公开(公告)号：US20230270861A1

公开(公告)日：2023-08-31

申请号：US18006482

申请日：2021-07-22

Applicant: The University of Chicago

Inventor： Ralph WEICHSELBAUM ,  Hua Laura LIANG ,  Yuzhu HOU

IPC: A61K41/00 ,  A61K31/4995 ,  C07K16/28 ,  A61N5/10 ,  C12N9/22 ,  C12N15/11 ,  A61P35/00

CPC classification number: A61K41/0038 ,  A61K31/4995 ,  C07K16/2827 ,  C07K16/2818 ,  A61N5/10 ,  C12N9/22 ,  C12N15/11 ,  A61P35/00 ,  C12N2310/20

Abstract: This disclosure relates to compositions and methods for treating cancer by modulating the artemin pathway.

公开(公告)号：US20230251245A1

公开(公告)日：2023-08-10

申请号：US18067192

申请日：2022-12-16

Applicant: The University of Chicago

Inventor： Katherine L. Rhodes ,  Kenneth A. Barr ,  Yoav Gilad

IPC: G01N33/50 ,  C12Q1/6809 ,  G16B5/30

CPC classification number: G01N33/5082 ,  C12Q1/6809 ,  G16B5/30 ,  G01N2570/00

Abstract: In aspects, the present disclosure provides methods of using multi-tissue organoids bodies including for analyzing the genome or transcriptome of a mammal, analyzing a cellular response to a treatment, determining an effect of a substance, or analyzing a cellular response to a treatment.

公开(公告)号：US20230234003A1

公开(公告)日：2023-07-27

申请号：US18012078

申请日：2021-07-07

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Chong Liu ,  Eli Hoenig

IPC: B01D71/02 ,  B01D67/00 ,  B01D61/02 ,  C02F1/44

CPC classification number: B01D71/022 ,  B01D67/0079 ,  B01D61/025 ,  C02F1/441 ,  B01D2323/36

Abstract: Molybdenum disulfide membranes for ionic and/or molecular filtration applications are provided. The membranes have high separation performance, including high water flux and high molecule and/or ion rejection, and do not need to be stored in a hydrated condition in order to enable their reuse. The membranes are based on stacked MoS2 sheets having small hydrophilic organic functional groups covalently bound thereto.

公开(公告)号：US20230218634A1

公开(公告)日：2023-07-13

申请号：US18088400

申请日：2022-12-23

Applicant: University of Chicago

Inventor： Russell Z. Szmulewitz ,  Suzanne D. Conzen

IPC: A61K31/567 ,  A61K31/437 ,  A61N5/10 ,  A61K31/573 ,  A61K31/569 ,  A61K45/06 ,  A61K31/4166

CPC classification number: A61K31/567 ,  A61K31/437 ,  A61N5/10 ,  A61K31/573 ,  A61K31/569 ,  A61K45/06 ,  A61K31/4166

Abstract: Embodiments of the invention are directed to the treatment of subjects with prostate cancer, in particular those with castration resistant prostate cancer, with glucocorticoid receptor antagonists. The prostate cancer may be one that has become resistant to androgen deprivation therapy, for example, by increase in glucocorticoid receptor expression and/or activity.

公开(公告)号：US11682819B2

公开(公告)日：2023-06-20

申请号：US17452654

申请日：2021-10-28

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： David Schuster ,  Aziza Suleymanzade ,  Jonathan Simon ,  Alexander Anferov

IPC: H01P1/219 ,  H01P7/04 ,  H01P11/00 ,  H01P1/209

CPC classification number: H01P7/04 ,  H01P1/209 ,  H01P1/219 ,  H01P11/008

Abstract: A millimeter-wave resonator is produced by drilling a plurality of holes into a piece of metal. Each hole forms an evanescent tube having a lowest cutoff frequency. The holes spatially intersect to form a seamless three-dimensional cavity whose fundamental cavity mode has a resonant frequency that is less than the cutoff frequencies of all the evanescent tubes. Below cutoff, the fundamental cavity mode does not couple to the waveguide modes, and therefore has a high internal Q. Millimeter waves can be coupled into any of the tubes to excite an evanescent mode that couples to the fundamental cavity mode. The tubes also provide spatial and optical access for transporting atoms into the cavity, where they can be trapped while spatially overlapping the fundamental cavity mode. The piece of metal may be superconducting, allowing the resonator to be used in a cryogenic environment for quantum computing and information processing.

