公开(公告)号：US07194904B2

公开(公告)日：2007-03-27

申请号：US11153368

申请日：2005-06-16

申请人： Hirofumi Higuchi

发明人： Hirofumi Higuchi

IPC分类号： G01P15/08

CPC分类号： G01C19/5719

摘要： A vibration-type angular velocity sensor realizing a suitably vibrating state of the vibrators by canceling the displacement of the vibrators caused by the gravity. The angular velocity sensor comprises base portions, vibrators coupled to the base portions, exciting means for driving and vibrating the vibrators in the x-direction, and detection means which, when an angular velocity is applied while the vibrators are being driven and vibrated, detects the angular velocity based on the vibrations of the vibrators in the y-direction at right angles with the x-direction, the angular velocity sensor further comprising position adjusting means for so adjusting the positions of the vibrators as to cancel the amount of displacement by which the vibrators are displaced by the gravity in the direction of the gravity.

摘要翻译： 一种振动型角速度传感器，其通过消除由重力引起的振动器的位移而实现振动器的适当振动的状态。 角速度传感器包括基部，耦合到基部的振动器，用于在x方向上驱动和振动振动器的激励装置，以及当振动器被驱动和振动时施加角速度时的检测装置， 基于振动器在y方向上与x方向成直角的振动的角速度，角速度传感器还包括位置调节装置，用于调节振动器的位置以消除振动器的位移量，由此， 振动器在重力方向上被重力移位。

公开(公告)号：US20060280751A1

公开(公告)日：2006-12-14

申请号：US10546293

申请日：2004-02-18

申请人： Toshio Murakami ,  Hirofumi Higuchi ,  Keiichi Makizumi ,  Toshihiro Maeda ,  Hiroshi Mizokami

发明人： Toshio Murakami ,  Hirofumi Higuchi ,  Keiichi Makizumi ,  Toshihiro Maeda ,  Hiroshi Mizokami

IPC分类号： A61K39/42 ,  C12Q1/70

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/1063 ,  C07K2317/34

摘要： A method for enhancing efficacy of a monoclonal antibody preparation is provided wherein antigens from patients are tested for their reactivity with said antibody. In accordance with the method of the invention, an amino acid sequence of an expressed protein is deduced from a nucleotide sequence determined by isolation and analysis of a target molecule gene in biopsy from patients and is compared with the previously determined amino acid sequence recognized by said monoclonal antibody preparation to thereby assess fitness of patients for administration of said monoclonal antibody preparation.

摘要翻译： 提供了增强单克隆抗体制剂功效的方法，其中测试来自患者的抗原与其抗体的反应性。 根据本发明的方法，通过从患者的活组织检查中分离和分析靶分子基因而确定的核苷酸序列推导出表达蛋白质的氨基酸序列，并将其与先前确定的所述 从而评估患者适用于所述单克隆抗体制剂的施用。

公开(公告)号：US07062970B2

公开(公告)日：2006-06-20

申请号：US10718630

申请日：2003-11-24

申请人： Hirofumi Higuchi

发明人： Hirofumi Higuchi

IPC分类号： G01P9/04

CPC分类号： G01C19/5719 ,  H02N1/008

摘要： A vibrator has a frame portion having a planar frame shape, an in-frame fixed portion which is fixed to a base portion and located in the inner space surrounded by the inner periphery of the frame portion, and a driving electrode comprising a first driving electrode disposed so as to confront the outer peripheral portion of the vibrator, and a second driving electrode which is equipped to the in-frame fixed portion so as to confront the inner peripheral portion of the frame portion, and the back-side portion of the in-frame fixed portion and the inner peripheral portion of the frame portion confronting the back-side portion are designed in an unevenly-shaped portion.

