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公开(公告)号：US20060183171A1
公开(公告)日：2006-08-17
申请号：US11378735
申请日：2006-03-17
申请人： Volker Schellenberger , Amy Liu
发明人： Volker Schellenberger , Amy Liu
IPC分类号： G01N33/53
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00319 , B01J2219/0052 , B01J2219/00524 , B01J2219/00533 , B01J2219/00596 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00707 , B01L3/5025 , B01L3/5085 , B01L3/50857 , B01L2300/0654 , B01L2300/0809 , B01L2300/161 , C40B60/14 , G01N35/1065 , G01N2035/00237
摘要： A high throughput screening method. At least one liquid sample is provided that includes an analyte that directly or indirectly produces a detectable characteristic in one or more first assays. A plurality of through holes is filled with portions of the liquid sample in a testing assembly that has a pair of opposing surfaces, each through hole extending from one of the opposing surfaces to the other of the opposing surfaces, with the through holes arranged in group. Surface tension holds the respective portions in the respective plurality of through holes. A detection is made of which of the through holes contains a liquid sample portion that includes said analyte. The detectable characteristic may be produced in various assays such as an absorbance transcription assay, a fluorescent transcription assay, a fluorescent secreted enzyme assay, or a microorganism screening assay.
摘要翻译： 高通量筛选方法。 提供至少一种液体样品，其包括在一个或多个第一测定中直接或间接产生可检测特征的分析物。 多个通孔在具有一对相对表面的测试组件中填充有液体样品的部分，每个通孔从相对表面中的一个延伸到另一个相对表面，通孔布置成 。 表面张力保持相应的多个通孔中的各个部分。 检测哪个通孔包含包含所述分析物的液体样品部分。 可以在各种测定中产生可检测特征，例如吸光度转录测定，荧光转录测定，荧光分泌酶测定或微生物筛选测定。
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52.发明申请Mutant E. coli appa phytase enzymes and natural variants thereof, nucleic acids encoding such phytase enzymes, vectors and host cells incorporating same and methods of making and using same 有权突变大肠杆菌植酸酶及其天然变体，编码这种植酸酶的核酸，与其结合的载体和宿主细胞以及制备和使用它们的方法公开(公告)号：US20060141562A1
公开(公告)日：2006-06-29
申请号：US10524234
申请日：2003-08-11
申请人： Beat Blattmann , Aldis Darzins , John Davis , Lance Encell , Thomas Morrison , Gregory Mrachko , Volker Schellenberger
发明人： Beat Blattmann , Aldis Darzins , John Davis , Lance Encell , Thomas Morrison , Gregory Mrachko , Volker Schellenberger
CPC分类号： C12N15/8243 , C12N9/16 , C12N15/8245
摘要： Cells producing mutant phytases having modified activity are provided, as well as the phytases so produced. Also provided are methods of making and producing such phytases and the use of the expressed phytase protein in feed as a supplement.
摘要翻译： 提供具有改变活性的产生突变体植酸酶的细胞，以及如此制备的植酸酶。 还提供了制备和生产这种植酸酶的方法以及在饲料中使用表达的植酸酶蛋白作为补充物。
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公开(公告)号：US20050164308A1
公开(公告)日：2005-07-28
申请号：US11011422
申请日：2004-12-14
CPC分类号： C12N9/86
摘要： The present invention provides beta-lactamase CD4+ T-cell epitopes, as well as novel variants that exhibit reduced immunogenic responses, as compared to the parental beta-lactamase. The present invention further provides DNA molecules that encode novel beta-lactamase variants, host cells comprising DNA encoding novel beta-lactamase variants, as well as methods for making beta-lactamases less immunogenic. In addition, the present invention provides various compositions that comprise these beta-lactamase variants that are less immunogenic than wild-type beta-lactamases.
