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公开(公告)号：US08323244B2
公开(公告)日：2012-12-04
申请号：US11731356
申请日：2007-03-30
申请人： Keith A. Miesel , Robert J. Coffey
发明人： Keith A. Miesel , Robert J. Coffey
CPC分类号： A61M5/14276 , A61M5/16859 , A61M2005/1726 , A61M2202/0464
摘要： Methods and systems for determining whether an implanted catheter used to deliver fluids to a selected internal delivery site is malfunctioning. The malfunctions may include that the infusion section of the catheter is not located at or has migrated away from the selected internal delivery site, is leaking, is blocked, etc. The determination is made by analyzing the pressure modulation of fluid within the catheter and determining whether the pressure of the fluid in the catheter is modulated by physiologic pressure changes experienced at the selected internal delivery site. The physiologic pressure modulations at the selected internal delivery site may be caused by, e.g., cardiac activity, respiration, changes in patient's posture, etc.
摘要翻译： 用于确定用于将流体输送到选择的内部递送部位的植入导管是否发生故障的方法和系统。 故障可能包括导管的输液部分不位于或已经偏离所选择的内部输送部位，正在泄漏，被阻塞等。通过分析导管内的流体的压力调节并确定 导管中液体的压力是否受选择的内部递送部位所经历的生理压力变化的调节。 选择的内部递送部位的生理压力调节可以由例如心脏活动，呼吸，患者姿势变化等引起。
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公开(公告)号：US20120296236A1
公开(公告)日：2012-11-22
申请号：US13561706
申请日：2012-07-30
IPC分类号： A61B5/11
CPC分类号： A61M5/14276 , A61B5/11 , A61B5/1116 , A61B5/4836 , A61B2562/0219 , A61M2005/14208 , A61M2205/17 , A61M2210/0693 , A61M2210/1053 , A61M2210/1078 , A61M2210/1089 , A61M2230/62 , A61N1/3605 , A61N1/37247
摘要： Posture-responsive therapy is delivered by the medical system based on posture state input from only one of multiple posture sensors at any given time. An example implantable medical system includes a first posture sensor and a second sensor. A processor controls therapy delivery to the patient based on at least one of a patient posture state or a patient activity level determined based on input from only one of the first or second posture sensors. In some examples, one of multiple posture sensors of an implantable posture-responsive medical system is used to automatically reorient another posture sensor (of the system), which has become disoriented. The disoriented posture sensor may be automatically reoriented for one or more posture states at a time.
摘要翻译： 姿态反应治疗由医疗系统基于在任何给定时间仅从多个姿势传感器中的一个输入的姿势状态来传送。 示例性可植入医疗系统包括第一姿态传感器和第二传感器。 处理器基于基于仅从第一或第二姿态传感器中的一个输入确定的患者姿势状态或患者活动水平中的至少一个来控制对患者的治疗递送。 在一些示例中，使用植入式姿势响应医疗系统的多个姿势传感器中的一个来自动地重新定向已经变得迷失方向的另一姿态传感器（该系统）。 错位姿态传感器可以一次自动地重新定向一个或多个姿势状态。
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公开(公告)号：US08231555B2
公开(公告)日：2012-07-31
申请号：US12433442
申请日：2009-04-30
CPC分类号： A61M5/14276 , A61B5/11 , A61B5/1116 , A61B5/4836 , A61B2562/0219 , A61M2005/14208 , A61M2205/17 , A61M2210/0693 , A61M2210/1053 , A61M2210/1078 , A61M2210/1089 , A61M2230/62 , A61N1/3605 , A61N1/37247
摘要： Posture-responsive therapy is delivered by the medical system based on posture state input from only one of multiple posture sensors at any given time. An example implantable medical system includes a first posture sensor and a second sensor. A processor controls therapy delivery to the patient based on at least one of a patient posture state or a patient activity level determined based on input from only one of the first or second posture sensors. In some examples, one of multiple posture sensors of an implantable posture-responsive medical system is used to automatically reorient another posture sensor (of the system), which has become disoriented. The disoriented posture sensor may be automatically reoriented for one or more posture states at a time.
