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    COMPOSITIONS AND METHODS OF USING CAPSID PROTEIN FROM FLAVIVIRUSES AND PESTIVIRUSES
    53.
    发明申请
    COMPOSITIONS AND METHODS OF USING CAPSID PROTEIN FROM FLAVIVIRUSES AND PESTIVIRUSES 审中-公开
    使用蚜虫蛋白质和杀虫剂的组合物和方法

    公开(公告)号：US20090104230A1

    公开(公告)日：2009-04-23

    申请号：US11972421

    申请日：2008-01-10

    申请人： David B. Weiner ,  Karuppiah Muthumani ,  Joo-Sung Yang

    发明人： David B. Weiner ,  Karuppiah Muthumani ,  Joo-Sung Yang

    IPC分类号： A61K39/00 ,  C12N5/06 ,  C12Q1/70 ,  A61K38/16 ,  A61K31/7088

    CPC分类号： A61K38/162 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/005 ,  C07K2319/02 ,  C12N2740/16222 ,  C12N2770/24122 ,  C12N2770/24322 ,  G01N33/56983 ,  G01N2469/20 ,  Y02A50/39 ,  Y02A50/394

    摘要： This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus including Flavivirus or Pestivirus capsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirus and/or anti-Pestivirus capsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.

    摘要翻译： 本发明提供了用黄病毒或瘟病毒衣壳蛋白（例如西尼罗河病毒（WNV）衣壳蛋白）及其功能片段诱导细胞死亡的方法。 本发明还提供了通过施用包含WNV或其它病毒（包括黄病毒或瘟病毒衣壳或其他蛋白质）的药物组合物或其编码的核酸分子来治疗患有特征在于过度增殖细胞的疾病的患者的方法。 公开了鉴定具有抗病毒和/或抗WNV和/或抗黄病毒和/或抗瘟病毒衣壳或其它蛋白质活性的化合物的方法。 本发明还提供包含衣壳或其它蛋白质或其片段，或编码其的核酸的疫苗组合物，来自WNV或其它病毒，包括黄病毒或瘟病毒和药学上可接受的载体。 本发明还提供用于鉴定暴露于WNV或其它病毒（包括黄病毒或瘟病毒）的个体的诊断方法和试剂盒。

    Compositions and methods for delivery of genetic material
    55.
    发明授权
    Compositions and methods for delivery of genetic material 有权
    用于遗传物质传递的组合物和方法

    公开(公告)号：US07001759B1

    公开(公告)日：2006-02-21

    申请号：US09359975

    申请日：1999-07-23

    申请人： David B. Weiner ,  William V. Williams ,  Bin Wang

    发明人： David B. Weiner ,  William V. Williams ,  Bin Wang

    IPC分类号： A61K31/167 ,  C12N15/63 ,  C12N15/87 ,  C07H21/04

    CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/0225 ,  A61K39/12 ,  A61K39/29 ,  A61K39/292 ,  A61K2039/53 ,  A61K2039/55516 ,  C12N15/63 ,  C12N2730/10134 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2760/20134 ,  C12N2770/24234 ,  Y02A50/464 ,  Y02A90/26 ,  Y10S514/818

    摘要： Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional, or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against pathogens are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.

    摘要翻译： 公开了将遗传物质引入个体细胞的方法和用于实施其的组合物和试剂盒。 所述方法包括使个体的细胞与多核苷酸功能增强子接触并向细胞施用不含逆转录病毒颗粒的核酸分子的步骤。 核酸分子包含编码蛋白质的核苷酸序列，该蛋白质包含与病原体抗原或与过度增殖或自身免疫疾病相关的抗原的表位相同或基本相似的至少一个表位， 涉及一种缺失的，非功能的或部分功能的基因或对个体产生治疗作用的蛋白质。 公开了预防和治疗个体免受病原体的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。

    Functional fragments of HIV-1 Vpr protein and methods of using the same
    56.
    发明授权
    Functional fragments of HIV-1 Vpr protein and methods of using the same 失效
    HIV-1 Vpr蛋白的功能片段及其使用方法

