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1.发明申请公开(公告)号：US20170100054A1
公开(公告)日：2017-04-13
申请号：US14981089
申请日：2015-12-28
申请人： California Institute of Technology , University of California Los Angeles , University of Southern California
发明人： Yu-Chong Tai , Tzung Hsiai , Yu Zhao , Xiaoxiao Zhang , Fei Yu
CPC分类号： A61B5/0538 , A61B5/6853
摘要： A portion of a concentric bipolar microelectrode sensor is attached to an inflatable balloon of a catheter. Another portion of the concentric bipolar microelectrode sensor is also attached to a body of the catheter. The inflatable balloon is guided to become in proximity of a tissue. The inflatable balloon is then inflated. The inflation increases the likelihood of contact between microelectrodes of the concentric bipolar microelectrode sensor with the tissue. A voltage is supplied to the microelectrodes. The tissue's impedance is accordingly measured over a frequency range. A disease of the tissue, such as a lesion, is diagnosed based on the measured impedance.
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2.发明授权公开(公告)号：US10736537B2
公开(公告)日：2020-08-11
申请号：US14981089
申请日：2015-12-28
申请人： California Institute of Technology , University of California Los Angeles , University of Southern California
发明人： Yu-Chong Tai , Tzung Hsiai , Yu Zhao , Xiaoxiao Zhang , Fei Yu
摘要： A portion of a concentric bipolar microelectrode sensor is attached to an inflatable balloon of a catheter. Another portion of the concentric bipolar microelectrode sensor is also attached to a body of the catheter. The inflatable balloon is guided to become in proximity of a tissue. The inflatable balloon is then inflated. The inflation increases the likelihood of contact between microelectrodes of the concentric bipolar microelectrode sensor with the tissue. A voltage is supplied to the microelectrodes. The tissue's impedance is accordingly measured over a frequency range. A disease of the tissue, such as a lesion, is diagnosed based on the measured impedance.
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公开(公告)号：US11730358B2
公开(公告)日：2023-08-22
申请号：US16786377
申请日：2020-02-10
CPC分类号： A61B3/101 , A61B5/6821 , A61B5/6867 , A61B10/0045 , G01F22/00 , G01G19/00 , G01N1/10 , G01N30/02 , G01N33/4875 , A61B2010/0067 , G01N2030/027
摘要： A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.
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公开(公告)号：US11523939B2
公开(公告)日：2022-12-13
申请号：US16418899
申请日：2019-05-21
摘要： A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
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5.发明授权公开(公告)号：US11154226B2
公开(公告)日：2021-10-26
申请号：US15179744
申请日：2016-06-10
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , G02B6/10 , G02B6/122 , G01J3/44 , G01N21/65 , G02B6/34 , G01N21/64 , G02B6/12
摘要： A medical sensor is described. In an example, the medical sensor includes a nanoscale tapered waveguide attached to a substrate. The nanoscale tapered waveguide includes a nanoscale channel that receives fluid and an excitation light and that outputs a response light. The excitation light propagates through the fluid. A receiving channel of the nanoscale channel is configured as a waveguide that receives and guides the excitation to a linearly tapered channel of the nanoscale channel. The linearly tapered channel has three dimensional linear tapering that focuses the excitation light guided from the receiving channel into an optical response channel of the nanoscale channel. In turn, the optical response channel is configured as a waveguide that outputs a response light in response to the excitation light focused from the linearly tapered channel. The response light corresponds to a response of an analyte of the fluid present in the optical response channel.
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公开(公告)号：US20190307928A1
公开(公告)日：2019-10-10
申请号：US16377979
申请日：2019-04-08
发明人： Mark S. Humayun , Carlos Eduardo da Silveira Franciozi , Tzu-Chieh Chou , Yu-Chong Tai , Damien C. Rodger , C. Thomas Vangsness, JR.
摘要： A polymeric substrate for treating a chondral or osteochondral defect includes a polymeric sheet having a predetermined shape and size for placement over a chondral or osteochondral defect. The polymeric sheet defines suture openings therein that allow fixation of the polymeric scaffold. Characteristically, the polymeric sheet includes biocompatible polymer. A method for treating a subject having a chondral or osteochondral defect is also provided.
