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公开(公告)号：US08476319B2
公开(公告)日：2013-07-02
申请号：US11908185
申请日：2006-03-10
IPC分类号： A61K31/23 , C07C69/533 , C07C69/58 , C07C69/28 , C07C69/30 , A61K31/225
CPC分类号： A61K31/20 , A61K31/045 , A61K31/075 , A61K31/19 , A61K31/215 , A61K31/23 , A61K31/231 , A61K2300/00
摘要： Methods of treating and/or preventing otitis media in a subject are provided. Methods of treating and/or preventing otitis externa are also provided.
摘要翻译： 提供了治疗和/或预防受试者中耳炎的方法。 还提供治疗和/或预防外耳炎的方法。
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公开(公告)号：US20120100039A1
公开(公告)日：2012-04-26
申请号：US13379573
申请日：2010-06-23
申请人： Maria A. Appeaning , Audrey A. Sherman , Michael A. Meis , Marie A. Boulos , Kevin D. Landgrebe , Kevin R. Schaffer , Matthew T. Scholz , Thu-Van T. Tran , Narina Y. Stepanova , Caroline M. Ylitalo
发明人： Maria A. Appeaning , Audrey A. Sherman , Michael A. Meis , Marie A. Boulos , Kevin D. Landgrebe , Kevin R. Schaffer , Matthew T. Scholz , Thu-Van T. Tran , Narina Y. Stepanova , Caroline M. Ylitalo
CPC分类号： A61L2/088
摘要： Light-activated antimicrobial devices and articles are disclosed. The devices include a light source and a light-activated antimicrobial article comprising a photosensitizer and a viscoelastic material such as a pressure sensitive adhesive adapted to receive light from the light source. The viscoelastic material may be adapted to transport light by total internal reflection. The photosensitizer may comprise a dye, a metal oxide or a composition that comprises anions that oxidize or react to form a gas. Upon activation of the light source, the photosensitizer absorbs light from the light source such that antimicrobial activity is exhibited. The photosensitizer may be included in the light-activated antimicrobial article or it may be provided as a topical composition that is separate from the article. The light-activated antimicrobial articles and devices may have constructions similar to those of wound dressings.
摘要翻译： 公开了光活化的抗微生物装置和制品。 所述装置包括光源和光活化的抗微生物制品，其包含光敏剂和粘弹性材料，例如适于接收来自光源的光的压敏粘合剂。 粘弹性材料可以适于通过全内反射传输光。 光敏剂可以包含染料，金属氧化物或包含氧化或反应形成气体的阴离子的组合物。 在光源激活时，光敏剂吸收光源的光，从而显示出抗微生物活性。 光敏剂可以包括在光激活的抗微生物制品中，或者它可以作为与制品分离的局部组合物提供。 光活化的抗菌制品和装置可以具有与伤口敷料相似的结构。
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公开(公告)号：US20120077886A1
公开(公告)日：2012-03-29
申请号：US13260589
申请日：2010-03-25
摘要： Melt additive ionic and non-ionic surfactants to impart stable durable hydrophilicity to thermoplastic polymers or blends thereof.
摘要翻译： 熔融添加剂离子和非离子表面活性剂，以赋予热塑性聚合物或其共混物稳定的持久亲水性。
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公开(公告)号：US08118766B2
公开(公告)日：2012-02-21
申请号：US11836353
申请日：2007-08-09
申请人： Robert A. Davis , Matthew T. Scholz , Triet M. Lu
发明人： Robert A. Davis , Matthew T. Scholz , Triet M. Lu
IPC分类号： A61M37/00
CPC分类号： A61M35/006
摘要： Skin antiseptic composition dispensers and methods of use are disclosed. The skin antiseptic composition dispenser may include a container with one or more walls that are substantially impermeable to ethylene oxide gas during normal ethylene oxide sterilization processes. In some embodiments, the container may include flexible walls free of metallic foil barrier layers. The containers may also include one or more vents in addition to one or more openings used to dispense the skin antiseptic composition within the container. The dispenser may include an applicator with a hydrophilic foam.
