Patent search ap:("10X GENOMICS Page INC.") AND inv:"Geoffrey McDermott"

51.

发明授权
Methods and systems for molecular composition generation 有权

公开(公告)号：US12049621B2

公开(公告)日：2024-07-30

申请号：US17093050

申请日：2020-11-09

Applicant: 10X GENOMICS, INC.

Inventor： Geoffrey McDermott , Andrew Price , Michael Schnall-Levin

IPC: C12N15/10

CPC classification number: C12N15/1065

Abstract: The present disclosure provides methods and systems for generation of compositions comprising two or more sets of molecules. Compositions herein may comprise sets of molecules of different types. Sets of molecules may be generated by attachment to supports. Different types of molecules may be used to generate a large number of unique molecules. One or more types of molecules may be used to identify one or more additional types of molecules. Compositions of the present disclosure may be used in, for example, nucleic acid sequencing.

52.

发明授权
Methods, kits, and compositions for processing extracellular molecules 有权

公开(公告)号：US11851700B1

公开(公告)日：2023-12-26

申请号：US17318364

申请日：2021-05-12

Applicant: 10x Genomics, Inc.

Inventor： Felice Alessio Bava , Geoffrey McDermott

IPC: C12Q1/6806 , C12N15/10

CPC classification number: C12Q1/6806 , C12N15/1013 , C12Q1/6806 , C12Q2521/30 , C12Q2563/159 , C12Q2563/179

Abstract: Disclosed are methods, compositions and kits for contacting a sample containing a biological particle with a catalyst associated with or attached to a support. The biological particle may be cells and/or nuclei. The catalyst may be an enzyme configured to digest an extracellular molecule, such as an extracellular biological molecule, including extracellular nucleic acid molecules. In some examples, the biological particle is an aggregate of cells that is processed to single cells with a nuclease that is attached to a bead support. The bead and nuclease may subsequently be removed from the system. The single cells that result from the method can be used in single cell-based droplet systems for obtaining genome or transcriptome profiles of single cells.

53.

发明公开
METHODS AND SYSTEMS FOR CHARACTERIZING ANALYTES FROM INDIVIDUAL CELLS OR CELL POPULATIONS 审中-公开

公开(公告)号：US20230383440A1

公开(公告)日：2023-11-30

申请号：US18231460

申请日：2023-08-08

Applicant: 10x Genomics, Inc.

Inventor： Jason Bell , Francesca Meschi , Geoffrey McDermott , Michael Schnall-Levin , Xinying Zheng

IPC: C40B30/04 , C07K14/74 , C12N15/85 , G01N33/532 , G01N33/543 , G01N33/548 , C12N15/10 , C12Q1/6804 , C12Q1/6806 , G01N33/50 , G01N33/53 , G01N33/58 , C12Q1/6818 , C12Q1/6827 , C12Q1/6881 , C12N15/11 , G01N33/569

CPC classification number: C40B30/04 , C07K14/70539 , C12N15/85 , G01N33/532 , G01N33/54306 , G01N33/548 , C12N15/1037 , C12N15/1075 , C12Q1/6804 , C12Q1/6806 , G01N33/505 , G01N33/5308 , G01N33/58 , C12Q1/6818 , C12Q1/6827 , C12Q1/6881 , C12N15/11 , G01N33/5304 , G01N33/5306 , C12N15/1055 , C12N15/1065 , G01N33/5032 , G01N33/54366 , G01N33/56977 , C12Q2537/164 , C12Q2565/1015 , C12Q2563/179 , C12Q2563/185 , C12N2310/20 , C40B70/00

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes.

54.

发明申请
METHODS AND SYSTEMS FOR ANALYSIS OF CHROMATIN 有权

公开(公告)号：US20210270818A1

公开(公告)日：2021-09-02

申请号：US17229859

申请日：2021-04-13

Applicant: 10X Genomics, Inc.

Inventor： Jason Bell , Francesca Meschi , Geoffrey McDermott , Michael Schnall-Levin , Xinying Zheng

IPC: G01N33/532 , C07K14/74 , C12N15/85 , G01N33/543 , G01N33/548 , C12N15/10 , C12Q1/6804 , C12Q1/6806 , G01N33/50 , G01N33/53 , G01N33/58 , C12Q1/6818 , C12Q1/6827 , C12Q1/6881 , C12N15/11 , G01N33/569

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins) and chromatin (e.g., accessible chromatin).

55.

发明申请
METHODS AND SYSTEMS FOR ANALYSIS OF MAJOR HISTOCOMPATABILITY COMPLEX 审中-公开

公开(公告)号：US20190367966A1

公开(公告)日：2019-12-05

申请号：US16375102

申请日：2019-04-04

Applicant: 10X Genomics, Inc.

Inventor： Kamila Belhocine , Jason Bell , Zachary Bent , Rajiv Bharadwaj , Christopher Hindson , Mohammad Rahimi Lenji , Bill Kengli Lin , Anthony Makarewicz , Geoffrey McDermott , Elliott Meer , Francesca Meschi , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Michael Schnall-Levin , Sarah Taylor , Jessica Michele Terry , Tobias Daniel Wheeler , Yifeng Yin , Xinying Zheng , Solongo Batjargal Ziraldo , Eswar Prasad Ramachandran Iyer , Luigi Jhon Alvarado Martinez

IPC: C12Q1/6806 , G01N33/53 , G01N33/58 , C12Q1/6804 , G01N33/50 , C12N15/10

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from one or more cells. Such polynucleotide processing may be useful for a variety of applications, including characterization of major histocompatibility complex (MHC) molecules. The compositions, methods, systems, and devices disclosed herein generally describe peptides and barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing MHC molecules from one or more cells.

56.

发明申请
METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES 审中-公开

公开(公告)号：US20190338353A1

公开(公告)日：2019-11-07

申请号：US16426762

申请日：2019-05-30

Applicant: 10X GENOMICS, INC.

Inventor： Phillip Belgrader , Zachary Bent , Rajiv Bharadwaj , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Michael Ybarra Lucero , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Tobias Daniel Wheeler , Indira Wu , Solongo Batjargal Ziraldo

IPC: C12Q1/6874 , C12N15/10 , C12Q1/683 , C12Q1/6806 , C12Q1/6804

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.

57.

发明申请
SINGLE CELL ANALYSIS OF TRANSPOSASE ACCESSIBLE CHROMATIN 审中-公开

公开(公告)号：US20180340171A1

公开(公告)日：2018-11-29

申请号：US15842713

申请日：2017-12-14

Applicant: 10X Genomics, Inc.

Inventor： Kamila Belhocine , Geoffrey McDermott , Francesca Meschi , Xinying Zheng

IPC: C12N15/10

Abstract: Methods and systems for sample preparation techniques that allow amplification (e.g., whole genome amplification) and sequencing of chromatin accessible regions of single cells are provided. The methods and systems generally operate by forming or providing partitions (e.g., droplets) including a single biological particle and a single bead comprising a barcoded oligonucleotide. The preparation of barcoded next-generation sequencing libraries prepared from a single cell is facilitated by the transposon-mediated transposition and fragmentation of a target nucleic acid sequence. The methods and systems may be configured to allow the implementation of single-operation or multi-operation chemical and/or biochemical processing within the partitions.