    公开(公告)号：US06818627B1

    公开(公告)日：2004-11-16

    申请号：US09485421

    申请日：2000-10-05

    申请人： Sundarasamy Mahalingam ,  Velpandi Ayyavoo ,  Mamata Patel ,  Thomas Kieber-Emmons ,  David B. Weiner

    发明人： Sundarasamy Mahalingam ,  Velpandi Ayyavoo ,  Mamata Patel ,  Thomas Kieber-Emmons ,  David B. Weiner

    IPC分类号： A61K4800

    CPC分类号： C07K14/005 ,  A61K47/64 ,  A61K47/6901 ,  A61K48/00 ,  A61K2039/53 ,  C12N2740/16322 ,  G01N33/56988 ,  G01N2500/00

    摘要： Conjugated compositions comprising a fragment of HIV-1 Vpr or a non-HIV-1 Vpr protein conjugated to a therapeutic compound and methods of using the same to deliver therapeutic compounds to a cell's nucleus or for the preparation of drug delivery particles are disclosed. Functional fragments of HIV-1 Vpr and functional non-HIV-1 Vpr proteins, and pharmaceutical compositions comprising the same are disclosed. Methods of inhibiting cell proliferation and methods of treating an individual who has a hyperproliferative disease are disclosed. Methods of identifying compounds that inhibit Vpr protein binding to the p6 domain of p55 or to p6 protein and kits for performing such methods are disclosed.

    摘要翻译： 公开了包含与治疗性化合物缀合的HIV-1Vpr片段或非HIV-1Vpr蛋白的片段的共轭组合物及其使用方法将治疗性化合物递送至细胞核或用于制备药物递送颗粒。 公开了HIV-1Vpr和功能性非HIV-1 Vpr蛋白的功能片段和包含其的药物组合物。 公开了抑制细胞增殖的方法和治疗具有过度增殖性疾病的个体的方法。 公开了鉴定抑制Vpr蛋白与p55或p6蛋白的p6结构域结合的化合物的方法和用于进行这些方法的试剂盒。

    Genetic immunization
    57.
    发明授权
    Genetic immunization 失效
    遗传免疫

    公开(公告)号：US06468982B1

    公开(公告)日：2002-10-22

    申请号：US08880576

    申请日：1997-06-23

    申请人： David B. Weiner ,  William V. Williams ,  Bin Wang

    发明人： David B. Weiner ,  William V. Williams ,  Bin Wang

    IPC分类号： A61K4800

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  C12N15/87 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2740/16334 ,  Y02A50/464 ,  Y02A90/26 ,  Y10S435/975 ,  Y10S514/818

    摘要： Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being, expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.

    摘要翻译： 公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。 所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞 蛋白质或与自身免疫疾病相关的蛋白质。 在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。 核酸分子不含病毒颗粒，能够在所述细胞中表达。 细胞可以与细胞刺激剂接触细胞。 公开了预防和治疗个体免受HIV感染的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。

    Genetic immunization
    60.
    发明授权
    Genetic immunization 失效
    遗传免疫

    公开(公告)号：US5593972A

    公开(公告)日：1997-01-14

    申请号：US125012

    申请日：1993-09-21

    申请人： David B. Weiner ,  William V. Williams ,  Bin Wang

    发明人： David B. Weiner ,  William V. Williams ,  Bin Wang

    IPC分类号： A61K48/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  C07K14/16 ,  C12N15/87 ,  A61K45/05 ,  A61K31/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  C12N15/87 ,  A61K2039/53 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2740/16334 ,  Y10S435/975 ,  Y10S514/818

    摘要： Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.

    摘要翻译： 公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。 所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞 蛋白质或与自身免疫疾病相关的蛋白质。 在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。 核酸分子不含病毒颗粒，能够在所述细胞中表达。 细胞可以与细胞刺激剂接触细胞。 公开了预防和治疗个体免受HIV感染的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。