摘要翻译： 振动器具有平面框架形状的框架部分，固定到基部并且位于由框架部分的内周围围的内部空间中的框架内固定部分，以及包括第一驱动电极 被设置为面对振动器的外周部分;以及第二驱动电极，其设置在框架内固定部分中以面对框架部分的内周部分，并且其内侧部分 框架固定部分和面对背面部分的框架部分的内周部分设计成不均匀部分。

公开(公告)号：US06658937B2

公开(公告)日：2003-12-09

申请号：US10192526

申请日：2002-07-11

申请人： Kenichi Ao ,  Hirofumi Higuchi

发明人： Kenichi Ao ,  Hirofumi Higuchi

IPC分类号： G01P2100

CPC分类号： G01C19/5719

摘要： An oscillatory angular rate sensor unit includes a mount base and a sensor element installed on the mount base. The sensor element includes an oscillator which produces angular velocity-caused oscillations in a first direction when the sensor element experiences angular motion during self-excited oscillation of the oscillator in a second direction opposite the first direction. A resonant frequency of the sensor unit in the first direction is set to a value less than or equal to a reciprocal of square root of two times a difference between resonant frequencies of the oscillator in the first and second directions, thereby eliminating an error output caused by undesirable acceleration acting on the sensor unit.

摘要翻译： 振荡角速率传感器单元包括安装基座和安装在安装基座上的传感器元件。 传感器元件包括振荡器，当传感器元件在与第一方向相反的第二方向的自激振荡期间经历角度运动时，在第一方向上产生角速度引起的振荡。 传感器单元在第一方向上的谐振频率被设置为小于或等于振荡器在第一和第二方向的谐振频率之差的两倍的平方根的倒数的值，从而消除了导致的误差输出 通过作用在传感器单元上​​的不希望的加速度。

公开(公告)号：US06388633B1

公开(公告)日：2002-05-14

申请号：US09498752

申请日：2000-02-07

申请人： Hiroaki Imaizumi ,  Koji Sakauchi ,  Shuji Hagiwara ,  Hirofumi Higuchi ,  Ryotaro Manabe

发明人： Hiroaki Imaizumi ,  Koji Sakauchi ,  Shuji Hagiwara ,  Hirofumi Higuchi ,  Ryotaro Manabe

IPC分类号： H01Q1302

CPC分类号： H01Q25/007 ,  H01Q1/247 ,  H01Q3/18 ,  H01Q5/45 ,  H01Q11/08 ,  H01Q13/065 ,  H01Q19/12 ,  H01Q19/17 ,  H01Q21/245 ,  H01Q25/00

摘要： When a converter 14 is rotated via a rotation mechanism 17, the arrangement inclination angle of two primary radiators 15a and 16b can be adjusted in the range of 0 to 20 deg. with respect to an axis which is in parallel with the ground. Also the reception polarization angle due to probes of the primary radiators 15a and 15b can be adjusted in the range of 0 to 20 deg. while maintaining a preset difference in polarization angle among the satellites. Therefore, the arrangement inclination angle of the primary radiators 15a and 16b for respectively receiving signals from the two satellites, and the reception polarization angle in the primary radiators 15a and 15b can be simultaneously easily adjusted by rotating the converter 14 via the rotation mechanism 17.

摘要翻译： 当转换器14通过旋转机构17旋转时，两个一次辐射器15a和16b的排列倾斜角度可以在0至20度的范围内调节。 相对于与地面平行的轴线。 此外，由于一次辐射器15a和15b的探针引起的接收偏振角也可以在0至20度的范围内调节。 同时保持卫星之间偏振角的预设差异。 因此，通过旋转机构17旋转转换器14，能够同时容易地调整用于分别接收来自两颗卫星的信号的一次辐射器15a和16b的配置倾斜角以及一次辐射体15a和15b中的接收偏振角。

公开(公告)号：US06308567B1

公开(公告)日：2001-10-30

申请号：US09458954

申请日：1999-12-10

申请人： Hirofumi Higuchi ,  Nobuyuki Ohya ,  Tsuyoshi Fukada

发明人： Hirofumi Higuchi ,  Nobuyuki Ohya ,  Tsuyoshi Fukada

IPC分类号： G01P904

CPC分类号： G01C19/56

摘要： A compact angular velocity sensor, which can improve an S/N (signal/noise) ratio. An angular velocity sensor includes an SOI substrate, four oscillatory masses movably supported to the SOI substrate, and four detection electrodes provided outer side of the oscillatory masses for detecting displacements of the oscillatory masses. The oscillatory masses are arranged point-symmetry with respect to a predetermined point K in a flat plane parallel to the SOI substrate. Each of the four oscillatory masses adjacent each other is oscillated in reverse phase in a circumstantial direction about the predetermined point K along the flat plane. When an angular velocity &OHgr; is generated about the predetermined point K, detection weights of the oscillatory masses are displaced along a direction perpendicular to oscillation direction in the flat plane. Capacitance changes between the detection weights and the detection electrodes are processed in a circuit portion so as to output angular velocity detection signal S1 due to Corioli's force with canceling external acceleration and centrifugal force acted to the detection weights of the oscillatory masses.

