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51.发明授权Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 有权乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US08735595B2
公开(公告)日：2014-05-27
申请号：US11675406
申请日：2007-02-15
申请人： Yu Gui Gu , Xiangdong Xu , Moshe Weitzberg , Hing L. Sham
发明人： Yu Gui Gu , Xiangdong Xu , Moshe Weitzberg , Hing L. Sham
IPC分类号： A61K31/4439 , A61K31/426 , C07D417/04 , C07D277/34
CPC分类号： C07D277/34 , C07D417/04
摘要： The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）的式（I）化合物，可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。
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52.发明授权Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DDP-IV) 失效作为二肽基肽酶-IV（DDP-IV）抑制剂的药物组合物公开(公告)号：US08637546B2
公开(公告)日：2014-01-28
申请号：US13437999
申请日：2012-04-03
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/445 , C07D295/00
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化和各种免疫调节疾病 。
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公开(公告)号：US07888374B2
公开(公告)日：2011-02-15
申请号：US11337862
申请日：2006-01-23
申请人： Gang Liu , Hing L. Sham , Bruce G. Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael D. Serby , Bo Liu , Mei Liu
发明人： Gang Liu , Hing L. Sham , Bruce G. Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael D. Serby , Bo Liu , Mei Liu
IPC分类号： C07D213/84 , A61K31/44
CPC分类号： C07D417/12 , C07D213/73 , C07D213/81 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
摘要： The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
摘要翻译： 本发明涉及作为c-jun N-末端激酶1,2或3（JNK1，JNK2或JNK3）的抑制剂的化合物，含有这些化合物的组合物和该化合物在预防或治疗调节疾病中的用途 通过激活JNK1，JNK2和JNK3。
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公开(公告)号：US20100331335A1
公开(公告)日：2010-12-30
申请号：US12701474
申请日：2010-02-05
申请人： Hing L. Sham , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
发明人： Hing L. Sham , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
IPC分类号： A61K31/498 , C07D409/04 , C07D409/14 , C07D405/14 , C07D409/12 , C07D471/04 , C07D487/04 , C07D417/14 , A61K31/4196 , A61K31/4709 , A61K31/4725 , A61K31/454 , A61K31/4535 , A61K31/4375 , A61K31/437 , A61K31/422 , A61K31/4245 , A61K31/4155 , A61K31/41 , A61K31/4178 , A61K31/497 , C12Q1/48 , C12N5/071 , A61P25/28 , A61P25/16 , A61P25/00
CPC分类号： C07D409/04 , A61K31/381 , A61K31/401 , A61K31/4196 , A61K31/4245 , A61K31/433 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/519 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
摘要翻译： 本公开提供了具有下式结构的c-Jun N-末端激酶（JNK）抑制剂：其盐或溶剂合物，其中环A，Ca，Cb，Z，R 5，W和Cy在本文中定义 。 本公开进一步提供药物组合物，包括本公开的化合物和制备和使用本公开的化合物和组合物的方法，例如治疗和预防各种疾病，例如阿尔茨海默病。
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55.发明申请Novel acetyl-CoA Carboxylase (ACC) Inhibitors and their use in Diabetes, Obesity and Metabolic Syndrome 有权新型乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用公开(公告)号：US20090048298A1
公开(公告)日：2009-02-19
申请号：US12259090
申请日：2008-10-27
申请人： Robert F. Keyes , Yu Gui Gu , Hing L. Sham
发明人： Robert F. Keyes , Yu Gui Gu , Hing L. Sham
IPC分类号： A61K31/4709 , C07D277/62 , C07D409/02 , A61K31/428
CPC分类号： C07D277/68 , C07D277/82 , C07D417/12
摘要： The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）的式（I）化合物，可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。
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公开(公告)号：US07320986B2
公开(公告)日：2008-01-22
申请号：US10792564
申请日：2004-03-03
申请人： Yunsong Tong , Akiyo K. Claiborne , Gaoquan Li , Nan-Horng Lin , Hing L. Sham , Thomas J. Sowin , Zhi-Fu Tao
发明人： Yunsong Tong , Akiyo K. Claiborne , Gaoquan Li , Nan-Horng Lin , Hing L. Sham , Thomas J. Sowin , Zhi-Fu Tao
IPC分类号： A61K31/4745 , A61K31/4162 , C07D487/14
CPC分类号： C07D249/08 , C07D231/12 , C07D231/54 , C07D233/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要： Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有式（I）的化合物可用于抑制蛋白激酶。 还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。
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57.发明授权Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US07238724B2
公开(公告)日：2007-07-03
申请号：US11036258
申请日：2005-01-13
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/40 , A61K31/401 , A61K31/454 , A61K31/4545 , A61K31/506 , C07D405/12 , C07D401/12 , C07D211/58 , C07D239/42
CPC分类号： C07D207/16 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）并可用于预防或治疗糖尿病，特别是II型糖尿病以及高血糖症，X综合症，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病的化合物 。
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58.发明授权公开(公告)号：US07049307B2
公开(公告)日：2006-05-23
申请号：US11020464
申请日：2004-12-22
申请人： Andrew J. Souers , Christine A. Collins , Ju Gao , Andrew S. Judd , Philip R. Kym , Mathew M. Mulhern , Hing L. Sham , Dariusz Wodka
发明人： Andrew J. Souers , Christine A. Collins , Ju Gao , Andrew S. Judd , Philip R. Kym , Mathew M. Mulhern , Hing L. Sham , Dariusz Wodka
IPC分类号： A61K31/55 , A61K31/416 , A61K31/5377 , A61K31/438 , A61K31/454
CPC分类号： C07D403/06 , C07D231/56 , C07D401/06 , C07D403/04 , C07D405/06 , C07D491/10
摘要： The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
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公开(公告)号：US06797825B2
公开(公告)日：2004-09-28
申请号：US10317336
申请日：2002-12-12
申请人： Nan-Horng Lin , Hing L. Sham , Ping Xia
发明人： Nan-Horng Lin , Hing L. Sham , Ping Xia
IPC分类号： C07D47102
CPC分类号： C07D401/06 , C07D209/34 , C07D403/06 , C07D471/04
摘要： Compounds having the formula or therapeutically acceptable salts thereof, are protein kinase inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
摘要翻译： 具有其配方的具有治疗上可接受的盐的化合物是蛋白激酶抑制剂。 公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。
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公开(公告)号：US08450363B2
公开(公告)日：2013-05-28
申请号：US12701474
申请日：2010-02-05
申请人： Hing L. Sham , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
发明人： Hing L. Sham , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
IPC分类号： A61K31/38 , A01N43/06 , C07D333/36
CPC分类号： C07D409/04 , A61K31/381 , A61K31/401 , A61K31/4196 , A61K31/4245 , A61K31/433 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/519 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
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