摘要翻译： 姿态反应治疗由医疗系统基于在任何给定时间仅从多个姿势传感器中的一个输入的姿势状态来传送。 示例性可植入医疗系统包括第一姿态传感器和第二传感器。 处理器基于基于仅从第一或第二姿态传感器中的一个输入确定的患者姿势状态或患者活动水平中的至少一个来控制对患者的治疗递送。 在一些示例中，使用植入式姿势响应医疗系统的多个姿势传感器中的一个来自动地重新定向已经变得迷失方向的另一姿态传感器（该系统）。 错位姿态传感器可以一次自动地重新定向一个或多个姿势状态。
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公开(公告)号：US20120130286A1
公开(公告)日：2012-05-24
申请号：US13362785
申请日：2012-01-31
申请人： Keith A. Miesel , Kenneth T. Heruth
发明人： Keith A. Miesel , Kenneth T. Heruth
IPC分类号： A61B5/11
CPC分类号： A61B5/4848 , A61B5/103 , A61B5/1116 , A61B5/4082 , A61B5/6825 , A61B5/686 , A61M5/14276 , A61N1/0531 , A61N1/0534 , A61N1/36071 , A61N1/36082 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/37235
摘要： A medical device delivers a therapy to a patient. Posture events are identified, e.g., a posture of the patient is periodically determined and/or posture transitions by the patient are identified, and each determined posture event is associated with a current therapy parameter set. A value of at least one posture metric is determined for each of a plurality of therapy parameter sets based on the posture events associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more posture metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of posture metrics, the list may be ordered according to the one of the posture metrics selected by the user.
摘要翻译： 医疗设备向患者传递治疗。 识别姿势事件，例如，周期性地确定患者的姿势和/或患者的姿势转换，并且每个确定的姿势事件与当前治疗参数组相关联。 基于与该治疗参数组相关联的姿势事件，为多个治疗参数组中的每一个确定至少一个姿势度量的值。 将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。 可以根据一个或多个姿势度量值对列表进行排序，以帮助评估治疗参数组。 在针对多个姿势度量确定值的情况下，可以根据用户选择的姿势度量中的一个排序列表。
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公开(公告)号：US20110296925A1
公开(公告)日：2011-12-08
申请号：US12793459
申请日：2010-06-03
CPC分类号： G01L9/0072 , G01L19/142 , G01L19/143 , G01L19/147 , H01L2224/48472 , Y10T29/49002 , Y10T29/53265
摘要： The disclosure is directed to a capacitive pressure sensor, and the assembly of a capacitive pressure sensor, that may be used within an implantable medical pump. In one example, a housing ferrule that encloses one capacitive plate and includes at least one protrusion for attaching a support structure of the capacitive plate. The at least one protrusion defines a smaller inner diameter as a reference point for securing the support structure while the ferrule provides a larger inner diameter to allow the support structure to tilt inside the ferrule to orient the capacitive plate into a desired plane. Despite manufacturing irregularities, the capacitive plate can be mounted in the desired plane parallel to another capacitive plate, a diaphragm, mounted to an edge of the ferrule. In another example, an assembly tool provides a stage to orient the capacitive plate and support structure within the ferrule at a desired depth.
摘要翻译： 本公开涉及电容式压力传感器以及可在可植入医疗泵内使用的电容式压力传感器的组件。 在一个示例中，壳体套圈包围一个电容板并且包括用于附接电容板的支撑结构的至少一个突起。 所述至少一个突出部限定较小的内径作为用于固定支撑结构的参考点，同时套圈提供更大的内径以允许支撑结构在套圈内部倾斜以将电容板定向到期望的平面。 尽管制造不规则，但是电容板可以安装在平行于另一个电容板的所需平面中，该电容板安装在套圈的边缘上。 在另一示例中，组装工具提供了将电容板和支撑结构定位在套圈内的阶段，以期望的深度。
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公开(公告)号：US08055348B2
公开(公告)日：2011-11-08
申请号：US11691405
申请日：2007-03-26
IPC分类号： A61N1/36
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/0476 , A61B5/4809 , A61B5/4815 , A61B5/4818 , A61M5/14276 , A61M2005/1726 , A61M2210/0693 , A61M2230/10 , A61M2230/40 , A61M2230/62 , A61M2230/63 , A61N1/36067 , A61N1/36082 , A61N1/36135 , A61N1/36585 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep. In addition, an electroencephalogram signal may be used to identify sleep states of the patient.
摘要翻译： 系统包括一个或多个传感器和处理器。 每个传感器产生作为患者的至少一个生理参数的函数的信号，当患者睡着时可以明显改变。 处理器监视生理参数，并根据参数确定患者是否睡着了。 在一些实施例中，处理器基于多个生理参数中的每一个来确定多个睡眠度量值，每个休眠度量值指示患者睡眠的概率。 处理器可以平均或以其他方式组合多个睡眠度量值以提供与阈值进行比较的整体睡眠度量值，以便确定患者是否睡着了。 此外，可以使用脑波信号来识别患者的睡眠状态。
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公开(公告)号：US08032224B2
公开(公告)日：2011-10-04
申请号：US11691413
申请日：2007-03-26
CPC分类号： A61M5/14276 , A61B3/113 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/0488 , A61B5/11 , A61B5/1459 , A61B5/4815 , A61B5/4824 , A61B5/4839 , A61B8/06 , A61B8/12 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/08 , A61N1/36071 , A61N1/36135 , A61N1/36146 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/37241 , G06F19/00
摘要： Techniques for controlling delivery of a therapy to a patient by a medical device, such as an implantable medical device (IMD), involve a sensitivity analysis of a performance metric. The performance metric may relate to efficacy or side effects of the therapy. For example, the performance metric may comprise a sleep quality metric, an activity level metric, a movement disorder metric for patients with Parkinson's disease, epilepsy, or the like. The sensitivity analysis identifies values of therapy parameters that defines a substantially maximum or minimum value of the performance metric. The identified therapy parameters are a baseline therapy parameter set, and a medical device may control delivery of the therapy based on the baseline therapy parameter set.