摘要翻译： 一个紧凑的角速度传感器，可以提高S / N（信号/噪声）比。 角速度传感器包括SOI基板，可移动地支撑到SOI基板的四个振荡块，以及设置在振荡块的外侧的四个检测电极，用于检测振荡质量的位移。 相对于与SOI衬底平行的平面中的预定点K，振荡质量被布置成点对称。 在彼此相邻的四个振荡质量块中的每一个沿着平面在围绕预定点K的环境方向上以相反方向振荡。 当围绕预定点K产生角速度OMEGA时，振荡质量的检测权重沿平面内与振荡方向垂直的方向移位。 在电路部分处理检测权重和检测电极之间的电容变化，以便通过抵消外部加速度和科氏力的角度来输出角速度检测信号S1，该离心力作用于振荡质量的检测重量。

公开(公告)号：US06052099A

公开(公告)日：2000-04-18

申请号：US252984

申请日：1999-02-19

申请人： Hiroaki Imaizumi ,  Koji Sakauchi ,  Shuji Hagiwara ,  Hirofumi Higuchi ,  Ryotaro Manabe

发明人： Hiroaki Imaizumi ,  Koji Sakauchi ,  Shuji Hagiwara ,  Hirofumi Higuchi ,  Ryotaro Manabe

IPC分类号： H01Q1/24 ,  H01Q13/06 ,  H01Q19/17 ,  H01Q25/00 ,  H01Q19/12

CPC分类号： H01Q13/065 ,  H01Q1/247 ,  H01Q19/17 ,  H01Q25/00

摘要： When a converter 14 is rotated via a rotation mechanism 17, the arrangement inclination angle of two primary radiators 15a and 15b can be adjusted in the range of 0 to 20 deg. with respect to an axis which is in parallel with the ground. Also the reception polarization angle due to probes of the primary radiators 15a and 15b can be adjusted in the range of 0 to 20 deg. while maintaining a preset difference in polarization angle among the satellites. Therefore, the arrangement inclination angle of the primary radiators 15a and 15b for respectively receiving signals from the two satellites, and the reception polarization angle in the primary radiators 15a and 15b can be simultaneously easily adjusted by rotating the converter 14 via the rotation mechanism 17.

公开(公告)号：US5824818A

公开(公告)日：1998-10-20

申请号：US698478

申请日：1996-08-15

申请人： Takafumi Abe ,  Toshiyuki Gotoh ,  Takako Uchiyama ,  Hirofumi Higuchi ,  Yoshikazu Shima ,  Kazuto Ikemoto

发明人： Takafumi Abe ,  Toshiyuki Gotoh ,  Takako Uchiyama ,  Hirofumi Higuchi ,  Yoshikazu Shima ,  Kazuto Ikemoto

IPC分类号： C07C67/20 ,  C07C69/66

CPC分类号： C07C67/20

摘要： A process for preparing a lactate which includes: (a) preparing lactonitrile from prussic acid and acetaldehyde, (b) hydrating the lactonitrile to form lactamide, (c) forming the desired lactate and formamide from lactamide and formate (or methanol and carbon monoxide), (d) separating and collecting components, having a lower boiling point than that of lactate from the reaction liquid in step (c), by distillation under specified conditions, and (e) dehydrating formamide from step (d) to form prussic acid and recycling the prussic acid to step (a). Heretofore, lactates had been manufactured by forming lactonitrile (cyanohydrin) from acetaldehyde and prussic acid, and then esterifying lactonitrile with a mineral acid or the like. However, in this conventional process, ammonium salts were formed as by-products in an amount equal to that of the lactate. According to the present invention, a lactate can be efficiently manufactured on a commercial scale without forming a large amount of the ammonium salts as by-products. In particular, the yield of the lactate can be increased by controlling the formation of 2-formyloxy propionate and also a dimer of a lactate.

