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公开(公告)号：US5837460A
公开(公告)日：1998-11-17
申请号：US712212
申请日：1996-09-03
IPC分类号： C07K14/53 , C07K14/535 , C07K14/54 , C07K14/55 , C07K14/61 , C07K16/06 , C07K16/24 , G01N33/68 , G01N33/74 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/74 , C07K14/53 , C07K14/535 , C07K14/5403 , C07K14/5409 , C07K14/55 , C07K14/61 , C07K16/065 , C07K16/243 , G01N33/68 , G01N33/6863 , G01N33/6869 , C07K2317/34 , C07K2317/73 , G01N2333/535 , G01N2500/00 , Y10S435/965
摘要： A method of identifying peptides which mimic biologically active proteins is disclosed. The method comprises the steps of making a recombinant antibody library from genetic material obtained from an animal which has been immunized against antibodies that bind to the biological active protein to the mimicked. Recombinant antibodies are screened to identify antibodies which compete with the biological active protein. Peptides which comprise the recombinant antibody's CDR sequences are synthesized. Synthetic peptides which mimic GM-CSF are also disclosed.
摘要翻译： 公开了鉴定模拟生物活性蛋白质的肽的方法。 该方法包括以下步骤：从已经针对结合生物活性蛋白的抗体免疫的动物获得的遗传物质制备重组抗体文库。 筛选重组抗体以鉴定与生物活性蛋白竞争的抗体。 合成包含重组抗体的CDR序列的肽。 还公开了模拟GM-CSF的合成肽。
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2.发明授权
公开(公告)号：US5637677A
公开(公告)日：1997-06-10
申请号：US940654
申请日：1992-09-03
申请人： Mark I. Greene , William V. Williams , David B. Weiner , Jeffrey A. Cohen , Thomas Kieber-Emmons , Robert M. Williams
发明人： Mark I. Greene , William V. Williams , David B. Weiner , Jeffrey A. Cohen , Thomas Kieber-Emmons , Robert M. Williams
IPC分类号： A61K39/00 , C07K14/005 , C07K14/14 , C07K14/16 , C07K14/725 , C07K14/73 , C07K14/74 , C07K16/10 , C07K7/00
CPC分类号： C07K14/005 , C07K14/7051 , C07K14/70514 , C07K14/70539 , C07K16/10 , C07K16/1063 , A61K39/00 , C12N2720/12022 , C12N2740/16122
摘要： A method of constructing biologically active compounds which mimic the biological activity of the biologically active protein or which block the activity of the biologically active protein is disclosed. A method of identifying specific and discrete portions of pathogen antigens which either serve as epitopes for neutralizing antibodies or which are involved in pathogen binding to host cell receptors is disclosed. A method of constructing biologically active compounds which compete with cellular receptors for binding to either biologically active proteins or pathogen antigens is disclosed.
摘要翻译： 公开了一种构建模拟生物活性蛋白的生物活性或阻断生物活性蛋白的活性的生物活性化合物的方法。 公开了鉴定作为中和抗体或参与病原体与宿主细胞受体结合的表位的病原体抗原的特异性和离散部分的方法。 公开了一种构建与细胞受体竞争结合生物活性蛋白或病原体抗原的生物活性化合物的方法。
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3.发明授权公开(公告)号：US06372884B1
公开(公告)日：2002-04-16
申请号：US08752816
申请日：1996-11-21
申请人： Mark I. Greene , William V. Williams , David B. Weiner , Jeffrey A. Cohen , Thomas Kieber-Emmons , Robert M. Williams
发明人： Mark I. Greene , William V. Williams , David B. Weiner , Jeffrey A. Cohen , Thomas Kieber-Emmons , Robert M. Williams
IPC分类号： C07K700
CPC分类号： C07K14/005 , A61K39/00 , C07K14/7051 , C07K14/70514 , C07K14/70539 , C07K16/10 , C07K16/1063 , C12N2720/12022 , C12N2740/16122
摘要： A method of constructing biologically active compounds which mimic the biological activity of the biologically active protein block the activity of the biologically active protein is disclosed. A method of identifying specific and discrete portions of pathogen antigens which either serve as epitopes for neutralizing antibodies or which are involved in pathogen binding to host cell receptors is disclosed. A method of constructing biologically active compounds which compete with cellular receptors for binding to either biologically active proteins or pathogen antigens is disclosed.