摘要翻译： 用于通过医疗装置（例如可植入医疗装置（IMD））控制对患者的治疗递送的技术涉及对性能度量的灵敏度分析。 性能指标可能与治疗的功效或副作用有关。 例如，性能度量可以包括睡眠质量度量，活动水平度量，帕金森病患者的运动障碍度量，癫痫等。 灵敏度分析确定定义性能度量的基本上最大或最小值的治疗参数的值。 所确定的治疗参数是基线治疗参数组，并且医疗装置可以基于基线治疗参数集来控制治疗的递送。
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公开(公告)号：US20100280578A1
公开(公告)日：2010-11-04
申请号：US12433588
申请日：2009-04-30
CPC分类号： A61M5/14276 , A61B5/11 , A61B5/1116 , A61B5/4836 , A61B2562/0219 , A61M2005/14208 , A61M2205/17 , A61M2210/0693 , A61M2210/1053 , A61M2210/1078 , A61M2210/1089 , A61M2230/62 , A61N1/3605 , A61N1/37247
摘要： Posture-responsive therapy is delivered by the medical system based on posture state input from only one of multiple posture sensors at any given time. An example implantable medical system includes a first posture sensor and a second sensor. A processor controls therapy delivery to the patient based on at least one of a patient posture state or a patient activity level determined based on input from only one of the first or second posture sensors. In some examples, one of multiple posture sensors of an implantable posture-responsive medical system is used to automatically reorient another posture sensor (of the system), which has become disoriented. The disoriented posture sensor may be automatically reoriented for one or more posture states at a time.
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公开(公告)号：US20100280417A1
公开(公告)日：2010-11-04
申请号：US12433442
申请日：2009-04-30
CPC分类号： A61M5/14276 , A61B5/11 , A61B5/1116 , A61B5/4836 , A61B2562/0219 , A61M2005/14208 , A61M2205/17 , A61M2210/0693 , A61M2210/1053 , A61M2210/1078 , A61M2210/1089 , A61M2230/62 , A61N1/3605 , A61N1/37247
摘要： Posture-responsive therapy is delivered by the medical system based on posture state input from only one of multiple posture sensors at any given time. An example implantable medical system includes a first posture sensor and a second sensor. A processor controls therapy delivery to the patient based on at least one of a patient posture state or a patient activity level determined based on input from only one of the first or second posture sensors. In some examples, one of multiple posture sensors of an implantable posture-responsive medical system is used to automatically reorient another posture sensor (of the system), which has become disoriented. The disoriented posture sensor may be automatically reoriented for one or more posture states at a time.
摘要翻译： 姿态反应治疗由医疗系统基于在任何给定时间仅从多个姿势传感器中的一个输入的姿势状态来传送。 示例性可植入医疗系统包括第一姿态传感器和第二传感器。 处理器基于基于仅从第一或第二姿态传感器中的一个输入确定的患者姿势状态或患者活动水平中的至少一个来控制对患者的治疗递送。 在一些示例中，使用植入式姿势响应医疗系统的多个姿势传感器中的一个来自动地重新定向已经变得迷失方向的另一姿态传感器（该系统）。 错位姿态传感器可以一次自动地重新定向一个或多个姿势状态。
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公开(公告)号：US20100168607A1
公开(公告)日：2010-07-01
申请号：US12721647
申请日：2010-03-11
申请人： Keith A. Miesel
发明人： Keith A. Miesel
CPC分类号： A61M5/14276 , A61M5/16859 , A61M27/006 , A61M2005/1726 , A61M2202/0464
摘要： A method for monitoring the status of an implanted catheter includes monitoring changes in pressure within a lumen of a catheter associated with physiological parameters (“physiological pressure”) and changes in pressure within the lumen of the catheter associated with bolus infusion of fluid into the catheter or bolus withdrawal of infusion from the catheter (“bolus pressure”). Methods that employ monitoring both physiological pressure and bolus pressure can provide information that cannot be obtained from monitoring physiological pressure or bolus pressure alone.
摘要翻译： 用于监测植入导管的状态的方法包括监测与生理参数（“生理压力”）相关联的导管的内腔内的压力变化以及与将液体推入导管相关联的导管内腔内的压力变化 或推注从导管中取出输注（“推注压力”）。 采用监测生理压力和推注压力的方法可以提供单独监测生理压力或推注压力不能获得的信息。
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