摘要翻译： 公开了皮肤防腐剂组合物分配器和使用方法。 皮肤消毒组合物分配器可以包括具有一个或多个壁的容器，所述壁在正常环氧乙烷灭菌过程中基本上不渗透环氧乙烷气体。 在一些实施例中，容器可以包括没有金属箔阻挡层的柔性壁。 除了用于分配容器内的皮肤消毒组合物的一个或多个开口之外，容器还可以包括一个或多个通气口。 分配器可以包括具有亲水性泡沫的涂布器。
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55.发明授权Water-in-oil emulsions with ethylene oxide groups, compositions, and methods 有权具有环氧乙烷基团的油包水乳液，组合物和方法公开(公告)号：US08026327B2
公开(公告)日：2011-09-27
申请号：US11256135
申请日：2005-10-21
CPC分类号： A61K8/86 , A01N59/12 , A61K8/06 , A61K8/064 , A61K8/8152 , A61K8/8158 , A61K33/18 , A61K47/34 , A61K47/58 , A61Q1/02 , A61Q17/005 , A61Q19/00 , C08L33/06 , C08L33/062 , C08L33/066 , Y10S514/844 , Y10S514/845 , A01N25/10 , A01N25/04 , A01N2300/00
摘要： Water-in-oil emulsions, compositions, and methods that include a vinyl polymer that includes ethylene oxide-containing side chains and alkyl-Y-containing side chains, wherein Y is O or NR, wherein R is H or CH3, and wherein the alkyl group of the alkyl-Y-containing side chain has at least 4 carbon atoms on average in a cyclic, branched-, or straight-chain configuration and optionally including one or more heteroatoms.
摘要翻译： 油包水乳液，组合物和方法，其包括含有含环氧乙烷的侧链和含烷基Y的侧链的乙烯基聚合物，其中Y为O或NR，其中R为H或CH 3，并且其中 含有烷基Y的侧链的烷基在环状，支链或直链构型中平均具有至少4个碳原子，并任选地包括一个或多个杂原子。
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公开(公告)号：US20110166594A1
公开(公告)日：2011-07-07
申请号：US13119267
申请日：2009-09-30
IPC分类号： A61B17/00
CPC分类号： A61F5/08
摘要： The present invention discloses a nasal dilator comprising at least one breathable layer of adhesive-coated high MVTR layer, such as a polyurethane film, one or more adhesive-coated high modulus “spring” elements for dilating the nasal passages by applying a tension force to the skin, and a carrier delivery system. The carrier delivery system comprises a separation line or split through the carrier to allow for easy delivery of the nasal dilator. The carrier aids in the handling and delivery of the thin adhesive-coated high MVTR layer.
摘要翻译： 本发明公开了一种鼻扩张器，其包括粘合剂涂覆的高MVTR层的至少一个透气层，例如聚氨酯膜，一个或多个粘合剂涂覆的高模量“弹簧”元件，用于通过施加张力来扩张鼻通道 皮肤和载体输送系统。 载体递送系统包括分离线或通过载体分离以允许容易地递送鼻扩张器。 载体有助于处理和输送薄的涂有粘合剂的高MVTR层。
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公开(公告)号：US07968562B2
公开(公告)日：2011-06-28
申请号：US12172712
申请日：2008-07-14
申请人： Raymond D. Skwierczynski , Terri F. Busch , Amy L. Gust-Heiting , Mary Fretland , Matthew T. Scholz
发明人： Raymond D. Skwierczynski , Terri F. Busch , Amy L. Gust-Heiting , Mary Fretland , Matthew T. Scholz
IPC分类号： A01N43/42 , A01N43/50 , A61K31/44 , A61K31/415 , C07D471/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00
CPC分类号： A61K31/437 , A61K9/0014 , A61K31/4355 , A61K31/4365 , A61K31/4375 , A61K31/4745 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/36 , A61K47/44
摘要： Pharmaceutical formulations comprising an immune response modifier (IRM) chosen from imidazoquinoline amines, imidazotetrahydroquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo-quinolineamines, oxazolo-quinolinamines, thiazolo-pyridinamines, oxazolo-pyridinamines, imidazonaphthyridine amines, tetrahydroimidazonaphthyridine amines, and thiazolonaphthyridine amines; a fatty acid; and a hydrophobic, aprotic component miscible with the fatty acid are useful for the treatment of dermal associated conditions. Novel topical formulations are provided. In one embodiment, the topical formulations are advantageous for treatment of actinic keratosis, postsurgical scars, basal cell carcinoma, atopic dermatitis, and warts.
