via genetically engineered near-infrared light-activated or light-inactivated proteins including chimeras including the photosensory modules of bacteriohytochromes and output modules that possess enzymatic activity and/or ability to bind to DNA, RNA, protein, or small molecules. DNA encoding these proteins are introduced as genes into live animals, plants or microbes, where their activities can be turned on by near-infrared light, controlled by the intensity of light, and turned off by near-infrared light of a different wavelength than the activating light. These proteins can regulate diverse cellular processes with high spatial and temporal precision, in a nontoxic manner, often using external light sources. For example, near-infrared light-activated proteins possessing nucleotidyl cyclase, protein kinase, protease, DNA-binding and RNA-binding activities are useful to control signal transduction, cell apoptosis, proliferation, adhesion, differentiation and other cell processes.

    Abstract translation: 提供了方法和构建物，用于通过基因工程的近红外光活化或光灭活的蛋白质来控制活的动物，植物或微生物的过程，包括嵌合体，包括细菌色素的感光模块和具有酶活性和/或结合能力的输出模块 到DNA，RNA，蛋白质或小分子。 编码这些蛋白质的DNA作为基因引入活的动物，植物或微生物中，其活性可以通过受光强度控制的近红外光照射，并被不同波长的近红外光所关闭 激活光线 这些蛋白质可以通过使用外部光源以无毒的方式调节具有高空间和时间精度的多种细胞过程。 例如，具有核苷酸环化酶，蛋白激酶，蛋白酶，DNA结合和RNA结合活性的近红外光活化蛋白质可用于控制信号转导，细胞凋亡，增殖，粘附，分化和其他细胞过程。

    Methods for Natural Product Optimization
    53.
    发明申请
    Methods for Natural Product Optimization 有权
    天然产物优化方法

    公开(公告)号：US20140287450A1

    公开(公告)日：2014-09-25

    申请号：US14273112

    申请日：2014-05-08

    Applicant: The University of Wyoming

    Inventor： Daniel Wall

    IPC: C12Q1/02

    CPC classification number: C12Q1/02 ,  C12N1/38 ,  C12N15/01 ,  C12P1/04 ,  C12P39/00

    Abstract: Methods and compositions for natural product optimization are provided. In particular, methods and compositions for selecting bacterial strains (e.g., predatory bacteria such as myxobacteria) which produce a desired compound (e.g., antibiotic, antifungal, or anticancer agent) are provided.

    Abstract translation: 提供了天然产物优化的方法和组合。 特别地，提供了用于选择产生所需化合物（例如抗生素，抗真菌剂或抗癌剂）的细菌菌株（例如捕食性细菌如粘液细菌）的方法和组合物。

    ENGINEERED INTRACELLULAR SIALYLATION PATHWAYS
    54.
    发明申请
    ENGINEERED INTRACELLULAR SIALYLATION PATHWAYS 审中-公开
    工程化的细胞分化途径

    公开(公告)号：US20140024812A1

    公开(公告)日：2014-01-23

    申请号：US14011231

    申请日：2013-08-27

    Applicant: THE UNIVERSITY OF WYOMING ,  HUMAN GENOME SCIENCES, INC. ,  THE JOHN HOPKINS UNIVERSITY

    Inventor： Donald JARVIS ,  Yuan C. LEE ,  Michael J. BETENBAUGH ,  Shawn LAWRENCE ,  Timothy A. COLEMAN

    IPC: C12P21/00

    CPC classification number: C12P21/005 ,  C12N15/52

    Abstract: Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.