摘要翻译： 公开了一种构建生物活性化合物的方法，其模拟生物活性蛋白的生物活性阻断生物活性蛋白的活性。 公开了鉴定作为中和抗体或参与病原体与宿主细胞受体结合的表位的病原体抗原的特异性和离散部分的方法。 公开了一种构建与细胞受体竞争结合生物活性蛋白或病原体抗原的生物活性化合物的方法。
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4.发明授权Methods and compositions for diagnosing and treating certain HIV infected patients 失效用于诊断和治疗某些HIV感染患者的方法和组合物
公开(公告)号：US5556744A
公开(公告)日：1996-09-17
申请号：US218025
申请日：1994-03-24
CPC分类号： C07K14/005 , C12N2740/16122 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： The present invention provides a panel of HIV peptides useful in diagnosing whether or not a patient is of vertical HIV transmission status, methods for diagnosing same, methods for identifying epitopes and peptides associated with non-transmission status, and pharmaceutical and vaccine compositions containing same.
摘要翻译： 本发明提供了一组可用于诊断患者是否具有垂直HIV传播状态的HIV肽组，用于诊断其的方法，用于鉴定与非传染状态相关的表位和肽的方法，以及含有其的药物和疫苗组合物。
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公开(公告)号：US08304234B2
公开(公告)日：2012-11-06
申请号：US11317548
申请日：2005-12-23
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K31/167 , C12N15/63 , C12N15/87 , C07H21/04
CPC分类号： A61K38/193 , A61K39/00 , A61K39/0011 , A61K39/0225 , A61K39/12 , A61K39/205 , A61K39/21 , A61K39/29 , A61K39/292 , A61K48/0008 , A61K2039/53 , A61K2039/545 , A61K2039/55511 , A61K2039/55566 , C07K14/005 , C12N15/87 , C12N2730/10122 , C12N2730/10134 , C12N2740/13022 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2760/20122 , C12N2760/20134 , C12N2770/24222 , C12N2770/24234 , Y02A50/464 , Y02A90/26
摘要： Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV am disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译： 公开了将遗传物质引入个体细胞的方法和用于实施其的组合物和试剂盒。 所述方法包括使个体的细胞与多核苷酸功能增强子接触并向细胞施用不含逆转录病毒颗粒的核酸分子的步骤。 核酸分子包含编码蛋白质的核苷酸序列，该蛋白质包含与病原体抗原或与过度增殖或自身免疫疾病相关的抗原的表位相同或基本相似的至少一个表位， 涉及缺失的，非功能的或部分功能的基因或对个体产生治疗作用的蛋白质。 公开了预防和治疗个体免受HIV的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。
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6.发明授权Compositions and methods for the abrogation of cellular proliferation utilizing the human immunodeficiency virus VPR protein 失效使用人类免疫缺陷病毒VPR蛋白消除细胞增殖的组合物和方法公开(公告)号：US06667157B1
公开(公告)日：2003-12-23
申请号：US08809186
申请日：1997-06-24
IPC分类号： G01N33567
CPC分类号： C07K14/005 , A61K38/162 , A61K48/00 , C12N2710/14143 , C12N2740/16322
摘要： Method of inhibiting proliferation of cells using vpr protein or nucleotide sequences that encode vpr are disclosed. Method of preventing lymphocyte activation using vpr protein or nucleotide sequences that encode vpr are disclosed. Methods of treating an individual diagnosed with or suspected of suffering from autoimmune disease, diseases characterized by proliferating cells and graft versus host disease by administering vpr protein or a functional fragment thereof, or a nucleic acid molecule that comprises a nucleotide sequence that encodes vpr protein or a functional fragment thereof are disclosed. Conjugated compositions for delivery of active agents to the nucleus of cells are disclosed.