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公开(公告)号：US20170348147A1
公开(公告)日：2017-12-07
申请号：US15685353
申请日：2017-08-24
发明人： Yu-Chong Tai , Nicholas E. Scianmarello , Karthik Murali , Mark S. Humayun , Ramiro Magalhaes Ribeiro
CPC分类号： A61F9/0017 , A61M5/14276 , A61M37/00 , A61M2005/14204 , A61M2205/04 , A61M2210/0612 , A61N1/0543 , A61N1/20 , A61N1/3787 , C25B1/04 , C25B9/00 , C25B15/02 , C25B15/08
摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
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公开(公告)号：US20170071785A1
公开(公告)日：2017-03-16
申请号：US15261435
申请日：2016-09-09
发明人： Yu-Chong Tai , Nicholas E. Scianmarello , Karthik Murali , Mark S. Humayun , Ramiro Magalhaes Ribeiro
CPC分类号： A61F9/0017 , A61M5/14276 , A61M37/00 , A61M2005/14204 , A61M2205/04 , A61M2210/0612 , A61N1/0543 , A61N1/20 , A61N1/3787
摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
摘要翻译： 描述了可植入医疗装置。 可植入医疗装置包括小分子发生器，小分子扩散器和连接两者的插管。 小分子发生器包括电解质储存器和一组电极。 电解质储存器的第一部分对于预定类别的小分子是不可渗透的。 电解液储存器的第二部分对小分子是可渗透的。 该组电极设置在电解质储存器的内部，并且构造成基于对该组电极的电力施加和电解质储存器内的电解质的存在来促进小分子的电解。 至少一部分小分子扩散剂对小分子是可渗透的。
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9.发明申请MEDICAL SENSOR HAVING A NANOSCALE TAPERED WAVEGUIDE FOR SPECTROSCOPY-BASED ANALYSIS OF FLUID 审中-公开具有纳米光栅波形的医用传感器，用于基于光谱分析的流体公开(公告)号：US20160361001A1
公开(公告)日：2016-12-15
申请号：US15179744
申请日：2016-06-10
IPC分类号： A61B5/1459 , G02B6/34 , G02B6/10 , A61B5/145 , G01J3/44 , G01N21/65 , A61B5/00 , G02B6/124 , G02B6/122
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/7246 , A61B5/7282 , A61B5/742 , A61B5/7475 , A61B2562/0233 , G01J3/44 , G01J3/4406 , G01N21/64 , G01N21/65 , G01N2021/653 , G02B6/107 , G02B6/1228 , G02B6/34 , G02B2006/12107
摘要： A medical sensor is described. In an example, the medical sensor includes a nanoscale tapered waveguide attached to a substrate. The nanoscale tapered waveguide includes a nanoscale channel that receives fluid and an excitation light and that outputs a response light. The excitation light propagates through the fluid. A receiving channel of the nanoscale channel is configured as a waveguide that receives and guides the excitation to a linearly tapered channel of the nanoscale channel. The linearly tapered channel has three dimensional linear tapering that focuses the excitation light guided from the receiving channel into an optical response channel of the nanoscale channel. In turn, the optical response channel is configured as a waveguide that outputs a response light in response to the excitation light focused from the linearly tapered channel. The response light corresponds to a response of an analyte of the fluid present in the optical response channel.
摘要翻译： 描述医疗传感器。 在一个示例中，医疗传感器包括附接到基底的纳米锥形波导管。 纳米级锥形波导包括接纳流体和激发光并输出响应光的纳米级通道。 激发光通过流体传播。 纳米级通道的接收通道被配置为将激发接收并引导到纳米级通道的线性锥形通道的波导。 线性锥形通道具有三维线性渐缩，其将从接收通道引导的激发光聚焦到纳米级通道的光学响应通道中。 反过来，光响应通道被配置为响应于从线性锥形通道聚焦的激发光输出响应光的波导。 响应光对应于存在于光学响应通道中的流体的分析物的响应。
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公开(公告)号：US20150290466A1
公开(公告)日：2015-10-15
申请号：US14749487
申请日：2015-06-24
发明人： Yu-Chong Tai , Yu Zhao , Mark S. Humayun , James D. Weiland
CPC分类号： A61F9/007 , A61F2/14 , A61F2250/0001 , A61N1/0529 , A61N1/0543 , A61N1/0551 , A61N1/36046 , A61N1/3605 , A61N1/3787 , C23F1/00 , H01F27/2804 , H01F2027/2809
摘要： A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil.
摘要翻译： 公开了一种三线圈电磁感应电力传输系统，用于视网膜假体和其他植入物。 第三缓冲线圈设置在外部发射线圈和埋在体内的接收器线圈之间，以提高效率和对准失准的鲁棒性。 可以使用微机械加工技术来制造一个或多个线圈，以在生物相容绝缘体的带中布置导体，将绝缘导体迹线的长度彼此纵向折叠，然后将它们螺旋化成环。 轨迹通过在折叠线上移动来改变环中的轴向位置。 迹线上的一个或多个U形部分可以被折叠，使得相邻的迹线可以彼此相对地突出，从而延长可以卷绕成线圈的所得到的带状物。
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