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公开(公告)号：US12004996B2
公开(公告)日：2024-06-11
申请号：US17984046
申请日：2022-11-09
CPC分类号： A61F9/0017 , A61K9/0051 , A61M31/002 , A61F2250/0068 , B01L2400/082 , G02C7/049
摘要： A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
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公开(公告)号：US20230166004A1
公开(公告)日：2023-06-01
申请号：US18070334
申请日：2022-11-28
发明人： Yu-Chong Tai , Kuang-Ming Shang , Hirotake Komatsu
CPC分类号： A61L27/3804 , C12N5/0068 , A61L27/56 , A61L27/54 , C12N2533/30 , C12N2535/10
摘要： A two-dimensional lattice or mesh scaffold for therapeutic cell implants is disclosed as well as methods for manufacture and use. The lattice is constructed of crisscrossing capillaries of hydrophobic parylene, such as parylene AF4, that may be coated with a hydrophilic polymer, such as parylene C, for cell adhesion. At each intersection of the crisscross, the intersecting capillaries are internally connected so as to allow oxygen to flow freely within. The walls of the capillaries are thin enough to be permeable to oxygen, on the scale of a micron thick, so that oxygen can flow through the lattice and permeate through the capillary walls. For some implants, cells are sandwiched between two or more lattices, the cells being slightly held apart from aggregation with each other by the lattice holes. The implants may then be surgically implanted within a subject.
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公开(公告)号：US20220389361A1
公开(公告)日：2022-12-08
申请号：US17776183
申请日：2020-11-13
摘要： A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided. The apparatus includes a membrane comprising multiple surface features on a first side of the membrane for cell placement. The surface features comprising one or more compartments within which a cell can be located. The membrane includes a material that is at least partially permeable to gas. A second side of the membrane defines a gas region. The second side of the membrane is separated from the first side of the membrane by the membrane. The apparatus further includes a media region for receiving media. The compartments are configured to at least partially reduce media flow shear forces on one or more cells in the compartments. The surface features may be ridges, protrusions, fins, wells, and/or posts.
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公开(公告)号：US10371640B2
公开(公告)日：2019-08-06
申请号：US15647039
申请日：2017-07-11
发明人： Yu-Chong Tai , Wendian Shi , Harvey Kasdan
摘要： The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from each of the one or more leukocyte types to classify the leukocyte population.
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公开(公告)号：US10031348B2
公开(公告)日：2018-07-24
申请号：US14881935
申请日：2015-10-13
摘要： A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
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公开(公告)号：US09980388B2
公开(公告)日：2018-05-22
申请号：US14974242
申请日：2015-12-18
发明人： Yu-Chong Tai , Han-Chieh Chang
CPC分类号： H05K1/189 , A61N1/0543 , A61N1/36046 , H05K3/064 , H05K2201/0154 , H05K2201/052 , H05K2201/1003 , H05K2201/10151
摘要： A biocompatible, micro-fabricated ribbon cable is described in which at least one set of conductors diverges laterally into a bypass wing that forms an aperture through the ribbon cable. The bypass wing is folded in a line through the aperture and over a central portion of the ribbon cable, resulting in a ribbon cable with a narrow, stacked region. The narrow region can fit through small incisions in membranes, such as through an incision in a sclera of an eyeball. The ribbon cable can have an integrally-formed electrode array for attaching to a retina of an eyeball and other electronics for sending signals to the electrode array.
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公开(公告)号：US20180016533A1
公开(公告)日：2018-01-18
申请号：US15647156
申请日：2017-07-11
发明人： Yu-Chong Tai , Yang Liu , Colin A. Cook , Yuman Fong , Nanhai G. Chen
摘要： A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. In other embodiments, the sides may be held apart by gas pressure alone. A 0.01 μm to 1000 μm parylene or other biocompatible coating over the bag outsides controls the permeability of the bag material and provides a bio-safe area for cell growth. An alternate configuration uses open-cell foam with skins coated with a biocompatible coating. Tubes going into multiple bags can be connected to a manifold that delivers gaseous oxygen or removes carbon dioxide and other waste gases. Multiple bags can be stacked together tightly, with o-ring spacers in between, and housed within a vessel to form a high-surface area, ultra-compact cell growing system. For cells growing on the bags, liquid nutrients can be fed by way of the tube spacers, and oxygen and waste gases permeated through the bag sides and transported within the bags.
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公开(公告)号：US09763825B2
公开(公告)日：2017-09-19
申请号：US15261435
申请日：2016-09-09
发明人： Yu-Chong Tai , Nicholas E. Scianmarello , Karthik Murali , Mark S. Humayun , Ramiro Magalhaes Ribeiro
CPC分类号： A61F9/0017 , A61M5/14276 , A61M37/00 , A61M2005/14204 , A61M2205/04 , A61M2210/0612 , A61N1/0543 , A61N1/20 , A61N1/3787
摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
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59.发明申请公开(公告)号：US20170100054A1
公开(公告)日：2017-04-13
申请号：US14981089
申请日：2015-12-28
申请人： California Institute of Technology , University of California Los Angeles , University of Southern California
发明人： Yu-Chong Tai , Tzung Hsiai , Yu Zhao , Xiaoxiao Zhang , Fei Yu
CPC分类号： A61B5/0538 , A61B5/6853
摘要： A portion of a concentric bipolar microelectrode sensor is attached to an inflatable balloon of a catheter. Another portion of the concentric bipolar microelectrode sensor is also attached to a body of the catheter. The inflatable balloon is guided to become in proximity of a tissue. The inflatable balloon is then inflated. The inflation increases the likelihood of contact between microelectrodes of the concentric bipolar microelectrode sensor with the tissue. A voltage is supplied to the microelectrodes. The tissue's impedance is accordingly measured over a frequency range. A disease of the tissue, such as a lesion, is diagnosed based on the measured impedance.
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60.发明授权In-situ heated deposition of parylene to enhance pore penetration into silicone 有权聚对二甲苯的原位加热沉积以增强孔中的渗透性公开(公告)号：US09469778B2
公开(公告)日：2016-10-18
申请号：US14509226
申请日：2014-10-08
发明人： Yu-Chong Tai , Dongyang Kang
IPC分类号： C23C16/00 , C09D165/04 , B05D1/00
CPC分类号： C09D165/04 , B05D1/60 , C03C17/328 , C03C2217/20 , C03C2217/76 , C03C2218/152 , C08G2261/3424 , C08G2261/65 , Y10T428/249958
摘要： Coating porous material, such as PDMS, with parylene N, C, D, and AF-4 by vapor deposition polymerization is described in which a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.
摘要翻译： 描述了通过气相沉积聚合将聚对二甲苯N，C，D和AF-4等多孔材料涂覆在多孔材料中，其中被覆多孔材料的表面的温度被加热至60℃至120℃。 ，或80℃和85℃。 聚对二甲苯形成多孔材料内的纳米根，其与聚对二甲苯的共形表面涂层连接。 在一些实施方案中，集成的微流体液相色谱装置中的水密分离室通过在微制造的PDMS中加热隧道并在加热的隧道内沉积聚对二甲苯来制造。
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