摘要翻译： 公开了使用vpr蛋白抑制细胞增殖的方法或编码vpr的核苷酸序列。 公开了使用vpr蛋白或编码vpr的核苷酸序列预防淋巴细胞活化的方法。 治疗患有或怀疑患有自身免疫疾病的个体的方法，通过施用vpr蛋白或其功能片段或包含编码vpr蛋白的核苷酸序列的核酸分子的核酸分子，或者包含编码vpr蛋白的核苷酸序列的核酸分子， 公开了其功能片段。 公开了将活性剂递送至细胞核的共轭组合物。
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7.发明授权Immunization with plasmid encoding immunogenic proteins and intracellular targeting sequences 有权用编码免疫原性蛋白质和细胞内靶向序列的质粒免疫公开(公告)号：US06248565B1
公开(公告)日：2001-06-19
申请号：US09496301
申请日：2000-02-02
IPC分类号： C12P2104
CPC分类号： A61K39/00 , A61K48/00 , A61K2039/53 , A61K2039/55522 , A61K2039/57 , C07K16/18 , C07K2317/73 , C07K2317/74
摘要： Improved vaccines are disclosed. The improved vaccines include a nucleotide sequence that encodes a coding sequence that comprises an immunogenic target protein linked to or comprising an intracellular cellular targeting sequence, the coding sequence being operably linked to regulatory elements are disclosed. Methods of immunizing individuals are disclosed.
摘要翻译： 公开了改进的疫苗。 改进的疫苗包括编码包含与胞内细胞靶向序列连接或包含细胞内靶向序列的免疫原性靶蛋白的编码序列的核苷酸序列，编码序列可操作地连接于调节元件。 公开了免疫个体的方法。
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公开(公告)号：US5981505A
公开(公告)日：1999-11-09
申请号：US979385
申请日：1997-11-26
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N15/87 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , A61K39/0011 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16322 , Y10S514/818
摘要： Methods of inducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译： PCT No.PCT / US94 / 00899 Sec。 371日期：1995年8月28日 102（e）日期1995年8月28日PCT 1994年1月26日PCT PCT。 公开号WO94 / 16737 日期1994年8月4日公开了将遗传物质诱导入个体细胞的方法和用于实施其的组合物和试剂盒。 所述方法包括使个体的细胞与多核苷酸功能增强子接触并向细胞施用不含逆转录病毒颗粒的核酸分子的步骤。 核酸分子包含编码蛋白质的核苷酸序列，该蛋白质包含与病原体抗原或与过度增殖或自身免疫疾病相关的抗原的表位相同或基本相似的至少一个表位， 涉及缺失的，非功能的或部分功能的基因或对个体产生治疗作用的蛋白质。 公开了预防和治疗个体免受HIV感染的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。
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公开(公告)号：US5840300A
公开(公告)日：1998-11-24
申请号：US526583
申请日：1995-09-11
CPC分类号： C07K16/00 , C07K16/1063 , A61K38/00
摘要： Methods and compositions for the generation of single chain antibody fragments.
摘要翻译： 用于产生单链抗体片段的方法和组合物。
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公开(公告)号：US07001759B1
公开(公告)日：2006-02-21
申请号：US09359975
申请日：1999-07-23
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K31/167 , C12N15/63 , C12N15/87 , C07H21/04
CPC分类号： A61K39/21 , A61K39/00 , A61K39/0011 , A61K39/0225 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/53 , A61K2039/55516 , C12N15/63 , C12N2730/10134 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2760/20134 , C12N2770/24234 , Y02A50/464 , Y02A90/26 , Y10S514/818
摘要： Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional, or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against pathogens are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译： 公开了将遗传物质引入个体细胞的方法和用于实施其的组合物和试剂盒。 所述方法包括使个体的细胞与多核苷酸功能增强子接触并向细胞施用不含逆转录病毒颗粒的核酸分子的步骤。 核酸分子包含编码蛋白质的核苷酸序列，该蛋白质包含与病原体抗原或与过度增殖或自身免疫疾病相关的抗原的表位相同或基本相似的至少一个表位， 涉及一种缺失的，非功能的或部分功能的基因或对个体产生治疗作用的蛋白质。 公开了预防和治疗个体免受病原体的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。
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