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51.发明授权Composite polymers, their preparation and their use in liquid chromatography 失效复合聚合物，其制备及其在液相色谱中的应用
公开(公告)号：US5053135A
公开(公告)日：1991-10-01
申请号：US521988
申请日：1990-05-11
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
IPC: B01J20/281 , B01D15/08 , B01J20/26 , B01J20/285 , B01J41/08 , C08F2/44 , C08K3/36 , C08L33/00 , C08L33/04 , G01N30/88
CPC classification number: C08K3/36 , B01D15/08 , B01J20/26 , C08F2/44 , Y10S524/903
Abstract: A homogeneous composite polymer containing, in an interpenetrated form, 20% to 80% by weight of silica and 80% to 20% by weight of a three-dimensional crosslinked acrylic, vinyl and/or allyl copolymer comprising, in a copolymerized form, 98% to 70% by weight of at least one monofunctional acrylic, vinyl or allyl monomer and 2 % to 30% by weight of a difunctional acrylic or allyl crosslinking monomer is useful in liquid chromatography.
Abstract translation: 一种均匀的复合聚合物，其以相互渗透的形式包含20重量％至80重量％的二氧化硅和80重量％至20重量％的三维交联的丙烯酸，乙烯基和/或烯丙基共聚物，其以共聚形式包含98 至少一种单官能丙烯酸，乙烯基或烯丙基单体的重量百分比至70％，双官能丙烯酸或烯丙基交联单体的重量百分比为2％至30％可用于液相色谱。
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52.发明授权公开(公告)号：US08906608B2
公开(公告)日：2014-12-09
申请号：US11495842
申请日：2006-07-28
Applicant: Egisto Boschetti , David Hammond
Inventor： Egisto Boschetti , David Hammond
CPC classification number: G01N33/6803 , C40B30/04 , G01N33/543 , G01N33/54306 , G01N33/6845
Abstract: The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures.
Abstract translation: 本发明涉及分子生物学，组合化学和生物化学领域。 特别地，本发明描述了用于动态地减少从复杂混合物中取出的分析物之间的方差的方法和试剂盒。
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公开(公告)号：US08741351B2
公开(公告)日：2014-06-03
申请号：US13371964
申请日：2012-02-13
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61K9/50
CPC classification number: A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
Abstract translation: 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地输送用于栓塞药物治疗的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US20120213831A1
公开(公告)日：2012-08-23
申请号：US13462004
申请日：2012-05-02
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61K9/14 , A61K31/4375 , A61K49/18 , A61K31/704 , A61P35/00 , B82Y5/00 , B82B1/00
CPC classification number: A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
Abstract translation: 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地输送用于栓塞药物治疗的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US08142815B2
公开(公告)日：2012-03-27
申请号：US10919257
申请日：2004-08-17
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.
Abstract translation: 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。
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Patent Agency Ranking
56.发明授权公开(公告)号：US07670592B2
公开(公告)日：2010-03-02
申请号：US12348867
申请日：2009-01-05
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
IPC: A61K49/00
CPC classification number: A61K9/1635 , A61K47/6927
Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.
Abstract translation: 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及聚乙烯醇微球的制造方法。
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公开(公告)号：US07591993B2
公开(公告)日：2009-09-22
申请号：US10692785
申请日：2003-10-27
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
CPC classification number: A61K9/1635 , A61K47/6927
Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.
Abstract translation: 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及聚乙烯醇微球的制造方法。
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公开(公告)号：US20090186094A1
公开(公告)日：2009-07-23
申请号：US12197187
申请日：2008-08-22
Applicant: Jean-Marie Vogel , Egisto Boschetti , Richard Thomas
Inventor： Jean-Marie Vogel , Egisto Boschetti , Richard Thomas
IPC: A61K9/14
CPC classification number: A61K9/14 , A61K31/78 , A61K31/785 , A61L27/3804 , A61L27/3839 , A61L27/50 , A61L31/005 , A61L31/14 , A61L2400/06
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.
Abstract translation: 本发明涉及包含可用于组织膨胀的生物相容性，可溶胀，亲水，无毒和基本上为球形的微球的可注射组合物。 本发明还涉及使用可注射组合物的组织膨胀方法，特别是用于治疗胃食管反流病，尿失禁或尿反流疾病的方法。
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公开(公告)号：US20080220077A1
公开(公告)日：2008-09-11
申请号：US12122590
申请日：2008-05-16
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
CPC classification number: A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
Abstract translation: 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地输送用于栓塞药物治疗的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US20080118569A1
公开(公告)日：2008-05-22
申请号：US12009181
申请日：2008-01-16
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
CPC classification number: A61L27/3834 , A61K9/0024 , A61K9/08 , A61K9/1635 , A61K9/1658 , A61K9/167 , A61K35/12 , A61K35/28 , A61K35/34 , A61K35/36 , A61L2400/06 , C12N5/0075 , C12N2533/30
Abstract: The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue construction and generation. The invention also relates to methods of tissue construction and generation, for the treatment of various tissue damage and defects, using the injectable compositions.
Abstract translation: 本发明涉及包含与用于组织构建和产生的干细胞相关的生物相容性，亲水性，无毒性和基本上为球形的微球的可注射组合物。 本发明还涉及使用可注射组合物来治疗各种组织损伤和缺陷的组织结构和产生方法。
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