摘要翻译： 与亲本β-内酰胺酶相比，本发明提供了β-内酰胺酶CD4 + T细胞表位，以及表现出降低的免疫原性应答的新型变体。 本发明进一步提供了编码新型β-内酰胺酶变体的DNA分子，包含编码新型β-内酰胺酶变体的DNA的宿主细胞，以及制备较少免疫原性的β-内酰胺酶的方法。 此外，本发明提供了包含与野生型β-内酰胺酶相比免疫原性较低的这些β-内酰胺酶变体的各种组合物。
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公开(公告)号：US06706503B2
公开(公告)日：2004-03-16
申请号：US10037677
申请日：2001-10-23
IPC分类号： C12P104
CPC分类号： C12N9/0006 , C07K14/245 , C12N15/102 , C12P7/18 , C12R1/01 , C12R1/19
摘要： The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced by the methods.
摘要翻译： 本发明提供了用于引导微生物进化的方法，所述微生物包括使用突变基因并在选择压力条件下生长。 该方法公开了可用于本发明方法的突变基因，并提供了例证通过该方法产生的进化微生物的ATCC沉积物。
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公开(公告)号：US06365410B1
公开(公告)日：2002-04-02
申请号：US09314847
申请日：1999-05-19
IPC分类号： C12N1574
CPC分类号： C12N9/0006 , C07K14/245 , C12N15/102 , C12P7/18 , C12R1/01 , C12R1/19
摘要： The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced by the methods.
摘要翻译： 本发明提供了用于引导微生物进化的方法，所述微生物包括使用突变基因并在选择压力条件下生长。 该方法公开了可用于本发明方法的突变基因，并提供了例证通过该方法产生的进化微生物的ATCC沉积物。
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56.发明授权公开(公告)号：US09062299B2
公开(公告)日：2015-06-23
申请号：US13392511
申请日：2010-08-02
申请人： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
发明人： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor DC coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子DC凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US08703717B2
公开(公告)日：2014-04-22
申请号：US12796640
申请日：2010-06-08
申请人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Willem P. Stemmer , Nathan Geething , Jeffrey L. Cleland
发明人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Willem P. Stemmer , Nathan Geething , Jeffrey L. Cleland
CPC分类号： A61K47/48246 , A61K38/00 , A61K47/64 , C07K14/001 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/75
摘要： The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of growth hormone-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生长激素的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗生长激素相关疾病的方法， 疾病和病症。
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58.发明授权Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same 有权与扩展的重组多肽融合的生长激素多肽及其制备和使用方法公开(公告)号：US08680050B2
公开(公告)日：2014-03-25
申请号：US12848984
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Jeffrey L. Cleland
发明人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Jeffrey L. Cleland
CPC分类号： C07K14/001 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/75
摘要： The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in administration to animals.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生长激素，编码组合物的分离的核酸和载体的组合物和含有其的宿主细胞的组合物，以及在给予动物时制备和使用这些组合物的方法。
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59.发明授权公开(公告)号：US08557961B2
公开(公告)日：2013-10-15
申请号：US13078499
申请日：2011-04-01
CPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
摘要： The present invention relates to compositions comprising alpha 1-antitrypsin linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of alpha 1-antitrypsin-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的α1-抗胰蛋白酶的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用这些组合物治疗α1- 抗胰蛋白酶相关疾病，病症和病症。
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60.发明申请BINDING FUSION PROTEINS, BINDING FUSION PROTEIN-DRUG CONJUGATES, XTEN-DRUG CONJUGATES AND METHODS OF MAKING AND USING SAME 有权结合融合蛋白，结合融合蛋白 - 药物结合物，XTEN-DRUG结合体及其制备和使用方法公开(公告)号：US20130165389A1
公开(公告)日：2013-06-27
申请号：US13631361
申请日：2012-09-28
申请人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Susan E. Alters , Nathan Geething
发明人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Susan E. Alters , Nathan Geething
CPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
摘要： The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸重组多肽（XTEN）连接的靶向部分，结合融合蛋白 - 药物共轭组合物和XTEN-药物共轭组合物的结合融合蛋白组合物，编码组合物和载体的分离的核酸和含有该重组多肽的宿主细胞 以及使用这些组合物治疗疾病，病症和病症的方法。
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