公开(公告)号：US11680091B2

公开(公告)日：2023-06-20

申请号：US15733530

申请日：2019-02-21

Applicant: The University of Chicago

Inventor： Shohei Koide ,  Shun-Ichi Tanaka ,  Akiko Koide

IPC: C07K14/78 ,  C40B40/10

CPC classification number: C07K14/78 ,  C40B40/10

Abstract: The current application describes various compositions and methods for the production of FN3-based binding proteins with improved stability properties. Aspects of the disclosure relate to polypeptides comprising a variant fibronectin type III (FN3) domain from Sulfolobus tokodaii or Pyrococcus horikoshii comprising one or more amino acid substitutions or insertions in a loop region of FN3, in a non-loop region of FN3, or in both.

公开(公告)号：US20230159340A1

公开(公告)日：2023-05-25

申请号：US17922848

申请日：2021-05-05

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： VLADISLAV KAMYSBAYEV ,  Dmitri V. Talapin

IPC: C01B32/921 ,  C01B32/914 ,  C23F1/10

CPC classification number: C01B32/921 ,  C01B32/914 ,  C23F1/10 ,  C01P2004/20

Abstract: Methods for modifying the surface termination of two-dimensional (2D) transition metal carbides (MXenes) are provided. The methods, which allow for versatile chemical modification of the terminating anions via halide exchange or substitution and elimination reactions in molten inorganic salts, provide a processing approach that is widely applicable to MXenes as a broad class of functional materials.

公开(公告)号：US20230158085A1

公开(公告)日：2023-05-25

申请号：US17812873

申请日：2022-07-15

Applicant: The University of Chicago ,  The Regents of the University of Michigan

Inventor： Cathyrn R. Nagler ,  Gabriel Nunez ,  Yun-Gi Kim

IPC: A61K35/742 ,  A23K50/75 ,  A23K10/18 ,  A23L33/135 ,  A23L33/00 ,  A61P31/04 ,  A61K9/00 ,  A61K31/194 ,  A61K45/06 ,  C12Q1/689

CPC classification number: A61K35/742 ,  A23K10/18 ,  A23K50/75 ,  A23L33/40 ,  A23L33/135 ,  A61K9/0031 ,  A61K9/0053 ,  A61K9/0056 ,  A61K31/194 ,  A61K45/06 ,  A61P31/04 ,  C12Q1/689 ,  A23V2002/00 ,  A61K2035/115

Abstract: Provided herein are compositions and methods for the inhibition of enteric infection. In particular, compositions comprising bacteria of the class Clostridia are administered to human and/or animal subjects to prevent or decrease susceptibility to enteric infection.

公开(公告)号：US20230117744A1

公开(公告)日：2023-04-20

申请号：US17914293

申请日：2021-03-23

Applicant: LOYOLA UNIVERSITY OF CHICAGO ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE

Inventor： Susan Baker ,  Xufang Deng ,  Kelly Milton Lager ,  Kay Faaberg ,  Alexandra DeVries

IPC: A61K39/215 ,  A61P31/14 ,  C12N7/00

Abstract: The present disclosure provides compositions, for example vaccine compositions comprising live, attenuated coronavirus. The disclosure also provides methods of using coronavirus vaccines, including methods of treating and/or preventing coronavirus infections, and provides methods of preparing coronavirus vaccines.

公开(公告)号：US11619660B2

公开(公告)日：2023-04-04

申请号：US16968471

申请日：2019-02-13

Applicant: The University of Chicago

Inventor： Gary Wolfowicz ,  Samuel James Whiteley ,  David Daniel Awschalom

IPC: G01R15/24

Abstract: Methods and systems are disclosed for sensing an environment electric field. In one exemplary implementation, a method includes disposing a sensor in the environment, wherein the sensor comprising a crystalline lattice and at least one optically-active defect in the crystalline lattice; pre-exciting the crystalline lattice to prepare at least one defect in a first charge state using a first optical beam at a first optical wavelength; converting at least one defect from the first charge state to a second charge state using a second optical beam at a second optical wavelength; monitoring a characteristics of photoluminescence emitted from the defect during or after the conversion of the at least one defect from the first charge state to the second charge state; and determining a characteristics of the electric field in the environment according to the monitored characteristics of the photoluminescence.