    Abstract translation: 提供了在感兴趣的细胞中操纵碳水化合物处理途径的方法。 方法是通过使用重组DNA技术和底物进料方法来操纵唾液酸化反应所涉及的多个途径，以使得能够在感兴趣的细胞中产生唾液酸化糖蛋白。 这些碳水化合物工程的努力包括实施新的碳水化合物生物测定，检查昆虫细胞系的选择以及使用生物信息学来鉴定关键加工酶的基因序列。 组合物包含感兴趣的细胞产生唾液酸化糖蛋白。 所述方法和组合物可用于糖蛋白的异源表达。

    Enhanced coalbed gas production system
    56.
    发明申请
    Enhanced coalbed gas production system 有权
    增强煤层气生产系统

    公开(公告)号：US20010045291A1

    公开(公告)日：2001-11-29

    申请号：US09875658

    申请日：2001-06-06

    Applicant: The University of Wyoming Research Corporation, d/b/a Western Research Institute

    Inventor： Charles G. Mones

    IPC: E21B043/16

    CPC classification number: E21B43/006

    Abstract: A method of stimulating coalbed methane production by injecting gas into a producer and subsequently placing the producer back on production is described. A decrease in water production may also result. The increase in gas production and decrease in water production may result from: (1) the displacement of water from the producer by gas; (2) the establishment of a mobile gas saturation at an extended distance into the coalbed, extending outward from the producer; and (3) the reduction in coalbed methane partial pressure between the coal matrix and the coal's cleat system.

    Abstract translation: 描述了通过将气体注入生产者并随后将生产者重新投入生产来刺激煤层气生产的方法。 也可能导致产水量下降。 天然气生产的增加和水的生产减少可能是由于：（1）生产者从天然气中排放水; （2）建立距离生产者向外延伸到煤层的较长距离的移动气体饱和度; 和（3）煤基质和煤的夹板系统之间煤层气分压的降低。

    THERMO-CHEMICAL PROCESSING OF COAL VIA SOLVENT EXTRACTION
    58.
    发明申请
    THERMO-CHEMICAL PROCESSING OF COAL VIA SOLVENT EXTRACTION 有权

    公开(公告)号：US20250026644A1

    公开(公告)日：2025-01-23

    申请号：US18640960

    申请日：2024-04-19

    Applicant: University of Wyoming

    Inventor： William SCHAFFERS ,  David BELL ,  John MYERS ,  Kaspars KRUTKRAMELIS ,  Paul BEHRENS

    IPC: C01B32/184 ,  C08L95/00 ,  C10B57/08 ,  C10G1/04

    Abstract: Described herein are integrated thermochemical processes for the deliberate decomposition, extraction and conversion of coal into high-value products and goods via solvent extraction, chemical reaction and/or separation. The described systems and methods are versatile and may be used to generate a variety of intermediate, derivative and finished high value products including chemicals (aromatics, asphaltenes, naphthalenes, phenols and precursors for the production of polyamides, polyurethanes, polyesters, graphitic materials), polymer composite products (resins, paints, coatings, adhesives), agricultural materials, building materials, carbon fiber, graphene products and other materials that are substantially more valuable that the energy generated via combustion.

    Synthetically modifiable ion channels
    60.
    发明授权
    Synthetically modifiable ion channels 有权

    公开(公告)号：US11976078B2

    公开(公告)日：2024-05-07

    申请号：US16081265

    申请日：2017-02-28

    Applicant: UNIVERSITY OF WYOMING

    Inventor： Bruce Alan Parkinson ,  John Hoberg ,  Jordan Brophy

    IPC: C07D487/22 ,  B82B3/00 ,  C01B32/182

    CPC classification number: C07D487/22 ,  B82B3/0014 ,  B82B3/0042

    Abstract: A new class of ordered functional nanoporous material (OFNMs) with a unique combination of electronic conductivity, gas transport ability, and ion transport properties are provided. The OFNM provided is highly ordered and contains nanometer scale pores lined with nitrogen atoms. The pores have dimensions of from 1.2 nm to 82 nm of longest linear extent across the pore. The functionality within the pore is controlled through selection of groups that extend into the pore. The degree of conjugated aromaticity is readily controlled to adjust the electrical conductivity properties of the resulting structure. By adjusting the groups external to the pore, three-dimensional structures are formed that are organic mimics of zeolites, metal organic frameworks (MOF), or perovskites.

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