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公开(公告)号：US20230204980A1
公开(公告)日：2023-06-29
申请号：US18175648
申请日：2023-02-28
Applicant: ACUCELA INC.
Inventor： Ryo KUBOTA , Philip M. BUSCEMI , Pascal LOSER , Ben CROOK , Massimo PINAZZA , Jim NIEBANCK , James PHILLIPS , Stefan BAUER
CPC classification number: G02C7/083 , G02C5/146 , G02C11/10 , G02C2200/08
Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.
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公开(公告)号：US20230168521A1
公开(公告)日：2023-06-01
申请号：US18160200
申请日：2023-01-26
Applicant: ACUCELA INC.
Inventor： Beat WYSS , Jean-Noel FEHR , Glenn NORONHA , Karim HAROUD , Julien SAUVET , Hans BERNHARD , Christian OGGENFUSS , Amitava GUPTA , Ryo KUBOTA
CPC classification number: G02C7/04 , G02C7/14 , G02C11/04 , G02C2202/24
Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.
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公开(公告)号：US20230118068A1
公开(公告)日：2023-04-20
申请号：US18067552
申请日：2022-12-16
Applicant: ACUCELA INC.
Inventor： Amitava GUPTA , Ryo KUBOTA
Abstract: A contact lens configured to decrease dark adaptation comprises one or more LEDs and directs light from the LED away from the fovea and toward the parafovea or perifoveal regions of the retina. In some embodiments, soft contact lens embedded with one or more arrays of microLEDs and electronics operating the LEDs is configured to be worn at night in order to inhibit dark adaptation and reduce oxygen consumption by the rods. The contact lens may be made of a single layer of a contact lens material or multiple layers sandwiching a flexible transparent plastic layer comprising the electronics and the LED arrays. The contact lens may be made of a hydrophilic hydrogel material that is biocompatible to the human cornea, or a silicone hydrogel material. The contact lens may be spherical and may provide refractive correction to the eye of the wearer.
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公开(公告)号：US20230026567A1
公开(公告)日：2023-01-26
申请号：US17936082
申请日：2022-09-28
Applicant: ACUCELA INC.
Inventor： Philip M. BUSCEMI , Ryo KUBOTA
IPC: A61N5/06
Abstract: A stimulus is configured to treat astigmatism with changes in retinal thickness, independently of, or in combination with, treatment for myopia. In some embodiments, a stimulus pattern is arranged with respect to an astigmatic axis of the eye to decrease ocular growth in relation to the astigmatic axis. In some embodiments, the apparatus is configured to direct light to regions of retina outside the macula in relation to the astigmatic axis of the eye. In some embodiments, the intensity is modulated to provide the effect. A lens, such as a contact lens or spectacle lens may be configured with a plurality of light sources, such as projection units having a light source and focusing optics that work together to project anteriorly or posteriorly defocused images onto the retina at locations eccentric to the fovea.
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公开(公告)号：US20220413318A1
公开(公告)日：2022-12-29
申请号：US17929852
申请日：2022-09-06
Applicant: ACUCELA INC.
Inventor： Ryo KUBOTA , Nabin JOSHI , Arkady SELENOW , Steven ALI , Stefan BAUER , Jean-Noel FEHR , Moritz HAEBERLI , Patrizia WEBER , Julien SAUVET , Amitava GUPTA
Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.
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Patent Agency Ranking
公开(公告)号：US20220257112A1
公开(公告)日：2022-08-18
申请号：US17662582
申请日：2022-05-09
Applicant: ACUCELA INC.
Inventor： Ryo KUBOTA , Stephan WYDER , Philip M. BUSCEMI , Matthias PFISTER , Alexander HOLZER
IPC: A61B3/10 , G01B9/02004 , G01B9/02091 , A61B3/12
Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.
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公开(公告)号：US20220221738A1
公开(公告)日：2022-07-14
申请号：US17657036
申请日：2022-03-29
Applicant: ACUCELA INC.
Inventor： Ryo KUBOTA , Amitava GUPTA
Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.
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公开(公告)号：US20210356767A1
公开(公告)日：2021-11-18
申请号：US17302827
申请日：2021-05-13
Applicant: ACUCELA INC.
Inventor： Ryo KUBOTA , Amitava GUPTA
Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.
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公开(公告)号：US20210031051A1
公开(公告)日：2021-02-04
申请号：US16947537
申请日：2020-08-05
Applicant: ACUCELA INC.
Inventor： Ryo KUBOTA , Karim HAROUD , Beat WYSS , Hans BERNARD , Jean-Noël FEHR , Patrizia WEBER , Moritz HAEBERLI , Amitava GUPTA
Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.
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公开(公告)号：US20160145198A1
公开(公告)日：2016-05-26
申请号：US14946721
申请日：2015-11-19
Applicant: Acucela Inc.
Inventor： Ian L. SCOTT , Vladimir A. KUKSA , Feng HONG , Ryo KUBOTA , Jennifer GAGE
IPC: C07C233/25 , C07C225/06 , C07C215/08
CPC classification number: C07C233/25 , A61K31/167 , A61K31/18 , C07B59/001 , C07B2200/05 , C07C211/49 , C07C211/52 , C07C215/08 , C07C215/14 , C07C215/42 , C07C215/68 , C07C217/08 , C07C217/10 , C07C217/58 , C07C225/06 , C07C225/22 , C07C233/36 , C07C233/43 , C07C233/62 , C07C275/40 , C07C311/08 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/24 , C07C335/18 , C07C2601/08 , C07C2601/14 , C07D277/28
Abstract: Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
Abstract translation: 提供了化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和病症如老年性黄斑变性和Stargardt氏病的方法。
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