摘要翻译： 一种制备乳酸的方法，其包括：（a）从丙二酸和乙醛制备乳腈，（b）使乳腈水合形成乳酰胺，（c）从乳酰胺和甲酸盐（或甲醇和一氧化碳）形成所需的乳酸盐和甲酰胺， ，（d）在步骤（c）中通过蒸馏从特定条件下蒸馏分离和收集沸点低于乳酸盐的组分，并且（e）从步骤（d）中将甲酰胺脱水形成二甲苯， 将重要的酸回收到步骤（a）。 迄今为止，已经通过从乙醛和氢溴酸形成乳腈（氰醇），然后用无机酸等使乳腈酯化来制造乳酸盐。 然而，在该常规方法中，形成铵盐，其量等于乳酸盐的副产物。 根据本发明，可以以商业规模有效地制造乳酸盐，而不会形成大量的作为副产物的铵盐。 特别地，通过控制2-甲酰氧基丙酸酯和乳酸二聚体的形成可以提高乳酸产率。

公开(公告)号：US5463123A

公开(公告)日：1995-10-31

申请号：US135062

申请日：1993-10-12

申请人： Takako Uchiyama ,  Hirofumi Higuchi

发明人： Takako Uchiyama ,  Hirofumi Higuchi

IPC分类号： B01J23/34 ,  B01J37/16 ,  C07B61/00 ,  C07C231/06 ,  C07C235/06

CPC分类号： C07C231/065 ,  C07C231/06

摘要： There is disclosed a process for producing .alpha.-hydroxyisobutyramide by hydration reaction of acetone cyanohydrin in the presence of a catalyst consisting essentially of manganese dioxide which process comprises pretreating the catalyst with a reducing agent. The above process is capable of eliminating the catalyst clogging trouble due to the deposition of the by-produced oxamide and thus proceeding with long-term reaction with the stabilized catalyst performance.

摘要翻译： 公开了在主要由二氧化锰组成的催化剂存在下，通过丙酮氰醇的水合反应制备α-羟基异丁酰胺的方法，该方法包括用还原剂预处理催化剂。 上述方法能够消除由于副产物酰胺沉积引起的催化剂堵塞问题，从而与稳定的催化剂性能进行长期反应。

公开(公告)号：US5391813A

公开(公告)日：1995-02-21

申请号：US135247

申请日：1993-10-12

申请人： Nobuyuki Muro ,  Takafumi Abe ,  Hirofumi Higuchi

发明人： Nobuyuki Muro ,  Takafumi Abe ,  Hirofumi Higuchi

IPC分类号： C07B61/00 ,  C07C67/20 ,  C07C69/675

CPC分类号： C07C67/20

摘要： There is disclosed a process for efficiently producing methyl .alpha.-hydroxyisobutyrate from .alpha.-hydroxyisobutyramide and methyl formate by means of reaction distillation which comprises feeding .alpha.-hydroxyisobutyramide and an alkali metal hydroxide in a continuous distillation column to prepare therein the dehydrated condensate of .alpha.-hydroxyisobutyramide with the alkali metal hydroxide as the catalyst and reacting remaining .alpha.-hydroxyisobutyramide with methyl formate in the presence of the dehydrated condensate as the catalyst.According to the above process, the objective methyl .alpha.-hydroxyisobutyrate is continuously obtained in high yield and high selectivity without any operational trouble.

摘要翻译： 公开了一种通过反应蒸馏从α-羟基异丁酰胺和甲酸甲酯有效生产α-羟基异丁酸甲酯的方法，其中包括在连续蒸馏塔中加入α-羟基异丁酰胺和碱金属氢氧化物，以制备α-羟基异丁酰胺的脱水缩合物 与碱金属氢氧化物作为催化剂，并在脱水缩合物作为催化剂存在下使残余的α-羟基异丁酰胺与甲酸甲酯反应。 根据上述方法，以高产率和高选择性连续获得目标α-羟基异丁酸甲酯，没有任何操作故障。