摘要翻译： 包含选自咪唑并喹啉胺，咪唑四氢喹啉胺，咪唑并吡啶胺，6,7-稠合的环烷基咪唑并吡啶胺，1,2-桥连的咪唑并喹啉胺，噻唑并喹啉胺，恶唑并喹啉胺，噻唑并 - 吡啶胺，恶唑啉 吡啶胺，咪唑并吡啶胺，四氢咪唑并吡啶胺和噻唑烷吡啶胺; 脂肪酸 并且与脂肪酸可混溶的疏水性非质子组分可用于治疗真皮相关病症。 提供新的局部制剂。 在一个实施方案中，局部制剂有利于治疗光化性角化病，术后瘢痕，基底细胞癌，特应性皮炎和疣。
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公开(公告)号：US07879746B2
公开(公告)日：2011-02-01
申请号：US10885150
申请日：2004-07-06
申请人： Thomas P. Klun , Wayne K. Dunshee , Kevin R. Schaffer , Jeffrey F. Andrews , Debra M. Neu , Matthew T. Scholz
发明人： Thomas P. Klun , Wayne K. Dunshee , Kevin R. Schaffer , Jeffrey F. Andrews , Debra M. Neu , Matthew T. Scholz
CPC分类号： B32B5/02 , A61F13/531 , A61F13/8405 , A61F2013/8414 , A61L15/20 , A61L15/24 , A61L15/46 , A61L2300/21 , A61L2300/404 , B32B27/02 , B32B2262/0253 , B32B2305/08 , B32B2307/7145 , B32B2307/724 , B32B2307/7265 , B32B2307/728 , B32B2323/00 , B32B2535/00 , B32B2555/02 , D01F1/10 , D01F1/103 , D01F6/06 , D01F6/46 , D01F11/06 , D06M13/184 , D06M13/207 , D06M16/00 , Y10T442/2525 , Y10T442/3976 , Y10T442/40 , Y10T442/696 , C08L23/12
摘要： Polypropylene fibers and devices that include a fatty acid monoglyceride added to the polypropylene as a melt additive are described. A hydrophilic enhancer material can be advantageously added to the polypropylene as a melt additive to enhance the hydrophilicity of the fibers and devices. An antimicrobial enhancer material can be added to the fibers to enhance the antimicrobial activity.
摘要翻译： 描述了聚丙烯纤维和包含作为熔融添加剂添加到聚丙烯中的脂肪酸单甘油酯的装置。 亲水增强剂材料可有利地作为熔融添加剂加入到聚丙烯中以增强纤维和设备的亲水性。 可以将抗微生物增强剂材料加入到纤维中以增强抗微生物活性。
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公开(公告)号：US20100331422A1
公开(公告)日：2010-12-30
申请号：US12878883
申请日：2010-09-09
IPC分类号： A61K31/155 , A61K31/045 , A61P31/04 , A61P31/12 , A61P31/10
CPC分类号： A61Q19/00 , A61K8/31 , A61K8/34 , A61K8/342 , A61K8/39 , A61K8/86 , A61K8/894 , A61K31/045 , A61Q17/005 , Y10S514/844 , Y10S514/938 , Y10S514/941
摘要： A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system comprised of at least one emulsifier present in at least 0.05% by weight wherein the composition in a polymer free state has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein the emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The hydroalcoholic composition is useful as a hand preparation such as a lotion or as a presurgical scrub replacement.
摘要翻译： 公开了一种水醇洗剂，其包含（a）重量比为约35:65至100:0的低级醇和水，和（b）至少0.5％至8％重量比的增稠剂体系，其包含至少一种 乳化剂以至少0.05重量％的量存在，其中无聚合物状态的组合物在23℃具有至少4,000厘泊的粘度，并且其中乳化剂由至少一个疏水基团和至少一个亲水基团组成。 水醇组合物可用作手制剂如洗剂或作为手术前洗涤剂。
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公开(公告)号：US07851522B2
公开(公告)日：2010-12-14
申请号：US11265911
申请日：2005-11-03
CPC分类号： C09J123/0853 , C08L33/14 , C08L33/26 , C08L39/06 , C08L2666/04 , Y10T442/2943
摘要： An aqueous adhesive composition includes a polymer adhesive material having a pH of less than 7, a cationic thickener or an anionic thickener formed from at least one anionic monomer having a pKa of less than 3, and water. The adhesive composition has a stringing length of 9 cm or less and a sag distance of 10 mm or less.
摘要翻译： 水性粘合剂组合物包括pH小于7的聚合物粘合剂材料，由至少一种pKa小于3的阴离子单体形成的阳离子增稠剂或阴离子增稠剂和水。 粘合剂组合物的拉丝长度为9cm以下，下垂距离为10mm以下。
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